DK157010C - Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser - Google Patents

Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser

Info

Publication number: DK157010C
Authority: DK; Denmark
Prior art keywords: phenyl; aminoalkylide; preparation; indolones; treatment
Prior art date: 1982-09-20

Application number

DK425383A

Other languages

English (en)

Other versions

DK157010B (da

DK425383A (da

DK425383D0 (da

Inventor

Harry Ralph Howard

Reinhard Sarges

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-20

Filing date

1983-09-19

Publication date

1990-03-26

1983-09-19 Application filed by Pfizer filed Critical Pfizer

1983-09-19 Publication of DK425383D0 publication Critical patent/DK425383D0/da

1984-05-03 Publication of DK425383A publication Critical patent/DK425383A/da

1989-10-30 Publication of DK157010B publication Critical patent/DK157010B/da

1990-03-26 Application granted granted Critical

1990-03-26 Publication of DK157010C publication Critical patent/DK157010C/da

Links

XRKBWYMXJJLQTN-UHFFFAOYSA-N 1-phenyl-3-pyrrolidin-2-ylideneindol-2-one Chemical class O=C1N(C=2C=CC=CC=2)C2=CC=CC=C2C1=C1CCCN1 XRKBWYMXJJLQTN-UHFFFAOYSA-N 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
239000003445 gaba agent Substances 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Dental Preparations (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK425383A 1982-09-20 1983-09-19 Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser DK157010C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42054482		1982-09-20
US06/420,544 US4476307A (en)	1982-09-20	1982-09-20	Heteroylidene indolone compounds

Publications (4)

Publication Number	Publication Date
DK425383D0 DK425383D0 (da)	1983-09-19
DK425383A DK425383A (da)	1984-05-03
DK157010B DK157010B (da)	1989-10-30
DK157010C true DK157010C (da)	1990-03-26

Family

ID=23666904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK425383A DK157010C (da)	1982-09-20	1983-09-19	Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser

Country Status (24)

Country	Link
US (1)	US4476307A (da)
EP (1)	EP0104860B1 (da)
JP (1)	JPS5976058A (da)
KR (1)	KR860001270B1 (da)
AT (1)	ATE25972T1 (da)
AU (1)	AU543115B2 (da)
CA (1)	CA1194871A (da)
DD (1)	DD213211A5 (da)
DE (1)	DE3370325D1 (da)
DK (1)	DK157010C (da)
ES (3)	ES8503328A1 (da)
FI (1)	FI77446C (da)
GR (1)	GR79732B (da)
HU (1)	HU189747B (da)
IE (1)	IE55923B1 (da)
IL (1)	IL69758A (da)
NO (1)	NO161557C (da)
NZ (1)	NZ205638A (da)
PH (1)	PH18297A (da)
PL (3)	PL141876B1 (da)
PT (1)	PT77360B (da)
SU (1)	SU1272983A3 (da)
YU (4)	YU189283A (da)
ZA (1)	ZA836933B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879391A (en) *	1982-09-20	1989-11-07	Pfizer Inc.	1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) *	1986-04-10	1988-07-26	E. I. Dupont De Nemours & Company	3,3-disubstituted indolines
WO1990008146A1 (en) *	1989-01-10	1990-07-26	Pfizer Inc.	Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) *	1990-01-12	1992-01-07	Major Thomas O	Apparatus and method for purification and recovery of refrigerant
US5158969A (en) *	1991-08-21	1992-10-27	Neurosearch A/S	Indole derivatives as potassium channel blockers
US5760250A (en) *	1991-11-05	1998-06-02	Zeneca Limited	Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) *	1999-10-13	2001-04-19	Boehringer Ingelheim Pharma	In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
AU2002341881B2 (en) *	2001-09-27	2008-05-08	Allergan, Inc.	3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
HRP20040987A2 (en) *	2002-03-27	2005-06-30	H. Lundbeck A/S	Method for manufacture of sertindole
FR2847811B1 (fr) *	2002-11-29	2005-01-07	Oreal	Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) *	2002-11-29	2004-06-04	Oreal	Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
RS53599B1 (sr)	2005-05-10	2015-02-27	Intermune, Inc.	Piridon derivati za modulaciju stresom aktiviranog sistema proteinskih kinaza
JP5627574B2 (ja)	2008-06-03	2014-11-19	インターミューン，インコーポレイテッド	炎症性および線維性疾患を治療するための化合物および方法
SI2380876T1 (sl)	2008-12-19	2014-12-31	Nippon Soda Co., Ltd.	Derivat 1-heterodiena in sredstvo za kontrolo Ĺˇkodljivih organizmov
CN102596931B (zh)	2009-11-12	2014-07-02	日本曹达株式会社	1-杂原子二烯衍生物和有害生物防除剂
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神分裂病を処置するための方法および組成物
CN106459042B (zh)	2014-04-02	2019-06-28	英特穆恩公司	抗纤维化吡啶酮类

