DK1368094T3 - 4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)-pyrazolo[1,5-a]-1,3,5-triazin, dens enantiomerer og farmaceutisk acceptable salte som corticotropin-frigivende faktor-receptor- ligander - Google Patents

4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)-pyrazolo[1,5-a]-1,3,5-triazin, dens enantiomerer og farmaceutisk acceptable salte som corticotropin-frigivende faktor-receptor- ligander

Info

Publication number: DK1368094T3
Authority: DK; Denmark
Prior art keywords: methoxypyrid; pyrazolo; butylamino; enantiomers; triazine
Prior art date: 2001-03-13

Application number

DK02713776T

Other languages

English (en)

Inventor

Paul J Gilligan

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-13

Filing date

2002-03-06

Publication date

2007-07-02

2002-03-06 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2007-07-02 Application granted granted Critical

2007-07-02 Publication of DK1368094T3 publication Critical patent/DK1368094T3/da

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title 1
239000003446 ligand Substances 0.000 title 1
LBWQSAZEYIZZCE-UHFFFAOYSA-N n-butan-2-yl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound CC1=NN2C(NC(C)CC)=NC(C)=NC2=C1C1=CC=C(OC)N=C1C LBWQSAZEYIZZCE-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

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DK02713776T 2001-03-13 2002-03-06 4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)-pyrazolo[1,5-a]-1,3,5-triazin, dens enantiomerer og farmaceutisk acceptable salte som corticotropin-frigivende faktor-receptor- ligander DK1368094T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27540301P	2001-03-13	2001-03-13
PCT/US2002/006837 WO2002072202A1 (en)	2001-03-13	2002-03-06	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

Publications (1)

Publication Number	Publication Date
DK1368094T3 true DK1368094T3 (da)	2007-07-02

Family

ID=23052141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02713776T DK1368094T3 (da)	2001-03-13	2002-03-06	4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)-pyrazolo[1,5-a]-1,3,5-triazin, dens enantiomerer og farmaceutisk acceptable salte som corticotropin-frigivende faktor-receptor- ligander

Country Status (35)

