NO20034023L - 4-(2-butylamino)-2,7-dimetyl-8-(2-metyl-6-metoksypyrid-3- yl)pyrazolo-[1,5-A]-1,3,5-triazin, dens enantiomerer og farmasöytisk akseptablesalter som kortikotropinfrigivende faktorreseptorligander - Google Patents

4-(2-butylamino)-2,7-dimetyl-8-(2-metyl-6-metoksypyrid-3- yl)pyrazolo-[1,5-A]-1,3,5-triazin, dens enantiomerer og farmasöytisk akseptablesalter som kortikotropinfrigivende faktorreseptorligander

Info

Publication number: NO20034023L
Authority: NO; Norway
Prior art keywords: methoxypyrid; pyrazolo; butylamino; enantiomers; triazine
Prior art date: 2001-03-13

Application number

NO20034023A

Other languages

English (en)

Other versions

NO328580B1 (no

NO20034023D0 (no

Inventor

Paul Joseph Gilligan

Original Assignee

Bristol Myers Squibb Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-13

Filing date

2003-09-11

Publication date

2003-09-11

2003-09-11 Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co

2003-09-11 Publication of NO20034023L publication Critical patent/NO20034023L/no

2003-09-11 Publication of NO20034023D0 publication Critical patent/NO20034023D0/no

2010-03-22 Publication of NO328580B1 publication Critical patent/NO328580B1/no

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 title 1
239000003446 ligand Substances 0.000 title 1
LBWQSAZEYIZZCE-UHFFFAOYSA-N n-butan-2-yl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine Chemical compound CC1=NN2C(NC(C)CC)=NC(C)=NC2=C1C1=CC=C(OC)N=C1C LBWQSAZEYIZZCE-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Addiction (AREA)
Diabetes (AREA)
Dermatology (AREA)
Virology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Nutrition Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)

NO20034023A 2001-03-13 2003-09-11 4-(2-butylamino)-2,7-dimetyl-8-(2-metyl-6-metoksypyrid-3-yl)pyrazolo-[1,5-A]-1,3,5-triazin, et farmasoytisk akseptabelt promedikament derav, farmasoytisk preparat, anvendelse av forbindelsen samt fremstilt gjenstand omfattende denne NO328580B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27540301P	2001-03-13	2001-03-13
PCT/US2002/006837 WO2002072202A1 (en)	2001-03-13	2002-03-06	4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, its enantiomers and pharmaceutically acceptable salts as corticotropin releasing factor receptor ligands

Publications (3)

Publication Number	Publication Date
NO20034023L true NO20034023L (no)	2003-09-11
NO20034023D0 NO20034023D0 (no)	2003-09-11
NO328580B1 NO328580B1 (no)	2010-03-22

Family

ID=23052141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034023A NO328580B1 (no)	2001-03-13	2003-09-11	4-(2-butylamino)-2,7-dimetyl-8-(2-metyl-6-metoksypyrid-3-yl)pyrazolo-[1,5-A]-1,3,5-triazin, et farmasoytisk akseptabelt promedikament derav, farmasoytisk preparat, anvendelse av forbindelsen samt fremstilt gjenstand omfattende denne

Country Status (35)

