DK1585749T3 - Diazepinoindol-derivater som kinaseinhibitorer - Google Patents

Diazepinoindol-derivater som kinaseinhibitorer

Info

Publication number: DK1585749T3
Authority: DK; Denmark
Prior art keywords: kinase inhibitors; diazepinoindole; derivatives; diazepinoindole derivatives; kinase
Prior art date: 2003-01-09

Application number

DK04700145T

Other languages

Danish (da)

English (en)

Inventor

Sacha Ninkovic

Michael J Bennett

Fen Agouron Wang

Suzanne P Benedict

Min Agouron Teng

Yuanjin Eugene Rui

Yong Wang

Jinjiang Zhu

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-09

Filing date

2004-01-05

Publication date

2008-09-22

2004-01-05 Application filed by Pfizer filed Critical Pfizer

2008-09-22 Application granted granted Critical

2008-09-22 Publication of DK1585749T3 publication Critical patent/DK1585749T3/da

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
BSYFXFLGOGQHFU-UHFFFAOYSA-N pyrrolo[2,3-g][1,2]benzodiazepine Chemical class N1=NC=CC=C2C3=NC=CC3=CC=C21 BSYFXFLGOGQHFU-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK04700145T 2003-01-09 2004-01-05 Diazepinoindol-derivater som kinaseinhibitorer DK1585749T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43939603P	2003-01-09	2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en)	2003-01-09	2004-01-05	Diazepinoindole derivatives as kinase inhibitors

Publications (1)

Publication Number	Publication Date
DK1585749T3 true DK1585749T3 (da)	2008-09-22

Family

ID=32713475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04700145T DK1585749T3 (da)	2003-01-09	2004-01-05	Diazepinoindol-derivater som kinaseinhibitorer

Country Status (34)

Country	Link
US (3)	US6967198B2 (de)
EP (2)	EP1585749B1 (de)
JP (1)	JP3990718B2 (de)
KR (1)	KR100697746B1 (de)
CN (1)	CN1759118B (de)
AP (1)	AP2048A (de)
AT (1)	ATE404564T1 (de)
AU (1)	AU2004203977B2 (de)
BR (1)	BRPI0406701A (de)
CA (1)	CA2512683C (de)
CR (1)	CR7899A (de)
CY (1)	CY1108408T1 (de)
DE (1)	DE602004015724D1 (de)
DK (1)	DK1585749T3 (de)
EA (1)	EA009337B1 (de)
EC (1)	ECSP055911A (de)
ES (1)	ES2309484T3 (de)
GE (1)	GEP20084367B (de)
HR (1)	HRP20050624A2 (de)
IL (1)	IL169082A (de)
IS (1)	IS7884A (de)
MA (1)	MA27703A1 (de)
MX (1)	MXPA05007352A (de)
NO (1)	NO20053775L (de)
NZ (1)	NZ540638A (de)
OA (1)	OA13017A (de)
PL (1)	PL378372A1 (de)
PT (1)	PT1585749E (de)
RS (1)	RS20050522A (de)
SI (1)	SI1585749T1 (de)
TN (1)	TNSN05176A1 (de)
UA (1)	UA80733C2 (de)
WO (1)	WO2004063198A1 (de)
ZA (1)	ZA200504674B (de)