Country	Link
US (4)	US20030125330A1 (da)
EP (1)	EP1368094B1 (da)
JP (1)	JP4549630B2 (da)
KR (1)	KR100875595B1 (da)
CN (1)	CN100427093C (da)
AR (1)	AR032986A1 (da)
AT (1)	ATE355102T1 (da)
AU (1)	AU2002245605B2 (da)
BG (1)	BG66331B1 (da)
BR (1)	BR0208357A (da)
CA (1)	CA2440553C (da)
CY (1)	CY1106607T1 (da)
CZ (1)	CZ20032481A3 (da)
DE (1)	DE60218434T2 (da)
DK (1)	DK1368094T3 (da)
EE (1)	EE05433B1 (da)
ES (1)	ES2282401T3 (da)
GE (1)	GEP20053608B (da)
HR (1)	HRP20030822B1 (da)
HU (1)	HU229317B1 (da)
IL (2)	IL157615A0 (da)
IS (1)	IS2839B (da)
MX (1)	MXPA03008185A (da)
MY (1)	MY146935A (da)
NO (1)	NO328580B1 (da)
NZ (1)	NZ528207A (da)
PL (1)	PL208278B1 (da)
PT (1)	PT1368094E (da)
RS (1)	RS50863B (da)
RU (1)	RU2292347C2 (da)
SK (1)	SK287603B6 (da)
TW (1)	TWI257388B (da)
UA (1)	UA74634C2 (da)
WO (1)	WO2002072202A1 (da)
ZA (1)	ZA200306995B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7094782B1 (en) *	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
BR0208357A (pt) *	2001-03-13	2004-06-29	Bristol Myers Squibb Pharma Co	Composto, composição farmacêutica, método de antagonização de um receptor de fator de liberação de corticotropina (crf), método de tratamento de disfunção, método de triagem de ligantes, método de detecção de receptores de crf, método de inibição da ligação de crf, artigo industrializado e usos do composto
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
AR041470A1 (es) *	2002-10-17	2005-05-18	Upjohn Co	Compuestos de pirrolo (1,2 - b) piridazina y sus usos
US7329658B2 (en) *	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) *	2003-02-10	2007-02-13	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
US7041671B2 (en) *	2003-04-02	2006-05-09	Pfizer Inc	Pyrrolo[1,2-b]pyridazine compounds and their uses
US7056920B2 (en)	2003-04-04	2006-06-06	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7034023B2 (en)	2003-04-04	2006-04-25	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
JP2006523675A (ja) *	2003-04-15	2006-10-19	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	ピロロ［１，２−ｂ］ピリダジン化合物及びそれらの使用
US7208596B2 (en) *	2003-11-25	2007-04-24	Bristol-Myers Squibb Pharma Company	Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US7153961B2 (en)	2003-11-25	2006-12-26	Bristol-Myers Squibb Pharma Co.	Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist
EP2094709B1 (en) *	2006-09-20	2010-09-15	Eli Lilly And Company	Thiazole pyrazolopyrimidines as crf1 receptor antagonists
HK1207304A1 (en) *	2012-04-23	2016-01-29	Hmnc Value Gmbh	Crhr1 antagonists for use in the treatment of patients having crh overactivity
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
KR102079844B1 (ko)	2016-09-20	2020-02-20	가톨릭대학교 산학협력단	담석 용해제를 포함하는 담낭 질환 치료용 약학 조성물
CN118845788A (zh)	2017-08-14	2024-10-29	云杉生物科学公司	促肾上腺皮质激素释放因子受体拮抗剂
EP4438124A3 (en)	2018-04-27	2024-12-18	Spruce Biosciences, Inc.	Methods for treating testicular and ovarian adrenal rest tumors
BR112023002497A2 (pt)	2020-08-12	2023-05-02	Spruce Biosciences Inc	Métodos e composições para tratamento da síndrome dos ovários policísticos
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW370529B (en)	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
RU2153494C2 (ru)	1993-10-12	2000-07-27	Дзе Дюпон Мерк Фармасьютикал Компани	1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
TW530047B (en)	1994-06-08	2003-05-01	Pfizer	Corticotropin releasing factor antagonists
EP0901476A4 (en)	1996-03-26	2001-08-16	Du Pont Pharm Co	PYRIDINES AND PYRIMIDINES FUSION ARYLOXY AND ARYLTHIO AND DERIVATIVES THEREOF
US6107300A (en)	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
WO1997044308A1 (en)	1996-05-24	1997-11-27	The Dow Chemical Company	Process for preparing aliphatic ester compounds and alkanols
IL127871A0 (en) *	1996-07-24	1999-10-28	Du Pont Pharm Co	Azolo triazines and pyrimidines
US6191131B1 (en) *	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
HU228962B1 (en)	1996-07-24	2013-07-29	Bristol Myers Squibb Pharma Co	Azolo triazines, pharmaceutical compositions containing them and use of the compounds
IL127566A0 (en) *	1996-08-28	1999-10-28	Pfizer	Substituted 6,5-hetero- bicyclic derivatives
PL337888A1 (en)	1997-07-03	2000-09-11	Du Pont Pharm Co	Imidazoprimidines and imidazopyridines for use in treating neurological disorders
UA62972C2 (en)	1997-07-03	2004-01-15		Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
WO1999001439A1 (en)	1997-07-03	1999-01-14	Du Pont Pharmaceuticals Company	Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists
EP1012151B1 (en)	1997-09-02	2002-08-07	Bristol-Myers Squibb Pharma Company	Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders
EP1049699B1 (en) *	1998-01-28	2004-04-21	Bristol-Myers Squibb Pharma Company	Pyrazolotriazines as crf antagonists
US6194410B1 (en)	1998-03-11	2001-02-27	Hoffman-La Roche Inc.	Pyrazolopyrimidine and pyrazolines and process for preparation thereof
WO1999051608A1 (en)	1998-04-03	1999-10-14	Du Pont Pharmaceuticals Company	THIAZOLO[4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
US6124463A (en)	1998-07-02	2000-09-26	Dupont Pharmaceuticals	Benzimidazoles as corticotropin release factor antagonists
DE60026297T2 (de) *	1999-05-21	2006-11-02	Bristol-Myers Squibb Co.	Pyrrolotriazin kinasehemmer
BR0208357A (pt) *	2001-03-13	2004-06-29	Bristol Myers Squibb Pharma Co	Composto, composição farmacêutica, método de antagonização de um receptor de fator de liberação de corticotropina (crf), método de tratamento de disfunção, método de triagem de ligantes, método de detecção de receptores de crf, método de inibição da ligação de crf, artigo industrializado e usos do composto

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Also Published As

Publication number	Publication date
HU229317B1 (en)	2013-10-28
JP2004530662A (ja)	2004-10-07
US20070054913A1 (en)	2007-03-08
EE200300435A (et)	2003-12-15
US20030125330A1 (en)	2003-07-03
NO20034023L (no)	2003-09-11
AR032986A1 (es)	2003-12-03
HUP0303480A3 (en)	2005-12-28
JP4549630B2 (ja)	2010-09-22
SK287603B6 (sk)	2011-03-04
MXPA03008185A (es)	2004-01-29
ZA200306995B (en)	2004-09-08
WO2002072202A1 (en)	2002-09-19
KR100875595B1 (ko)	2008-12-23
CN100427093C (zh)	2008-10-22
US7157578B2 (en)	2007-01-02
RS50863B (sr)	2010-08-31
DE60218434T2 (de)	2007-11-08
PL368644A1 (en)	2005-04-04
BR0208357A (pt)	2004-06-29
US20080139567A1 (en)	2008-06-12
EP1368094A1 (en)	2003-12-10
KR20030080086A (ko)	2003-10-10
MY146935A (en)	2012-10-15
GEP20053608B (en)	2005-09-12
HK1057182A1 (en)	2004-03-19
CN1509196A (zh)	2004-06-30
YU71503A (sh)	2006-05-25
IL157615A (en)	2009-09-01
IS2839B (is)	2013-06-15
UA74634C2 (uk)	2006-01-16
NZ528207A (en)	2006-02-24
EP1368094B1 (en)	2007-02-28
HRP20030822A2 (en)	2004-04-30
EP1368094A4 (en)	2004-03-31
US7662817B2 (en)	2010-02-16
BG66331B1 (bg)	2013-06-28
US7358252B2 (en)	2008-04-15
CZ20032481A3 (cs)	2007-12-27
AU2002245605B2 (en)	2006-02-02
ES2282401T3 (es)	2007-10-16
PT1368094E (pt)	2007-05-31
HUP0303480A2 (hu)	2004-01-28
CY1106607T1 (el)	2012-01-25
CA2440553C (en)	2010-06-08
RU2003130093A (ru)	2005-03-20
NO328580B1 (no)	2010-03-22
NO20034023D0 (no)	2003-09-11
US20040014760A1 (en)	2004-01-22
RU2292347C2 (ru)	2007-01-27
ATE355102T1 (de)	2006-03-15
PL208278B1 (pl)	2011-04-29
CA2440553A1 (en)	2002-09-19
BG108189A (bg)	2004-09-30
EE05433B1 (et)	2011-06-15
DE60218434D1 (en)	2007-04-12
TWI257388B (en)	2006-07-01
SK11572003A3 (sk)	2004-02-03
IL157615A0 (en)	2004-03-28
HRP20030822B1 (en)	2008-01-31
IS6947A (is)	2003-09-10

