DK1206457T3 - Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER - Google Patents
Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ERInfo
- Publication number
- DK1206457T3 DK1206457T3 DK00959401T DK00959401T DK1206457T3 DK 1206457 T3 DK1206457 T3 DK 1206457T3 DK 00959401 T DK00959401 T DK 00959401T DK 00959401 T DK00959401 T DK 00959401T DK 1206457 T3 DK1206457 T3 DK 1206457T3
- Authority
- DK
- Denmark
- Prior art keywords
- ppaps
- biaryl
- thia
- oxa
- modulators
- Prior art date
Links
- 208000020369 Polymerase proofreading-related adenomatous polyposis Diseases 0.000 title 1
- 241000534944 Thia Species 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15116299P | 1999-08-27 | 1999-08-27 | |
| PCT/US2000/023358 WO2001016120A1 (en) | 1999-08-27 | 2000-08-23 | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1206457T3 true DK1206457T3 (da) | 2004-02-16 |
Family
ID=22537578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00959401T DK1206457T3 (da) | 1999-08-27 | 2000-08-23 | Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6417212B1 (da) |
| EP (1) | EP1206457B1 (da) |
| JP (1) | JP2003508389A (da) |
| AR (1) | AR025386A1 (da) |
| AT (1) | ATE252091T1 (da) |
| AU (1) | AU7073400A (da) |
| CA (1) | CA2382966A1 (da) |
| DE (1) | DE60005973T2 (da) |
| DK (1) | DK1206457T3 (da) |
| ES (1) | ES2204684T3 (da) |
| PE (1) | PE20010529A1 (da) |
| PT (1) | PT1206457E (da) |
| WO (1) | WO2001016120A1 (da) |
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| AU2000265105A1 (en) * | 2000-08-02 | 2002-02-13 | Pharmanutrients | Methods and compositions for the prevention and treatment of syndrome x |
| JP4790969B2 (ja) * | 2000-08-11 | 2011-10-12 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| DK1313716T3 (da) | 2000-08-23 | 2007-08-27 | Lilly Co Eli | Oxazolyl-arylpropionsyrederivater og anvendelse deraf som PPAR-agonister |
| CA2420178A1 (en) | 2000-08-23 | 2002-03-07 | Eli Lilly And Company | Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists |
| CA2418134A1 (en) | 2000-08-23 | 2002-02-28 | Eli Lilly And Company | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
| GB0029974D0 (en) | 2000-12-08 | 2001-01-24 | Glaxo Group Ltd | Chemical compounds |
| GB0031109D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7105551B2 (en) * | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
| KR20070120617A (ko) | 2001-01-26 | 2007-12-24 | 쉐링 코포레이션 | 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물 |
| IL156445A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
| GB0113231D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
| CN1543451A (zh) * | 2001-06-07 | 2004-11-03 | 过氧化物酶体增生剂激活的受体的调节剂 | |
| DE60216094T2 (de) * | 2001-06-07 | 2007-06-06 | Eli Lilly And Co., Indianapolis | Modulatoren der peroxisom-proliferator-aktivierten rezeptoren (ppar) |
| US20110065129A1 (en) | 2001-07-27 | 2011-03-17 | Lowe Derek B | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| AR036237A1 (es) * | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
| WO2003016291A1 (en) | 2001-08-10 | 2003-02-27 | Nippon Chemiphar Co., Ltd. | ACTIVATOR FOR PEROXISOME PROLIFERATOR-RESPONSIVE RECEPTOR δ |
| IL160845A0 (en) | 2001-09-14 | 2004-08-31 | Tularik Inc | Linked biaryl compounds |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| EP1429756B1 (en) | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
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| US6867224B2 (en) | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
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| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
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| CN1662487A (zh) | 2002-06-19 | 2005-08-31 | 伊莱利利公司 | 酰胺连接基过氧化物酶体增殖物激活受体调节剂 |
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| US7192970B2 (en) * | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
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| CN1751037A (zh) | 2003-02-14 | 2006-03-22 | 伊莱利利公司 | 作为ppar调节剂的磺酰胺衍生物 |
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| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
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| JP2020523326A (ja) | 2017-06-14 | 2020-08-06 | フォーディー ファーマ リサーチ リミテッド４Ｄ Ｐｈａｒｍａ Ｒｅｓｅａｒｃｈ Ｌｉｍｉｔｅｄ | 細菌株を含む組成物 |
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| JPH08325264A (ja) | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体 |
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| PT859608E (pt) * | 1995-09-18 | 2004-06-30 | Ligand Pharm Inc | Tratamento de niddm com agonistas de rxr |
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| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
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| US6586455B1 (en) * | 1996-12-31 | 2003-07-01 | The Salk Institute For Biological Studies | Treatment of liposarcomas using a combination of thiazolidinediones and retinoid X receptor selective agonists |
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| GB9817118D0 (en) * | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
-
2000
- 2000-08-23 WO PCT/US2000/023358 patent/WO2001016120A1/en not_active Ceased
- 2000-08-23 DE DE60005973T patent/DE60005973T2/de not_active Expired - Lifetime
- 2000-08-23 AU AU70734/00A patent/AU7073400A/en not_active Abandoned
- 2000-08-23 AT AT00959401T patent/ATE252091T1/de not_active IP Right Cessation
- 2000-08-23 CA CA002382966A patent/CA2382966A1/en not_active Abandoned
- 2000-08-23 PT PT00959401T patent/PT1206457E/pt unknown
- 2000-08-23 DK DK00959401T patent/DK1206457T3/da active
- 2000-08-23 JP JP2001519687A patent/JP2003508389A/ja not_active Withdrawn
- 2000-08-23 US US09/644,457 patent/US6417212B1/en not_active Expired - Fee Related
- 2000-08-23 EP EP00959401A patent/EP1206457B1/en not_active Expired - Lifetime
- 2000-08-23 ES ES00959401T patent/ES2204684T3/es not_active Expired - Lifetime
- 2000-08-25 PE PE2000000876A patent/PE20010529A1/es not_active Application Discontinuation
- 2000-08-25 AR ARP000104410A patent/AR025386A1/es unknown
-
2002
- 2002-04-11 US US10/121,373 patent/US6610696B2/en not_active Expired - Fee Related
-
2003
- 2003-05-07 US US10/434,425 patent/US6825222B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60005973D1 (de) | 2003-11-20 |
| WO2001016120A9 (en) | 2002-07-11 |
| PT1206457E (pt) | 2004-03-31 |
| ES2204684T3 (es) | 2004-05-01 |
| US20040019090A1 (en) | 2004-01-29 |
| WO2001016120A1 (en) | 2001-03-08 |
| CA2382966A1 (en) | 2001-03-08 |
| EP1206457B1 (en) | 2003-10-15 |
| DE60005973T2 (de) | 2004-05-13 |
| AR025386A1 (es) | 2002-11-27 |
| AU7073400A (en) | 2001-03-26 |
| ATE252091T1 (de) | 2003-11-15 |
| US6825222B2 (en) | 2004-11-30 |
| JP2003508389A (ja) | 2003-03-04 |
| US6417212B1 (en) | 2002-07-09 |
| US6610696B2 (en) | 2003-08-26 |
| EP1206457A1 (en) | 2002-05-22 |
| US20030045558A1 (en) | 2003-03-06 |
| PE20010529A1 (es) | 2001-05-18 |
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