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CA2473886C (en) *	2002-01-22	2012-08-21	The Regents Of The University Of California	Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
JP3990718B2 (ja) *	2003-01-09	2007-10-17	ファイザー・インク	キナーゼ阻害剤としてのジアゼピノインドール誘導体
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AU2006279541A1 (en)	2005-08-15	2007-02-22	The Regents Of The University Of California	VEGF-activated FAS ligands
JP4935675B2 (ja)	2005-08-25	2012-05-23	宇部興産株式会社	光学活性（Ｓ又はＲ）−α−アミノ酸及び光学活性（Ｒ又はＳ）−α−アミノ酸エステルの製造方法
WO2007025303A2 (en) *	2005-08-26	2007-03-01	The Regents Of The University Of California	Non-steroidal antiandrogens
CN101415417A (zh) *	2006-04-04	2009-04-22	辉瑞产品公司	(2r,z)-2-氨基-2-环己基-n-(5-(1-甲基-1h-吡唑-4-基)-1-氧代-2,6-二氢-1h-[1,2]二氮杂卓并[4,5,6-cd]吲哚-8-基)乙酰胺的组合疗法
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US8211901B2 (en)	2009-05-22	2012-07-03	Shenzhen Chipscreen Biosciences Ltd.	Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh)	2009-06-04	2013-03-13	深圳微芯生物科技有限责任公司	作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
CN103748094B (zh)	2011-05-06	2016-06-29	扎夫根股份有限公司	三环磺酰胺化合物及其制备和使用方法
EP2793882A4 (de)	2011-12-22	2015-04-29	Threshold Pharmaceuticals Inc	Verabreichung von hypoxie-aktivierten prodrugs in kombination mit chk1-inhibitoren zur behandlung von krebs
MX2014008071A (es)	2011-12-31	2015-07-06	Beigene Ltd	Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
MX353578B (es)	2011-12-31	2018-01-19	Beigene Ltd	Dihidrodiazpinocarbazolonas tetra o penta-ciclicas fusionadas como inhibidores de poli (adp-ribosa) polimerasa (parp).
CN102746211B (zh) *	2012-06-27	2015-05-27	上海泰坦化学有限公司	一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) *	2013-05-22	2018-08-21	開曼群島商百濟神州生物科技有限公司	作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
CN112472699A (zh)	2013-07-26	2021-03-12	种族肿瘤学公司	改善比生群及衍生物的治疗益处的组合方法
WO2015069489A1 (en)	2013-11-06	2015-05-14	Merck Patent Gmbh	Predictive biomarker for hypoxia-activated prodrug therapy
SG11201610500WA (en)	2014-06-17	2017-01-27	Vertex Pharma	Method for treating cancer using a combination of chk1 and atr inhibitors
EA037366B1 (ru) *	2015-08-25	2021-03-18	Бейджин, Лтд.	Способ получения ингибитора parp, кристаллические формы и их применения
AU2016331955B2 (en)	2015-09-30	2022-07-21	Vertex Pharmaceuticals Incorporated	Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
CN110087730B (zh)	2016-09-27	2023-03-28	百济神州(苏州)生物科技有限公司	使用包含parp抑制剂的组合产品治疗癌症
JP6541635B2 (ja) *	2016-10-28	2019-07-10	ベイジーンリミテッド	Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
CN115433187B (zh)	2017-02-28	2023-10-27	百济神州(苏州)生物科技有限公司	稠合的四环或五环二氢二氮杂䓬并咔唑酮的盐的结晶形式组合物及其用途
US11661581B2 (en) *	2017-05-25	2023-05-30	University Of Massachusetts	Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
RU2764243C2 (ru) *	2017-09-22	2022-01-14	ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи	Гетероциклические соединения в качестве ингибиторов PAD
EP3461480A1 (de)	2017-09-27	2019-04-03	Onxeo	Kombination von checkpoint-hemmern des dna-schädigungsantwort-zellzyklus und belinostat zur behandlung von krebs
JP2022523028A (ja) *	2019-01-25	2022-04-21	ヌメディー，インコーポレイテッド	特発性肺線維症を処置するための方法
CN114072410B (zh) *	2019-08-01	2023-08-01	正大天晴药业集团股份有限公司	作为parp抑制剂吲哚并七元酰肟化合物
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WO2022011458A1 (en) *	2020-07-13	2022-01-20	Ontario Institute For Cancer Research (Oicr)	Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
AU2021318572A1 (en) *	2020-07-31	2023-02-16	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Indolo heptamyl oxime analog crystal as PARP inhibitor and method for preparing same

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2004
- 2004-01-05 JP JP2006500278A patent/JP3990718B2/ja not_active Expired - Fee Related
- 2004-01-05 SI SI200430830T patent/SI1585749T1/sl unknown
- 2004-01-05 HR HR20050624A patent/HRP20050624A2/hr not_active Application Discontinuation
- 2004-01-05 OA OA1200500197A patent/OA13017A/en unknown
- 2004-01-05 BR BR0406701-0A patent/BRPI0406701A/pt not_active IP Right Cessation
- 2004-01-05 ES ES04700145T patent/ES2309484T3/es not_active Expired - Lifetime
- 2004-01-05 CA CA2512683A patent/CA2512683C/en not_active Expired - Fee Related
- 2004-01-05 PL PL378372A patent/PL378372A1/pl not_active Application Discontinuation
- 2004-01-05 EA EA200500893A patent/EA009337B1/ru not_active IP Right Cessation
- 2004-01-05 KR KR1020057012806A patent/KR100697746B1/ko not_active Expired - Fee Related
- 2004-01-05 MX MXPA05007352A patent/MXPA05007352A/es active IP Right Grant
- 2004-01-05 PT PT04700145T patent/PT1585749E/pt unknown
- 2004-01-05 GE GEAP20048886A patent/GEP20084367B/en unknown
- 2004-01-05 RS YUP-2005/0522A patent/RS20050522A/sr unknown
- 2004-01-05 EP EP04700145A patent/EP1585749B1/de not_active Expired - Lifetime
- 2004-01-05 AT AT04700145T patent/ATE404564T1/de not_active IP Right Cessation
- 2004-01-05 AU AU2004203977A patent/AU2004203977B2/en not_active Ceased
- 2004-01-05 EP EP08155745A patent/EP1947102A1/de not_active Withdrawn
- 2004-01-05 NZ NZ540638A patent/NZ540638A/en unknown
- 2004-01-05 DK DK04700145T patent/DK1585749T3/da active
- 2004-01-05 WO PCT/IB2004/000026 patent/WO2004063198A1/en not_active Ceased
- 2004-01-05 CN CN2004800063838A patent/CN1759118B/zh not_active Expired - Fee Related
- 2004-01-05 DE DE602004015724T patent/DE602004015724D1/de not_active Expired - Lifetime
- 2004-01-05 AP AP2005003353A patent/AP2048A/xx active
- 2004-01-09 US US10/754,171 patent/US6967198B2/en not_active Expired - Fee Related
- 2004-05-01 UA UAA200506730A patent/UA80733C2/uk unknown
2005
- 2005-06-08 IL IL169082A patent/IL169082A/en not_active IP Right Cessation
- 2005-06-08 ZA ZA200504674A patent/ZA200504674B/en unknown
- 2005-06-09 IS IS7884A patent/IS7884A/is unknown
- 2005-07-08 TN TNP2005000176A patent/TNSN05176A1/fr unknown
- 2005-07-08 MA MA28375A patent/MA27703A1/fr unknown
- 2005-07-08 CR CR7899A patent/CR7899A/es unknown
- 2005-07-08 EC EC2005005911A patent/ECSP055911A/es unknown
- 2005-07-22 US US11/187,089 patent/US7132533B2/en not_active Expired - Fee Related
- 2005-08-08 NO NO20053775A patent/NO20053775L/no unknown
2006
- 2006-06-23 US US11/426,132 patent/US7462713B2/en not_active Expired - Fee Related
2008
- 2008-10-13 CY CY20081101127T patent/CY1108408T1/el unknown

