DK1504269T3 - Diagnostisk test til bestemmelse af koncentrationen af forbigående proteolytisk aktivitet i sammensatte biologiske medier - Google Patents

Diagnostisk test til bestemmelse af koncentrationen af forbigående proteolytisk aktivitet i sammensatte biologiske medier

Info

Publication number
DK1504269T3
DK1504269T3 DK03747454T DK03747454T DK1504269T3 DK 1504269 T3 DK1504269 T3 DK 1504269T3 DK 03747454 T DK03747454 T DK 03747454T DK 03747454 T DK03747454 T DK 03747454T DK 1504269 T3 DK1504269 T3 DK 1504269T3
Authority
DK
Denmark
Prior art keywords
thrombin
activity
measured
blood
sample
Prior art date
Application number
DK03747454T
Other languages
Danish (da)
English (en)
Inventor
Peter Giesen
Hendrick C Hemker
Dieri Raed Al
Suzette L Beguin
Robert Wagenvoord
Original Assignee
Synapse Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synapse Bv filed Critical Synapse Bv
Application granted granted Critical
Publication of DK1504269T3 publication Critical patent/DK1504269T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK03747454T 2002-05-01 2003-05-01 Diagnostisk test til bestemmelse af koncentrationen af forbigående proteolytisk aktivitet i sammensatte biologiske medier DK1504269T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076744 2002-05-01
PCT/EP2003/004705 WO2003093831A1 (fr) 2002-05-01 2003-05-01 Test de diagnostique permettant de determiner la concentration d'une activite proteolytique transitoire dans des milieux biologiques composites

Publications (1)

Publication Number Publication Date
DK1504269T3 true DK1504269T3 (da) 2007-12-03

Family

ID=29286179

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03747454T DK1504269T3 (da) 2002-05-01 2003-05-01 Diagnostisk test til bestemmelse af koncentrationen af forbigående proteolytisk aktivitet i sammensatte biologiske medier

Country Status (11)

Country Link
US (1) US8802386B2 (fr)
EP (1) EP1504269B1 (fr)
JP (1) JP4718833B2 (fr)
CN (1) CN100350252C (fr)
AT (1) ATE368229T1 (fr)
AU (1) AU2003232720B9 (fr)
CA (1) CA2484554C (fr)
DE (1) DE60315151T2 (fr)
DK (1) DK1504269T3 (fr)
ES (1) ES2291661T3 (fr)
WO (1) WO2003093831A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004059055A1 (de) * 2004-12-07 2006-06-08 Dade Behring Marburg Gmbh Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
ES2357112T3 (es) * 2005-01-07 2011-04-18 Stichting Katholieke Universiteit Ensayo de hemostasia.
DE102005008066A1 (de) * 2005-02-22 2006-08-24 Haemosys Gmbh Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe
EP1717588A1 (fr) * 2005-04-29 2006-11-02 Synapse B.V. Mesure de l'activité thrombique dans le sang total
EP1742063B1 (fr) 2005-07-07 2010-09-08 Asulab S.A. Système de détermination différentielle du taux d'une enzyme protéolytique dans un fluide corporel
JP5461175B2 (ja) * 2006-06-06 2014-04-02 トロームビノスコープ ベスローテン フェンノートシャップ 生体媒質中で酵素活性を決定する方法
DE602007011661D1 (de) * 2006-11-02 2011-02-10 Thrombinoscope B V Verfahren zur messung der konzentration transienter proteolytischer aktivität in zellen enthaltenden zusammengesetzten biologischen medien
EP2088435B1 (fr) * 2008-02-07 2011-07-13 Synapse B.V. Mesure de la chronologie de l'activé enzymatique corrigée pour les impacts des perturbations liées à la réaction de l'enzyme avec un substrat
FR2933496B1 (fr) * 2008-07-02 2012-10-05 Lfb Biotechnologies Procede de mesure du taux de facteur vii active dans un echantillon
CN102124346B (zh) * 2008-07-16 2014-01-15 雷迪奥米特医学公司 凝血酶底物和测定样本中生物活性凝血酶水平的测定法
DE102009040879B4 (de) * 2009-09-09 2012-12-06 Andreas Hettich Gmbh & Co. Kg Verfahren zur Bestimmung der Gerinnungszeit
JP5999776B2 (ja) * 2010-09-15 2016-09-28 デビオファーマ インターナショナル ソシエテ アノニムＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓａ 血液成分を含むフィブリノゲン含有サンプルからターゲット分子又は粒子を分離する方法
EP2465941A1 (fr) * 2010-12-20 2012-06-20 Siemens Healthcare Diagnostics Products GmbH Procédé de détermination simultanée de plusieurs protéases de coagulation
EP3321373B1 (fr) * 2011-07-13 2020-01-15 T2 Biosystems, Inc. Procédés de rmn destinés à surveiller la formation d'un caillot sanguin
RU2518247C2 (ru) * 2011-07-26 2014-06-10 Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе
JP6491880B2 (ja) * 2011-08-23 2019-03-27 シナプス・ビー．ブイ．Ｓｙｎａｐｓｅ Ｂ．Ｖ． 異物表面との接触による血液凝固系の活性化の熱安定性阻害剤
EP2677037B1 (fr) 2012-06-21 2016-04-13 Synapse B.V. Mesure simultanée de la génération de thrombine et résistance des caillots dans du plasma et du sang entier
WO2014098056A1 (fr) 2012-12-18 2014-06-26 第一三共株式会社 Procédé de mesure de la production de thrombine
US10633645B2 (en) * 2015-12-30 2020-04-28 General Electric Company Calcium controlled activation of platelets via electrical stimulation
EP3363912B1 (fr) 2017-02-17 2020-10-28 Synapse B.V. Dosage à étalonnage automatique pour déterminer la production d'une enzyme protéolytique, moyens dédiés et utilisations associées
CN110082447B (zh) * 2019-05-09 2024-05-31 同济大学 同步表征水样溶解性有机质结构/理化/浓度特性的仪器
US12522855B2 (en) 2019-07-31 2026-01-13 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods and kits for identifying thrombus origin and optimizing post-ischemic event treatment
CN112067575A (zh) * 2020-09-09 2020-12-11 吴俊� 血液纤维蛋白溶解功能检测方法
CN114958963B (zh) * 2022-07-29 2023-09-05 深圳传世生物医疗有限公司 一种作用于凝血酶的抗凝药物检测试剂盒及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60009879T2 (de) * 1999-03-04 2005-03-31 Synapse B.V. Bestimmung von biologisch aktiven formen von proteolytischen enzymen
US6740496B1 (en) * 1999-03-04 2004-05-25 Synapse B.V. Determination of biologically active forms of proteolytic enzymes

Also Published As

Publication number Publication date
CN100350252C (zh) 2007-11-21
AU2003232720B9 (en) 2009-12-03
DE60315151D1 (de) 2007-09-06
US20060051828A1 (en) 2006-03-09
EP1504269B1 (fr) 2007-07-25
US8802386B2 (en) 2014-08-12
JP4718833B2 (ja) 2011-07-06
AU2003232720B2 (en) 2009-10-29
JP2005528097A (ja) 2005-09-22
CN1650170A (zh) 2005-08-03
CA2484554A1 (fr) 2003-11-13
AU2003232720A1 (en) 2003-11-17
DE60315151T2 (de) 2008-04-10
EP1504269A1 (fr) 2005-02-09
WO2003093831A1 (fr) 2003-11-13
CA2484554C (fr) 2012-12-04
ES2291661T3 (es) 2008-03-01
ATE368229T1 (de) 2007-08-15

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