DK1305437T3 - Ekspression af biologisk aktive polypeptider i andemad - Google Patents

Ekspression af biologisk aktive polypeptider i andemad

Info

Publication number
DK1305437T3
DK1305437T3 DK01967946.3T DK01967946T DK1305437T3 DK 1305437 T3 DK1305437 T3 DK 1305437T3 DK 01967946 T DK01967946 T DK 01967946T DK 1305437 T3 DK1305437 T3 DK 1305437T3
Authority
DK
Denmark
Prior art keywords
duckweed
expression
biologically active
active polypeptides
polypeptide
Prior art date
Application number
DK01967946.3T
Other languages
Danish (da)
English (en)
Inventor
John Gasdaska
Anne-Marie Stomp
Lynn Dickey
Original Assignee
Biolex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolex Therapeutics Inc filed Critical Biolex Therapeutics Inc
Application granted granted Critical
Publication of DK1305437T3 publication Critical patent/DK1305437T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/56IFN-alpha
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DK01967946.3T 2000-07-31 2001-07-26 Ekspression af biologisk aktive polypeptider i andemad DK1305437T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22170500P 2000-07-31 2000-07-31
US29333001P 2001-05-23 2001-05-23
PCT/US2001/023400 WO2002010414A2 (en) 2000-07-31 2001-07-26 Expression of biologically active polypeptides in duckweed

Publications (1)

Publication Number Publication Date
DK1305437T3 true DK1305437T3 (da) 2010-12-13

Family

ID=26916048

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01967946.3T DK1305437T3 (da) 2000-07-31 2001-07-26 Ekspression af biologisk aktive polypeptider i andemad

Country Status (13)

