DK165975C - 3-(substitueret amino)-carbonylderivater af 2,2,5,5-tetramethylpyrrolin eller -pyrrolidin og farmaceutisk acceptable salte deraf, fremgangsmaade til deres fremstilling, antiarrhytmisk farmaceutisk praeparat indeholdende dem og fremgangsmaade til praeparatets fremstilling - Google Patents

3-(substitueret amino)-carbonylderivater af 2,2,5,5-tetramethylpyrrolin eller -pyrrolidin og farmaceutisk acceptable salte deraf, fremgangsmaade til deres fremstilling, antiarrhytmisk farmaceutisk praeparat indeholdende dem og fremgangsmaade til praeparatets fremstilling

Info

Publication number: DK165975C
Authority: DK; Denmark
Prior art keywords: preparation; arrythmtic; tetramethylpyrroline; pyrrolidine; pharmaceutically acceptable
Prior art date: 1983-01-21

Application number

DK448684A

Other languages

English (en)

Other versions

DK448684D0 (da

DK448684A (da

DK165975B (da

Inventor

Kalman Hideg

Olga H Hankovszky

Laszlo Frank

Ilona Bodi

Jozsef Csak

Original Assignee

Alkaloida Vegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-01-21

Filing date

1984-09-20

Publication date

1993-07-26

1983-01-21 Priority claimed from HU83191A external-priority patent/HU190704B/hu

1983-02-04 Priority claimed from HU38483A external-priority patent/HU189224B/hu

1983-02-04 Priority claimed from HU38683A external-priority patent/HU190707B/hu

1983-02-04 Priority claimed from HU38583A external-priority patent/HU190706B/hu

1984-09-20 Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar

1984-09-20 Publication of DK448684D0 publication Critical patent/DK448684D0/da

1984-11-21 Publication of DK448684A publication Critical patent/DK448684A/da

1993-02-22 Publication of DK165975B publication Critical patent/DK165975B/da

1993-07-26 Application granted granted Critical

1993-07-26 Publication of DK165975C publication Critical patent/DK165975C/da

Links

238000000034 method Methods 0.000 title 2
-1 AMINO Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK448684A 1983-01-21 1984-09-20 3-(substitueret amino)-carbonylderivater af 2,2,5,5-tetramethylpyrrolin eller -pyrrolidin og farmaceutisk acceptable salte deraf, fremgangsmaade til deres fremstilling, antiarrhytmisk farmaceutisk praeparat indeholdende dem og fremgangsmaade til praeparatets fremstilling DK165975C (da)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
HU19183		1983-01-21
HU83191A HU190704B (en)	1983-01-21	1983-01-21	Process for preparing n-up-1-acyl-n-up-2-alkyl-diamines
HU38483A HU189224B (en)	1983-02-04	1983-02-04	Process for preparing derivatives of n,n'-diacyl-diamino-alkane
HU38683		1983-02-04
HU38683A HU190707B (en)	1983-02-04	1983-02-04	Process for preparing new quinazolinone derivatives
HU38583A HU190706B (en)	1983-02-04	1983-02-04	Process for preparing new phthalimide derivatives
HU38483		1983-02-04
HU38583		1983-02-04
PCT/HU1984/000005 WO1984002907A1 (en)	1983-01-21	1984-01-23	New alkyl diamine derivatives
HU8400005		1984-01-23

Publications (4)

Publication Number	Publication Date
DK448684D0 DK448684D0 (da)	1984-09-20
DK448684A DK448684A (da)	1984-11-21
DK165975B DK165975B (da)	1993-02-22
DK165975C true DK165975C (da)	1993-07-26

Family

ID=27451957

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK448684A DK165975C (da)	1983-01-21	1984-09-20	3-(substitueret amino)-carbonylderivater af 2,2,5,5-tetramethylpyrrolin eller -pyrrolidin og farmaceutisk acceptable salte deraf, fremgangsmaade til deres fremstilling, antiarrhytmisk farmaceutisk praeparat indeholdende dem og fremgangsmaade til praeparatets fremstilling

Country Status (7)

