DK1506190T3 - (Imidazol-1-yl-methyl)-pyridazin som NMDA-receptor-blokker - Google Patents

(Imidazol-1-yl-methyl)-pyridazin som NMDA-receptor-blokker

Info

Publication number: DK1506190T3
Authority: DK; Denmark
Prior art keywords: pyridazine; imidazol; methyl; nmda receptor; receptor blocker
Prior art date: 2002-05-16

Application number

DK03752750T

Other languages

English (en)

Inventor

Neidhart Marie-Paule Heitz

Bernd Buettelmann

Georg Jaeschke

Emmanuel Pinard

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-16

Filing date

2003-05-16

Publication date

2006-10-16

2003-05-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-10-16 Application granted granted Critical

2006-10-16 Publication of DK1506190T3 publication Critical patent/DK1506190T3/da

Links

GFSWLEBKUPUQNQ-UHFFFAOYSA-N 3-(imidazol-1-ylmethyl)pyridazine Chemical compound C1=CN=CN1CC1=CC=CN=N1 GFSWLEBKUPUQNQ-UHFFFAOYSA-N 0.000 title 1
239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Psychology (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK03752750T 2002-05-16 2003-05-16 (Imidazol-1-yl-methyl)-pyridazin som NMDA-receptor-blokker DK1506190T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02010217		2002-05-16

Publications (1)

Publication Number	Publication Date
DK1506190T3 true DK1506190T3 (da)	2006-10-16

Family

ID=29433072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03752750T DK1506190T3 (da)	2002-05-16	2003-05-16	(Imidazol-1-yl-methyl)-pyridazin som NMDA-receptor-blokker

Country Status (30)

Country	Link
US (1)	US7005432B2 (da)
EP (1)	EP1506190B1 (da)
JP (1)	JP4267569B2 (da)
KR (1)	KR100632868B1 (da)
CN (1)	CN1312151C (da)
AR (1)	AR040010A1 (da)
AT (1)	ATE329912T1 (da)
AU (1)	AU2003242542B2 (da)
BR (1)	BR0311177A (da)
CA (1)	CA2485926C (da)
CL (1)	CL2004001251A1 (da)
CY (1)	CY1105159T1 (da)
DE (1)	DE60306152T2 (da)
DK (1)	DK1506190T3 (da)
ES (1)	ES2265581T3 (da)
HR (1)	HRP20041060B1 (da)
IL (1)	IL164922A (da)
MA (1)	MA27117A1 (da)
ME (1)	MEP76708A (da)
MX (1)	MXPA04011253A (da)
NO (1)	NO329605B1 (da)
NZ (1)	NZ536310A (da)
PL (1)	PL211340B1 (da)
PT (1)	PT1506190E (da)
RS (1)	RS51200B (da)
RU (1)	RU2317294C2 (da)
SI (1)	SI1506190T1 (da)
TN (1)	TNSN04224A1 (da)
WO (1)	WO2003097637A1 (da)
ZA (1)	ZA200408789B (da)

