DK1432701T3 - Heterocycliske forbindelser til anvendelse ved behandlingen af lidelser i urinvejene - Google Patents

Heterocycliske forbindelser til anvendelse ved behandlingen af lidelser i urinvejene

Info

Publication number: DK1432701T3
Authority: DK; Denmark
Prior art keywords: disorders; treatment; urinary tract; heterocyclic compounds; heterocyclic
Prior art date: 2001-10-05

Application number

DK02782863T

Other languages

Danish (da)

English (en)

Inventor

Jeff W Corbett

Amedeo Leonardi

Gianni Motta

Rodolfo Testa

Carlo Riva

Original Assignee

Recordati Ireland Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-05

Filing date

2002-10-07

Publication date

2006-05-08

2002-10-07 Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd

2006-05-08 Application granted granted Critical

2006-05-08 Publication of DK1432701T3 publication Critical patent/DK1432701T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Quinoline Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK02782863T 2001-10-05 2002-10-07 Heterocycliske forbindelser til anvendelse ved behandlingen af lidelser i urinvejene DK1432701T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2001MI002060A ITMI20012060A1 (it)	2001-10-05	2001-10-05	Nuovi eterocilcli n-acilati

Publications (1)

Publication Number	Publication Date
DK1432701T3 true DK1432701T3 (da)	2006-05-08

Family

ID=11448476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02782863T DK1432701T3 (da)	2001-10-05	2002-10-07	Heterocycliske forbindelser til anvendelse ved behandlingen af lidelser i urinvejene

Country Status (32)

Country	Link
US (2)	US20030181446A1 (es)
EP (1)	EP1432701B1 (es)
JP (1)	JP2005508952A (es)
KR (1)	KR20040048930A (es)
CN (1)	CN1564820A (es)
AP (1)	AP1705A (es)
AR (1)	AR036743A1 (es)
AT (1)	ATE313540T1 (es)
AU (1)	AU2002346979B9 (es)
BR (1)	BR0213067A (es)
CA (1)	CA2458456A1 (es)
CO (1)	CO5570679A2 (es)
CY (1)	CY1104991T1 (es)
DE (1)	DE60208221T2 (es)
DK (1)	DK1432701T3 (es)
EA (1)	EA200400507A1 (es)
EC (1)	ECSP045095A (es)
ES (1)	ES2253568T3 (es)
HR (1)	HRP20040392A2 (es)
HU (1)	HUP0401598A2 (es)
IT (1)	ITMI20012060A1 (es)
MA (1)	MA27067A1 (es)
MX (1)	MXPA04002962A (es)
NO (1)	NO20041833L (es)
NZ (1)	NZ532511A (es)
OA (1)	OA12663A (es)
PL (1)	PL369763A1 (es)
SI (1)	SI1432701T1 (es)
TN (1)	TNSN04053A1 (es)
WO (1)	WO2003031436A1 (es)
YU (1)	YU27204A (es)
ZA (1)	ZA200403356B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR035521A1 (es) *	2000-12-22	2004-06-02	Lundbeck & Co As H	Derivados de 3-indolina y composicion farmaceutica que los comprende
ES2323451T7 (es)	2001-07-20	2011-08-01	Psychogenics Inc.	Tratamiento para el trastorno de hiperactividad con deficit de atencion.
ITMI20012060A1 (it) *	2001-10-05	2003-04-05	Recordati Chem Pharm	Nuovi eterocilcli n-acilati
US20040058962A1 (en) *	2002-06-14	2004-03-25	Amedeo Leonardi	Phenylalkylamines and pyridylalkylamines
US20040215284A1 (en) *	2003-01-30	2004-10-28	Recordati S.A.	Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists
AR047759A1 (es) *	2003-09-26	2006-02-22	Vertex Pharma	Derivados de fenil - piperazina como moduladores de receptores muscarnicos
CN1914204A (zh) *	2003-12-09	2007-02-14	弗特克斯药品有限公司	萘啶衍生物及其作为毒蕈碱性受体调节剂的用途
US20050165025A1 (en) *	2004-01-22	2005-07-28	Recordati Ireland Ltd.	Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7553967B2 (en) *	2004-03-12	2009-06-30	Wyeth	1,2-Dihydroquinoline derivatives and method for using the same to treat HIV infections
US7534796B2 (en)	2005-02-18	2009-05-19	Wyeth	Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en)	2005-02-18	2009-05-26	Wyeth	4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en)	2005-02-18	2009-09-01	Wyeth	7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7531542B2 (en)	2005-05-18	2009-05-12	Wyeth	Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en)	2005-05-26	2009-09-01	Wyeth	Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
DE102005027168A1 (de) *	2005-06-13	2006-12-14	Merck Patent Gmbh	Tetrahydrochinoline
US7749995B2 (en)	2006-05-11	2010-07-06	Janssen Pharmaceutica Nv	3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors
EP2034998A1 (en)	2006-05-11	2009-03-18	Janssen Pharmaceutica, N.V.	1,2,3,4-tetrahydro-quinoline derivatives as cetp inhibitors
TW200811158A (en) *	2006-06-27	2008-03-01	Sanofi Aventis	Piperidine or pyrrolidine urea derivatives, their preparation and their therapeutic application
TW200811170A (en)	2006-06-27	2008-03-01	Sanofi Aventis	Urea derivatives of tropane, their preparation and their therapeutic application
FR2902790A1 (fr) *	2006-06-27	2007-12-28	Sanofi Aventis Sa	Derives d'urees de piperidine ou pyrrolidine,leur preparation et leur application en therapeutique
BRPI0713198A2 (pt)	2006-07-19	2012-10-16	Osurf Ohio State University Res Foundation	modulares seletivos de receptores de androgênio, seus análogos e derivados, e seus usos
DK2178870T3 (en) *	2007-08-17	2018-10-22	Lg Chemical Ltd	INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE
CA2722340A1 (en) *	2008-04-24	2009-10-29	Marc Diamond	Small-molecule inhibitors of the androgen receptor
FR2969151B1 (fr) *	2010-12-17	2016-11-04	Oreal	Derives du 4-amino et leur utilisation pour la coloration d'oxydation des fibres keratiniques.
JP6407285B2 (ja)	2013-09-09	2018-10-17	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ調節因子
JP6397488B2 (ja)	2013-09-20	2018-09-26	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ＲＯＲγ調節因子
AR107032A1 (es) *	2015-12-09	2018-03-14	Padlock Therapeutics Inc	Inhibidores bicíclicos de pad4
CN108299397B (zh) *	2018-03-21	2019-01-29	佳木斯大学附属第一医院	一种用于降血压的活性药物及其制备方法
WO2025217141A1 (en) *	2024-04-09	2025-10-16	Enanta Pharmaceuticals, Inc.	Pharmaceutical compounds and compositions as modulators of mas-related g-protein receptor x2

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1027611A (en) *	1962-01-04	1966-04-27	May & Baker Ltd	Phenoxy- and phenylthio-alkylamines and acid addition salts thereof
GB1166538A (en) *	1967-06-10	1969-10-08	Pfizer Ltd	Substituted Tetrahydroquinolines
US3983121A (en) *	1974-07-01	1976-09-28	Council Of Scientific And Industrial Research	1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof
US4011324A (en) *	1976-01-20	1977-03-08	Pfizer Inc.	Esters and amides of pyrimido[4,5-b]quinolin-4(3H)-one-2-carboxylic acids as antiulcer agents
US4461896A (en) *	1979-02-07	1984-07-24	Norwich Eaton Pharmaceuticals, Inc.	1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
CH653021A5 (fr) *	1981-04-24	1985-12-13	Delalande Sa	Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
US4585773A (en) *	1984-07-11	1986-04-29	Bristol-Myers Company	Isoindolinyl-alkyl-piperazines
EP0189612B1 (en) *	1984-12-21	1992-11-04	Duphar International Research B.V	New pharmaceutical compositions having a psychotropic activity
US4831031A (en) *	1988-01-22	1989-05-16	Pfizer Inc.	Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5641504A (en) *	1988-06-09	1997-06-24	Alza Corporation	Skin permeation enhancer compositions using glycerol monolinoleate
IE920040A1 (en) *	1991-01-09	1992-07-15	Alza Corp	Bioerodible devices and compositions for diffusional release¹of agents
US5443459A (en) *	1991-01-30	1995-08-22	Alza Corporation	Osmotic device for delayed delivery of agent
JPH05117276A (ja) *	1991-10-23	1993-05-14	Sumitomo Pharmaceut Co Ltd	新規な３環性キノキサリンジオン誘導体
US5629019A (en) *	1992-02-27	1997-05-13	Alza Corporation	Formulations with hydrophobic permeation enhancers
ZA933349B (en) *	1992-05-13	1994-06-15	Alza Corp	Transdermal administration of oxybutynin
US5512293A (en) *	1992-07-23	1996-04-30	Alza Corporation	Oral sustained release drug delivery device
US5573776A (en) *	1992-12-02	1996-11-12	Alza Corporation	Oral osmotic device with hydrogel driving member
US5533971A (en) *	1993-09-03	1996-07-09	Alza Corporation	Reduction of skin irritation during electrotransport
IT1270993B (it) *	1994-03-18	1997-05-26	Recordati Chem Pharm	Derivati chinzolilamminici attivi come alfa-antagonisti
FR2729144A1 (fr) *	1995-01-06	1996-07-12	Smithkline Beecham Lab	Nouvelles diamines, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu' agents anti-arythmiques
US5859014A (en) *	1995-06-09	1999-01-12	Syntex (U.S.A.) Inc.	Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists
US5780058A (en) *	1995-07-21	1998-07-14	Alza Corporation	Oral delivery of discrete units
US6096339A (en) *	1997-04-04	2000-08-01	Alza Corporation	Dosage form, process of making and using same
EP0882717B1 (en) *	1996-10-01	2010-09-08	Kyowa Hakko Kirin Co., Ltd.	Nitrogenous heterocyclic compounds
CA2220649C (en) *	1996-12-03	2007-02-13	F. Hoffmann-La Roche Ag	4-hydroxy-piperidine derivatives
EP0846683B1 (en) *	1996-12-03	2001-09-19	F. Hoffmann-La Roche Ag	4-Hydroxy-piperidine derivatives
US6281227B1 (en) *	1996-12-13	2001-08-28	Aventis Pharma Deutschland Gmbh	Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds
JP4642946B2 (ja) *	1996-12-20	2011-03-02	アルザコーポレイション	ゲル組成物および方法
US6169086B1 (en) *	1997-01-27	2001-01-02	Daiichi Pharmaceutical Co., Ltd.	Pyrazole derivatives
IT1293804B1 (it) *	1997-08-01	1999-03-10	Recordati Chem Pharm	Diarilalchilpiperazine attive sulle basse vie urinarie
JP2001512110A (ja) *	1997-08-01	2001-08-21	レコルダチエッセ．ア．，ケミカルアンドファーマシューティカルカンパニー	１，４−ジ置換ピペラジン
US6039977A (en) *	1997-12-09	2000-03-21	Alza Corporation	Pharmaceutical hydrogel formulations, and associated drug delivery devices and methods
BR9909146A (pt) *	1998-03-26	2000-12-05	Shionogi & Co	Derivados de indol apresentando uma atividade antiviral
US6174547B1 (en) *	1999-07-14	2001-01-16	Alza Corporation	Dosage form comprising liquid formulation
US6306861B1 (en) *	1999-07-30	2001-10-23	Recordati S.A. Chemical And Pharmaceutical Company	Thienopyrancecarboxamide derivatives
US6365591B1 (en) *	1999-10-18	2002-04-02	Recordati, S.A., Chemical And Pharmacueticals Company	Isoxazolecarboxamide derivatives
US6403594B1 (en) *	1999-10-18	2002-06-11	Recordati, S.A. Chemical And Pharmaceutical Company	Benzopyran derivatives
AR035521A1 (es) *	2000-12-22	2004-06-02	Lundbeck & Co As H	Derivados de 3-indolina y composicion farmaceutica que los comprende
US20030060513A1 (en) *	2001-09-27	2003-03-27	Arneric Stephen P.	Pharmaceutical composition
ITMI20012060A1 (it) *	2001-10-05	2003-04-05	Recordati Chem Pharm	Nuovi eterocilcli n-acilati

2001
- 2001-10-05 IT IT2001MI002060A patent/ITMI20012060A1/it unknown
2002
- 2002-10-04 AR ARP020103760A patent/AR036743A1/es not_active Application Discontinuation
- 2002-10-07 WO PCT/EP2002/011282 patent/WO2003031436A1/en not_active Ceased
- 2002-10-07 EP EP02782863A patent/EP1432701B1/en not_active Expired - Lifetime
- 2002-10-07 NZ NZ532511A patent/NZ532511A/en unknown
- 2002-10-07 JP JP2003534419A patent/JP2005508952A/ja not_active Withdrawn
- 2002-10-07 YU YU27204A patent/YU27204A/sh unknown
- 2002-10-07 DK DK02782863T patent/DK1432701T3/da active
- 2002-10-07 HR HR20040392A patent/HRP20040392A2/hr not_active Application Discontinuation
- 2002-10-07 SI SI200230244T patent/SI1432701T1/sl unknown
- 2002-10-07 DE DE60208221T patent/DE60208221T2/de not_active Expired - Fee Related
- 2002-10-07 HU HU0401598A patent/HUP0401598A2/hu unknown
- 2002-10-07 CN CNA028197283A patent/CN1564820A/zh active Pending
- 2002-10-07 OA OA1200400088A patent/OA12663A/en unknown
- 2002-10-07 PL PL02369763A patent/PL369763A1/xx not_active Application Discontinuation
- 2002-10-07 EA EA200400507A patent/EA200400507A1/ru unknown
- 2002-10-07 CA CA002458456A patent/CA2458456A1/en not_active Abandoned
- 2002-10-07 US US10/266,088 patent/US20030181446A1/en not_active Abandoned
- 2002-10-07 ES ES02782863T patent/ES2253568T3/es not_active Expired - Lifetime
- 2002-10-07 AP APAP/P/2004/002997A patent/AP1705A/en active
- 2002-10-07 AT AT02782863T patent/ATE313540T1/de not_active IP Right Cessation
- 2002-10-07 MX MXPA04002962A patent/MXPA04002962A/es unknown
- 2002-10-07 BR BR0213067-0A patent/BR0213067A/pt not_active IP Right Cessation
- 2002-10-07 AU AU2002346979A patent/AU2002346979B9/en not_active Ceased
- 2002-10-07 US US10/266,104 patent/US20030162777A1/en not_active Abandoned
- 2002-10-07 KR KR10-2004-7004948A patent/KR20040048930A/ko not_active Withdrawn
2004
- 2004-03-11 MA MA27571A patent/MA27067A1/fr unknown
- 2004-04-02 TN TNP2004000053A patent/TNSN04053A1/en unknown
- 2004-05-04 CO CO04040886A patent/CO5570679A2/es not_active Application Discontinuation
- 2004-05-04 NO NO20041833A patent/NO20041833L/no not_active Application Discontinuation
- 2004-05-04 ZA ZA200403356A patent/ZA200403356B/en unknown
- 2004-05-05 EC EC2004005095A patent/ECSP045095A/es unknown
2006
- 2006-03-03 CY CY20061100304T patent/CY1104991T1/el unknown

Also Published As

Publication number	Publication date
AR036743A1 (es)	2004-09-29
ZA200403356B (en)	2004-11-08
AU2002346979B9 (en)	2006-03-02
DE60208221T2 (de)	2006-08-03
EP1432701B1 (en)	2005-12-21
MXPA04002962A (es)	2005-06-20
CA2458456A1 (en)	2003-04-17
OA12663A (en)	2006-06-19
JP2005508952A (ja)	2005-04-07
NO20041833L (no)	2004-07-05
ATE313540T1 (de)	2006-01-15
DE60208221D1 (de)	2006-01-26
EA200400507A1 (ru)	2004-10-28
NZ532511A (en)	2005-10-28
HUP0401598A2 (hu)	2004-12-28
HK1067362A1 (en)	2005-04-08
ECSP045095A (es)	2004-08-27
ES2253568T3 (es)	2006-06-01
CY1104991T1 (el)	2010-03-03
US20030162777A1 (en)	2003-08-28
CN1564820A (zh)	2005-01-12
MA27067A1 (fr)	2004-12-20
YU27204A (sh)	2006-08-17
US20030181446A1 (en)	2003-09-25
HRP20040392A2 (en)	2004-10-31
WO2003031436A1 (en)	2003-04-17
AP1705A (en)	2007-01-02
TNSN04053A1 (en)	2006-06-01
AU2002346979B2 (en)	2005-09-29
KR20040048930A (ko)	2004-06-10
WO2003031436A8 (en)	2004-05-27
BR0213067A (pt)	2004-09-28
EP1432701A1 (en)	2004-06-30
ITMI20012060A1 (it)	2003-04-05
PL369763A1 (en)	2005-05-02
AP2004002997A0 (en)	2004-03-31
CO5570679A2 (es)	2005-10-31
SI1432701T1 (sl)	2006-04-30

Publication	Publication Date	Title
DK1432701T3 (da)	2006-05-08	Heterocycliske forbindelser til anvendelse ved behandlingen af lidelser i urinvejene
DK1343773T3 (da)	2007-02-05	Thiazolderivater til behandling af PPAR-beslægtede forstyrrelser
DK1423381T3 (da)	2007-05-07	17beta-hydroxysteroid-dehydrogenase type 3-inhibitorer til behandling af androgenafhængige sygdomme
IS7099A (is)	2004-01-08	Efnasambönd til að meðhöndla bólgutruflanir
DK1446122T5 (da)	2006-08-14	Anvendelse af flibanserin til behandling af uregelmæssigheder ved könsdriften
DK1575597T3 (da)	2009-03-16	Anvendelse af rimexolon til behandling af öjentörhed
DK1474416T3 (da)	2008-01-14	Dihydrobenzodiazepin-2-on-derivater til behandlingen af neurologiske lidelser
NO20035609D0 (no)	2003-12-16	Fremgangsmåte for kontinuerlig naftabehandling
DK1701941T3 (da)	2012-08-13	Forbindelser til behandling af sygdomme med celleproliferation
DK1562932T3 (da)	2007-08-13	4 tetrazolyl-4-phenylpiperidinderivater til behandling af smerter
DK1592384T3 (da)	2012-12-17	Cop 1 til behandling af inflammatoriske tarmsygdomme
DK1231920T3 (da)	2007-04-10	Anvendelse af epinastin til behandling af allergisk rhinitis/conjunctivitis
DK1392318T3 (da)	2007-06-25	15-keto-prostaglandiner til behandling af lægemiddelinduceret forstoppelse
DK1701944T3 (da)	2009-11-09	2-(amino-substituerede)-4-aryl-pyramidiner og relaterede forbindelser til behandling af inflammationssygdomme
DK1487828T3 (da)	2009-02-02	Morpholinyl-urea-derivater til anvendelse til behandling af inflammatoriske sygdomme
NO20034473D0 (no)	2003-10-06	Anvendelse av selektive cox-2-inhibitorer ved behandling av urininkontinens
DK1516596T3 (da)	2009-11-23	Forbedret system til behandling af stress-urinkontinens
DK1413305T3 (da)	2006-09-18	Aryl(eller heteroaryl)-azolylcarbinolderivater til behandling af urininkontinens
DK1727801T3 (da)	2009-05-11	Til behandling af smerter anvendelige piperaziner
DK1344526T3 (da)	2008-09-15	Midler til forebyggelse/behandling af inflammatoriske luftvejslidelser
DK1401424T3 (da)	2007-02-26	Carbamatforbindelser til anvendelse ved forebyggelse eller behandling af psykotiske forstyrrelser
DK1434588T3 (da)	2011-08-15	2-(amino-3,4-dioxo-1cyclobuten-1-yl)aminoalkylsyrederivater til behandling af smerte
DK1530462T3 (da)	2011-02-14	1-phenyl-2-dimethylaminomethylcyclohexanforbindelser til behandling af depressionssymtomer. smerte og inkontinens
DK1309322T3 (da)	2006-10-23	Anvendelse af 3-benzoylphenyleddikesyrederivater til behandling af retinale lidelser
DK1257278T3 (da)	2006-06-12	Anvendelse af mirtazapin til behandling af sövnforstyrrelser