Country	Link
US (4)	US4703056A (da)
EP (1)	EP0134225B1 (da)
JP (1)	JPH0615527B2 (da)
DE (1)	DE3473442D1 (da)
DK (1)	DK165975C (da)
FI (1)	FI76070C (da)
WO (1)	WO1984002907A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1984002907A1 (en) *	1983-01-21	1984-08-02	Alkaloida Vegyeszeti Gyar	New alkyl diamine derivatives
FI892362A7 (fi) *	1988-06-01	1989-12-02	Eisai Co Ltd	Buteeni- tai propeenihappojohdannainen
US5177089A (en) *	1988-06-01	1993-01-05	Eisai Co., Ltd.	Butenoic or propenoic acid derivative
HUP9700392A1 (hu) *	1997-02-10	1999-09-28	ICN Magyarország Részvénytársaság	Egy vagy két hatóanyagot tartalmazó kardioprotektív hatású gyógyszerkészítmények
US9724351B2 (en)	2012-08-23	2017-08-08	Alios Biopharma, Inc.	Compounds for the treatment of paramoxyvirus viral infections
PH12021550330A1 (en)	2013-08-21	2022-09-28	Janssen Biopharma Inc	Antiviral compounds
KR20180050646A (ko) *	2015-09-04	2018-05-15	디아이씨 가부시끼가이샤	안정제 화합물, 액정 조성물 및 표시 소자
CN107849458B (zh)	2015-09-04	2021-07-27	Dic株式会社	液晶组合物及使用其的液晶显示元件
SG11202002032SA (en)	2017-09-22	2020-04-29	Jubilant Epipad LLC	Heterocyclic compounds as pad inhibitors
CA3076476A1 (en)	2017-10-18	2019-04-25	Jubilant Epipad LLC	Imidazo-pyridine compounds as pad inhibitors
BR112020008851A2 (pt)	2017-11-06	2020-10-20	Jubilant Prodel LLC	composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
PL3704120T3 (pl)	2017-11-24	2024-09-16	Jubilant Episcribe Llc	Związki heterocykliczne jako inhibitory prmt5
SG11202008950PA (en)	2018-03-13	2020-10-29	Jubilant Prodel LLC	Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE109345C (da) *
DE109347C (da) *
DE109346C (da) *
US3020288A (en) *		1962-02-06		Hypotensive compounds
GB190004799A (en) *	1900-03-13	1900-05-19	George William Johnson	The Manufacture of Para-amidophenyl Glyoxylic Acid, its Substitution Products and Homologues.
US3502692A (en) *	1962-06-13	1970-03-24	American Cyanamid Co	Cyclic nitroxides and process for preparing same
GB983134A (en) *	1962-06-13	1965-02-10	American Cyanamid Co	Cyclic nitroxides and process for preparing same
US3250771A (en) *	1962-12-17	1966-05-10	Geigy Chem Corp	5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
US3535334A (en) *	1966-12-07	1970-10-20	Sumitomo Chemical Co	1-piperonoyl-3-indolyl aliphatic acid derivatives
US3715354A (en) *	1968-10-04	1973-02-06	Endo Lab	Oxoisoindoles
US3631706A (en) *	1969-02-25	1972-01-04	Western Electric Co	Methods of and apparatus for forming an article having a tubular portion
US4002757A (en) *	1974-12-26	1977-01-11	A. H. Robins Company, Incorporated	N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides
US4111901A (en) *	1977-06-06	1978-09-05	Borg-Warner Corporation	Hindered five-membered nitrogen rings as polyolefin stabilizers
IL57415A (en) *	1978-05-30	1984-08-31	Smith Kline French Lab	Nitropyrrole compounds,process for preparing them and pharmaceutical compositions containing them
DE3119796A1 (de) *	1981-05-19	1982-12-23	Hoechst Ag, 6000 Frankfurt	Substituierte tryptaminderivate von thienyloxpropanolaminen, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen sowie ihre verwendung
US4452989A (en) *	1982-06-01	1984-06-05	Charles Of The Ritz Group Ltd.	Substantive moisturizing derivatives of 2-pyrrolidone-5-carboxylic acid and compositions containing same
DE3331874A1 (de) *	1982-09-13	1984-04-05	Sandoz-Patent-GmbH, 7850 Lörrach	Neue thiophenderivate
US4643758A (en) *	1982-09-30	1987-02-17	Eli Lilly And Company	Herbicidal furyl-, thienyl- and pyrrolyl-2-pyrrolidinones
HU189214B (en) *	1983-01-20	1986-06-30	Alkaloida Vegyeszeti Gyar,Hu	Process for preparing pyrroline and pyrrolidine carboxamide derivatives
WO1984002907A1 (en) *	1983-01-21	1984-08-02	Alkaloida Vegyeszeti Gyar	New alkyl diamine derivatives
JPH0699307B2 (ja) *	1987-08-20	1994-12-07	キッセイ薬品工業株式会社	抗痴呆剤
US4920224A (en) *	1988-03-24	1990-04-24	Pfizer Inc.	Quinazolin-4(3H)-one derivatives as anticoccidial agents

1984
- 1984-01-23 WO PCT/HU1984/000005 patent/WO1984002907A1/en not_active Ceased
- 1984-01-23 EP EP84900530A patent/EP0134225B1/en not_active Expired
- 1984-01-23 US US06/662,298 patent/US4703056A/en not_active Expired - Fee Related
- 1984-01-23 DE DE8484900530T patent/DE3473442D1/de not_active Expired
- 1984-01-23 JP JP59500633A patent/JPH0615527B2/ja not_active Expired - Lifetime
- 1984-09-20 DK DK448684A patent/DK165975C/da active
- 1984-09-21 FI FI843721A patent/FI76070C/fi not_active IP Right Cessation
1987
- 1987-10-16 US US07/109,819 patent/US4897413A/en not_active Expired - Fee Related
1989
- 1989-11-27 US US07/441,370 patent/US5028609A/en not_active Expired - Fee Related
1990
- 1990-10-31 US US07/607,165 patent/US5032600A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5032600A (en)	1991-07-16
JPH0615527B2 (ja)	1994-03-02
EP0134225A1 (en)	1985-03-20
US4897413A (en)	1990-01-30
EP0134225B1 (en)	1988-08-17
WO1984002907A1 (en)	1984-08-02
US5028609A (en)	1991-07-02
FI76070C (fi)	1988-09-09
DE3473442D1 (de)	1988-09-22
JPS60500669A (ja)	1985-05-09
DK448684D0 (da)	1984-09-20
DK448684A (da)	1984-11-21
DK165975B (da)	1993-02-22
FI843721A0 (fi)	1984-09-21
FI76070B (fi)	1988-05-31
FI843721L (fi)	1984-09-21
US4703056A (en)	1987-10-27

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DK170785A (da)	1985-10-18	4-substituerede-piperazin-2-carboxylsyre-derivater og farmaceutisk acceptable salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse
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