DK1246813T3 - Fremgangsmåde til fremstilling af Citalopram - Google Patents

Fremgangsmåde til fremstilling af Citalopram

Info

Publication number: DK1246813T3
Authority: DK; Denmark
Prior art keywords: preparing citalopram; citalopram; preparation; preparing; phtalid
Prior art date: 1999-12-30

Application number

DK99962133T

Other languages

English (en)

Inventor

Hans Petersen

Michael Harold Rock

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-30

Filing date

1999-12-30

Publication date

2004-03-01

1999-12-30 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2004-03-01 Application granted granted Critical

2004-03-01 Publication of DK1246813T3 publication Critical patent/DK1246813T3/da

Links

WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title abstract 2
229960001653 citalopram Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/44—Palladium
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
- B01J23/74—Iron group metals
- B01J23/755—Nickel

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Cephalosporin Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK99962133T 1999-12-30 1999-12-30 Fremgangsmåde til fremstilling af Citalopram DK1246813T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/DK1999/000740 WO2001049672A1 (en)	1999-12-30	1999-12-30	Method for the preparation of citalopram

Publications (1)

Publication Number	Publication Date
DK1246813T3 true DK1246813T3 (da)	2004-03-01

Family

ID=8157174

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99962133T DK1246813T3 (da)	1999-12-30	1999-12-30	Fremgangsmåde til fremstilling af Citalopram

Country Status (28)

Country	Link
US (2)	US20020198391A1 (da)
EP (1)	EP1246813B1 (da)
JP (1)	JP2003519218A (da)
KR (1)	KR100653141B1 (da)
CN (1)	CN1211377C (da)
AT (1)	ATE253568T1 (da)
AU (1)	AU1858400A (da)
BR (1)	BR9917604A (da)
CA (1)	CA2395733C (da)
CZ (1)	CZ20022627A3 (da)
DE (1)	DE69912652T2 (da)
DK (1)	DK1246813T3 (da)
EA (1)	EA004055B1 (da)
ES (1)	ES2207312T3 (da)
HK (1)	HK1052512B (da)
HR (1)	HRP20020633A2 (da)
HU (1)	HUP0203840A3 (da)
IL (2)	IL150367A0 (da)
IS (1)	IS2167B (da)
MX (1)	MXPA02006504A (da)
NO (1)	NO328359B1 (da)
PL (1)	PL198803B1 (da)
PT (1)	PT1246813E (da)
SI (1)	SI1246813T1 (da)
SK (1)	SK11052002A3 (da)
TR (1)	TR200201688T2 (da)
UA (1)	UA73336C2 (da)
WO (1)	WO2001049672A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ514671A (en)	1999-04-14	2003-10-31	H	Method for the preparation of citalopram
EA004742B1 (ru)	1999-12-28	2004-08-26	Х.Лундбекк А/С	Способ получения циталопрама
TR200201783T2 (tr)	2000-01-14	2002-12-23	H. Lundbeck A/S	5-Siyanofatalid hazırlamak için yöntem
NL1017417C1 (nl)	2000-03-03	2001-03-16	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
NL1017500C1 (nl)	2000-03-13	2001-04-26	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
KR20020080481A (ko)	2000-03-13	2002-10-23	하. 룬트벡 아크티에 셀스카브	시탈로프람의 제조 방법
CZ20023100A3 (cs) *	2000-03-13	2003-02-12	H. Lundbeck A/S	Způsob výroby citalopramu
SK14512002A3 (sk)	2000-03-14	2003-03-04	H. Lundbeck A/S	Spôsob výroby citalopramu, medziprodukt a citalopram výrobený týmto spôsobom
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US6339182B1 (en) *	2000-06-20	2002-01-15	Chevron U.S.A. Inc.	Separation of olefins from paraffins using ionic liquid solutions
TR200504022T1 (tr) *	2003-03-24	2006-08-21	Hetero Drugs Limited	(S)-sitalopram oksalatın yeni sıvı kristal formları.
CN100457747C (zh) *	2006-11-21	2009-02-04	浙江大学	抗抑郁药西酞普兰关键中间体5-氰基苯酞的制备工艺
CN103127815B (zh) *	2013-02-19	2015-10-28	浙江大学	一种利用卤硫作用提高二氧化硫捕集性能的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (da)	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
US4665181A (en) *	1984-05-17	1987-05-12	Pennwalt Corporation	Anti-inflammatory phthalazinones
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
JPH0881456A (ja) *	1994-09-14	1996-03-26	Sumitomo Chem Co Ltd	１，１，３，３−テトラクロロ−１，３−ジヒドロイソベンゾフラン誘導体の製造法
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
TR200000066T2 (tr)	1997-07-08	2000-11-21	H. Lundbeck A/S	Sitalopram hazırlanması için yöntem.
UA62985C2 (en) *	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
ES2149734T3 (es)	1997-11-11	2003-02-16	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
PL199423B1 (pl)	1998-10-20	2008-09-30	Lundbeck & Co As H	Sposób wytwarzania citalopramu
CN1149208C (zh)	1998-12-23	2004-05-12	H.隆德贝克有限公司	制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
NZ514671A (en)	1999-04-14	2003-10-31	H	Method for the preparation of citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
CH692298A5 (de)	1999-10-25	2002-04-30	Lundbeck & Co As H	Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
EA004742B1 (ru)	1999-12-28	2004-08-26	Х.Лундбекк А/С	Способ получения циталопрама
TR200201783T2 (tr)	2000-01-14	2002-12-23	H. Lundbeck A/S	5-Siyanofatalid hazırlamak için yöntem
NL1017415C1 (nl)	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IL144817A0 (en)	2000-08-18	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
JP3798982B2 (ja)	2000-12-22	2006-07-19	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法
CA2359810C (en)	2000-12-28	2002-11-05	H. Lundbeck A/S	Process for the preparation of pure citalopram