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US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives
GB0218876D0 (en) *	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
CN100579579C (zh) *	2002-10-01	2010-01-13	诺华疫苗和诊断公司	抗癌及抗感染性疾病组合物及其使用方法
WO2006117052A1 (de) *	2005-05-03	2006-11-09	Merck Patent Gmbh	Organische elektrolumineszenzvorrichtung und in deren herstellung verwendete boronsäure- und borinsäure-derivate
US20090054392A1 (en) *	2007-08-20	2009-02-26	Wyeth	Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
JP5315710B2 (ja) *	2008-02-07	2013-10-16	セントラル硝子株式会社	１−ブロモ−３−フルオロ−５−ジフルオロメチルベンゼンの製造方法
DE102008015033A1 (de)	2008-03-17	2009-09-24	Aicuris Gmbh & Co. Kg	Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
MX2010009649A (es) *	2008-03-27	2010-12-17	Evotecv Neurosciences Gmbh	Metodos para tratar trastornos utilizando un antagonista selectivo del subtipo nr2b de nmda.
MY170610A (en)	2009-02-05	2019-08-20	Takeda Pharmaceuticals Co	Pyridazinone compounds
US8883788B2 (en)	2010-08-04	2014-11-11	Takeda Pharmaceutical Company Limited	Fused heterocyclic ring compound
WO2012019106A2 (en) *	2010-08-06	2012-02-09	Board Of Regents Of The University Of Nebraska	Positive and negative modulators of nmda receptors
WO2013160728A1 (en)	2012-04-26	2013-10-31	Alma Mater Studiorum - Universita' Di Bologna	Dual targeting compounds for the treatment of alzheimer's disease
US9981950B2 (en) *	2014-08-15	2018-05-29	Janssen Pharmaceuticals, Inc.	Triazoles as NR2B receptor inhibitors
DE102015011861B4 (de)	2015-09-10	2018-03-01	Rudolf Schindler	Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
ES2821010T3 (es)	2015-12-09	2021-04-23	Cadent Therapeutics Inc	Moduladores heteroaromáticos del receptor NMDA y usos de los mismos
MA44008A (fr)	2016-02-10	2018-12-19	Janssen Pharmaceutica Nv	1,2,3-triazoles substitués utilisés comme modulateurs de nmda sélectifs de nr2b
JP6850300B2 (ja)	2016-02-18	2021-03-31	シンジェンタパーティシペーションズアーゲー	殺有害生物活性ピラゾール誘導体
WO2017158147A1 (en)	2016-03-18	2017-09-21	Savira Pharmaceuticals Gmbh	Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158151A1 (en)	2016-03-18	2017-09-21	Savira Pharmaceuticals Gmbh	Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
TW201819376A (zh)	2016-10-06	2018-06-01	比利時商健生藥品公司	經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
CA3047403A1 (en)	2016-12-22	2018-06-28	Cadent Therapeutics, Inc.	Nmda receptor modulators and uses thereof
EP3774732A4 (en)	2018-04-04	2022-02-09	Janssen Pharmaceutica NV	PYRIDINE AND SUBSTITUTED PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
CA3108519A1 (en)	2018-08-03	2020-04-30	Cadent Therapeutics, Inc.	Heteroaromatic nmda receptor modulators and uses thereof
CN113993583A (zh)	2019-06-14	2022-01-28	詹森药业有限公司	取代的吡唑并[4,3-b]吡啶及其作为GLUN2B受体调节剂的用途
PH12021552839A1 (en)	2019-06-14	2022-10-03	Janssen Pharmaceutica Nv	Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
EP3982958A1 (en)	2019-06-14	2022-04-20	Janssen Pharmaceutica NV	Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
MX2021015511A (es)	2019-06-14	2022-01-31	Janssen Pharmaceutica Nv	Carbamatos de pirazina y sus usos como moduladores del receptor glun2b.
JP2022536773A (ja)	2019-06-14	2022-08-18	ヤンセンファーマシューティカエヌ．ベー．	置換ピラゾロピラジン及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用
BR112021025132A2 (pt)	2019-06-14	2022-01-25	Janssen Pharmaceutica Nv	Carbamatos de piridina e seu uso como moduladores do receptor glun2b
CR20210580A (es)	2019-06-14	2022-01-31	Janssen Pharmaceutica Nv	Amidas depirazol-piridina sustituidos y su uso como moduladores del receptor glun2b
CN114478210A (zh) *	2022-02-26	2022-05-13	江苏壹药新材料有限公司	一种7-氯萘-2-甲醛的合成方法

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US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives

2003
- 2003-05-09 US US10/434,955 patent/US7005432B2/en not_active Expired - Fee Related
- 2003-05-15 AR ARP030101685A patent/AR040010A1/es active IP Right Grant
- 2003-05-16 MX MXPA04011253A patent/MXPA04011253A/es active IP Right Grant
- 2003-05-16 CA CA002485926A patent/CA2485926C/en not_active Expired - Fee Related
- 2003-05-16 RS YUP-985/04A patent/RS51200B/sr unknown
- 2003-05-16 KR KR1020047018485A patent/KR100632868B1/ko not_active Expired - Fee Related
- 2003-05-16 EP EP03752750A patent/EP1506190B1/en not_active Expired - Lifetime
- 2003-05-16 BR BR0311177-6A patent/BR0311177A/pt not_active IP Right Cessation
- 2003-05-16 AT AT03752750T patent/ATE329912T1/de active
- 2003-05-16 CN CNB038111926A patent/CN1312151C/zh not_active Expired - Fee Related
- 2003-05-16 PL PL374224A patent/PL211340B1/pl unknown
- 2003-05-16 PT PT03752750T patent/PT1506190E/pt unknown
- 2003-05-16 RU RU2004136979/04A patent/RU2317294C2/ru not_active IP Right Cessation
- 2003-05-16 ES ES03752750T patent/ES2265581T3/es not_active Expired - Lifetime
- 2003-05-16 SI SI200330332T patent/SI1506190T1/sl unknown
- 2003-05-16 DE DE60306152T patent/DE60306152T2/de not_active Expired - Lifetime
- 2003-05-16 DK DK03752750T patent/DK1506190T3/da active
- 2003-05-16 HR HR20041060 patent/HRP20041060B1/xx not_active IP Right Cessation
- 2003-05-16 ME MEP-767/08A patent/MEP76708A/xx unknown
- 2003-05-16 WO PCT/EP2003/005151 patent/WO2003097637A1/en not_active Ceased
- 2003-05-16 NZ NZ536310A patent/NZ536310A/en not_active IP Right Cessation
- 2003-05-16 AU AU2003242542A patent/AU2003242542B2/en not_active Ceased
- 2003-05-16 JP JP2004505370A patent/JP4267569B2/ja not_active Expired - Fee Related
2004
- 2004-05-24 CL CL200401251A patent/CL2004001251A1/es unknown
- 2004-10-28 NO NO20044666A patent/NO329605B1/no not_active IP Right Cessation
- 2004-10-28 IL IL164922A patent/IL164922A/en not_active IP Right Cessation
- 2004-10-29 ZA ZA2004/08789A patent/ZA200408789B/en unknown
- 2004-11-11 TN TNP2004000224A patent/TNSN04224A1/fr unknown
- 2004-11-12 MA MA27943A patent/MA27117A1/fr unknown
2006
- 2006-08-22 CY CY20061101161T patent/CY1105159T1/el unknown

