DK157010C - Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser - Google Patents

Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser

Info

Publication number: DK157010C
Authority: DK; Denmark
Prior art keywords: phenyl; aminoalkylide; preparation; indolones; treatment
Prior art date: 1982-09-20

Application number

DK425383A

Other languages

English (en)

Other versions

DK157010B (da

DK425383A (da

DK425383D0 (da

Inventor

Harry Ralph Howard

Reinhard Sarges

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-20

Filing date

1983-09-19

Publication date

1990-03-26

1983-09-19 Application filed by Pfizer filed Critical Pfizer

1983-09-19 Publication of DK425383D0 publication Critical patent/DK425383D0/da

1984-05-03 Publication of DK425383A publication Critical patent/DK425383A/da

1989-10-30 Publication of DK157010B publication Critical patent/DK157010B/da

1990-03-26 Application granted granted Critical

1990-03-26 Publication of DK157010C publication Critical patent/DK157010C/da

Links

XRKBWYMXJJLQTN-UHFFFAOYSA-N 1-phenyl-3-pyrrolidin-2-ylideneindol-2-one Chemical class O=C1N(C=2C=CC=CC=2)C2=CC=CC=C2C1=C1CCCN1 XRKBWYMXJJLQTN-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
239000003445 gaba agent Substances 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Dental Preparations (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK425383A 1982-09-20 1983-09-19 Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser DK157010C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42054482		1982-09-20
US06/420,544 US4476307A (en)	1982-09-20	1982-09-20	Heteroylidene indolone compounds

Publications (4)

Publication Number	Publication Date
DK425383D0 DK425383D0 (da)	1983-09-19
DK425383A DK425383A (da)	1984-05-03
DK157010B DK157010B (da)	1989-10-30
DK157010C true DK157010C (da)	1990-03-26

Family

ID=23666904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK425383A DK157010C (da)	1982-09-20	1983-09-19	Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser

Country Status (24)

Country	Link
US (1)	US4476307A (da)
EP (1)	EP0104860B1 (da)
JP (1)	JPS5976058A (da)
KR (1)	KR860001270B1 (da)
AT (1)	ATE25972T1 (da)
AU (1)	AU543115B2 (da)
CA (1)	CA1194871A (da)
DD (1)	DD213211A5 (da)
DE (1)	DE3370325D1 (da)
DK (1)	DK157010C (da)
ES (3)	ES525737A0 (da)
FI (1)	FI77446C (da)
GR (1)	GR79732B (da)
HU (1)	HU189747B (da)
IE (1)	IE55923B1 (da)
IL (1)	IL69758A (da)
NO (1)	NO161557C (da)
NZ (1)	NZ205638A (da)
PH (1)	PH18297A (da)
PL (3)	PL141370B1 (da)
PT (1)	PT77360B (da)
SU (1)	SU1272983A3 (da)
YU (4)	YU189283A (da)
ZA (1)	ZA836933B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879391A (en) *	1982-09-20	1989-11-07	Pfizer Inc.	1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
WO1990008146A1 (en) *	1989-01-10	1990-07-26	Pfizer Inc.	Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) *	1990-01-12	1992-01-07	Major Thomas O	Apparatus and method for purification and recovery of refrigerant
US5158969A (en) *	1991-08-21	1992-10-27	Neurosearch A/S	Indole derivatives as potassium channel blockers
US5760250A (en) *	1991-11-05	1998-06-02	Zeneca Limited	Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) *	1999-10-13	2001-04-19	Boehringer Ingelheim Pharma	In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US20030225152A1 (en) *	2001-09-27	2003-12-04	Andrews Steven W.	3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US20050101788A1 (en) *	2002-03-27	2005-05-12	Jacopo Zanon	Method for manufacture of sertindole
FR2847813A1 (fr) *	2002-11-29	2004-06-04	Oreal	Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
FR2847811B1 (fr) *	2002-11-29	2005-01-07	Oreal	Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
AP2007004244A0 (en)	2005-05-10	2007-12-31	Intermune Inc	Method of modulating stress-activated protein kinase system
EP2296653B1 (en)	2008-06-03	2016-01-27	Intermune, Inc.	Compounds and methods for treating inflammatory and fibrotic disorders
WO2010070910A1 (ja)	2008-12-19	2010-06-24	日本曹達株式会社	1－ヘテロジエン誘導体および有害生物防除剤
JP5537562B2 (ja)	2009-11-12	2014-07-02	日本曹達株式会社	１−ヘテロジエン誘導体および有害生物防除剤
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
RU2692485C2 (ru)	2014-04-02	2019-06-25	Интермьюн, Инк.	Противофиброзные пиридиноны