1999
- 1999-12-30 WO PCT/DK1999/000740 patent/WO2001049672A1/en not_active Ceased
- 1999-12-30 PL PL355531A patent/PL198803B1/pl not_active IP Right Cessation
- 1999-12-30 SK SK1105-2002A patent/SK11052002A3/sk unknown
- 1999-12-30 AT AT99962133T patent/ATE253568T1/de not_active IP Right Cessation
- 1999-12-30 JP JP2001550212A patent/JP2003519218A/ja active Pending
- 1999-12-30 KR KR1020027008572A patent/KR100653141B1/ko not_active Expired - Fee Related
- 1999-12-30 BR BR9917604-1A patent/BR9917604A/pt not_active Application Discontinuation
- 1999-12-30 UA UA2002065265A patent/UA73336C2/uk unknown
- 1999-12-30 CN CNB998170674A patent/CN1211377C/zh not_active Expired - Fee Related
- 1999-12-30 CZ CZ20022627A patent/CZ20022627A3/cs unknown
- 1999-12-30 SI SI9930473T patent/SI1246813T1/xx unknown
- 1999-12-30 ES ES99962133T patent/ES2207312T3/es not_active Expired - Lifetime
- 1999-12-30 TR TR2002/01688T patent/TR200201688T2/xx unknown
- 1999-12-30 IL IL15036799A patent/IL150367A0/xx unknown
- 1999-12-30 EA EA200200728A patent/EA004055B1/ru not_active IP Right Cessation
- 1999-12-30 HK HK03104874.0A patent/HK1052512B/zh not_active IP Right Cessation
- 1999-12-30 MX MXPA02006504A patent/MXPA02006504A/es active IP Right Grant
- 1999-12-30 HU HU0203840A patent/HUP0203840A3/hu unknown
- 1999-12-30 PT PT99962133T patent/PT1246813E/pt unknown
- 1999-12-30 DE DE69912652T patent/DE69912652T2/de not_active Expired - Lifetime
- 1999-12-30 CA CA002395733A patent/CA2395733C/en not_active Expired - Fee Related
- 1999-12-30 HR HRP20020633 patent/HRP20020633A2/hr not_active Application Discontinuation
- 1999-12-30 DK DK99962133T patent/DK1246813T3/da active
- 1999-12-30 AU AU18584/00A patent/AU1858400A/en not_active Abandoned
- 1999-12-30 EP EP99962133A patent/EP1246813B1/en not_active Expired - Lifetime
2002
- 2002-06-19 IS IS6433A patent/IS2167B/is unknown
- 2002-06-23 IL IL150367A patent/IL150367A/en not_active IP Right Cessation
- 2002-06-27 US US10/186,337 patent/US20020198391A1/en not_active Abandoned
- 2002-06-28 NO NO20023150A patent/NO328359B1/no not_active IP Right Cessation
2005
- 2005-11-23 US US11/285,922 patent/US7271273B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1391566A (zh)	2003-01-15
AU1858400A (en)	2001-07-16
IS6433A (is)	2002-06-19
KR20020073495A (ko)	2002-09-26
US7271273B2 (en)	2007-09-18
SK11052002A3 (sk)	2003-01-09
DE69912652T2 (de)	2004-06-09
IL150367A (en)	2010-06-16
IL150367A0 (en)	2002-12-01
EP1246813B1 (en)	2003-11-05
MXPA02006504A (es)	2002-12-09
ES2207312T3 (es)	2004-05-16
NO328359B1 (no)	2010-02-01
WO2001049672A1 (en)	2001-07-12
UA73336C2 (en)	2005-07-15
KR100653141B1 (ko)	2006-12-01
CA2395733A1 (en)	2001-07-12
ATE253568T1 (de)	2003-11-15
HUP0203840A2 (en)	2003-05-28
CA2395733C (en)	2007-03-20
EP1246813A1 (en)	2002-10-09
PL198803B1 (pl)	2008-07-31
PT1246813E (pt)	2004-02-27
HK1052512B (zh)	2006-03-03
CZ20022627A3 (cs)	2002-10-16
JP2003519218A (ja)	2003-06-17
HK1052512A1 (en)	2003-09-19
BR9917604A (pt)	2002-12-31
IS2167B (is)	2006-11-15
EA004055B1 (ru)	2003-12-25
PL355531A1 (en)	2004-05-04
US20060079700A1 (en)	2006-04-13
HRP20020633A2 (en)	2004-12-31
SI1246813T1 (en)	2004-08-31
US20020198391A1 (en)	2002-12-26
EA200200728A1 (ru)	2002-12-26
DE69912652D1 (de)	2003-12-11
NO20023150D0 (no)	2002-06-28
TR200201688T2 (tr)	2002-11-21
HUP0203840A3 (en)	2005-02-28
NO20023150L (no)	2002-06-28
CN1211377C (zh)	2005-07-20