Country	Link
US (4)	US20030125330A1 (no)
EP (1)	EP1368094B1 (no)
JP (1)	JP4549630B2 (no)
KR (1)	KR100875595B1 (no)
CN (1)	CN100427093C (no)
AR (1)	AR032986A1 (no)
AT (1)	ATE355102T1 (no)
AU (1)	AU2002245605B2 (no)
BG (1)	BG66331B1 (no)
BR (1)	BR0208357A (no)
CA (1)	CA2440553C (no)
CY (1)	CY1106607T1 (no)
CZ (1)	CZ20032481A3 (no)
DE (1)	DE60218434T2 (no)
DK (1)	DK1368094T3 (no)
EE (1)	EE05433B1 (no)
ES (1)	ES2282401T3 (no)
GE (1)	GEP20053608B (no)
HR (1)	HRP20030822B1 (no)
HU (1)	HU229317B1 (no)
IL (2)	IL157615A0 (no)
IS (1)	IS2839B (no)
MX (1)	MXPA03008185A (no)
MY (1)	MY146935A (no)
NO (1)	NO328580B1 (no)
NZ (1)	NZ528207A (no)
PL (1)	PL208278B1 (no)
PT (1)	PT1368094E (no)
RS (1)	RS50863B (no)
RU (1)	RU2292347C2 (no)
SK (1)	SK287603B6 (no)
TW (1)	TWI257388B (no)
UA (1)	UA74634C2 (no)
WO (1)	WO2002072202A1 (no)
ZA (1)	ZA200306995B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7094782B1 (en) *	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
AR041470A1 (es) *	2002-10-17	2005-05-18	Upjohn Co	Compuestos de pirrolo (1,2 - b) piridazina y sus usos
US7329658B2 (en)	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) *	2003-02-10	2007-02-13	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
US7041671B2 (en)	2003-04-02	2006-05-09	Pfizer Inc	Pyrrolo[1,2-b]pyridazine compounds and their uses
US7034023B2 (en) *	2003-04-04	2006-04-25	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
US7056920B2 (en)	2003-04-04	2006-06-06	Pfizer Inc	Pyrrolo[1,2-B]pyridazine compounds and their uses
BRPI0409444A (pt) *	2003-04-15	2006-04-18	Pharmacia & Upjohn Co Llc	compostos de pirrolo[1,2-b]piridazina e suas utilizações
US7208596B2 (en) *	2003-11-25	2007-04-24	Bristol-Myers Squibb Pharma Company	Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US7153961B2 (en)	2003-11-25	2006-12-26	Bristol-Myers Squibb Pharma Co.	Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist
KR101088239B1 (ko)	2006-09-20	2011-11-30	일라이 릴리 앤드 캄파니	Ｃｒｆ１ 수용체 길항제로서의 티아졸 피라졸로피리미딘
JP2015516979A (ja) *	2012-04-23	2015-06-18	ホルスボールマッシュマイヤーニューロケミーゲーエムベーハーＨｏｌｓｂｏｅｒｍａｓｃｈｍｅｙｅｒＮｅｕｒｏｃｈｅｍｉｅＧｍｂｈ	Ｃｒｈ過剰活性を有する患者の治療に用いるためのｃｒｈｒ１アンタゴニスト
GB201210686D0 (en)	2012-06-15	2012-08-01	Holsboermaschmeyer Neurochemie Gmbh	V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
GB201310782D0 (en)	2013-06-17	2013-07-31	Max Planck Innovation Gmbh	Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms
KR102079844B1 (ko)	2016-09-20	2020-02-20	가톨릭대학교 산학협력단	담석 용해제를 포함하는 담낭 질환 치료용 약학 조성물
BR112020002967A2 (pt)	2017-08-14	2020-08-11	Spruce Biosciences, Inc.	antagonistas de receptor de fator de liberação de corticotropina
MX2020011344A (es)	2018-04-27	2021-02-09	Spruce Biosciences Inc	Métodos para tratar tumores en reposo suprarrenales testiculares y de ovarios.
