DK168439B1 - 1-Cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carboxylsyrer, deres fremstilling og lægemiddel indeholdende disse forbindelser - Google Patents

1-Cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carboxylsyrer, deres fremstilling og lægemiddel indeholdende disse forbindelser Download PDF

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Publication number
DK168439B1
DK168439B1 DK009186A DK9186A DK168439B1 DK 168439 B1 DK168439 B1 DK 168439B1 DK 009186 A DK009186 A DK 009186A DK 9186 A DK9186 A DK 9186A DK 168439 B1 DK168439 B1 DK 168439B1
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Prior art keywords
methyl
group
oxo
dihydro
naphthyridine
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DK009186A
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Danish (da)
English (en)
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DK9186D0 (da
DK9186A (da
Inventor
Uwe Petersen
Klaus Grohe
Hans-Joachim Zeiler
Karl Georg Metzger
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Bayer Ag
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Publication of DK9186D0 publication Critical patent/DK9186D0/da
Publication of DK9186A publication Critical patent/DK9186A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Peptides Or Proteins (AREA)
DK009186A 1985-01-10 1986-01-09 1-Cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carboxylsyrer, deres fremstilling og lægemiddel indeholdende disse forbindelser DK168439B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3500562 1985-01-10
DE3500562 1985-01-10
DE19853508816 DE3508816A1 (de) 1985-01-10 1985-03-13 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
DE3508816 1985-03-13

Publications (3)

Publication Number Publication Date
DK9186D0 DK9186D0 (da) 1986-01-09
DK9186A DK9186A (da) 1986-07-11
DK168439B1 true DK168439B1 (da) 1994-03-28

Family

ID=25828438

Family Applications (1)

Application Number Title Priority Date Filing Date
DK009186A DK168439B1 (da) 1985-01-10 1986-01-09 1-Cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carboxylsyrer, deres fremstilling og lægemiddel indeholdende disse forbindelser

Country Status (21)

Country Link
US (1) US4840954A (fr)
EP (1) EP0187376B1 (fr)
JP (1) JPH0653741B2 (fr)
KR (1) KR910002645B1 (fr)
CN (1) CN1003236B (fr)
AT (1) ATE76076T1 (fr)
AU (3) AU574550B2 (fr)
CA (2) CA1339373C (fr)
DE (2) DE3508816A1 (fr)
DK (1) DK168439B1 (fr)
ES (5) ES8802520A1 (fr)
FI (2) FI86721C (fr)
GR (1) GR860031B (fr)
HU (1) HU193623B (fr)
IE (1) IE58412B1 (fr)
IL (2) IL77538A (fr)
NO (2) NO163331C (fr)
NZ (2) NZ229861A (fr)
PH (2) PH25055A (fr)
PL (2) PL148759B1 (fr)
PT (1) PT81810B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
FR2650276B1 (fr) * 1989-07-28 1991-10-18 Bellon Labor Sa Roger Nouveaux derives de benzonaphtyridine-1,8 leur preparation et les compositions qui les contiennent
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
KR960704887A (ko) * 1993-10-14 1996-10-09 챨스 엠. 브록 퀴놀리지논형 화합물 (Quinolizinone type compounds)
US5945380A (en) * 1995-05-26 1999-08-31 Bayer Aktiengesellschaft Pyridyl-thiazoles and their use to protect plants against infections by micro-organisms
US5739342A (en) * 1997-03-03 1998-04-14 Abbott Laboratories Process for the preparation of nicotinic acids
HUP0002353A3 (en) * 1998-01-29 2001-11-28 Daiichi Asubio Pharma Co Ltd 1-cycloalkyl-1,8-naphthyridin-4-one derivatives with phoshodiesterase iv inhibitory activity and pharmaceutical compositions containing them
KR100364226B1 (ko) * 1998-03-18 2003-01-24 주식회사 엘지생명과학 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법
BR0212864A (pt) * 2001-09-26 2004-08-17 Bayer Pharmaceuticals Corp Derivados de 1,6-naftiridina como antidiabéticos
ES2294179T3 (es) 2001-10-15 2008-04-01 Lg Life Sciences Ltd. Nuevo procedimiento para la preparacion de derivados de beta-ceto-ester intermediarios en la sintesis de antibioticos.
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
JOP20190045A1 (ar) 2016-09-14 2019-03-14 Bayer Ag مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها.
EP3296298A1 (fr) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 1-aryl-naphtyridin-3-ylcarboxamides substitués en position 7 et leur utilisation
CN109206424A (zh) * 2018-09-18 2019-01-15 佳木斯大学 依诺沙星-邻苯二甲酸药物盐单晶体及其制备方法
CN115784988B (zh) * 2022-12-13 2025-10-21 湖北省生物农药工程研究中心 一种多取代含氮杂环衍生物及其制备方法与应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175836A (fr) * 1977-09-20 1984-10-09 Marcel Pesson Production de derives de l'acide 1,4- dihydroquinoline-3-carboxylique
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
JPS5531042A (en) * 1978-08-25 1980-03-05 Dainippon Pharmaceut Co Ltd 1,8-naphthylidine derivative and its salt
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
JPS5649382A (en) * 1979-09-28 1981-05-02 Dainippon Pharmaceut Co Ltd 6-fluoro-7-cyclic amino-1,8-naphthylidine derivative and its salt
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3037417A1 (de) * 1980-10-03 1982-05-06 Vdo Adolf Schindling Ag, 6000 Frankfurt Einrichtung zur ermittlung des wegspezifischen kraftstoffverbrauchs
JPS57106681A (en) * 1980-12-24 1982-07-02 Dainippon Pharmaceut Co Ltd 1,8-naphthyridine derivative and its salt
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS6028978A (ja) * 1983-07-27 1985-02-14 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン誘導体
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS6032790A (ja) * 1983-08-01 1985-02-19 Dainippon Pharmaceut Co Ltd １，８−ナフチリジン類
JPS6089480A (ja) * 1983-10-21 1985-05-20 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体
JPS60126284A (ja) * 1983-12-09 1985-07-05 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体およびその塩
US4616019A (en) * 1984-01-26 1986-10-07 Abbott Laboratories Naphthyridine antibacterial compounds
CA1285279C (fr) * 1984-02-17 1991-06-25 Joseph P. Sanchez Derives 7-amine d'acides 1-cyclopropyl-6,8-difluoro-1,4- dihydro-4-oxo-3-quinolinecarboxyliques et d'acides 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine- 3-carboxyliques, utilises comme agents antibacteriens
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
JPS60197686A (ja) * 1984-03-19 1985-10-07 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
JPS60172981A (ja) * 1984-02-17 1985-09-06 Dai Ichi Seiyaku Co Ltd １，８−ナフチリジン誘導体
EP0160578B1 (fr) * 1984-02-17 1989-11-23 Daiichi Seiyaku Co., Ltd. Dérivés de la 1,8-naphtyridine
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS6172753A (ja) * 1984-09-18 1986-04-14 Dainippon Pharmaceut Co Ltd ピリジルケトン誘導体
US4663457A (en) * 1985-01-23 1987-05-05 Warner-Lambert Company 1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and their esters, useful as intermediates for preparing the 7-amine substituted naphthyridines
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
EP0207420B1 (fr) * 1985-06-26 1992-05-06 Daiichi Pharmaceutical Co., Ltd. Dérivés d'acide pyridonecarboxylique