Also Published As

Publication number	Publication date
WO2003097637A1 (en)	2003-11-27
MXPA04011253A (es)	2005-01-25
MA27117A1 (fr)	2004-12-20
AR040010A1 (es)	2005-03-09
MEP76708A (en)	2011-12-20
DE60306152T2 (de)	2007-04-26
ZA200408789B (en)	2005-12-28
EP1506190A1 (en)	2005-02-16
CN1653062A (zh)	2005-08-10
HK1080845A1 (en)	2006-05-04
RU2317294C2 (ru)	2008-02-20
AU2003242542B2 (en)	2008-10-16
CL2004001251A1 (es)	2005-04-22
DE60306152D1 (de)	2006-07-27
SI1506190T1 (sl)	2006-10-31
PL374224A1 (en)	2005-10-03
CA2485926A1 (en)	2003-11-27
KR100632868B1 (ko)	2006-10-13
US20030229096A1 (en)	2003-12-11
RS98504A (sr)	2006-12-15
CA2485926C (en)	2009-11-24
RU2004136979A (ru)	2005-07-10
BR0311177A (pt)	2005-03-15
TNSN04224A1 (fr)	2007-03-12
HRP20041060B1 (en)	2012-11-30
ATE329912T1 (de)	2006-07-15
US7005432B2 (en)	2006-02-28
PT1506190E (pt)	2006-11-30
IL164922A (en)	2012-01-31
ES2265581T3 (es)	2007-02-16
JP2005532326A (ja)	2005-10-27
JP4267569B2 (ja)	2009-05-27
EP1506190B1 (en)	2006-06-14
NZ536310A (en)	2007-08-31
RS51200B (sr)	2010-12-31
NO329605B1 (no)	2010-11-22
KR20040106558A (ko)	2004-12-17
AU2003242542A1 (en)	2003-12-02
CY1105159T1 (el)	2009-11-04
HRP20041060A2 (en)	2005-06-30
CN1312151C (zh)	2007-04-25
NO20044666L (no)	2004-12-15
PL211340B1 (pl)	2012-05-31
IL164922A0 (en)	2005-12-18

Publication	Publication Date	Title
NO20044666L (no)	2004-12-15	(Imidazol-1-yl-metyl)-pyridazin som NMDA-reseptor-blokker
DK1414440T3 (da)	2007-05-21	N-phenylpyrrolguanidinderivater som melanocortinreceptorligander
PL379420A1 (pl)	2006-09-04	Pochodne blokerów receptora angiotensyny II
DK1663996T3 (da)	2012-10-01	(Thio)carbamoylcyclohexanderivater som D3/D2-receptorantagonister
AU2003257094A1 (en)	2004-02-25	Substituted benzimidazole compounds
DE60328925D1 (de)	2009-10-01	Jittergenerator
EP1832069B8 (en)	2018-05-16	Voip network infrastructure components
DK1501809T3 (da)	2008-05-13	Trizolderivater som tachykininreceptorantagonister
DK1492786T3 (da)	2007-02-12	Pyridinoylpiperidiner som 5-HT1F-agonister
DK1501826T3 (da)	2007-01-29	Substituerede indoler som alpha-1-agonister
ZA200409339B (en)	2006-02-22	Novel benzimidazole derivatives.
AU2003902860A0 (en)	2003-06-26	Benzimidazole compounds
NO20051042L (no)	2005-03-31	Pyrimidylsulfonamidderivater som kemokinreseptormodulatorer
NO20052797D0 (no)	2005-06-09	Fenyl eller heteroaryl aminoalkanderivater som IP-reseptorantagonister
DK1802307T3 (da)	2008-06-30	Pyrrolidinderivater som histamin-receptor-ligander
DK1833791T3 (da)	2011-10-24	2,3,4,9-tetrahydor-1H-carbazolderivater som CRTH2 receptorantagonister
AU2003257032A1 (en)	2004-02-23	Antibodies against c3a receptor
DK1068202T3 (da)	2009-03-16	1-(-heteroarylpropyl- eller -prop-2-enyl)-4benzylpipderidiner som NMDA-receptor-antagonister
DK1636221T3 (da)	2009-10-12	3-Heterocyclyl-azetidin-forbindelser, som er nytte som NK1/NK2 receptorantagonister
NO20042198L (no)	2004-07-09	Tetrahydrokarbazolderivater som ligander for G-proteinkoplede reseptorer (GPCR).
DK1648882T3 (da)	2008-11-24	3-fluor-piperidiner som NMDA/NR2B-antagonister
NO20044373L (no)	2004-10-14	Azetidinderivater som CCR-3-reseptorantagonister
AP2006003840A0 (en)	2006-12-31	Indole-2-carboxamidine derivatives as NMDA receptor antagonists
DK1636206T3 (da)	2008-02-11	Imidazolderivater som glutamatreceptorantagonister
DK1560828T3 (da)	2006-09-04	Imidazoquinolinderivater som adenosin-A3-receptorligander