DK1653950T3 - Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme - Google Patents

Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme

Info

Publication number: DK1653950T3
Authority: DK; Denmark
Prior art keywords: valsatan; olmesartan; eprosartan; telmisartan; candesartan
Prior art date: 2003-07-31

Application number

DK04766269T

Other languages

Danish (da)

English (en)

Inventor

Nicoletta Almirante

Soldato Piero Del

Ennio Ongini

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-31

Filing date

2004-07-20

Publication date

2008-05-26

2004-07-20 Application filed by Nicox Sa filed Critical Nicox Sa

2008-05-26 Application granted granted Critical

2008-05-26 Publication of DK1653950T3 publication Critical patent/DK1653950T3/da

Links

RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 title 2
102000008873 Angiotensin II receptor Human genes 0.000 title 1
108050000824 Angiotensin II receptor Proteins 0.000 title 1
239000002083 C09CA01 - Losartan Substances 0.000 title 1
239000002080 C09CA02 - Eprosartan Substances 0.000 title 1
239000002053 C09CA06 - Candesartan Substances 0.000 title 1
239000005537 C09CA07 - Telmisartan Substances 0.000 title 1
208000024172 Cardiovascular disease Diseases 0.000 title 1
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical class O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title 1
239000005480 Olmesartan Substances 0.000 title 1
-1 Valsatan Substances 0.000 title 1
229960000932 candesartan Drugs 0.000 title 1
SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 title 1
229960004563 eprosartan Drugs 0.000 title 1
OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 title 1
229960004773 losartan Drugs 0.000 title 1
VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 title 1
229960005117 olmesartan Drugs 0.000 title 1
229960005187 telmisartan Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

DK04766269T 2003-07-31 2004-07-20 Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme DK1653950T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03102379		2003-07-31
PCT/EP2004/051550 WO2005011646A2 (en)	2003-07-31	2004-07-20	Nitrooxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-ii receptor blockers for the treatment of cardiovascular diseases

Publications (1)

Publication Number	Publication Date
DK1653950T3 true DK1653950T3 (da)	2008-05-26

Family

ID=34112476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04766269T DK1653950T3 (da)	2003-07-31	2004-07-20	Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme

Country Status (29)

Country	Link
US (1)	US20060276523A1 (de)
EP (1)	EP1653950B1 (de)
JP (1)	JP2007500684A (de)
KR (1)	KR20060056352A (de)
CN (1)	CN100496490C (de)
AR (1)	AR045145A1 (de)
AT (1)	ATE383155T1 (de)
AU (1)	AU2004260830B2 (de)
BR (1)	BRPI0413028A (de)
CA (1)	CA2534451A1 (de)
CY (1)	CY1110447T1 (de)
DE (1)	DE602004011230T2 (de)
DK (1)	DK1653950T3 (de)
EC (1)	ECSP066334A (de)
ES (1)	ES2299861T3 (de)
HR (1)	HRP20060084A2 (de)
IL (1)	IL172703A0 (de)
IS (1)	IS2534B (de)
MA (1)	MA27987A1 (de)
MX (1)	MXPA06001263A (de)
NO (1)	NO20060900L (de)
NZ (1)	NZ544463A (de)
PL (2)	PL1653950T3 (de)
PT (1)	PT1653950E (de)
RU (1)	RU2374240C2 (de)
SI (1)	SI1653950T1 (de)
UA (1)	UA87983C2 (de)
WO (1)	WO2005011646A2 (de)
ZA (1)	ZA200600856B (de)