Country Link
US (4) US6815184B2 (de)
EP (1) EP1305437B1 (de)
JP (1) JP4795619B2 (de)
CN (2) CN101676400A (de)
AT (1) ATE479761T1 (de)
AU (2) AU8822601A (de)
CA (1) CA2417415C (de)
CY (1) CY1110959T1 (de)
DE (1) DE60142971D1 (de)
DK (1) DK1305437T3 (de)
NZ (1) NZ523912A (de)
PT (1) PT1305437E (de)
WO (1) WO2002010414A2 (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US7161064B2 (en) * 1997-08-12 2007-01-09 North Carolina State University Method for producing stably transformed duckweed using microprojectile bombardment
AU4570397A (en) 1997-10-10 1999-05-03 Yeda Research And Development Co. Ltd. Transgenic lemnaceae
US8022270B2 (en) 2000-07-31 2011-09-20 Biolex Therapeutics, Inc. Expression of biologically active polypeptides in duckweed
US7959910B2 (en) 2000-07-31 2011-06-14 Biolex Therapeutics, Inc. C-terminally truncated interferon alpha variants
NZ523912A (en) * 2000-07-31 2005-03-24 Biolex Inc Expression of biologically active polypeptides in duckweed
US7632983B2 (en) 2000-07-31 2009-12-15 Biolex Therapeutics, Inc. Expression of monoclonal antibodies in duckweed
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
US7176024B2 (en) * 2003-05-30 2007-02-13 Biolex, Inc. Bioreactor for growing biological materials supported on a liquid surface
PT1692182E (pt) * 2003-11-05 2010-05-13 Roche Glycart Ag Anticorpos de cd20 com uma afinidade de ligação acrescida ao receptor fc e uma função efectora acrescida
US7659445B2 (en) * 2004-02-11 2010-02-09 Biolex Therapeutics, Inc. Expression of plasminogen and microplasminogen in duck weed
DK1756273T3 (da) * 2004-06-14 2010-02-01 Novozymes As Signalpeptid til frembringelse af et polypeptid
US7527947B2 (en) 2004-06-14 2009-05-05 Novozymes A/S Signal peptide for producing a polypeptide
US20060024272A1 (en) * 2004-07-29 2006-02-02 Large Scale Biology Corporation C-terminally truncated interferon
ES2755976T3 (es) 2005-02-07 2020-04-24 Roche Glycart Ag Moléculas de unión a antígeno que se unen a EGFR, vectores que las codifican y usos de las mismas
US20060223096A1 (en) * 2005-03-25 2006-10-05 Glycart Biotechnology Ag Antigen binding molecules directed to MCSP and having increased Fc receptor binding affinity and effector function
JP2008539753A (ja) * 2005-05-09 2008-11-20 グリクアート バイオテクノロジー アクチェンゲゼルシャフト 修飾fc領域およびfc受容体との結合変更を有する抗原結合分子
RU2482132C2 (ru) 2005-08-26 2013-05-20 Роше Гликарт Аг Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью
EP1976883B1 (de) * 2006-01-17 2012-10-03 Medarex, Inc. Monoklonale antikörper gegen cd30 ohne fucosyl- und xylosylreste
US7622573B2 (en) * 2006-01-17 2009-11-24 Biolex, Inc. Expression control elements from the lemnaceae family
AR062223A1 (es) * 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
KR20090088852A (ko) 2006-09-05 2009-08-20 메다렉스, 인코포레이티드 골형성 단백질의 항체와 이의 수용체 및 이의 사용방법
SG178789A1 (en) 2007-02-16 2012-03-29 Merrimack Pharmaceuticals Inc Antibodies against erbb3 and uses thereof
EP2150608B1 (de) 2007-05-07 2017-11-29 Protalix Ltd. Grossvolumiger einweg-bioreaktor
AU2008279087A1 (en) * 2007-07-25 2009-01-29 Biolex Therapeutics, Inc. Controlled release interferon drug products and treatment of HCV infection using same
WO2009070642A1 (en) 2007-11-28 2009-06-04 Medimmune, Llc Protein formulation
CN102271704A (zh) 2008-11-28 2011-12-07 梅里亚有限公司 重组禽流感疫苗及其用途
US20100209966A1 (en) * 2009-02-18 2010-08-19 Biolex Therapeutics, Inc. Aseptic bioreactor system for processing biological materials
US20120220015A1 (en) 2009-05-26 2012-08-30 Biolex Therapeutics Compositions and methods for production of aglycosylated plasminogen
EP2445336A2 (de) 2009-06-23 2012-05-02 Biolex Therapeutics, Inc. Verfahren und zusammensetzungen für die kryokonservierung von wasserlinsen
AU2010288469A1 (en) 2009-08-31 2012-03-01 Roche Glycart Ag Affinity-matured humanized anti CEA monoclonal antibodies
AR079767A1 (es) 2009-12-28 2012-02-15 Merial Ltd Antigeno ndv (virus de la enfermedad de newcastle) recombinante y usos del mismo
NZ602278A (en) 2010-03-12 2014-12-24 Biolex Therapeutics Inc Bluetongue virus recombinant vaccines and uses thereof
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
WO2012009705A1 (en) 2010-07-15 2012-01-19 Zyngenia, Inc. Ang-2 binding complexes and uses thereof
CA2827170A1 (en) 2011-02-11 2012-08-16 David M. Hilbert Monovalent and multivalent multispecific complexes and uses thereof
ES2657856T3 (es) 2011-03-02 2018-03-07 Roche Glycart Ag Anticuerpos CEA
EP2714738B1 (de) 2011-05-24 2018-10-10 Zyngenia, Inc. Multivalente und monovalente multispezifische komplexe und ihre verwendungen
US9603906B2 (en) 2012-02-01 2017-03-28 Protalix Ltd. Inhalable liquid formulations of DNase I
BR112014021521B1 (pt) 2012-04-05 2022-05-10 Basf Plant Science Company Gmbh Método para aumentar a resistência à infecção por phakopsora em uma planta de soja transgênica, método para a produção de uma planta de soja transgênica, método para a produção de um produto e método para criar uma planta transgênica resistente a fungos
BR112015021707A2 (pt) 2013-03-06 2017-12-05 Hadasit Med Res Service uso de células de planta que expresam um inibidor de polipeptídeo tnfalfa em terapia.
CA2904035A1 (en) 2013-03-06 2014-09-12 Protalix Ltd. Tnf alpha inhibitor polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
TWI463012B (zh) * 2013-04-01 2014-12-01 Lemnaceae Fermentation Inc 浮萍水解物及其用途
JP2016531088A (ja) 2013-06-17 2016-10-06 アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー 5t4標的化免疫融合分子および方法
WO2015027109A1 (en) * 2013-08-21 2015-02-26 Cold Spring Harbor Laboratory Transformation of duckweed and uses thereof
CN103609304B (zh) * 2013-11-22 2015-08-19 中国科学院成都生物研究所 一种快速提高浮萍淀粉含量的方法
WO2016164308A1 (en) 2015-04-06 2016-10-13 Subdomain, Llc De novo binding domain containing polypeptides and uses thereof
ES2975747T3 (es) 2015-11-30 2024-07-12 Univ California Administración de carga útil específica de tumor y activación inmunitaria utilizando un anticuerpo humano que se dirige a un antígeno de superficie celular de tumor altamente específico
JP2019515874A (ja) 2016-03-01 2019-06-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 改変された細胞死誘導を有するオビヌツズマブ変異体
IL245102A0 (en) 2016-04-13 2016-07-31 Yeda Res & Dev Cultivation of wolffia plants
WO2018089829A1 (en) 2016-11-10 2018-05-17 Fortis Therapeutics, Inc. Cd46-specific effector cells and uses thereof
BR112020009136A2 (pt) 2017-11-14 2020-10-13 Arcellx, Inc. polipeptídeos que contêm domínio d e usos dos mesmos
WO2019099440A1 (en) 2017-11-14 2019-05-23 Arcellx, Inc. Multifunctional immune cell therapies
AU2021320333A1 (en) 2020-08-07 2023-03-30 Fortis Therapeutics, Inc. Immunoconjugates targeting CD46 and methods of use thereof
KR20230113286A (ko) 2020-10-13 2023-07-28 아비타이드 엘엘씨 Aav8 친화성 제제
WO2022081779A1 (en) 2020-10-13 2022-04-21 Avitide LLC Affinity ligand libraries of three-helix bundle proteins and uses thereof
CN117241866A (zh) 2021-02-19 2023-12-15 艾维泰有限责任公司 Aav2亲和剂
CN117425484A (zh) 2021-03-26 2024-01-19 阿奇利克斯股份有限公司 多功能免疫细胞疗法
JP2025500274A (ja) 2021-12-24 2025-01-09 アヴィタイド エルエルシー Ch1ドメイン親和性リガンド及びエージェント
WO2024025911A1 (en) 2022-07-29 2024-02-01 Avitide LLC An affinity agent comprising a ligand that binds vce and comprises seq id no: 1
CN120187741A (zh) 2022-09-09 2025-06-20 瑞普利金公司 亲和剂