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3506683A (en) *	1963-10-07	1970-04-14	Upjohn Co	3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) *	1968-12-18	1971-06-30	Pfizer Ltd	Novel indoline derivatives
US3723457A (en) *	1969-09-30	1973-03-27	Eisai Co Ltd	Indoline-2-one derivatives and preparation thereof
GB1374414A (en) *	1972-06-12	1974-11-20	Sterling Drug Inc	1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung

1982
- 1982-09-20 US US06/420,544 patent/US4476307A/en not_active Expired - Fee Related
1983
- 1983-09-16 CA CA000436845A patent/CA1194871A/en not_active Expired
- 1983-09-18 IL IL69758A patent/IL69758A/xx unknown
- 1983-09-19 NO NO833367A patent/NO161557C/no unknown
- 1983-09-19 KR KR1019830004396A patent/KR860001270B1/ko not_active Expired
- 1983-09-19 PT PT77360A patent/PT77360B/pt not_active IP Right Cessation
- 1983-09-19 SU SU833646758A patent/SU1272983A3/ru active
- 1983-09-19 DD DD83254923A patent/DD213211A5/de unknown
- 1983-09-19 DK DK425383A patent/DK157010C/da not_active IP Right Cessation
- 1983-09-19 DE DE8383305484T patent/DE3370325D1/de not_active Expired
- 1983-09-19 NZ NZ205638A patent/NZ205638A/en unknown
- 1983-09-19 GR GR72470A patent/GR79732B/el unknown
- 1983-09-19 EP EP83305484A patent/EP0104860B1/en not_active Expired
- 1983-09-19 IE IE2193/83A patent/IE55923B1/en not_active IP Right Cessation
- 1983-09-19 AU AU19252/83A patent/AU543115B2/en not_active Ceased
- 1983-09-19 FI FI833335A patent/FI77446C/fi not_active IP Right Cessation
- 1983-09-19 AT AT83305484T patent/ATE25972T1/de not_active IP Right Cessation
- 1983-09-19 HU HU833235A patent/HU189747B/hu unknown
- 1983-09-19 ZA ZA836933A patent/ZA836933B/xx unknown
- 1983-09-19 ES ES525737A patent/ES8503328A1/es not_active Expired
- 1983-09-20 PH PH29565A patent/PH18297A/en unknown
- 1983-09-20 PL PL1983250769A patent/PL141876B1/pl unknown
- 1983-09-20 PL PL1983243826A patent/PL141609B1/pl unknown
- 1983-09-20 PL PL1983250768A patent/PL141370B1/pl unknown
- 1983-09-20 YU YU01892/83A patent/YU189283A/xx unknown
- 1983-09-20 JP JP58174025A patent/JPS5976058A/ja active Granted
1984
- 1984-04-25 ES ES531907A patent/ES531907A0/es active Granted
- 1984-04-25 ES ES531908A patent/ES531908A0/es active Granted
1986
- 1986-10-01 YU YU01692/86A patent/YU169286A/xx unknown
- 1986-10-01 YU YU01691/86A patent/YU169186A/xx unknown
- 1986-10-01 YU YU01693/86A patent/YU169386A/xx unknown