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WO2006008196A1 (en) *	2004-07-20	2006-01-26	Nicox S.A.	Process for preparing nitrooxy esters, nitrooxy thioesters, nitrooxy carbonates and nitrooxy thiocarbonates, intermediates useful in said process and preparation thereof
WO2006079610A1 (en) *	2005-01-31	2006-08-03	Nicox S.A.	Nitrooxy sartan derivatives as angiotensin ii receptor blockers for the treatment of cardiovascular and inflammatory diseases
RU2306930C1 (ru) *	2005-12-28	2007-09-27	Михаил Владимирович Покровский	Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
CN101024643A (zh)	2006-02-20	2007-08-29	上海艾力斯医药科技有限公司	咪唑－5－羧酸类衍生物、制备方法及其应用
TW200821303A (en) *	2006-08-08	2008-05-16	Speedel Experimenta Ag	Organic compounds
CA2668744C (en)	2006-11-17	2015-09-15	Queen's University At Kingston	Compounds and methods for treating protein folding disorders
ATE525371T1 (de)	2006-12-06	2011-10-15	Shanghai Allist Pharmaceutical Inc	Salze von imidazol-5-carbonsäure-derivaten, herstellungsverfahren und verwendung davon
TW200831079A (en) *	2006-12-13	2008-08-01	Merck & Co Inc	Angiotensin II receptor antagonists
EP2121664B1 (de) *	2006-12-13	2013-10-16	Merck Sharp & Dohme Corp.	Dinitrat-derivate als antagonisten des angiotensin-ii-rezeptors
CN101214242A (zh)	2007-01-05	2008-07-09	上海艾力斯医药科技有限公司	新的药用组合物
EP1980559A1 (de) *	2007-04-10	2008-10-15	CTG Pharma S.r.l.	Kardiovaskuläre Wirkstoffe
CN101317842A (zh)	2007-06-07	2008-12-10	上海艾力斯医药科技有限公司	一种咪唑-5-羧酸衍生物的治疗用途
CN101407511B (zh) *	2007-10-11	2013-01-09	上海艾力斯生物医药有限公司	一种结晶型的咪唑-5-羧酸衍生物
AR069340A1 (es) *	2007-11-26	2010-01-13	Merck & Co Inc	Antagonistas del receptor de angiotensina ii
JP5570996B2 (ja)	2007-12-14	2014-08-13	エアロデザインズインコーポレイテッド	エアロゾル化可能な食料品の送達
WO2009094242A1 (en) *	2008-01-24	2009-07-30	Merck & Co., Inc.	Angiotensin ii receptor antagonists
JP2011511079A (ja)	2008-02-08	2011-04-07	メルク・シャープ・エンド・ドーム・コーポレイション	アンジオテンシンｉｉ受容体アンタゴニスト
WO2009106470A2 (en) *	2008-02-26	2009-09-03	Nicox S.A.	Angiotensin ii receptor antagonists
WO2009106471A2 (en) *	2008-02-26	2009-09-03	Nicox S.A.	New angiotensin ii receptor blocker derivatives
AU2009246670A1 (en) *	2008-05-15	2009-11-19	Merck Sharp & Dohme Corp.	Angiotensin II receptor antagonists
CN101596189A (zh) *	2008-06-05	2009-12-09	上海艾力斯生物医药有限公司	含有咪唑-5-羧酸类衍生物的药用组合物
US20110077279A1 (en) *	2008-06-09	2011-03-31	Nicoletta Almirante	Angiotensin ii receptor antagonists
AR073259A1 (es) *	2008-07-29	2010-10-28	Merck & Co Inc	Derivados de furosemida utiles como diureticos
WO2010015447A1 (en) *	2008-08-08	2010-02-11	Nicox S.A.	Angiotensin ii receptor antagonists
EP2194048A1 (de)	2008-12-02	2010-06-09	Dirk Sartor	Nitratester zur Behandlung von vaskularen und metabolischen Krankheiten
AU2009322613A1 (en)	2008-12-05	2011-06-23	Merck Sharp & Dohme Corp.	Nitrooxy derivatives as angiotensin II receptor antagonists
MY173823A (en)	2009-01-23	2020-02-24	Hanmi Science Co Ltd	Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
AR080925A1 (es)	2010-04-19	2012-05-16	Cardiolynx Ag	Derivados de valsartan que portan donadores de no para el tratamiento de las enfermedades vasculares y metabolicas
EP2560634A1 (de) *	2010-04-23	2013-02-27	Piramal Enterprises Limited	Stickoxidfreisetzende prodrugs aus therapeutika
WO2011160974A2 (en)	2010-06-21	2011-12-29	Nicox S.A.	Statin derivatives
JO3350B1 (ar)	2011-03-07	2019-03-13	Merck Sharp & Dohme	مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CN103275074B (zh) *	2013-06-21	2016-08-10	黄冈鲁班药业股份有限公司	一种奥美沙坦衍生物及其制备方法
CN105820125B (zh) *	2015-01-09	2018-12-07	北京中医药大学	一种用于治疗高血压的化合物及其制备方法和用途
US10456405B2 (en)	2015-09-07	2019-10-29	Zhejiang Huahai Pharmaceutical Co., Ltd	Nitric oxide-releasing prodrug molecule of substituted quinazolines
CN106800537B (zh) *	2017-01-18	2019-02-01	广东隆赋药业股份有限公司	丁苯酞-替米沙坦杂合物及其制备方法和用途
CN108892624B (zh) *	2018-06-20	2020-12-15	重庆威鹏药业有限公司	沙库巴曲硝基氧衍生物及其制备方法和应用
CN114105881B (zh) *	2020-08-31	2024-01-26	沈阳海诺威医药科技有限公司	血小板聚集抑制剂及其制备方法和用途

