DK1238065T3 - Faktor X-analog med forbedret evne til aktivering - Google Patents

Faktor X-analog med forbedret evne til aktivering

Info

Publication number
DK1238065T3
DK1238065T3 DK00949465T DK00949465T DK1238065T3 DK 1238065 T3 DK1238065 T3 DK 1238065T3 DK 00949465 T DK00949465 T DK 00949465T DK 00949465 T DK00949465 T DK 00949465T DK 1238065 T3 DK1238065 T3 DK 1238065T3
Authority
DK
Denmark
Prior art keywords
analog
factor
enhanced activation
activation capability
amino acid
Prior art date
Application number
DK00949465T
Other languages
Danish (da)
English (en)
Inventor
Michele Himmelspach
Uwe Schlokat
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Application granted granted Critical
Publication of DK1238065T3 publication Critical patent/DK1238065T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK00949465T 1999-08-10 2000-08-07 Faktor X-analog med forbedret evne til aktivering DK1238065T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0137799A AT410216B (de) 1999-08-10 1999-08-10 Faktor x-analogon mit verbesserter aktivierbarkeit
PCT/EP2000/007631 WO2001010896A2 (fr) 1999-08-10 2000-08-07 Analogue de facteur x a activation amelioree

Publications (1)

Publication Number Publication Date
DK1238065T3 true DK1238065T3 (da) 2008-07-07

Family

ID=3512576

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00949465T DK1238065T3 (da) 1999-08-10 2000-08-07 Faktor X-analog med forbedret evne til aktivering

Country Status (9)

Country Link
US (1) US6958322B1 (fr)
EP (1) EP1238065B1 (fr)
AT (2) AT410216B (fr)
AU (1) AU778571B2 (fr)
CA (1) CA2380844A1 (fr)
DE (1) DE60038312T2 (fr)
DK (1) DK1238065T3 (fr)
ES (1) ES2302696T3 (fr)
WO (1) WO2001010896A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040480A1 (en) * 2001-07-20 2003-02-27 Rasmus Rojkjaer Pharmaceutical composition comprising factor VII polypeptides and factor XI polypeptides
WO2006018204A1 (fr) * 2004-08-17 2006-02-23 Zlb Behring Gmbh Polypeptides modifies dependant de la vitamine k
EP1728798A1 (fr) 2005-06-01 2006-12-06 ZLB Behring GmbH Polypeptides du facteur X de la coagulation avec propiertés d'activation modifiées
MX2008006313A (es) 2005-11-15 2008-11-06 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (fr) * 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptides du facteur de coagulation X avec des propriétés d'activation modifiées
WO2008141824A2 (fr) 2007-05-22 2008-11-27 Baxter International Inc. Procédé de purification préparative de furine humaine
EP2235188A2 (fr) * 2007-12-31 2010-10-06 Baxter International Inc. Animaux non humains transgéniques exprimant des facteurs de coagulation du sang humain, et leurs utilisations
AU2010279463A1 (en) * 2009-08-04 2012-03-01 Baxter Healthcare S.A. Transgenic mouse knockout for FVIII and VWF - model of hemophilia A
US9371522B2 (en) 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
WO2014018120A1 (fr) 2012-07-25 2014-01-30 Catalyst Biosciences, Inc. Polypeptides modifiés du facteur x et leurs utilisations
ES2761730T3 (es) 2013-01-31 2020-05-20 Pfizer Composiciones y procedimientos para contrarrestar la inhibición del factor Xa
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
EP3049434A1 (fr) 2013-09-24 2016-08-03 Pfizer Inc. Compositions comprenant des populations hétérogènes de protéines de facteur xa de coagulation humain de recombinaison
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
FR3050992A1 (fr) * 2016-05-06 2017-11-10 Lab Francais Du Fractionnement Mutants du facteur x

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5597799A (en) 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
ATE158816T1 (de) 1990-11-26 1997-10-15 Genetics Inst Expression von pace in wirtszellen und verfahren zu dessen verwendung
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle

Also Published As

Publication number Publication date
WO2001010896A2 (fr) 2001-02-15
ATA137799A (de) 2002-07-15
DE60038312T2 (de) 2009-03-26
AU6280700A (en) 2001-03-05
ES2302696T3 (es) 2008-08-01
WO2001010896A3 (fr) 2002-07-11
EP1238065B1 (fr) 2008-03-12
CA2380844A1 (fr) 2001-02-15
AT410216B (de) 2003-03-25
DE60038312D1 (de) 2008-04-24
AU778571B2 (en) 2004-12-09
ATE389013T1 (de) 2008-03-15
EP1238065A2 (fr) 2002-09-11
US6958322B1 (en) 2005-10-25

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