DK1230238T3 - Fremgangsmåde til fremstillingen af fumagillin - Google Patents

Fremgangsmåde til fremstillingen af fumagillin

Info

Publication number: DK1230238T3
Authority: DK; Denmark
Prior art keywords: fumagillin; preparation; salt; liberation; organic acid
Prior art date: 1999-06-11

Application number

DK00938947T

Other languages

English (en)

Inventor

Istvan Hermecz

Kalman Simon

Gyula Farkas

Andrea Gyorbiro

Anna Szabo

Arpadne Vasvari

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-11

Filing date

2000-06-06

Publication date

2007-08-13

2000-06-06 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2007-08-13 Application granted granted Critical

2007-08-13 Publication of DK1230238T3 publication Critical patent/DK1230238T3/da

Links

NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 title abstract 2
NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 title abstract 2
229960000936 fumagillin Drugs 0.000 title abstract 2
230000001476 alcoholic effect Effects 0.000 abstract 1
OLRILZDTQKZQIG-PNLOCOOESA-N n-cyclohexylcyclohexanamine;(2e,4e,6e,8e)-10-[[(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid Chemical compound C1CCCCC1NC1CCCCC1.C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 OLRILZDTQKZQIG-PNLOCOOESA-N 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK00938947T 1999-06-11 2000-06-06 Fremgangsmåde til fremstillingen af fumagillin DK1230238T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9901943A HUP9901943A2 (hu)	1999-06-11	1999-06-11	Eljárás fumagillin előállítására
PCT/HU2000/000054 WO2000076994A2 (en)	1999-06-11	2000-06-06	Process for the preparation of fumagillin

Publications (1)

Publication Number	Publication Date
DK1230238T3 true DK1230238T3 (da)	2007-08-13

Family

ID=89998483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00938947T DK1230238T3 (da)	1999-06-11	2000-06-06	Fremgangsmåde til fremstillingen af fumagillin

Country Status (13)

Country	Link
US (1)	US6521764B1 (da)
EP (1)	EP1230238B1 (da)
JP (1)	JP3923798B2 (da)
AT (1)	ATE361292T1 (da)
AU (1)	AU5416600A (da)
CA (1)	CA2374639C (da)
CY (1)	CY1106728T1 (da)
DE (1)	DE60034699T2 (da)
DK (1)	DK1230238T3 (da)
ES (1)	ES2284500T3 (da)
HU (2)	HUP9901943A2 (da)
PT (1)	PT1230238E (da)
WO (1)	WO2000076994A2 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2217283A2 (en) *	2007-11-28	2010-08-18	Mersana Therapeutics, Inc.	Biocompatible biodegradable fumagillin analog conjugates
CN105622593B (zh) *	2016-02-25	2018-06-26	中国农业科学院蜜蜂研究所	一种烟曲霉素的提取方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE36735C (de)			L. ET1ENNE in Paris, 99 Avenue Parmentier	Rohrverbindung
DD36735A (da) *
AT193076B (de) *	1953-12-17	1957-11-25	Abbott Lab	Verfahren zur Herstellung von neuen Salzen des Fumagillins
AT281289B (de) *	1968-01-17	1970-05-11	Chinoin Gyogyszer Es Vegyeszet	Verfahren zur Herstellung eines neuen Fumagillinsalzes
US5328930A (en)	1993-03-01	1994-07-12	Emory University	Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin

1999
- 1999-06-11 HU HU9901943A patent/HUP9901943A2/hu unknown
2000
- 2000-06-06 HU HU0201574A patent/HU227695B1/hu unknown
- 2000-06-06 DK DK00938947T patent/DK1230238T3/da active
- 2000-06-06 AT AT00938947T patent/ATE361292T1/de active
- 2000-06-06 ES ES00938947T patent/ES2284500T3/es not_active Expired - Lifetime
- 2000-06-06 DE DE60034699T patent/DE60034699T2/de not_active Expired - Lifetime
- 2000-06-06 CA CA002374639A patent/CA2374639C/en not_active Expired - Fee Related
- 2000-06-06 WO PCT/HU2000/000054 patent/WO2000076994A2/en not_active Ceased
- 2000-06-06 JP JP2001503852A patent/JP3923798B2/ja not_active Expired - Fee Related
- 2000-06-06 EP EP00938947A patent/EP1230238B1/en not_active Expired - Lifetime
- 2000-06-06 PT PT00938947T patent/PT1230238E/pt unknown
- 2000-06-06 US US10/009,116 patent/US6521764B1/en not_active Expired - Lifetime
- 2000-06-06 AU AU54166/00A patent/AU5416600A/en not_active Abandoned
2007
- 2007-07-13 CY CY20071100934T patent/CY1106728T1/el unknown

Also Published As

Publication number	Publication date
CY1106728T1 (el)	2012-05-23
JP3923798B2 (ja)	2007-06-06
HUP0201574A3 (en)	2003-08-28
DE60034699D1 (de)	2007-06-14
CA2374639C (en)	2008-07-15
JP2003502324A (ja)	2003-01-21
AU5416600A (en)	2001-01-02
WO2000076994A3 (en)	2001-02-08
HUP0201574A2 (en)	2002-08-28
ES2284500T3 (es)	2007-11-16
PT1230238E (pt)	2007-06-22
HU227695B1 (en)	2011-12-28
DE60034699T2 (de)	2008-01-17
US6521764B1 (en)	2003-02-18
HU9901943D0 (en)	1999-08-30
EP1230238A2 (en)	2002-08-14
ATE361292T1 (de)	2007-05-15
HUP9901943A2 (hu)	2001-12-28
CA2374639A1 (en)	2000-12-21
EP1230238B1 (en)	2007-05-02
WO2000076994A2 (en)	2000-12-21

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