Also Published As

Publication number	Publication date
AU1925283A (en)	1984-03-29
FI833335A0 (fi)	1983-09-19
ES8505951A1 (es)	1985-06-01
YU189283A (en)	1987-10-31
ES531908A0 (es)	1985-06-01
DK157010B (da)	1989-10-30
FI833335A7 (fi)	1984-03-21
ES8505950A1 (es)	1985-06-01
DE3370325D1 (en)	1987-04-23
EP0104860A1 (en)	1984-04-04
PL141609B1 (en)	1987-08-31
DD213211A5 (de)	1984-09-05
ES525737A0 (es)	1985-02-16
ES531907A0 (es)	1985-06-01
JPS5976058A (ja)	1984-04-28
US4476307A (en)	1984-10-09
IE55923B1 (en)	1991-02-27
PL141370B1 (en)	1987-07-31
EP0104860B1 (en)	1987-03-18
NO161557B (no)	1989-05-22
PH18297A (en)	1985-05-24
ZA836933B (en)	1985-05-29
YU169386A (en)	1987-10-31
KR860001270B1 (ko)	1986-09-04
IL69758A0 (en)	1983-12-30
GR79732B (da)	1984-10-31
AU543115B2 (en)	1985-04-04
DK425383A (da)	1984-05-03
KR840006239A (ko)	1984-11-22
NO161557C (no)	1989-08-30
PT77360A (en)	1983-10-01
JPS6241711B2 (da)	1987-09-04
CA1194871A (en)	1985-10-08
PL250768A1 (en)	1985-07-02
ATE25972T1 (de)	1987-04-15
IE832193L (en)	1984-03-20
IL69758A (en)	1986-12-31
NO833367L (no)	1984-03-21
SU1272983A3 (ru)	1986-11-23
YU169286A (en)	1987-10-31
ES8503328A1 (es)	1985-02-16
HU189747B (en)	1986-07-28
PL250769A1 (en)	1985-07-02
FI77446C (fi)	1989-03-10
PT77360B (en)	1986-05-19
PL141876B1 (en)	1987-09-30
PL243826A1 (en)	1985-04-24
FI77446B (fi)	1988-11-30
DK425383D0 (da)	1983-09-19
YU169186A (en)	1987-10-31
NZ205638A (en)	1986-12-05

Legal Events

Date	Code	Title	Description
1993-05-24	PBP	Patent lapsed

Publication	Publication Date	Title
DK157010C (da)	1990-03-26	Analogifremgangsmaade til fremstilling af 1-phenyl-3-(aminoalkyliden)-2(1h,3h)-indolon-forbindelser
DK162770C (da)	1992-04-27	Analogifremgangsmaade til fremstilling af 3,20-dioxo-1,4-pregnadien-17alfa-ol-17-heteroaromatiske carboxylater
DK0800519T3 (da)	2004-03-01	Steroidreceptormodulatorforbindelser og fremgangsmåder
DK0758904T3 (da)	2010-01-18	Fremgangsmåder og sammensætninger til behandling af glomerulonephritis
DK0785792T3 (da)	1999-10-18	Præparat til behandling af ovariale af østrogen afhængige sygdomme
MY107799A (en)	1996-06-29	Neuroprotective indolone and related derivatives
DE3774918D1 (de)	1992-01-16	Cancerostatisches mittel.
DK283881A (da)	1981-12-28	Fremgangsmaade til fremstilling af pyrazinyl1,2,4-oxadiazol-5-oner
FI823860A0 (fi)	1982-11-10	3-(1-substituerade-4-piperidyl)-1,2-bensisoxazoler, en process foer framstaellning daerav, en farmaceutisk komposition innehaollande dessa och deras anvaendning som laekemedel
FI913943A0 (fi)	1991-08-21	Nya kroman- och tiokromanderivat.
SE8801275D0 (sv)	1988-04-08	New uses of dopamine agonists
DK0556329T3 (da)	1996-05-06	Substituerede piperaziner som midler til behandling af centralnervesystemet
NO853698L (no)	1986-03-24	I-substituerte tetralinderivater, fremstilling og anvendel se derav.
DK322583A (da)	1984-01-15	Middel til behandling af saar
DK0417003T3 (da)	1994-07-25	Anvendelse af antiprogestomimetiske forbindelser til fremme af ovulation
DK149590C (da)	1987-02-09	Analogifremgangsmaade til fremstilling af 2-aryl-3,4-diaza-bicyclo(4,1,0)hepten-(2)-on-(5)-forbindelser
DE3378979D1 (en)	1989-02-23	1-acyl-3-pyridylmethylguanidines and their use as antihypertensive agents
AR010304A1 (es)	2000-06-07	Compuestos de dimesilato de cis-1-(3-etoxifenil)-1-4-fenilpiperazin-1-il) -4-metilciclohexano; procedimiento para su preparacion y composicionfarmaceutica
DK146007C (da)	1983-10-17	Analogifremgangsmaade til fremstilling af d-homosteroider