JP2023537598A (ja)	2020-08-12	2023-09-04	スプルースバイオサイエンシーズ，インク．	多嚢胞性卵巣症候群を処置するための方法および組成物
US11708372B2 (en)	2021-11-19	2023-07-25	Spruce Biosciences, Inc.	Crystalline composition of tildacerfont and methods of use and preparation thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW370529B (en)	1992-12-17	1999-09-21	Pfizer	Pyrazolopyrimidines
JP3398152B2 (ja)	1993-10-12	2003-04-21	ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー	１ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
TW574214B (en)	1994-06-08	2004-02-01	Pfizer	Corticotropin releasing factor antagonists
CA2249598A1 (en)	1996-03-26	1997-10-02	Paul Joseph Gilligan	Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives
US6107300A (en)	1996-03-27	2000-08-22	Dupont Pharmaceuticals	Arylamino fused pyrimidines
WO1997044308A1 (en)	1996-05-24	1997-11-27	The Dow Chemical Company	Process for preparing aliphatic ester compounds and alkanols
AU747708B2 (en)	1996-07-24	2002-05-23	Du Pont Pharmaceuticals Company	Azolo triazines and pyrimidines
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
CZ299451B6 (cs) *	1996-07-24	2008-07-30	Bristol-Myers Squibb Pharma Company	[1,5-a]-Pyrazolo-1,3,5- triaziny jejich použití afarmaceutické kompozice na jejich bázi
PL332040A1 (en) *	1996-08-28	1999-08-16	Pfizer	Substitution 6,5-heterobicyclic derivatives
EP0994860A1 (en)	1997-07-03	2000-04-26	Du Pont Pharmaceuticals Company	Aryl-and arylamino-substituted heterocycles as corticotropin releasing hormone antagonists
UA62972C2 (en)	1997-07-03	2004-01-15		Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
JP2002507996A (ja)	1997-07-03	2002-03-12	デュポンファーマシューティカルズカンパニー	神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
WO1999011643A1 (en)	1997-09-02	1999-03-11	Du Pont Pharmaceuticals Company	Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders
IL137019A0 (en) *	1998-01-28	2001-06-14	Du Pont Pharm Co	Azolo triazines and pyrimidines
US6194410B1 (en)	1998-03-11	2001-02-27	Hoffman-La Roche Inc.	Pyrazolopyrimidine and pyrazolines and process for preparation thereof
WO1999051608A1 (en)	1998-04-03	1999-10-14	Du Pont Pharmaceuticals Company	THIAZOLO[4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
US6124463A (en)	1998-07-02	2000-09-26	Dupont Pharmaceuticals	Benzimidazoles as corticotropin release factor antagonists
IL144977A0 (en) *	1999-05-21	2002-06-30	Bristol Myers Squibb Co	Pyrrolotriazine derivatives and pharmaceutical compositions containing the same
ES2282401T3 (es) *	2001-03-13	2007-10-16	Bristol-Myers Squibb Pharma Company	4-(2-butilamino)-2,7-dimetil-8-(2-metil-6-metoxipirid-3-il) pirazolo - 1,5-a-1,3,5-triazina, sus enantiomeros y sales farmaceuticamente aceptables como ligandos del receptor del factor liberador de croticotropina.