Also Published As

Publication number	Publication date
CA2512683A1 (en)	2004-07-29
TNSN05176A1 (fr)	2007-06-11
NZ540638A (en)	2007-12-21
US7462713B2 (en)	2008-12-09
US20070135415A1 (en)	2007-06-14
JP3990718B2 (ja)	2007-10-17
HK1086257A1 (en)	2006-09-15
ES2309484T3 (es)	2008-12-16
DE602004015724D1 (de)	2008-09-25
OA13017A (en)	2006-11-10
WO2004063198A1 (en)	2004-07-29
CN1759118B (zh)	2010-12-08
MXPA05007352A (es)	2006-02-17
CY1108408T1 (el)	2014-02-12
BRPI0406701A (pt)	2005-12-20
ZA200504674B (en)	2006-07-26
CA2512683C (en)	2010-03-16
EP1585749A1 (de)	2005-10-19
CR7899A (es)	2005-08-05
EP1947102A1 (de)	2008-07-23
MA27703A1 (fr)	2006-01-02
IS7884A (is)	2005-06-09
IL169082A (en)	2011-02-28
EA009337B1 (ru)	2007-12-28
PL378372A1 (pl)	2006-04-03
EA200500893A1 (ru)	2006-02-24
KR20050092397A (ko)	2005-09-21
AP2048A (en)	2009-09-24
GEP20084367B (en)	2008-05-13
HRP20050624A2 (en)	2006-02-28
JP2006516274A (ja)	2006-06-29
US20050075499A1 (en)	2005-04-07
SI1585749T1 (sl)	2008-10-31
UA80733C2 (en)	2007-10-25
AU2004203977A1 (en)	2004-07-29
EP1585749B1 (de)	2008-08-13
AP2005003353A0 (en)	2005-09-30
CN1759118A (zh)	2006-04-12
RS20050522A (sr)	2007-12-31
AU2004203977B2 (en)	2010-06-17
NO20053775D0 (no)	2005-08-08
ATE404564T1 (de)	2008-08-15
US6967198B2 (en)	2005-11-22
NO20053775L (no)	2005-09-16
US7132533B2 (en)	2006-11-07
KR100697746B1 (ko)	2007-03-22
ECSP055911A (es)	2005-11-22
PT1585749E (pt)	2008-10-23
US20060004052A1 (en)	2006-01-05

Publication	Publication Date	Title
DK1585749T3 (da)	2008-09-22	Diazepinoindol-derivater som kinaseinhibitorer
DK1789041T3 (da)	2008-09-08	Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK1658292T3 (da)	2007-11-12	Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer
DK1797042T3 (da)	2009-03-02	Indozolonderivater som 11B-HSD1-inhibitorer
DK1944305T3 (da)	2012-01-30	Quinolinderivater som phosphodiesteraseinhibitorer
DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1699797T3 (da)	2010-01-04	Pyrrolotriazinforbindelser som kinasehæmmere
DK1720882T3 (da)	2011-04-11	Pyrazolopyrimidin-derivater som cyclin-afhængige kinaseinhibitorer
DK1534290T3 (da)	2012-04-10	Hidtil ukendte kinasehæmmere
NO20055680D0 (no)	2005-12-01	Heksahydropyridoisokinoliner som DPP-IV-inhibitorer
DK1881976T3 (da)	2013-02-04	Substituerede amidderivater som proteinkinaseinhibitorer
ATE520671T1 (de)	2011-09-15	Pyrimidin-harnstoff-derivate als kinase-hemmer
DK1667991T3 (da)	2008-08-18	Quinazolinderivater som tyrosinkinaseinhibitorer
DK2039685T3 (da)	2013-03-25	Heterobicycliske forbindelser som P38-inhibitorer
DK1711481T4 (da)	2013-08-26	Krystallinsk monohydrat som kinaseinhibitorer
DK1959951T3 (da)	2010-03-01	Heteroaryl-substituerede piperidinderivater som L-CPT1-inhibitorer
ATE452891T1 (de)	2010-01-15	Pyrimidopyrimidone als kinaseinhibitoren
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