Publication	Publication Date	Title
DK1368094T3 (da)	2007-07-02	4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)-pyrazolo[1,5-a]-1,3,5-triazin, dens enantiomerer og farmaceutisk acceptable salte som corticotropin-frigivende faktor-receptor- ligander
NO20021356D0 (no)	2002-03-19	Alkylendiamin-substituerte pyrazolo[1,5,-a]-1,5-pyrimidiner og pyrazolo[1,5-a]-1,3,5-triaziner
ATE388713T1 (de)	2008-03-15	4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate
AU2004209447A8 (en)	2004-08-19	Pyrazolo`1,5-a!`1,3,5!triazine derivatives as cannabinoid receptor ligands
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
DE50213202D1 (de)	2009-02-26	Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
DK1397351T3 (da)	2010-01-18	Pyrimidin-, triazin- og pyrazinderivater som glutamatreceptorer
MXPA03008525A (es)	2003-12-08	Derivados de imidazo(1,2-a)-piridina como antagonistas de mglur5.
EE200200192A (et)	2003-06-16	5-(2-asendatud-5-heterotsüklüülsulfonüülpürid-3-üül)dihüdropürasolo[4,3-d]pürimidii n-7-oonid kui fosfodiesteraasi inhibiitorid
NO20022738D0 (no)	2002-06-07	Pyrrolo(2,3-d)pyrimidinforbindelser
ITMI20001977A0 (it)	2000-09-08	Procedimento per realizzare sedute ed elementi di arredo, relative sedute ed elementi.
PL375083A1 (en)	2005-11-14	Arylamine substututed bicyclic heteroaromatic compounds as p38 kinase inhibitors
DK1220856T3 (da)	2005-03-14	Pyrazolo[4,3-d]pyrimidinderivater
EE200300400A (et)	2003-12-15	Pürimidiiniühendid, nende valmistamismeetod ning kasutamine
NO20043565L (no)	2004-11-25	Heteroaryl-substituerte 2-pyridinyl- og 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater.
ATE231866T1 (de)	2003-02-15	Pyrazolo(4, 3-d)pyrimidine
PL369644A1 (en)	2005-02-21	Spiro and dispiro -1,2,4-trioxalane antimalarials
NO20014050D0 (no)	2001-08-20	1-aryl-1,3,5-triazin-4-tion-2,6-dioner, fremstilling derav og anvendelse derav som herbicider
DE60302220D1 (de)	2005-12-15	1-(alkyl), 1-(heteroaryl)alkyl und 1-[aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(h)-one derivate
DK1560830T3 (da)	2007-02-26	Derivater af [6,7-dihydro-5H-imidazo[1,2-A]imidazol-3-sulfonylamino]propionamid og anvendelse deraf som inhibitorer af interaktionen mellem CAM'er og leukointegriner
IL175753A0 (en)	2006-09-05	PROCESSES FOR THE PREPARATION OF PYRAZOLO [1,5-a]-1,3,5-TRIAZINES AND INTERMEDIATES THEREOF
IL164377A (en)	2011-07-31	Methods of preparation of 2-(7-chloro-1,8-naphthyridine-2yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone
ATE294180T1 (de)	2005-05-15	Substituierte 3,4-dihydro-pyrimido (1,2- a)pyrimidine und 3,4-dihydropyrazino (1,2- a)pyrimidine
SI1490363T1 (sl)	2006-06-30	Postopki za pripravo 2-(7-kloro-1,8-naftiridin-2-il) -3-(5-metil-2-okso-heksil)-1-izoindolinona
AR028349A1 (es)	2003-05-07	Proceso para preparar rcido 6-(4-clorofenil)-2,2 dimetil-7-fenil-2,3-dihidro-1h-pirrolizin-5-ilacético