DK1403264T3 - Fremgangsmåde til industriel syntese af methyldiesteren af 5-amino-3-carboxylmethyl-4-cyano-2-thiophencarboxylsyre - Google Patents

Fremgangsmåde til industriel syntese af methyldiesteren af 5-amino-3-carboxylmethyl-4-cyano-2-thiophencarboxylsyre

Info

Publication number: DK1403264T3
Authority: DK; Denmark
Prior art keywords: carboxylmethyl; cyano; amino; thiophenecarboxylic acid; industrial synthesis
Prior art date: 2002-09-24

Application number

DK03292317T

Other languages

Danish (da)

English (en)

Inventor

Jean-Pierre Lecouve

Pascal Langlois

Lucile Vaysse-Ludot

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-24

Filing date

2003-09-22

Publication date

2005-04-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29415190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1403264(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-22 Application filed by Servier Lab filed Critical Servier Lab

2005-04-04 Application granted granted Critical

2005-04-04 Publication of DK1403264T3 publication Critical patent/DK1403264T3/da

Links

KNPBNTMMZCNVIE-UHFFFAOYSA-N 5-amino-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid Chemical compound NC=1SC(C(O)=O)=C(CC(O)=O)C=1C#N KNPBNTMMZCNVIE-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
-1 methyl diester Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK03292317T 2002-09-24 2003-09-22 Fremgangsmåde til industriel syntese af methyldiesteren af 5-amino-3-carboxylmethyl-4-cyano-2-thiophencarboxylsyre DK1403264T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0211764A FR2844796A1 (fr)	2002-09-24	2002-09-24	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
EP03292317A EP1403264B1 (fr)	2002-09-24	2003-09-22	Procédé de synthèse industriel du diester méthylique de l'acide 5-amino-3-carboxyméthyl-4-cyano-2-thiophénecarboxylique

Publications (1)

Publication Number	Publication Date
DK1403264T3 true DK1403264T3 (da)	2005-04-04

Family

ID=29415190

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03292317T DK1403264T3 (da)	2002-09-24	2003-09-22	Fremgangsmåde til industriel syntese af methyldiesteren af 5-amino-3-carboxylmethyl-4-cyano-2-thiophencarboxylsyre

Country Status (38)

Country	Link
US (3)	US7105683B2 (sr)
EP (1)	EP1403264B1 (sr)
JP (1)	JP4136865B2 (sr)
KR (1)	KR100551503B1 (sr)
CN (2)	CN1280285C (sr)
AP (1)	AP1942A (sr)
AR (1)	AR041356A1 (sr)
AT (1)	ATE286041T1 (sr)
AU (2)	AU2003282178A1 (sr)
BR (1)	BR0304194A (sr)
CA (1)	CA2442875C (sr)
DE (1)	DE60300252T2 (sr)
DK (1)	DK1403264T3 (sr)
EA (1)	EA007496B1 (sr)
EC (1)	ECSP055742A (sr)
ES (1)	ES2235144T3 (sr)
FR (1)	FR2844796A1 (sr)
GE (1)	GEP20074140B (sr)
HR (1)	HRP20050360B1 (sr)
IL (1)	IL167314A (sr)
IS (1)	IS2136B (sr)
MA (1)	MA26101A1 (sr)
ME (1)	ME00451B (sr)
MX (1)	MXPA03008645A (sr)
MY (1)	MY131939A (sr)
NI (1)	NI200500065A (sr)
NO (1)	NO328697B1 (sr)
NZ (1)	NZ528400A (sr)
OA (1)	OA12933A (sr)
PL (1)	PL214414B1 (sr)
PT (1)	PT1403264E (sr)
RS (1)	RS50929B (sr)
SG (1)	SG110070A1 (sr)
SI (1)	SI1403264T1 (sr)
TN (1)	TNSN05089A1 (sr)
UA (1)	UA79991C2 (sr)
WO (1)	WO2004029035A1 (sr)
ZA (1)	ZA200307410B (sr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2844795B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
PT1534305E (pt) *	2003-05-07	2007-02-28	Osteologix As	Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis
PT1622630E (pt) *	2003-05-07	2012-10-11	Osteologix As	Combinações de estrôncio para a profilaxia/tratamento de patologias da cartilagem e/ou do osso
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
US20080167513A1 (en) *	2004-02-26	2008-07-10	Osteologlx A/S	Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions
DK1768748T4 (da)	2004-06-25	2019-06-11	Mokwalo Spf S A	Sammensætninger omfattende strontium og vitamin D og anvendelser deraf
FR2875807B1 (fr) *	2004-09-30	2006-11-17	Servier Lab	Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
US20070292529A1 (en) *	2006-06-19	2007-12-20	Tabbiner Philip S	Strontium compositions and methods of treating osteoporotic conditions
CN101665483B (zh) *	2008-09-01	2013-01-23	河北医科大学	一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011110597A1 (de)	2010-03-11	2011-09-15	Azad Pharmaceutical Ingredients Ag	Verfahren zur herstellung von strontiumranelat
CN103319454B (zh) *	2013-06-14	2014-06-18	广东众生药业股份有限公司	一种高纯度雷尼酸四乙酯及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR415850A (fr)	1909-07-22	1910-10-05	Gustave Auguste Ferrie	Dispositif de mesure permettant de lire directement la valeur d'une grandeur fonction de deux variables
FR2651497B1 (fr) *	1989-09-01	1991-10-25	Adir	Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2844796A1 (fr) *	2002-09-24	2004-03-26	Servier Lab	Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
FR2844797B1 (fr) *	2002-09-24	2004-10-22	Servier Lab	Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