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CA2018438C (en) *	1989-06-14	2000-08-08	Joseph Alan Finkelstein	Imidazolyl-alkenoic acids
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2004
- 2004-07-20 PL PL04766269T patent/PL1653950T3/pl unknown
- 2004-07-20 BR BRPI0413028-6A patent/BRPI0413028A/pt not_active IP Right Cessation
- 2004-07-20 KR KR1020067001893A patent/KR20060056352A/ko not_active Ceased
- 2004-07-20 NZ NZ544463A patent/NZ544463A/en unknown
- 2004-07-20 WO PCT/EP2004/051550 patent/WO2005011646A2/en not_active Ceased
- 2004-07-20 DK DK04766269T patent/DK1653950T3/da active
- 2004-07-20 CN CNB200480022483XA patent/CN100496490C/zh not_active Expired - Fee Related
- 2004-07-20 US US10/566,292 patent/US20060276523A1/en not_active Abandoned
- 2004-07-20 AU AU2004260830A patent/AU2004260830B2/en not_active Ceased
- 2004-07-20 ES ES04766269T patent/ES2299861T3/es not_active Expired - Lifetime
- 2004-07-20 UA UAA200600273A patent/UA87983C2/ru unknown
- 2004-07-20 PL PL379420A patent/PL379420A1/pl not_active Application Discontinuation
- 2004-07-20 DE DE602004011230T patent/DE602004011230T2/de not_active Expired - Lifetime
- 2004-07-20 EP EP04766269A patent/EP1653950B1/de not_active Expired - Lifetime
- 2004-07-20 SI SI200430655T patent/SI1653950T1/sl unknown
- 2004-07-20 JP JP2006521571A patent/JP2007500684A/ja active Pending
- 2004-07-20 PT PT04766269T patent/PT1653950E/pt unknown
- 2004-07-20 HR HR20060084A patent/HRP20060084A2/hr not_active Application Discontinuation
- 2004-07-20 AT AT04766269T patent/ATE383155T1/de not_active IP Right Cessation
- 2004-07-20 CA CA002534451A patent/CA2534451A1/en not_active Abandoned
- 2004-07-20 MX MXPA06001263A patent/MXPA06001263A/es active IP Right Grant
- 2004-07-20 RU RU2006105804/04A patent/RU2374240C2/ru not_active IP Right Cessation
- 2004-07-28 AR ARP040102685A patent/AR045145A1/es unknown
2005
- 2005-12-20 IL IL172703A patent/IL172703A0/en not_active IP Right Cessation
2006
- 2006-01-30 EC EC2006006334A patent/ECSP066334A/es unknown
- 2006-01-30 ZA ZA200600856A patent/ZA200600856B/en unknown
- 2006-02-13 MA MA28789A patent/MA27987A1/fr unknown
- 2006-02-24 NO NO20060900A patent/NO20060900L/no not_active Application Discontinuation
- 2006-02-27 IS IS8332A patent/IS2534B/is unknown
2008
- 2008-04-07 CY CY20081100385T patent/CY1110447T1/el unknown