2002
- 2002-03-06 ES ES02713776T patent/ES2282401T3/es not_active Expired - Lifetime
- 2002-03-06 CA CA2440553A patent/CA2440553C/en not_active Expired - Fee Related
- 2002-03-06 KR KR1020037011913A patent/KR100875595B1/ko not_active Expired - Fee Related
- 2002-03-06 IL IL15761502A patent/IL157615A0/xx unknown
- 2002-03-06 EP EP02713776A patent/EP1368094B1/en not_active Expired - Lifetime
- 2002-03-06 NZ NZ528207A patent/NZ528207A/en not_active IP Right Cessation
- 2002-03-06 HR HR20030822A patent/HRP20030822B1/xx not_active IP Right Cessation
- 2002-03-06 MX MXPA03008185A patent/MXPA03008185A/es active IP Right Grant
- 2002-03-06 CZ CZ20032481A patent/CZ20032481A3/cs unknown
- 2002-03-06 DK DK02713776T patent/DK1368094T3/da active
- 2002-03-06 BR BR0208357-4A patent/BR0208357A/pt active Search and Examination
- 2002-03-06 JP JP2002571157A patent/JP4549630B2/ja not_active Expired - Fee Related
- 2002-03-06 EE EEP200300435A patent/EE05433B1/xx not_active IP Right Cessation
- 2002-03-06 HU HU0303480A patent/HU229317B1/hu not_active IP Right Cessation
- 2002-03-06 CN CNB028064151A patent/CN100427093C/zh not_active Expired - Fee Related
- 2002-03-06 AU AU2002245605A patent/AU2002245605B2/en not_active Ceased
- 2002-03-06 US US10/092,312 patent/US20030125330A1/en not_active Abandoned
- 2002-03-06 RU RU2003130093/04A patent/RU2292347C2/ru not_active IP Right Cessation
- 2002-03-06 WO PCT/US2002/006837 patent/WO2002072202A1/en not_active Ceased
- 2002-03-06 GE GE5322A patent/GEP20053608B/en unknown
- 2002-03-06 RS YUP-715/03A patent/RS50863B/sr unknown
- 2002-03-06 SK SK1157-2003A patent/SK287603B6/sk not_active IP Right Cessation
- 2002-03-06 PT PT02713776T patent/PT1368094E/pt unknown
- 2002-03-06 DE DE60218434T patent/DE60218434T2/de not_active Expired - Lifetime
- 2002-03-06 AT AT02713776T patent/ATE355102T1/de active
- 2002-03-06 PL PL368644A patent/PL208278B1/pl unknown
- 2002-03-12 MY MYPI20020879A patent/MY146935A/en unknown
- 2002-03-13 AR ARP020100908A patent/AR032986A1/es not_active Application Discontinuation
- 2002-03-13 TW TW091104706A patent/TWI257388B/zh not_active IP Right Cessation
- 2002-06-03 UA UA2003109244A patent/UA74634C2/uk unknown
2003
- 2003-02-05 US US10/358,652 patent/US7157578B2/en not_active Expired - Lifetime
- 2003-08-27 IL IL157615A patent/IL157615A/en not_active IP Right Cessation
- 2003-09-08 ZA ZA200306995A patent/ZA200306995B/en unknown
- 2003-09-10 IS IS6947A patent/IS2839B/is unknown
- 2003-09-11 NO NO20034023A patent/NO328580B1/no not_active IP Right Cessation
- 2003-09-23 BG BG108189A patent/BG66331B1/bg unknown
2006
- 2006-11-07 US US11/593,715 patent/US7358252B2/en not_active Expired - Lifetime
2007
- 2007-05-18 CY CY20071100678T patent/CY1106607T1/el unknown
2008
- 2008-02-13 US US12/030,439 patent/US7662817B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HU229317B1 (en)	2013-10-28
KR20030080086A (ko)	2003-10-10
DE60218434T2 (de)	2007-11-08
PT1368094E (pt)	2007-05-31
YU71503A (sh)	2006-05-25
DE60218434D1 (en)	2007-04-12
US20080139567A1 (en)	2008-06-12
RU2003130093A (ru)	2005-03-20
HK1057182A1 (en)	2004-03-19
US7358252B2 (en)	2008-04-15
EP1368094A1 (en)	2003-12-10
ATE355102T1 (de)	2006-03-15
IS6947A (is)	2003-09-10
CA2440553A1 (en)	2002-09-19
MXPA03008185A (es)	2004-01-29
GEP20053608B (en)	2005-09-12
US7157578B2 (en)	2007-01-02
EE05433B1 (et)	2011-06-15
CZ20032481A3 (cs)	2007-12-27
US20030125330A1 (en)	2003-07-03
KR100875595B1 (ko)	2008-12-23
PL368644A1 (en)	2005-04-04
HRP20030822B1 (en)	2008-01-31
NZ528207A (en)	2006-02-24
HUP0303480A3 (en)	2005-12-28
EP1368094B1 (en)	2007-02-28
BG108189A (bg)	2004-09-30
US20040014760A1 (en)	2004-01-22
US7662817B2 (en)	2010-02-16
UA74634C2 (uk)	2006-01-16
PL208278B1 (pl)	2011-04-29
WO2002072202A1 (en)	2002-09-19
IS2839B (is)	2013-06-15
TWI257388B (en)	2006-07-01
SK11572003A3 (sk)	2004-02-03
HRP20030822A2 (en)	2004-04-30
NO328580B1 (no)	2010-03-22
BG66331B1 (bg)	2013-06-28
AR032986A1 (es)	2003-12-03
CA2440553C (en)	2010-06-08
RS50863B (sr)	2010-08-31
CY1106607T1 (el)	2012-01-25
HUP0303480A2 (hu)	2004-01-28
BR0208357A (pt)	2004-06-29
RU2292347C2 (ru)	2007-01-27
NO20034023D0 (no)	2003-09-11
US20070054913A1 (en)	2007-03-08
AU2002245605B2 (en)	2006-02-02
JP4549630B2 (ja)	2010-09-22
SK287603B6 (sk)	2011-03-04
EE200300435A (et)	2003-12-15
ZA200306995B (en)	2004-09-08
EP1368094A4 (en)	2004-03-31
CN100427093C (zh)	2008-10-22
DK1368094T3 (da)	2007-07-02
JP2004530662A (ja)	2004-10-07
ES2282401T3 (es)	2007-10-16
CN1509196A (zh)	2004-06-30
IL157615A0 (en)	2004-03-28
IL157615A (en)	2009-09-01
MY146935A (en)	2012-10-15