Also Published As

Publication number Publication date
NO855134L (no) 1986-07-11
US4840954A (en) 1989-06-20
DE3586048D1 (en) 1992-06-17
ES557514A0 (es) 1988-03-01
IL77538A (en) 1992-05-25
AU1835988A (en) 1988-09-15
PH24769A (en) 1990-10-01
CN1003236B (zh) 1989-02-08
FI860073A0 (fi) 1986-01-08
IE860062L (en) 1986-07-10
ES557516A0 (es) 1987-10-16
KR860005818A (ko) 1986-08-13
EP0187376A2 (fr) 1986-07-16
JPH0653741B2 (ja) 1994-07-20
PL148191B1 (en) 1989-09-30
CA1320206C (fr) 1993-07-13
CA1339373C (fr) 1997-08-26
HU193623B (en) 1987-11-30
JPS61161284A (ja) 1986-07-21
FI892675A0 (fi) 1989-06-01
PL264565A1 (en) 1988-01-07
ATE76076T1 (de) 1992-05-15
AU7311887A (en) 1987-09-10
CN86100126A (zh) 1986-07-09
ES557785A0 (es) 1988-04-16
EP0187376A3 (en) 1988-05-04
PL148759B1 (en) 1989-11-30
NO860199L (no) 1986-07-11
GR860031B (en) 1986-04-29
NZ229861A (en) 1989-10-27
NO163331B (no) 1990-01-29
FI860073A7 (fi) 1986-07-11
PL257419A1 (en) 1987-07-27
ES557515A0 (es) 1988-02-16
ES8802520A1 (es) 1988-06-16
PT81810A (en) 1986-02-01
FI892675L (fi) 1989-06-01
NO163331C (no) 1990-05-09
DK9186D0 (da) 1986-01-09
ES8801919A1 (es) 1988-03-01
DK9186A (da) 1986-07-11
IL89168A0 (en) 1989-09-10
HUT40126A (en) 1986-11-28
FI86721C (fi) 1992-10-12
ES8801796A1 (es) 1988-02-16
AU574550B2 (en) 1988-07-07
DE3508816A1 (de) 1986-07-10
ES8800222A1 (es) 1987-10-16
NZ214746A (en) 1989-10-27
AU5216486A (en) 1987-01-22
EP0187376B1 (fr) 1992-05-13
PT81810B (pt) 1988-05-27
IE58412B1 (en) 1993-09-22
KR910002645B1 (ko) 1991-04-27
PH25055A (en) 1991-01-28
AU576449B2 (en) 1988-08-25
ES550767A0 (es) 1988-06-16
ES8802225A1 (es) 1988-04-16
FI86721B (fi) 1992-06-30
FI892675A7 (fi) 1989-06-01

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