2002
- 2002-09-24 FR FR0211764A patent/FR2844796A1/fr active Pending
2003
- 2003-09-17 MY MYPI20033534A patent/MY131939A/en unknown
- 2003-09-22 DE DE60300252T patent/DE60300252T2/de not_active Expired - Lifetime
- 2003-09-22 BR BR0304194-8A patent/BR0304194A/pt not_active Application Discontinuation
- 2003-09-22 GE GEAP20038760A patent/GEP20074140B/en unknown
- 2003-09-22 AU AU2003282178A patent/AU2003282178A1/en not_active Abandoned
- 2003-09-22 AT AT03292317T patent/ATE286041T1/de active
- 2003-09-22 WO PCT/FR2003/002776 patent/WO2004029035A1/fr not_active Ceased
- 2003-09-22 DK DK03292317T patent/DK1403264T3/da active
- 2003-09-22 HR HRP20050360AA patent/HRP20050360B1/hr not_active IP Right Cessation
- 2003-09-22 PT PT03292317T patent/PT1403264E/pt unknown
- 2003-09-22 RS YUP-2005/0242A patent/RS50929B/sr unknown
- 2003-09-22 ES ES03292317T patent/ES2235144T3/es not_active Expired - Lifetime
- 2003-09-22 EP EP03292317A patent/EP1403264B1/fr not_active Expired - Lifetime
- 2003-09-22 JP JP2003330438A patent/JP4136865B2/ja not_active Expired - Fee Related
- 2003-09-22 AP AP2005003259A patent/AP1942A/xx active
- 2003-09-22 UA UAA200503859A patent/UA79991C2/uk unknown
- 2003-09-22 ME MEP-2008-685A patent/ME00451B/me unknown
- 2003-09-22 AU AU2003248279A patent/AU2003248279B2/en not_active Ceased
- 2003-09-22 OA OA1200500082A patent/OA12933A/en unknown
- 2003-09-22 SI SI200330013T patent/SI1403264T1/xx unknown
- 2003-09-23 ZA ZA200307410A patent/ZA200307410B/xx unknown
- 2003-09-23 EA EA200300926A patent/EA007496B1/ru not_active IP Right Cessation
- 2003-09-23 PL PL362367A patent/PL214414B1/pl unknown
- 2003-09-23 KR KR1020030065785A patent/KR100551503B1/ko not_active Expired - Fee Related
- 2003-09-23 NO NO20034237A patent/NO328697B1/no not_active IP Right Cessation
- 2003-09-23 NZ NZ528400A patent/NZ528400A/en not_active IP Right Cessation
- 2003-09-23 MX MXPA03008645A patent/MXPA03008645A/es active IP Right Grant
- 2003-09-23 CA CA002442875A patent/CA2442875C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103454A patent/AR041356A1/es not_active Application Discontinuation
- 2003-09-24 US US10/669,738 patent/US7105683B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB031348076A patent/CN1280285C/zh not_active Expired - Fee Related
- 2003-09-24 SG SG200305554A patent/SG110070A1/en unknown