Legal Events

Date	Code	Title	Description
2017-10-23	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20034023D0 (no)	2003-09-11	4-(2-butylamino)-2,7-dimetyl-8-(2-metyl-6-metoksypyrid-3- yl)pyrazolo-[1,5-A]-1,3,5-triazin, dens enantiomerer og farmasöytisk akseptablesalter som kortikotropinfrigivende faktorreseptorligander
NO20021356D0 (no)	2002-03-19	Alkylendiamin-substituerte pyrazolo[1,5,-a]-1,5-pyrimidiner og pyrazolo[1,5-a]-1,3,5-triaziner
DK1235830T3 (da)	2004-03-29	Pyrrolo[2,3-d]pyrimidin-forbindelser som proteinkinaseinhibitorer
DK1430056T3 (da)	2006-02-27	Substituerede 2-pyrimidinyl - 6,7,8,9-tetrahydropyrimido-[1,2-a]pyrimidin-4-on- og 7-pyrimidinyl-2,3-dihydroimidazo [1,2-a] pyrimidin-5 (1H) onderivater mod neurodegenerative lidelser
AU2004209447A8 (en)	2004-08-19	Pyrazolo`1,5-a!`1,3,5!triazine derivatives as cannabinoid receptor ligands
EP1599482A4 (en)	2008-10-01	PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES
IS6993A (is)	2003-10-13	Ljóstæknileg upplausn af (1-bensýl-4-metýlpiperidín-3-ýl)-metýlamíni og notkun hennar til framleiðslu á pýrróló 2,3-pýrimidín afleiðum sem prótein kínasa hindrar
ATE388713T1 (de)	2008-03-15	4-amino-6-phenyl-pyrrolo(2,3-d)pyrimidin derivate
ATE260917T1 (de)	2004-03-15	N-(5,7-dimethoxy(1,2,4)triazolo(1,5-a)pyrimidin 2-yl)arylsulfonamid verbindungen und deren verwendung als herbizide
DE50209483D1 (de)	2007-03-29	Xanthinderivate, deren herstellung und deren verwendung als arzneimittel
HUP0203131A3 (en)	2004-06-28	Amino substituted pyrazolo[1,5-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines, pharmaceutical compositions containing them and their use
DE50213202D1 (de)	2009-02-26	Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
EE200300400A (et)	2003-12-15	Pürimidiiniühendid, nende valmistamismeetod ning kasutamine
ATE231866T1 (de)	2003-02-15	Pyrazolo(4, 3-d)pyrimidine
MXPA03008965A (es)	2004-02-12	Uso de compuestos de imidazo [1,2-a]-piridinas sustituidas como medicamentos.
IL175753A0 (en)	2006-09-05	PROCESSES FOR THE PREPARATION OF PYRAZOLO [1,5-a]-1,3,5-TRIAZINES AND INTERMEDIATES THEREOF
MXPA03008894A (es)	2003-12-08	Uso de compuestos de imidazo[1,2-a]-piridin-3-il-amidas e imidazo [1,2-a]-piridin-3-il-aminas sustituidas como medicamentos.
NO20041178L (no)	2004-04-22	Fremgangsmate for fremstilling av 6-(4-klorfenyl)-2,2-dimetyl-7-fenyl-2,3-dihydro-1H-pyrrolizin-5-yl-eddiksyre
ATE294180T1 (de)	2005-05-15	Substituierte 3,4-dihydro-pyrimido (1,2- a)pyrimidine und 3,4-dihydropyrazino (1,2- a)pyrimidine
IL164377A0 (en)	2005-12-18	Methods of preparation of the 2-(7-chloro-1,8-naphthyridine-2yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone
TH52800A (th)	2002-08-30	ไพราโซโลไตรอะซีนที่ถูกแทนที่ที่เป็นซีเลคทีฟอินเวอร์สอะโกนิสท์สำหรับ gaba-a แอลฟา 5 รีเซพเตอร์ซับไทพ์
SI1325010T1 (en)	2005-10-31	Substituted 3.4-dihydro-pyrimido (1,2-a)pyrimidines and 3.4-dihydropyrazino (1,2-a)pyrimidines
AU2002325550A1 (en)	2003-03-18	(1,2,4)triazolo(1,5-a)pyrimidine derivative
IL203601A (en)	2015-03-31	6-Hello-7-History (optionally converted amino) -Pyrazolo [15, - a] pyrimidine and its use in drug preparation
AU2002241194A1 (en)	2002-10-03	Pyrazolo`4,3-d.pyrimidinone compounds as cgmp pde inhibitors