IS6947A - 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-(1,5-A-)-1,3,5 triazine, handhverfur þess og lyfjafræðilega ásættanleg sölt sem tenglar við viðtaka fyrir "corticotropin releasing factor" - Google Patents

4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-(1,5-A-)-1,3,5 triazine, handhverfur þess og lyfjafræðilega ásættanleg sölt sem tenglar við viðtaka fyrir "corticotropin releasing factor"

Info

Publication number: IS6947A
Authority: IS; Iceland
Prior art keywords: methoxypyrid; pyrazolo; butylamino; enantiomers; triazine
Prior art date: 2001-03-13

Application number

IS6947A

Other languages

English (en)

Other versions

IS2839B (is

Inventor

J. Gilligan Paul

Original Assignee

Bristol-Myers Squibb Pharma Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-13

Filing date

2003-09-10

Publication date

2003-09-10

2003-09-10 Application filed by Bristol-Myers Squibb Pharma Company filed Critical Bristol-Myers Squibb Pharma Company

2003-09-10 Publication of IS6947A publication Critical patent/IS6947A/is

2013-06-15 Publication of IS2839B publication Critical patent/IS2839B/is

Links

-1 2-butylamino Chemical group 0.000 title 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title 1
JUXWUYWPUDKPSD-UHFFFAOYSA-N pyrazolo[1,5-a][1,3,5]triazine Chemical compound N1=CN=CN2N=CC=C21 JUXWUYWPUDKPSD-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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IS6947A 2001-03-13 2003-09-10 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-(1,5-A-)-1,3,5 triazine, handhverfur þess og lyfjafræðilega ásættanleg sölt sem tenglar við viðtaka fyrir "corticotropin releasing factor" IS2839B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27540301P	2001-03-13	2001-03-13
PCT/US2002/006837 WO2002072202A1 (en)	2001-03-13	2002-03-06	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

Publications (2)

Publication Number	Publication Date
IS6947A true IS6947A (is)	2003-09-10
IS2839B IS2839B (is)	2013-06-15

Family

ID=23052141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS6947A IS2839B (is)	2001-03-13	2003-09-10	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-(1,5-A-)-1,3,5 triazine, handhverfur þess og lyfjafræðilega ásættanleg sölt sem tenglar við viðtaka fyrir "corticotropin releasing factor"

Country Status (35)

Country	Link
US (4)	US20030125330A1 (is)
EP (1)	EP1368094B1 (is)
JP (1)	JP4549630B2 (is)
KR (1)	KR100875595B1 (is)
CN (1)	CN100427093C (is)
AR (1)	AR032986A1 (is)
AT (1)	ATE355102T1 (is)
AU (1)	AU2002245605B2 (is)
BG (1)	BG66331B1 (is)
BR (1)	BR0208357A (is)
CA (1)	CA2440553C (is)
CY (1)	CY1106607T1 (is)
CZ (1)	CZ20032481A3 (is)
DE (1)	DE60218434T2 (is)
DK (1)	DK1368094T3 (is)
EE (1)	EE05433B1 (is)
ES (1)	ES2282401T3 (is)
GE (1)	GEP20053608B (is)
HR (1)	HRP20030822B1 (is)
HU (1)	HU229317B1 (is)
IL (2)	IL157615A0 (is)
IS (1)	IS2839B (is)
MX (1)	MXPA03008185A (is)
MY (1)	MY146935A (is)
NO (1)	NO328580B1 (is)
NZ (1)	NZ528207A (is)
PL (1)	PL208278B1 (is)
PT (1)	PT1368094E (is)
RS (1)	RS50863B (is)
RU (1)	RU2292347C2 (is)
SK (1)	SK287603B6 (is)
TW (1)	TWI257388B (is)
UA (1)	UA74634C2 (is)
WO (1)	WO2002072202A1 (is)
ZA (1)	ZA200306995B (is)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7094782B1 (en) *	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
AR041470A1 (es) *	2002-10-17	2005-05-18	Upjohn Co	Compuestos de pirrolo (1,2 - b) piridazina y sus usos
US7329658B2 (en)	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) *	2003-02-10	2007-02-13	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
US7041671B2 (en)	2003-04-02	2006-05-09	Pfizer Inc	Pyrrolo[1,2-b]pyridazine compounds and their uses
US7034023B2 (en) *	2003-04-04	2006-04-25	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7056920B2 (en)	2003-04-04	2006-06-06	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
BRPI0409444A (pt) *	2003-04-15	2006-04-18	Pharmacia & Upjohn Co Llc	compostos de pirrolo[1,2-b]piridazina e suas utilizações
US7208596B2 (en) *	2003-11-25	2007-04-24	Bristol-Myers Squibb Pharma Company	Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US7153961B2 (en)	2003-11-25	2006-12-26	Bristol-Myers Squibb Pharma Co.	Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist
KR101088239B1 (ko)	2006-09-20	2011-11-30	일라이 릴리 앤드 캄파니	Ｃｒｆ１ 수용체 길항제로서의 티아졸 피라졸로피리미딘
JP2015516979A (ja) *	2012-04-23	2015-06-18	ホルスボールマッシュマイヤーニューロケミーゲーエムベーハーＨｏｌｓｂｏｅｒｍａｓｃｈｍｅｙｅｒＮｅｕｒｏｃｈｅｍｉｅＧｍｂｈ	Ｃｒｈ過剰活性を有する患者の治療に用いるためのｃｒｈｒ１アンタゴニスト
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
KR102079844B1 (ko)	2016-09-20	2020-02-20	가톨릭대학교 산학협력단	담석 용해제를 포함하는 담낭 질환 치료용 약학 조성물
BR112020002967A2 (pt)	2017-08-14	2020-08-11	Spruce Biosciences, Inc.	antagonistas de receptor de fator de liberação de corticotropina
MX2020011344A (es)	2018-04-27	2021-02-09	Spruce Biosciences Inc	Métodos para tratar tumores en reposo suprarrenales testiculares y de ovarios.
JP2023537598A (ja)	2020-08-12	2023-09-04	スプルースバイオサイエンシーズ，インク．	多嚢胞性卵巣症候群を処置するための方法および組成物
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW370529B (en)	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
JP3398152B2 (ja)	1993-10-12	2003-04-21	ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー	１ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
TW574214B (en)	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
CA2249598A1 (en)	1996-03-26	1997-10-02	Paul Joseph Gilligan	Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives
US6107300A (en)	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
WO1997044308A1 (en)	1996-05-24	1997-11-27	The Dow Chemical Company	Process for preparing aliphatic ester compounds and alkanols
AU747708B2 (en)	1996-07-24	2002-05-23	Du Pont Pharmaceuticals Company	Azolo triazines and pyrimidines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
CZ299451B6 (cs) *	1996-07-24	2008-07-30	Bristol-Myers Squibb Pharma Company	[1,5-a]-Pyrazolo-1,3,5- triaziny jejich použití afarmaceutické kompozice na jejich bázi
PL332040A1 (en) *	1996-08-28	1999-08-16	Pfizer	Substitution 6,5-heterobicyclic derivatives
EP0994860A1 (en)	1997-07-03	2000-04-26	Du Pont Pharmaceuticals Company	Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists
UA62972C2 (en)	1997-07-03	2004-01-15		Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
JP2002507996A (ja)	1997-07-03	2002-03-12	デュポンファーマシューティカルズカンパニー	神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
WO1999011643A1 (en)	1997-09-02	1999-03-11	Du Pont Pharmaceuticals Company	Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders
IL137019A0 (en) *	1998-01-28	2001-06-14	Du Pont Pharm Co	Azolo triazines and pyrimidines
US6194410B1 (en)	1998-03-11	2001-02-27	Hoffman-La Roche Inc.	Pyrazolopyrimidine and pyrazolines and process for preparation thereof
WO1999051608A1 (en)	1998-04-03	1999-10-14	Du Pont Pharmaceuticals Company	THIAZOLO[4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
US6124463A (en)	1998-07-02	2000-09-26	Dupont Pharmaceuticals	Benzimidazoles as corticotropin release factor antagonists
IL144977A0 (en) *	1999-05-21	2002-06-30	Bristol Myers Squibb Co	Pyrrolotriazine derivatives and pharmaceutical compositions containing the same
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.

2002
- 2002-03-06 ES ES02713776T patent/ES2282401T3/es not_active Expired - Lifetime
- 2002-03-06 CA CA2440553A patent/CA2440553C/en not_active Expired - Fee Related
- 2002-03-06 KR KR1020037011913A patent/KR100875595B1/ko not_active Expired - Fee Related
- 2002-03-06 IL IL15761502A patent/IL157615A0/xx unknown
- 2002-03-06 EP EP02713776A patent/EP1368094B1/en not_active Expired - Lifetime
- 2002-03-06 NZ NZ528207A patent/NZ528207A/en not_active IP Right Cessation
- 2002-03-06 HR HR20030822A patent/HRP20030822B1/xx not_active IP Right Cessation
- 2002-03-06 MX MXPA03008185A patent/MXPA03008185A/es active IP Right Grant
- 2002-03-06 CZ CZ20032481A patent/CZ20032481A3/cs unknown
- 2002-03-06 DK DK02713776T patent/DK1368094T3/da active
- 2002-03-06 BR BR0208357-4A patent/BR0208357A/pt active Search and Examination
- 2002-03-06 JP JP2002571157A patent/JP4549630B2/ja not_active Expired - Fee Related
- 2002-03-06 EE EEP200300435A patent/EE05433B1/xx not_active IP Right Cessation
- 2002-03-06 HU HU0303480A patent/HU229317B1/hu not_active IP Right Cessation
- 2002-03-06 CN CNB028064151A patent/CN100427093C/zh not_active Expired - Fee Related
- 2002-03-06 AU AU2002245605A patent/AU2002245605B2/en not_active Ceased
- 2002-03-06 US US10/092,312 patent/US20030125330A1/en not_active Abandoned
- 2002-03-06 RU RU2003130093/04A patent/RU2292347C2/ru not_active IP Right Cessation
- 2002-03-06 WO PCT/US2002/006837 patent/WO2002072202A1/en not_active Ceased
- 2002-03-06 GE GE5322A patent/GEP20053608B/en unknown
- 2002-03-06 RS YUP-715/03A patent/RS50863B/sr unknown
- 2002-03-06 SK SK1157-2003A patent/SK287603B6/sk not_active IP Right Cessation
- 2002-03-06 PT PT02713776T patent/PT1368094E/pt unknown
- 2002-03-06 DE DE60218434T patent/DE60218434T2/de not_active Expired - Lifetime
- 2002-03-06 AT AT02713776T patent/ATE355102T1/de active
- 2002-03-06 PL PL368644A patent/PL208278B1/pl unknown
- 2002-03-12 MY MYPI20020879A patent/MY146935A/en unknown
- 2002-03-13 AR ARP020100908A patent/AR032986A1/es not_active Application Discontinuation
- 2002-03-13 TW TW091104706A patent/TWI257388B/zh not_active IP Right Cessation
- 2002-06-03 UA UA2003109244A patent/UA74634C2/uk unknown
2003
- 2003-02-05 US US10/358,652 patent/US7157578B2/en not_active Expired - Lifetime
- 2003-08-27 IL IL157615A patent/IL157615A/en not_active IP Right Cessation
- 2003-09-08 ZA ZA200306995A patent/ZA200306995B/en unknown
- 2003-09-10 IS IS6947A patent/IS2839B/is unknown
- 2003-09-11 NO NO20034023A patent/NO328580B1/no not_active IP Right Cessation
- 2003-09-23 BG BG108189A patent/BG66331B1/bg unknown
2006
- 2006-11-07 US US11/593,715 patent/US7358252B2/en not_active Expired - Lifetime
2007
- 2007-05-18 CY CY20071100678T patent/CY1106607T1/el unknown
2008
- 2008-02-13 US US12/030,439 patent/US7662817B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HU229317B1 (en)	2013-10-28
KR20030080086A (ko)	2003-10-10
DE60218434T2 (de)	2007-11-08
PT1368094E (pt)	2007-05-31
YU71503A (sh)	2006-05-25
DE60218434D1 (en)	2007-04-12
US20080139567A1 (en)	2008-06-12
RU2003130093A (ru)	2005-03-20
HK1057182A1 (en)	2004-03-19
US7358252B2 (en)	2008-04-15
EP1368094A1 (en)	2003-12-10
ATE355102T1 (de)	2006-03-15
CA2440553A1 (en)	2002-09-19
MXPA03008185A (es)	2004-01-29
GEP20053608B (en)	2005-09-12
US7157578B2 (en)	2007-01-02
EE05433B1 (et)	2011-06-15
CZ20032481A3 (cs)	2007-12-27
NO20034023L (no)	2003-09-11
US20030125330A1 (en)	2003-07-03
KR100875595B1 (ko)	2008-12-23
PL368644A1 (en)	2005-04-04
HRP20030822B1 (en)	2008-01-31
NZ528207A (en)	2006-02-24
HUP0303480A3 (en)	2005-12-28
EP1368094B1 (en)	2007-02-28
BG108189A (bg)	2004-09-30
US20040014760A1 (en)	2004-01-22
US7662817B2 (en)	2010-02-16
UA74634C2 (uk)	2006-01-16
PL208278B1 (pl)	2011-04-29
WO2002072202A1 (en)	2002-09-19
IS2839B (is)	2013-06-15
TWI257388B (en)	2006-07-01
SK11572003A3 (sk)	2004-02-03
HRP20030822A2 (en)	2004-04-30
NO328580B1 (no)	2010-03-22
BG66331B1 (bg)	2013-06-28
AR032986A1 (es)	2003-12-03
CA2440553C (en)	2010-06-08
RS50863B (sr)	2010-08-31
CY1106607T1 (el)	2012-01-25
HUP0303480A2 (hu)	2004-01-28
BR0208357A (pt)	2004-06-29
RU2292347C2 (ru)	2007-01-27
NO20034023D0 (no)	2003-09-11
US20070054913A1 (en)	2007-03-08
AU2002245605B2 (en)	2006-02-02
JP4549630B2 (ja)	2010-09-22
SK287603B6 (sk)	2011-03-04
EE200300435A (et)	2003-12-15
ZA200306995B (en)	2004-09-08
EP1368094A4 (en)	2004-03-31
CN100427093C (zh)	2008-10-22
DK1368094T3 (da)	2007-07-02
JP2004530662A (ja)	2004-10-07
ES2282401T3 (es)	2007-10-16
CN1509196A (zh)	2004-06-30
IL157615A0 (en)	2004-03-28
IL157615A (en)	2009-09-01
MY146935A (en)	2012-10-15

Publication	Publication Date	Title
IS2839B (is)	2013-06-15	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)pyrazolo-(1,5-A-)-1,3,5 triazine, handhverfur þess og lyfjafræðilega ásættanleg sölt sem tenglar við viðtaka fyrir "corticotropin releasing factor"
ATE530530T1 (de)	2011-11-15	Diaminopyrimidincarbonsäureamidderivat
DK1429761T3 (da)	2007-02-05	Hidtil ukendte 4,5-dihydro-1H-pyrazolderivater med CB1-antagonistisk virkning
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DK1250328T4 (da)	2010-06-28	Dihydro-1,3,5-triazindiaminderivater og terapeutisk anvendelse deraf
EA200300834A1 (ru)	2004-02-26	Антагонисты фактора, высвобождающего кортикотропин
DK1397351T3 (da)	2010-01-18	Pyrimidin-, triazin- og pyrazinderivater som glutamatreceptorer
NO2015009I1 (no)	2015-03-30	Nintedanib, tautomere og salter derav, spesielt Nintedanib og fysiologiske akseptable salter derav, spesielt Nintedanib esilat; 3-Z-[l-(4-(N-((4-metylpiperazin-1-yl)-metylkarbonyl)-N-metylamino)- anilino)-1-fenylmetylen]-6-metoksykarbonyl-2-indolinon - Se blant annet kravene 1, 2, 5 (t) og 6 i basispatentet
IS6957A (is)	2003-09-15	Tatrat sölt af 5,8,14,-tríasatetrasýkló[10.3.1.02,11.04,9]-hexadeka-2(11),3,5,7,9,-pentaen og lyfjafræðilegar samsetningar af þeim
ATE448238T1 (de)	2009-11-15	3-beta-d-ribofuranosylthiazolo(4,5- delta)pyridimin-nucleoside und ihre verwendung
ATE424202T1 (de)	2009-03-15	Substituierte 2-thio-3,5-dicyano-4-phenyl-6- aminopyridine und ihre verwendung
IS6566A (is)	2002-09-24	Indólín-2-ón afleiður, framleiðsla og notkun þeirra sem mjaltavaka (ocytocin) viðtakabindlar
EE05223B1 (et)	2009-10-15	Triasoloprimidiini hendid, meetod nende valmistamiseks ning nende kasutamine
NO20016368D0 (no)	2001-12-27	Respiratorisk syncytialvirus-replikasjonsinhibitorer
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ATE284886T1 (de)	2005-01-15	Benzimidazolderivate, ihre herstellung und therapeutische verwendung
EE200400088A (et)	2004-10-15	CCR1 retseptori suhtes antagonistlikku aktiivsustomavad piperasiiniderivaadid
DK1027891T3 (da)	2005-05-09	Neuropeptid-Y-antagonister
DE50211897D1 (de)	2008-04-24	3H-NAPHTHOÄ2,1-bÜ-PYRAN-DERIVATE SOWIE DEREN VERWENDUNG
IT1317288B1 (it)	2003-05-27	Struttura di tavola, particolarmente per ponteggi, scaffalature,soppalchi e simili.
ATE346069T1 (de)	2006-12-15	3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino(4, - b)indol-1-karboxamid-derivate, ihre herstellung und therapeutische verwendung
IT1320401B1 (it)	2003-11-26	Procedimento per la fabbricazione di componenti di un'ossatura ecomponenti di ossatura.
DE50310743D1 (de)	2008-12-18	Wässrige formulierungen von (2-hydroxymethyl-indanyl-4-oxy)-phenyl-4,4,4- trifluorbutan-1-sulfonat
DK1373216T3 (da)	2005-02-21	4,5-dihydro-1H-pyrazolderivater med CB1-antagonistisk aktivitet