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3506683A (en) *	1963-10-07	1970-04-14	Upjohn Co	3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) *	1968-12-18	1971-06-30	Pfizer Ltd	Novel indoline derivatives
US3723457A (en) *	1969-09-30	1973-03-27	Eisai Co Ltd	Indoline-2-one derivatives and preparation thereof
GB1374414A (en) *	1972-06-12	1974-11-20	Sterling Drug Inc	1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung

1982
- 1982-09-20 US US06/420,544 patent/US4476307A/en not_active Expired - Fee Related
1983
- 1983-09-16 CA CA000436845A patent/CA1194871A/en not_active Expired
- 1983-09-18 IL IL69758A patent/IL69758A/xx unknown
- 1983-09-19 NO NO833367A patent/NO161557C/no unknown
- 1983-09-19 ES ES525737A patent/ES525737A0/es active Granted
- 1983-09-19 GR GR72470A patent/GR79732B/el unknown
- 1983-09-19 DE DE8383305484T patent/DE3370325D1/de not_active Expired
- 1983-09-19 DD DD83254923A patent/DD213211A5/de unknown
- 1983-09-19 IE IE2193/83A patent/IE55923B1/en not_active IP Right Cessation
- 1983-09-19 KR KR1019830004396A patent/KR860001270B1/ko not_active Expired
- 1983-09-19 SU SU833646758A patent/SU1272983A3/ru active
- 1983-09-19 NZ NZ205638A patent/NZ205638A/en unknown
- 1983-09-19 AT AT83305484T patent/ATE25972T1/de not_active IP Right Cessation
- 1983-09-19 ZA ZA836933A patent/ZA836933B/xx unknown
- 1983-09-19 PT PT77360A patent/PT77360B/pt not_active IP Right Cessation
- 1983-09-19 FI FI833335A patent/FI77446C/fi not_active IP Right Cessation
- 1983-09-19 DK DK425383A patent/DK157010C/da not_active IP Right Cessation
- 1983-09-19 HU HU833235A patent/HU189747B/hu unknown
- 1983-09-19 EP EP83305484A patent/EP0104860B1/en not_active Expired
- 1983-09-19 AU AU19252/83A patent/AU543115B2/en not_active Ceased
- 1983-09-20 PL PL1983250768A patent/PL141370B1/pl unknown
- 1983-09-20 JP JP58174025A patent/JPS5976058A/ja active Granted
- 1983-09-20 PL PL1983250769A patent/PL141876B1/pl unknown
- 1983-09-20 YU YU01892/83A patent/YU189283A/xx unknown
- 1983-09-20 PL PL1983243826A patent/PL141609B1/pl unknown
- 1983-09-20 PH PH29565A patent/PH18297A/en unknown
1984
- 1984-04-25 ES ES531907A patent/ES8505950A1/es not_active Expired
- 1984-04-25 ES ES531908A patent/ES531908A0/es active Granted
1986
- 1986-10-01 YU YU01692/86A patent/YU169286A/xx unknown
- 1986-10-01 YU YU01693/86A patent/YU169386A/xx unknown
- 1986-10-01 YU YU01691/86A patent/YU169186A/xx unknown

