DK168523B1 - N-substituerede 2-aminothiazoler, fremgangsmåde til deres fremstilling og præparater, der indeholder dem - Google Patents

N-substituerede 2-aminothiazoler, fremgangsmåde til deres fremstilling og præparater, der indeholder dem Download PDF

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Publication number
DK168523B1
DK168523B1 DK197786A DK197786A DK168523B1 DK 168523 B1 DK168523 B1 DK 168523B1 DK 197786 A DK197786 A DK 197786A DK 197786 A DK197786 A DK 197786A DK 168523 B1 DK168523 B1 DK 168523B1
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DK
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Prior art keywords
group
formula
acid
hydrogen atom
alkyl
Prior art date
Application number
DK197786A
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Danish (da)
English (en)
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DK197786A (da
DK197786D0 (da
Inventor
Claude Coquelet
Daniel Sincholle
Claude Bonne
Alain Alazet
Original Assignee
Chauvin Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chauvin Lab Sa filed Critical Chauvin Lab Sa
Publication of DK197786D0 publication Critical patent/DK197786D0/da
Publication of DK197786A publication Critical patent/DK197786A/da
Application granted granted Critical
Publication of DK168523B1 publication Critical patent/DK168523B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK197786A 1985-04-30 1986-04-30 N-substituerede 2-aminothiazoler, fremgangsmåde til deres fremstilling og præparater, der indeholder dem DK168523B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8506568A FR2581063B1 (fr) 1985-04-30 1985-04-30 Amino-2 thiazoles n-substitues, leur procede de preparation et leur application en therapeutique
FR8506568 1985-04-30

Publications (3)

Publication Number Publication Date
DK197786D0 DK197786D0 (da) 1986-04-30
DK197786A DK197786A (da) 1986-10-31
DK168523B1 true DK168523B1 (da) 1994-04-11

Family

ID=9318828

Family Applications (1)

Application Number Title Priority Date Filing Date
DK197786A DK168523B1 (da) 1985-04-30 1986-04-30 N-substituerede 2-aminothiazoler, fremgangsmåde til deres fremstilling og præparater, der indeholder dem

Country Status (11)

Country Link
US (1) US4785008A (de)
EP (1) EP0202157B1 (de)
JP (1) JPH0629270B2 (de)
AT (1) ATE45734T1 (de)
CA (1) CA1289144C (de)
DE (1) DE3665176D1 (de)
DK (1) DK168523B1 (de)
ES (1) ES8900045A1 (de)
FR (1) FR2581063B1 (de)
IE (1) IE59141B1 (de)
PT (1) PT82480B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) * 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
US4868183A (en) * 1986-07-21 1989-09-19 Otsuka Pharmaceutical Factory, Inc. N-pyrazinyl substituted P-aminophenols
JPS6339868A (ja) * 1986-08-04 1988-02-20 Otsuka Pharmaceut Factory Inc ジ低級アルキルフエノ−ル誘導体
FR2612187B1 (fr) * 1987-03-12 1989-07-21 Sanofi Sa Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
CA2027584A1 (en) * 1989-02-23 1990-08-24 Otsuka Pharmaceutical Factory, Inc. P-aminophenol derivatives, and processes for production of and uses for the same
JPH03111178U (de) * 1990-02-27 1991-11-14
US6225305B1 (en) 1993-10-04 2001-05-01 Glaxo Wellcome Inc. Substituted urea and isothiorea derivatives as no synthase inhibitors
US6297276B1 (en) 1993-10-04 2001-10-02 Glaxosmithkline Substituted urea and isothiourea derivatives as no synthase inhibitors
US6090846A (en) * 1994-06-01 2000-07-18 Glaxo Wellcome Inc. Substituted urea and isothiourea derivatives as no synthase inhibitors
GB9418912D0 (en) * 1994-09-20 1994-11-09 Fisons Corp Pharmaceutically active compounds
US6100282A (en) 1998-01-02 2000-08-08 Hoffman-La Roche Inc. Thiazole derivatives
ATE365158T1 (de) * 1999-04-28 2007-07-15 Inst Med Molecular Design Inc Pyrimidincarbonsäurederivate
AU779908B2 (en) * 1999-09-10 2005-02-17 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2007002461A1 (en) * 2005-06-23 2007-01-04 Dr. Reddy's Laboratories Ltd. 3,4-substituted thiazoles as ampk activators
WO2007005785A1 (en) * 2005-07-04 2007-01-11 Dr. Reddy's Laboratories Ltd. Thiazoles derivatives as ampk activator
WO2009115557A2 (en) * 2008-03-19 2009-09-24 Bayer Cropscience Sa Fungicide hydroximoyl-tetrazole derivatives
US10696638B2 (en) 2017-12-26 2020-06-30 Industrial Technology Research Institute Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same
JP2021525269A (ja) 2018-05-29 2021-09-24 セルシィ セラピューティクス，インコーポレーテッド 疼痛処置のための化合物、それを含む組成物及びそれを使用する方法
SG11202110561XA (en) 2019-05-10 2021-10-28 Cersci Therapeutics Inc Manufacturing methods and polymorphs of a thiazoline anti-hyperalgesic agent
CN118546107A (zh) * 2024-05-15 2024-08-27 中国药科大学 一类2-噻唑氨基苯酚衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL264710A (de) * 1960-05-13
US3299087A (en) * 1961-04-24 1967-01-17 Geigy Chem Corp Nu, nu'-bis-(thiazolyl)-phenylenediamines
US3467666A (en) * 1966-11-07 1969-09-16 Geigy Chem Corp 2-substituted aminothiazoles
BE795907A (fr) * 1972-02-25 1973-06-18 Luso Farmaco Inst 2-amino-4-arylthiazoles 5-substitues et leur preparation
JPS565747B2 (de) * 1973-10-24 1981-02-06
JPS5742629B2 (de) * 1973-10-29 1982-09-09
JPS5833870B2 (ja) * 1976-01-12 1983-07-22 塩野義製薬株式会社 チアゾリン誘導体
DK150068C (da) * 1978-06-02 1987-06-29 Pfizer Analogifremgangsmaade til fremstilling af aminothiazoler

Also Published As

Publication number Publication date
US4785008A (en) 1988-11-15
IE861119L (en) 1986-10-30
DE3665176D1 (en) 1989-09-28
DK197786A (da) 1986-10-31
ES8900045A1 (es) 1988-11-16
CA1289144C (en) 1991-09-17
JPS6277375A (ja) 1987-04-09
EP0202157A1 (de) 1986-11-20
JPH0629270B2 (ja) 1994-04-20
ES554503A0 (es) 1988-11-16
FR2581063A1 (fr) 1986-10-31
IE59141B1 (en) 1994-01-12
FR2581063B1 (fr) 1987-07-17
PT82480A (en) 1986-05-01
DK197786D0 (da) 1986-04-30
ATE45734T1 (de) 1989-09-15
PT82480B (pt) 1988-03-03
EP0202157B1 (de) 1989-08-23

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Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed