DK1465921T3 - Agonister til corticotropinfrigörelsesfaktor receptor-2 - Google Patents

Agonister til corticotropinfrigörelsesfaktor receptor-2

Info

Publication number: DK1465921T3
Authority: DK; Denmark
Prior art keywords: agonists; factor receptor; release factor; corticotropin release; corticotropin
Prior art date: 2002-01-16

Application number

DK03703867T

Other languages

Danish (da)

English (en)

Inventor

Robert Joseph Isfort

Wieslaw Adam Mazur

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-16

Filing date

2003-01-16

Publication date

2006-11-27

2003-01-16 Application filed by Procter & Gamble filed Critical Procter & Gamble

2006-11-27 Application granted granted Critical

2006-11-27 Publication of DK1465921T3 publication Critical patent/DK1465921T3/da

Links

102400000739 Corticotropin Human genes 0.000 title 1
101800000414 Corticotropin Proteins 0.000 title 1
239000000556 agonist Substances 0.000 title 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
229960000258 corticotropin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Neurology (AREA)
Zoology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK03703867T 2002-01-16 2003-01-16 Agonister til corticotropinfrigörelsesfaktor receptor-2 DK1465921T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US34911702P	2002-01-16	2002-01-16
US37633702P	2002-04-29	2002-04-29
US38889502P	2002-06-14	2002-06-14
US41198802P	2002-09-19	2002-09-19

Publications (1)

Publication Number	Publication Date
DK1465921T3 true DK1465921T3 (da)	2006-11-27

Family

ID=27617822

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK03703867T DK1465921T3 (da)	2002-01-16	2003-01-16	Agonister til corticotropinfrigörelsesfaktor receptor-2
DK03731965T DK1465923T3 (da)	2002-01-16	2003-01-16	Corticotroprinafgivende faktor 2-receptoragonister

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK03731965T DK1465923T3 (da)	2002-01-16	2003-01-16	Corticotroprinafgivende faktor 2-receptoragonister

Country Status (29)

Country	Link
US (7)	US7192924B2 (pl)
EP (4)	EP1465921B1 (pl)
JP (3)	JP4508648B2 (pl)
KR (3)	KR100758857B1 (pl)
CN (3)	CN100475844C (pl)
AR (3)	AR038142A1 (pl)
AT (4)	ATE362488T1 (pl)
AU (2)	AU2003205197B2 (pl)
BR (3)	BR0306826A (pl)
CA (3)	CA2470656C (pl)
CY (1)	CY1106133T1 (pl)
DE (4)	DE60318547T2 (pl)
DK (2)	DK1465921T3 (pl)
ES (4)	ES2309909T3 (pl)
IL (5)	IL162529A0 (pl)
MA (3)	MA27592A1 (pl)
MX (3)	MXPA04006884A (pl)
MY (1)	MY140306A (pl)
NO (3)	NO20043371L (pl)
NZ (3)	NZ533599A (pl)
PE (3)	PE20030849A1 (pl)
PL (3)	PL371364A1 (pl)
PT (2)	PT1465921E (pl)
RU (1)	RU2294333C2 (pl)
SA (3)	SA03230565B1 (pl)
SI (1)	SI1465921T1 (pl)
TW (3)	TW200302278A (pl)
WO (3)	WO2003062268A2 (pl)
ZA (1)	ZA200404995B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002024732A2 (en) *	2000-09-22	2002-03-28	Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US7192924B2 (en) *	2002-01-16	2007-03-20	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists
WO2005103690A2 (en) *	2004-04-24	2005-11-03	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2)
CN101687025A (zh) *	2005-03-30	2010-03-31	诺华疫苗和诊断公司	B型流感嗜血杆菌
US7815905B2 (en)	2006-01-27	2010-10-19	Research Development Foundation	Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors
WO2009046874A1 (en) *	2007-09-11	2009-04-16	Mondobiotech Laboratories Ag	Therapeutic combination of trh-potentiating peptide and stresscopin
KR20100056507A (ko) *	2007-09-11	2010-05-27	몬도바이오테크 래보래토리즈 아게	치료제로서의 펩티드 ｐｒｏ－ｇｌｙ－ｔｈｒ－ｃｙｓ－ｇｌｕ－ｉｌｅ－ｃｙｓ－ａｌａ－ｔｙｒ－ａｌａ－ａｌａ－ｃｙｓ－ｔｈｒ－ｇｌｙ－ｃｙｓ의 용도
EP2190533A2 (en) *	2007-09-11	2010-06-02	Mondobiotech Laboratories AG	Use of a peptide as a therapeutic agent
SG171957A1 (en) *	2008-11-04	2011-07-28	Janssen Pharmaceutica Nv	Crhr2 peptide agonists and uses thereof
EP2206726A1 (en) *	2009-01-08	2010-07-14	Universite Joseph Fourier	Non-invasive tools for detecting vulnerable atherosclerotic plaques
US20110105397A1 (en) *	2009-11-04	2011-05-05	Gengo Peter J	Method for treating heart failure with stresscopin-like peptides
WO2013063046A1 (en)	2011-10-24	2013-05-02	Research Development Foundation	Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors
CN108310396B (zh)	2012-02-14	2022-07-15	加利福尼亚大学董事会	用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
JOP20170153A1 (ar) *	2016-07-15	2019-01-30	Lilly Co Eli	نظائر urocortin-2 جديدة معدلة بحمض دهني لعلاج داء السكري وأمراض الكلى المزمنة
AU2017345785A1 (en) *	2016-10-20	2019-05-16	Cortene Inc.	Methods of treating diseases resulting from a maladapted stress response
CN110755434B (zh) *	2018-07-27	2022-03-15	中国医学科学院药物研究所	化合物palosuran防治骨骼肌萎缩等疾病的用途
WO2025184558A1 (en) *	2024-02-28	2025-09-04	Caradon Therapeutics, Inc.	Modified urocortin 3
TW202544027A (zh) *	2024-04-19	2025-11-16	美商紐羅克里生物科學有限公司	促皮質素釋放因子受體２（ｃｒｆｒ２）促效劑
AU2025204485B2 (en) *	2024-04-30	2025-12-11	Hanmi Pharm. Co. Ltd.	Use of crf2 receptor agonist and the acylated conjugates thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5235036A (en)	1991-05-31	1993-08-10	The Salk Institute For Biological Studies	Crf analogs
EP0860501A3 (en)	1994-06-14	1999-05-19	Neurocrine Biosciences, Inc.	Corticotropin-releasing factor2 receptors
US5786203A (en)	1994-06-14	1998-07-28	Neurocrine Biosciences, Inc.	Isolated nucleic acid encoding corticotropin-releasing factor2 receptors
US5663292A (en)	1994-12-12	1997-09-02	The Salk Institute For Biological Studies	Cyclic CRF analogs
US5824771A (en)	1994-12-12	1998-10-20	The Salk Institute For Biological Studies	Cyclic CRF agonists
US5660824A (en)	1995-05-24	1997-08-26	Grabstein; Kenneth H.	Muscle trophic factor
EP0845035A2 (en)	1995-06-13	1998-06-03	The Salk Institute For Biological Studies	Urocortin peptides
US5869450A (en) *	1996-03-06	1999-02-09	The Regents Of The University Of California	Anti-inflammatory compositions and method with corticotropin-releasing factor analogs
DK1305334T3 (da)	2000-08-04	2009-02-02	Res Dev Foundation	Urocortinproteiner og anvendelser deraf
WO2002024732A2 (en) *	2000-09-22	2002-03-28	Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften	Methods for improving the antagonistic/agonistic properties of peptidic antagonists/agonists of the corticotropin-releasing factor receptor (crfr)
US20020082409A1 (en)	2000-10-26	2002-06-27	Hsu Sheau Yu	Stresscopins and their uses
US6670140B2 (en) *	2001-03-06	2003-12-30	The Procter & Gamble Company	Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
US7192924B2 (en) *	2002-01-16	2007-03-20	The Procter & Gamble Company	Corticotropin releasing factor 2 receptor agonists

2002
- 2002-12-11 US US10/317,251 patent/US7192924B2/en not_active Expired - Fee Related
- 2002-12-11 US US10/317,252 patent/US6936585B2/en not_active Expired - Lifetime
- 2002-12-11 US US10/315,964 patent/US7192923B2/en not_active Expired - Fee Related
2003
- 2003-01-10 TW TW092100535A patent/TW200302278A/zh unknown
- 2003-01-10 TW TW092100532A patent/TW200302276A/zh unknown
- 2003-01-10 TW TW092100533A patent/TWI300442B/zh not_active IP Right Cessation
- 2003-01-14 PE PE2003000041A patent/PE20030849A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000040A patent/PE20030974A1/es not_active Application Discontinuation
- 2003-01-14 PE PE2003000039A patent/PE20030747A1/es not_active Application Discontinuation
- 2003-01-15 MY MYPI20030136A patent/MY140306A/en unknown
- 2003-01-15 AR ARP030100099A patent/AR038142A1/es unknown
- 2003-01-15 AR ARP030100100A patent/AR038143A1/es unknown
- 2003-01-15 AR ARP030100101A patent/AR038144A1/es unknown
- 2003-01-16 AU AU2003205197A patent/AU2003205197B2/en not_active Ceased
- 2003-01-16 BR BR0306826-9A patent/BR0306826A/pt not_active IP Right Cessation
- 2003-01-16 WO PCT/US2003/001451 patent/WO2003062268A2/en not_active Ceased
- 2003-01-16 AT AT03731965T patent/ATE362488T1/de not_active IP Right Cessation
- 2003-01-16 EP EP03703867A patent/EP1465921B1/en not_active Expired - Lifetime
- 2003-01-16 AT AT03731963T patent/ATE383372T1/de not_active IP Right Cessation
- 2003-01-16 PT PT03703867T patent/PT1465921E/pt unknown
- 2003-01-16 JP JP2003562145A patent/JP4508648B2/ja not_active Expired - Fee Related
- 2003-01-16 MX MXPA04006884A patent/MXPA04006884A/es active IP Right Grant
- 2003-01-16 EP EP03731963A patent/EP1465922B1/en not_active Expired - Lifetime
- 2003-01-16 WO PCT/US2003/001461 patent/WO2003062269A2/en not_active Ceased
- 2003-01-16 BR BR0306878-1A patent/BR0306878A/pt not_active IP Right Cessation
- 2003-01-16 CA CA2470656A patent/CA2470656C/en not_active Expired - Fee Related
- 2003-01-16 AU AU2003237419A patent/AU2003237419B2/en not_active Ceased
- 2003-01-16 KR KR1020047011052A patent/KR100758857B1/ko not_active Expired - Fee Related
- 2003-01-16 ES ES06117810T patent/ES2309909T3/es not_active Expired - Lifetime
- 2003-01-16 JP JP2003562154A patent/JP4489434B2/ja not_active Expired - Fee Related
- 2003-01-16 PL PL03371364A patent/PL371364A1/pl unknown
- 2003-01-16 EP EP06117810A patent/EP1724283B1/en not_active Expired - Lifetime
- 2003-01-16 ES ES03731965T patent/ES2287484T3/es not_active Expired - Lifetime
- 2003-01-16 IL IL15252903A patent/IL162529A0/xx unknown
- 2003-01-16 DE DE60318547T patent/DE60318547T2/de not_active Expired - Lifetime
- 2003-01-16 DK DK03703867T patent/DK1465921T3/da active
- 2003-01-16 EP EP03731965A patent/EP1465923B1/en not_active Expired - Lifetime
- 2003-01-16 CN CNB038023520A patent/CN100475844C/zh not_active Expired - Fee Related
- 2003-01-16 KR KR1020047011051A patent/KR100735586B1/ko not_active Expired - Fee Related
- 2003-01-16 DE DE60313845T patent/DE60313845T2/de not_active Expired - Lifetime
- 2003-01-16 ES ES03731963T patent/ES2299701T3/es not_active Expired - Lifetime
- 2003-01-16 WO PCT/US2003/001454 patent/WO2003062277A1/en not_active Ceased
- 2003-01-16 PT PT03731965T patent/PT1465923E/pt unknown
- 2003-01-16 DE DE60321730T patent/DE60321730D1/de not_active Expired - Lifetime
- 2003-01-16 NZ NZ533599A patent/NZ533599A/en unknown
- 2003-01-16 RU RU2004124847/13A patent/RU2294333C2/ru active
- 2003-01-16 DK DK03731965T patent/DK1465923T3/da active
- 2003-01-16 NZ NZ533600A patent/NZ533600A/en unknown
- 2003-01-16 MX MXPA04006885A patent/MXPA04006885A/es active IP Right Grant
- 2003-01-16 IL IL16253003A patent/IL162530A0/xx unknown
- 2003-01-16 CN CNB038023644A patent/CN100391972C/zh not_active Expired - Fee Related
- 2003-01-16 BR BR0306838-2A patent/BR0306838A/pt not_active Application Discontinuation
- 2003-01-16 AT AT06117810T patent/ATE398632T1/de not_active IP Right Cessation
- 2003-01-16 JP JP2003562146A patent/JP4508649B2/ja not_active Expired - Fee Related
- 2003-01-16 CN CNA038023709A patent/CN1617887A/zh active Pending
- 2003-01-16 IL IL16243103A patent/IL162431A0/xx unknown
- 2003-01-16 MX MXPA04006883A patent/MXPA04006883A/es active IP Right Grant
- 2003-01-16 PL PL03373139A patent/PL373139A1/pl not_active Application Discontinuation
- 2003-01-16 CA CA2470731A patent/CA2470731C/en not_active Expired - Fee Related
- 2003-01-16 AT AT03703867T patent/ATE334147T1/de not_active IP Right Cessation
- 2003-01-16 PL PL03373529A patent/PL373529A1/pl not_active Application Discontinuation
- 2003-01-16 SI SI200330360T patent/SI1465921T1/sl unknown
- 2003-01-16 CA CA2470743A patent/CA2470743C/en not_active Expired - Fee Related
- 2003-01-16 KR KR1020047011057A patent/KR100758858B1/ko not_active Expired - Fee Related
- 2003-01-16 DE DE60307044T patent/DE60307044T2/de not_active Expired - Lifetime
- 2003-01-16 NZ NZ533598A patent/NZ533598A/en unknown
- 2003-01-16 ES ES03703867T patent/ES2269976T3/es not_active Expired - Lifetime
- 2003-03-01 SA SA3230565A patent/SA03230565B1/ar unknown
- 2003-03-01 SA SA03230564D patent/SA03230564A/ar unknown
- 2003-03-01 SA SA3230564A patent/SA03230564B1/ar unknown
2004
- 2004-06-24 ZA ZA2004/04995A patent/ZA200404995B/en unknown
- 2004-07-13 MA MA27780A patent/MA27592A1/fr unknown
- 2004-07-13 MA MA27779A patent/MA27591A1/fr unknown
- 2004-07-13 MA MA27778A patent/MA27590A1/fr unknown
- 2004-08-13 NO NO20043371A patent/NO20043371L/no not_active Application Discontinuation
- 2004-08-13 NO NO20043366A patent/NO20043366L/no not_active Application Discontinuation
- 2004-08-16 NO NO20043396A patent/NO20043396L/no not_active Application Discontinuation
2005
- 2005-05-04 US US11/121,612 patent/US7462597B2/en not_active Expired - Fee Related
2006
- 2006-07-28 CY CY20061101051T patent/CY1106133T1/el unknown
2007
- 2007-02-02 US US11/701,576 patent/US7608701B2/en not_active Expired - Fee Related
- 2007-02-02 US US11/701,912 patent/US7632933B2/en not_active Expired - Fee Related
2009
- 2009-01-07 IL IL196384A patent/IL196384A0/en unknown
- 2009-03-24 IL IL197774A patent/IL197774A0/en unknown
- 2009-10-26 US US12/605,718 patent/US7897731B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MA27590A1 (fr)	2005-11-01
CA2470743C (en)	2011-12-13
DE60307044D1 (de)	2006-09-07
IL162530A0 (en)	2005-11-20
EP1724283A3 (en)	2007-04-11
US20060025339A1 (en)	2006-02-02
ES2287484T3 (es)	2007-12-16
PT1465921E (pt)	2006-12-29
ATE383372T1 (de)	2008-01-15
SA03230564B1 (ar)	2006-10-31
IL162431A0 (en)	2005-11-20
JP4508648B2 (ja)	2010-07-21
SA03230565A (ar)	2005-12-03
NZ533598A (en)	2007-03-30
PE20030849A1 (es)	2003-12-01
IL162529A0 (en)	2005-11-20
JP2005522191A (ja)	2005-07-28
RU2294333C2 (ru)	2007-02-27
WO2003062268A3 (en)	2003-11-27
EP1465921A2 (en)	2004-10-13
DK1465923T3 (da)	2007-07-02
WO2003062277A1 (en)	2003-07-31
KR100735586B1 (ko)	2007-07-04
CA2470656A1 (en)	2003-07-31
AU2003205197B2 (en)	2006-03-02
SA03230565B1 (ar)	2006-10-31
JP2005521387A (ja)	2005-07-21
ES2299701T3 (es)	2008-06-01
ATE334147T1 (de)	2006-08-15
AR038142A1 (es)	2004-12-29
RU2004124847A (ru)	2005-04-20
IL196384A0 (en)	2011-07-31
SI1465921T1 (sl)	2006-10-31
AR038144A1 (es)	2004-12-29
CA2470656C (en)	2011-06-28
KR20040082389A (ko)	2004-09-24
US20100197579A1 (en)	2010-08-05
CY1106133T1 (el)	2011-06-08
CN100475844C (zh)	2009-04-08
IL197774A0 (en)	2009-12-24
US20030148957A1 (en)	2003-08-07
ES2269976T3 (es)	2007-04-01
JP4489434B2 (ja)	2010-06-23
MXPA04006885A (es)	2004-12-06
US20030148956A1 (en)	2003-08-07
DE60313845T2 (de)	2008-01-31
NO20043371L (no)	2004-10-06
US7897731B2 (en)	2011-03-01
TW200302278A (en)	2003-08-01
US20090124793A1 (en)	2009-05-14
CN100391972C (zh)	2008-06-04
ZA200404995B (en)	2005-06-29
US7192924B2 (en)	2007-03-20
EP1724283A2 (en)	2006-11-22
DE60318547D1 (de)	2008-02-21
CN1617887A (zh)	2005-05-18
DE60318547T2 (de)	2008-12-24
EP1465921B1 (en)	2006-07-26
TW200302276A (en)	2003-08-01
BR0306838A (pt)	2005-04-05
CA2470731A1 (en)	2003-07-31
US7192923B2 (en)	2007-03-20
CN1617885A (zh)	2005-05-18
KR100758857B1 (ko)	2007-09-14
PE20030747A1 (es)	2003-10-23
CN1617886A (zh)	2005-05-18
JP4508649B2 (ja)	2010-07-21
DE60321730D1 (de)	2008-07-31
AR038143A1 (es)	2004-12-29
ES2309909T3 (es)	2008-12-16
CA2470731C (en)	2011-06-21
DE60313845D1 (de)	2007-06-28
TW200302277A (en)	2003-08-01
US20080004435A1 (en)	2008-01-03
EP1465922A2 (en)	2004-10-13
DE60307044T2 (de)	2007-02-15
MA27591A1 (fr)	2005-11-01
AU2003237419B2 (en)	2006-04-13
EP1465922B1 (en)	2008-01-09
US7632933B2 (en)	2009-12-15
KR20040082390A (ko)	2004-09-24
MA27592A1 (fr)	2005-11-01
TWI300442B (en)	2008-09-01
US6936585B2 (en)	2005-08-30
EP1724283B1 (en)	2008-06-18
JP2005525101A (ja)	2005-08-25
SA03230564A (ar)	2005-12-03
PT1465923E (pt)	2007-08-06
CA2470743A1 (en)	2003-07-31
US7608701B2 (en)	2009-10-27
KR20040082392A (ko)	2004-09-24
MXPA04006884A (es)	2004-12-06
PL373529A1 (pl)	2005-09-05
MY140306A (en)	2009-12-31
BR0306826A (pt)	2005-09-06
ATE398632T1 (de)	2008-07-15
EP1465923B1 (en)	2007-05-16
PE20030974A1 (es)	2003-12-26
US7462597B2 (en)	2008-12-09
BR0306878A (pt)	2004-10-26
NZ533600A (en)	2007-02-23
ATE362488T1 (de)	2007-06-15
US20030148958A1 (en)	2003-08-07
WO2003062269A3 (en)	2003-11-06
EP1465923A1 (en)	2004-10-13
WO2003062269A2 (en)	2003-07-31
KR100758858B1 (ko)	2007-09-14
WO2003062268A2 (en)	2003-07-31
HK1078095A1 (zh)	2006-03-03
PL373139A1 (pl)	2005-08-22
MXPA04006883A (es)	2004-12-06
NO20043366L (no)	2004-10-06
PL371364A1 (pl)	2005-06-13
NZ533599A (en)	2007-03-30
NO20043396L (no)	2004-10-06

Publication	Publication Date	Title
DK1465921T3 (da)	2006-11-27	Agonister til corticotropinfrigörelsesfaktor receptor-2
NO20055742D0 (no)	2005-12-05	Gjenget forbindelse for stalror
IS7525A (is)	2004-11-11	Skjalaformgerðar kennimerki
DE60308850D1 (de)	2006-11-16	Pyridinoylpiperidine als 5-ht1f agonisten
DK1540907T3 (da)	2012-12-10	Konferencesystem
EP1782189A4 (en)	2008-05-07	DEVICE MANAGEMENT SYSTEM
DE602005023460D1 (de)	2010-10-21	Antimykotische polypeptide
DE502004005652D1 (de)	2008-01-17	Kontrolliertes freisetzungssystem enthaltend saccharoseacetatisobutyrat
MA28545B1 (fr)	2007-04-03	Amides tri (cyclo) substitués
DE602004011999D1 (de)	2008-04-03	Mehrbenutzer-übertragungssystem
ITTO20050184A1 (it)	2005-09-23	Connettore rapido
IS7582A (is)	2004-12-03	Hraðlosandi lyfjablanda
DE60324018D1 (de)	2008-11-20	Agonisten
DE502005008468D1 (de)	2009-12-24	Bildaufnahmesystem
ITMI20020198A0 (it)	2002-02-05	(per)aloeteri
ITMO20040105A1 (it)	2004-08-04	Apparato di lancio
DE10224030B4 (de)	2005-03-10	Spannsystem
DE502005002052D1 (de)	2008-01-03	Transportvorrichtung
EP1783217A4 (en)	2008-10-08	STABILIZED PROLIN TRANSPORT
DE502005005082D1 (de)	2008-10-02	Bildaufnahmesystem
ATE491683T1 (de)	2011-01-15	Muskarine agonisten
ES1052410Y (es)	2003-05-01	Dispositivo para sujecion de pequeñas piezas metalicas.
FI6455U1 (fi)	2004-11-11	Virtuaali-ikkunajärjestelmä
DE102005045405B8 (de)	2008-01-17	Kamerasystem
DE50309974D1 (de)	2008-07-24	Löseeinheit