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8315980D0 (en) 1983-06-10 1983-07-13 Biogen Nv Producing hybrid dna sequences
US4956282A (en) 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
US5256410A (en) * 1988-12-01 1993-10-26 Schering Corporation Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
US5850032A (en) 1992-04-01 1998-12-15 Union Camp Corporation Method for production of plant biological products in precocious neomorphic embryoids
US6288302B1 (en) * 1992-11-04 2001-09-11 National Science Council Of R.O.C. Application of α-amylase gene promoter and signal sequence in the production of recombinant proteins in transgenic plants and transgenic plant seeds
US5569828A (en) 1993-03-24 1996-10-29 Pioneer Hi-Bred International, Inc. Maize chlorotic dwarf virus and resistance thereto
US5780709A (en) * 1993-08-25 1998-07-14 Dekalb Genetics Corporation Transgenic maize with increased mannitol content
US5693506A (en) 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US6020169A (en) 1995-07-20 2000-02-01 Washington State University Research Foundation Production of secreted foreign polypeptides in plant cell culture
US6066781A (en) 1997-02-13 2000-05-23 Applied Phytologics, Inc. Production of mature proteins in plants
AU746826B2 (en) * 1997-02-13 2002-05-02 Regents Of The University Of California, The Production of mature proteins in plants
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
US7161064B2 (en) * 1997-08-12 2007-01-09 North Carolina State University Method for producing stably transformed duckweed using microprojectile bombardment
IL132580A0 (en) * 1997-08-12 2001-03-19 Univ North Carolina State Genetically engineered duckweed
AU4570397A (en) 1997-10-10 1999-05-03 Yeda Research And Development Co. Ltd. Transgenic lemnaceae
US6095546A (en) * 1997-12-03 2000-08-01 Tekonsha Engineering Company Trailer hitch cover and accessory components
US6096546A (en) 1998-01-30 2000-08-01 Board Of Trustees, Rutgers, The State University Of New Jersey Methods for recovering polypeptides from plants and portions thereof
CA2323604A1 (en) 1998-03-19 1999-09-23 Valentis, Inc. Interferon alpha plasmids and delivery systems, and methods of making and using the same
NZ523912A (en) * 2000-07-31 2005-03-24 Biolex Inc Expression of biologically active polypeptides in duckweed

Also Published As

Publication number Publication date
CN101676400A (zh) 2010-03-24
US6815184B2 (en) 2004-11-09
CN1451048A (zh) 2003-10-22
WO2002010414A2 (en) 2002-02-07
NZ523912A (en) 2005-03-24
CA2417415C (en) 2012-10-09
CY1110959T1 (el) 2015-06-11
JP2004504848A (ja) 2004-02-19
US20120258491A1 (en) 2012-10-11
JP4795619B2 (ja) 2011-10-19
US20050060776A1 (en) 2005-03-17
CA2417415A1 (en) 2002-02-07
AU2001288226B2 (en) 2007-07-26
US20090282584A1 (en) 2009-11-12
HK1055317A1 (en) 2004-01-02
EP1305437A2 (de) 2003-05-02
PT1305437E (pt) 2010-11-12
US20020088027A1 (en) 2002-07-04
ATE479761T1 (de) 2010-09-15
AU8822601A (en) 2002-02-13
WO2002010414A3 (en) 2002-12-27
DE60142971D1 (de) 2010-10-14
WO2002010414A9 (en) 2003-10-30
EP1305437B1 (de) 2010-09-01

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