- 2003-09-24 CN CNB2006100073351A patent/CN100393707C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27320A patent/MA26101A1/fr unknown
2005
- 2005-03-08 IL IL167314A patent/IL167314A/en not_active IP Right Cessation
- 2005-03-18 NI NI200500065A patent/NI200500065A/es unknown
- 2005-03-23 TN TNP2005000089A patent/TNSN05089A1/fr unknown
- 2005-04-19 IS IS7808A patent/IS2136B/xx unknown
- 2005-04-22 EC EC2005005742A patent/ECSP055742A/es unknown
2006
- 2006-02-21 US US11/358,034 patent/US7462714B2/en not_active Expired - Fee Related
- 2006-02-21 US US11/358,496 patent/US7238815B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20060142596A1 (en)	2006-06-29
ECSP055742A (es)	2005-07-06
EA007496B1 (ru)	2006-10-27
ME00451B (me)	2011-10-10
RS20050242A (sr)	2007-06-04
AR041356A1 (es)	2005-05-11
AU2003248279A1 (en)	2004-04-08
HK1096661A1 (zh)	2007-06-08
JP4136865B2 (ja)	2008-08-20
NO328697B1 (no)	2010-04-26
CA2442875A1 (fr)	2004-03-24
CN100393707C (zh)	2008-06-11
PL214414B1 (pl)	2013-07-31
CN1280285C (zh)	2006-10-18
CN1500783A (zh)	2004-06-02
SG110070A1 (en)	2005-04-28
IL167314A (en)	2010-04-29
FR2844796A1 (fr)	2004-03-26
EP1403264A1 (fr)	2004-03-31
US20040059135A1 (en)	2004-03-25
MA26101A1 (fr)	2004-04-01
AU2003248279B2 (en)	2009-08-06
EA200300926A1 (ru)	2004-04-29
EP1403264B1 (fr)	2004-12-29
US7462714B2 (en)	2008-12-09
GEP20074140B (en)	2007-06-25
NI200500065A (es)	2006-01-03
HRP20050360B1 (hr)	2013-08-31
AU2003282178A1 (en)	2004-04-19
US7105683B2 (en)	2006-09-12
AP2005003259A0 (en)	2005-03-31
PL362367A1 (en)	2004-04-05
DE60300252T2 (de)	2005-12-22
US7238815B2 (en)	2007-07-03
ZA200307410B (en)	2004-07-07
ATE286041T1 (de)	2005-01-15
MXPA03008645A (es)	2005-04-19
JP2004269495A (ja)	2004-09-30
CN1817869A (zh)	2006-08-16
WO2004029035A1 (fr)	2004-04-08
PT1403264E (pt)	2005-04-29
NO20034237D0 (no)	2003-09-23
NO20034237L (no)	2004-03-25
KR100551503B1 (ko)	2006-02-13
HK1061845A1 (en)	2004-10-08
MY131939A (en)	2007-09-28
BR0304194A (pt)	2004-09-08
NZ528400A (en)	2004-06-25
KR20040026627A (ko)	2004-03-31
IS7808A (is)	2005-04-19
ES2235144T3 (es)	2005-07-01
US20060142567A1 (en)	2006-06-29
CA2442875C (fr)	2009-06-02
IS2136B (is)	2006-08-15
DE60300252D1 (de)	2005-02-03
AP1942A (en)	2009-01-28
SI1403264T1 (en)	2005-04-30
HRP20050360A2 (en)	2005-06-30
TNSN05089A1 (fr)	2007-05-14
OA12933A (en)	2006-10-13
RS50929B (sr)	2010-08-31
UA79991C2 (en)	2007-08-10

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