Also Published As

Publication number	Publication date
CN100496490C (zh)	2009-06-10
AR045145A1 (es)	2005-10-19
CY1110447T1 (el)	2015-04-29
DE602004011230D1 (de)	2008-02-21
ES2299861T3 (es)	2008-06-01
PT1653950E (pt)	2008-04-11
PL379420A1 (pl)	2006-09-04
NO20060900L (no)	2006-02-24
AU2004260830A1 (en)	2005-02-10
PL1653950T3 (pl)	2008-08-29
EP1653950B1 (de)	2008-01-09
NZ544463A (en)	2009-10-30
MA27987A1 (fr)	2006-07-03
AU2004260830B2 (en)	2010-04-29
DE602004011230T2 (de)	2009-01-02
IL172703A0 (en)	2006-04-10
MXPA06001263A (es)	2006-04-11
UA87983C2 (ru)	2009-09-10
SI1653950T1 (sl)	2008-06-30
IS8332A (is)	2006-02-27
CN1832742A (zh)	2006-09-13
BRPI0413028A (pt)	2006-10-03
KR20060056352A (ko)	2006-05-24
JP2007500684A (ja)	2007-01-18
CA2534451A1 (en)	2005-02-10
WO2005011646A2 (en)	2005-02-10
ZA200600856B (en)	2007-05-30
ATE383155T1 (de)	2008-01-15
ECSP066334A (es)	2006-07-28
HRP20060084A2 (hr)	2006-04-30
EP1653950A2 (de)	2006-05-10
WO2005011646A3 (en)	2005-04-21
IS2534B (is)	2009-08-15
HK1095093A1 (zh)	2007-04-27
US20060276523A1 (en)	2006-12-07
RU2374240C2 (ru)	2009-11-27
RU2006105804A (ru)	2007-09-20

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DK1653950T3 (da)	2008-05-26	Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme
NO2012017I2 (no)	2012-11-09	Azilsartan medoxomil og farmasøytisk akseptabelt salt derav, innbefattende kaliumsalt
DE602005007447D1 (de)	2008-07-24	Axiale Verriegelungseinrichtung mit Verriegelungskeil
IL181550A0 (en)	2007-07-04	Purification of olmesartan medoxomil
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DE602005007633D1 (de)	2008-07-31	Wärmegeregelte, fluidische selbstmontage
TWI351075B (en)	2011-10-21	Semiconductor device, embedded memory, and method of fabricating the same
WO2009058950A3 (en)	2009-07-16	Pharmaceutical formulations comprising telmisartan and hydrochlorothiazide
FI20090094L (fi)	2009-03-13	Olmesartaanimedoksomiilin ja amlodipiinin kiinteä annostusmuoto
DK1626964T3 (da)	2009-04-20	Nye benzimidazolderivater
EP2272853A4 (de)	2011-05-18	Spiro-phosphor-oxazolin, synthese und verwendungen
DE502005009133D1 (de)	2010-04-15	Hydraulik-dehnspannfutter
DE602006013878D1 (de)	2010-06-02	Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
ATE492546T1 (de)	2011-01-15	6-phenyl-1h-imidazoä4,5-cü-pyridin-4- carbonitrilderivate als cathepsin-hemmer
ATE463496T1 (de)	2010-04-15	6-phenyl-1h-imidazoä4, 5-cüpyridin-4-carbonitril- derivate als cathepsin-k- und -s-hemmer
ZA200800213B (en)	2008-12-31	Benzimidazole derivatives as 5-HT6, 5-HT24
IL176630A0 (en)	2006-10-31	Benzimidazole derivatives
SE0600781L (sv)	2006-10-20	Halvledaranordning av kiselkarbid
DK1870409T3 (da)	2010-08-09	Benzimidazolforbindelser
EP1853274A4 (de)	2010-12-15	2-methylen-19-nor- (20s-24s) - 1alpha, 25-d hydroxyvitamin-d2
CL2004000379A1 (es)	2005-01-21	Uso de una combinacion farmaceutica de lercanidipina con un bloqueador de los receptores de angiotensina ii, seleccionado de olmesartan, irbesartan, valsartan, telmisartan y losartan, para tratar la hipertension.
DE502006009099D1 (de)	2011-04-28	Baumaschine, sowie schwenkeinrichtung
IL176140A0 (en)	2006-10-05	Candesartan cilexetil polymorphs
DK1906972T3 (da)	2013-12-16	LPA2-receptoragonist til behandling af diarré
DE602006000612D1 (de)	2008-04-17	Beidseitig tragbare Orthese