Publication	Publication Date	Title
MXPA03005222A (es)	2004-03-26	Derivado de metanosulfonamido-benzofurano, su procedimiento de preparacion y su utilizacion como intermediario de sisntesis.
UA74360C2 (uk)	2005-12-15	Кристалічна основа циталопраму
DK1159274T3 (da)	2003-07-21	Fremgangsmåde til fremstilling af citalopram
DK1309581T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af citalopram
NO20023150L (no)	2002-06-28	Fremgangsmate for fremstilling av citalopram
DK1181713T3 (da)	2005-01-31	Fremgangsmåde til fremstilling af rent citalopram
EA200001129A3 (ru)	2001-10-22	Способ получения 4-карбоксиамино-2-замещенного-1,2,3,4-тетрагидрохинолина
MXPA04005766A (es)	2004-09-10	Metodo para la preparacion del escitalopram.
NO20041200L (no)	2004-03-23	Fremgangsmate for fremstilling av citalopram.
DK1325022T3 (da)	2007-02-19	Fremgangsmåde til fremstilling af 21-hydroxy-6,19-oxidoprogesteron (21OH-6OP)
AR042652A1 (es)	2005-06-29	Bromhidrato de escitalopram y un metodo para su preparacion
EA200200101A1 (ru)	2002-06-27	Получение замещенных пиперидин-4-онов
DK1296970T3 (da)	2008-07-14	Fremgangsmåde til fremstilling af citalopram
BG107047A (en)	2003-04-30	Method for the preparation of citalopram
BR0109364A (pt)	2002-12-24	Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram
DK1206452T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
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DK1232151T3 (da)	2003-10-27	Fremgangsmåde til fremstilling af benzofuranonoximer
BG106958A (en)	2003-03-31	Method for the preparation of citalopram
DK0975618T3 (da)	2001-12-27	Ny fremgangsmåde til fremstilling af 3-N,N-dicyclobutylamino-8-fluor-3,4-dihydro-2H-1-benzopyran-5-carboxamid
DK0934256T3 (da)	2002-12-02	Fremgangsmåde til fremstilling af cyanocinnamamider
DK0796256T3 (da)	2004-05-10	Fremgangsmåde til fremstilling af ranitidin
DK1131273T3 (da)	2004-03-01	1,4-Diaryl-2-fluor-1-buten-3-olforbindelser og deres anvendelse til fremstilling af 1,4-diaryl-2-fluor-1,3-butadien- og 1,4-diaryl-2-fluor-2-butenforbindelser
BR0306702A (pt)	2004-12-28	Processo para a preparação de um composto, composto, processo para a preparação de fitona, e, vitamina e obtida de fitona