Also Published As

Publication number	Publication date
JPS6241711B2 (da)	1987-09-04
ES8505951A1 (es)	1985-06-01
KR840006239A (ko)	1984-11-22
NO161557C (no)	1989-08-30
FI77446B (fi)	1988-11-30
ES8503328A1 (es)	1985-02-16
JPS5976058A (ja)	1984-04-28
YU169186A (en)	1987-10-31
NO833367L (no)	1984-03-21
HU189747B (en)	1986-07-28
YU189283A (en)	1987-10-31
FI833335A0 (fi)	1983-09-19
NO161557B (no)	1989-05-22
PH18297A (en)	1985-05-24
DK157010B (da)	1989-10-30
CA1194871A (en)	1985-10-08
DD213211A5 (de)	1984-09-05
ES525737A0 (es)	1985-02-16
ES531907A0 (es)	1985-06-01
US4476307A (en)	1984-10-09
PL141609B1 (en)	1987-08-31
KR860001270B1 (ko)	1986-09-04
PL141370B1 (en)	1987-07-31
ZA836933B (en)	1985-05-29
FI833335A7 (fi)	1984-03-21
YU169386A (en)	1987-10-31
IL69758A (en)	1986-12-31
AU1925283A (en)	1984-03-29
YU169286A (en)	1987-10-31
SU1272983A3 (ru)	1986-11-23
DK425383A (da)	1984-05-03
PT77360A (en)	1983-10-01
PL250768A1 (en)	1985-07-02
NZ205638A (en)	1986-12-05
ATE25972T1 (de)	1987-04-15
IL69758A0 (en)	1983-12-30
IE55923B1 (en)	1991-02-27
PT77360B (en)	1986-05-19
PL250769A1 (en)	1985-07-02
EP0104860B1 (en)	1987-03-18
ES531908A0 (es)	1985-06-01
EP0104860A1 (en)	1984-04-04
PL243826A1 (en)	1985-04-24
ES8505950A1 (es)	1985-06-01
IE832193L (en)	1984-03-20
DK425383D0 (da)	1983-09-19
PL141876B1 (en)	1987-09-30
GR79732B (da)	1984-10-31
AU543115B2 (en)	1985-04-04
DE3370325D1 (en)	1987-04-23
FI77446C (fi)	1989-03-10

Legal Events

Date	Code	Title	Description
1993-05-24	PBP	Patent lapsed

Publication	Publication Date	Title
DK425383D0 (da)	1983-09-19	Fremgangsmade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser
DK0800519T3 (da)	2004-03-01	Steroidreceptormodulatorforbindelser og fremgangsmåder
DK0758904T3 (da)	2010-01-18	Fremgangsmåder og sammensætninger til behandling af glomerulonephritis
DK163145C (da)	1992-06-22	Analogifremgangsmaade til fremstilling af 6-substituerede s-triazoloe3,4-aaaftalazin-derivater
MY107799A (en)	1996-06-29	Neuroprotective indolone and related derivatives
DE3774918D1 (de)	1992-01-16	Cancerostatisches mittel.
FI913943A0 (fi)	1991-08-21	Nya kroman- och tiokromanderivat.
DK0556329T3 (da)	1996-05-06	Substituerede piperaziner som midler til behandling af centralnervesystemet
NO853698L (no)	1986-03-24	I-substituerte tetralinderivater, fremstilling og anvendel se derav.
DK158496C (da)	1990-10-29	Middel til behandling af saar
DK0417003T3 (da)	1994-07-25	Anvendelse af antiprogestomimetiske forbindelser til fremme af ovulation
DK361282A (da)	1983-02-13	Fremgangsmaade til fremstilling af o-alkyl-o-carbamoylglycerophosphocholiner
DK532679A (da)	1980-06-17	Fremgangsmaade til fremstilling af 2-aryl-3,4-diaza-bicyclo (4,1,0)hepten-(2)-on-(5).
DK146007C (da)	1983-10-17	Analogifremgangsmaade til fremstilling af d-homosteroider