DK174662B1 - Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin - Google Patents

Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin Download PDF

Info

Publication number: DK174662B1
Authority: DK; Denmark
Prior art keywords: somatotropin; naturalizing; solubilizing; dimerization; reducing dimerization
Prior art date: 1988-12-16

Application number

DK198906390A

Other languages

Danish (da)

English (en)

Other versions

DK639089A (da

DK639089D0 (da

Inventor

Kevin Michael Mccoy

Robert A Frost

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-16

Filing date

1989-12-15

Publication date

2003-08-18

1989-12-15 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1989-12-15 Publication of DK639089D0 publication Critical patent/DK639089D0/da

1990-06-17 Publication of DK639089A publication Critical patent/DK639089A/da

2003-08-18 Application granted granted Critical

2003-08-18 Publication of DK174662B1 publication Critical patent/DK174662B1/da

Links

102000018997 Growth Hormone Human genes 0.000 title abstract 2
108010051696 Growth Hormone Proteins 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000006471 dimerization reaction Methods 0.000 title 1
230000003381 solubilizing effect Effects 0.000 title 1
239000012670 alkaline solution Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003398 denaturant Substances 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
238000004153 renaturation Methods 0.000 abstract 1
230000007928 solubilization Effects 0.000 abstract 1
238000005063 solubilization Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Plant Substances (AREA)

DK198906390A 1988-12-16 1989-12-15 Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin DK174662B1 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/285,477 US5064943A (en)	1988-12-16	1988-12-16	Method for solubilization and naturation of somatotropin

Publications (3)

Publication Number	Publication Date
DK639089D0 DK639089D0 (da)	1989-12-15
DK639089A DK639089A (da)	1990-06-17
DK174662B1 true DK174662B1 (da)	2003-08-18

Family

ID=23094405

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198906390A DK174662B1 (da)	1988-12-16	1989-12-15	Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin

Country Status (18)

Country	Link
US (1)	US5064943A (es)
EP (1)	EP0373325B1 (es)
JP (1)	JPH02222697A (es)
KR (1)	KR0148681B1 (es)
AT (1)	ATE136309T1 (es)
AU (1)	AU628443B2 (es)
CA (1)	CA2005478C (es)
DE (1)	DE68926153T2 (es)
DK (1)	DK174662B1 (es)
ES (1)	ES2087065T3 (es)
FI (1)	FI102179B1 (es)
GR (1)	GR3019691T3 (es)
HU (1)	HU213572B (es)
IE (1)	IE74848B1 (es)
IL (1)	IL92135A (es)
NZ (1)	NZ231681A (es)
PT (1)	PT92305B (es)
ZA (1)	ZA899626B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5340926A (en) *	1983-03-25	1994-08-23	Celltech, Limited	Process for the recovery of recombinantly produced protein from insoluble aggregate
US5332805A (en) *	1984-02-03	1994-07-26	Celltech Limited	Process for the recovery of recombinantly produced chymosin from insoluble aggregate
US5317324A (en) *	1991-06-20	1994-05-31	Sumitomo Metal Mining Co., Ltd.	Printed antenna
US5151501A (en) *	1991-12-20	1992-09-29	American Cyanamid Company	Method for solubilization and naturation of somatotropins utilizing sulfolane
WO1994001453A1 (en) *	1992-07-02	1994-01-20	Pitman-Moore, Inc.	A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
ZA94169B (en) *	1993-01-26	1994-09-07	Lilly Co Eli	Non-denaturing potency assay for bovine somatotropin
US5567620A (en) *	1993-01-26	1996-10-22	Eli Lilly And Company	Non-denaturing potency assay for somatotropin
US6489450B2 (en)	1998-07-09	2002-12-03	University Technology Corporation	High pressure refolding of protein aggregates and inclusion bodies
JP2002534975A (ja) *	1999-01-25	2002-10-22	ノボザイムスアクティーゼルスカブ	高ｐＨにおいてのタンパク質の回収
WO2002062827A2 (en) *	2000-10-31	2002-08-15	The Regents Of The University Of Colorado, A Body Corporate	Improved protein disaggregation and refolding using high pressure
CA2443365C (en) *	2002-11-19	2010-01-12	F. Hoffmann-La Roche Ag	Methods for the recombinant production of antifusogenic peptides
SG162834A1 (en)	2006-07-14	2010-07-29	Genentech Inc	Refolding of recombinant proteins
EP2059523A2 (en) *	2006-09-15	2009-05-20	Barofold, Inc.	High pressure treatment of proteins for reduced immunogenicity
BR102013026129A2 (pt) *	2013-10-10	2016-05-24	Ouro Fino Participações E Empreendimentos S A	processo para a produção de somatotropina bovina recombinate ativa e produto obtido

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1983004418A1 (en) *	1982-06-07	1983-12-22	Celltech Limited	A process for the preparation of chymosin
US4511503A (en) *	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
ATE107356T1 (de) *	1983-03-25	1994-07-15	Celltech Ltd	Verfahren zur herstellung eines proteins.
CA1267615A (en) *	1984-08-27	1990-04-10	Dan Hadary	Method for recovering purified growth hormones from genetically engineered microorganisms
US4652630A (en) *	1985-02-22	1987-03-24	Monsanto Company	Method of somatotropin naturation
ES8800957A1 (es) *	1985-02-22	1987-12-01	Monsanto Co	Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4677196A (en) *	1985-09-06	1987-06-30	International Minerals & Chemical Corp.	Purification and activation of proteins from insoluble inclusion bodies
AU3439089A (en) *	1988-08-05	1990-03-05	Ralph Akyuz	Skin protection lotion
JP2531272B2 (ja) *	1988-08-11	1996-09-04	日本電気株式会社	フレ―ム同期制御方式

1988
- 1988-12-16 US US07/285,477 patent/US5064943A/en not_active Expired - Lifetime
1989
- 1989-10-19 EP EP89119409A patent/EP0373325B1/en not_active Expired - Lifetime
- 1989-10-19 DE DE68926153T patent/DE68926153T2/de not_active Expired - Fee Related
- 1989-10-19 AT AT89119409T patent/ATE136309T1/de not_active IP Right Cessation
- 1989-10-19 ES ES89119409T patent/ES2087065T3/es not_active Expired - Lifetime
- 1989-10-27 IL IL9213589A patent/IL92135A/en not_active IP Right Cessation
- 1989-11-06 IE IE356189A patent/IE74848B1/en not_active IP Right Cessation
- 1989-11-14 PT PT92305A patent/PT92305B/pt not_active IP Right Cessation
- 1989-12-08 NZ NZ231681A patent/NZ231681A/xx unknown
- 1989-12-14 AU AU46750/89A patent/AU628443B2/en not_active Expired
- 1989-12-14 CA CA002005478A patent/CA2005478C/en not_active Expired - Fee Related
- 1989-12-14 JP JP1322768A patent/JPH02222697A/ja active Pending
- 1989-12-15 DK DK198906390A patent/DK174662B1/da not_active IP Right Cessation
- 1989-12-15 KR KR1019890018683A patent/KR0148681B1/ko not_active Expired - Fee Related
- 1989-12-15 HU HU896639A patent/HU213572B/hu not_active IP Right Cessation
- 1989-12-15 ZA ZA899626A patent/ZA899626B/xx unknown
- 1989-12-15 FI FI896021A patent/FI102179B1/fi not_active IP Right Cessation
1996
- 1996-04-22 GR GR950403213T patent/GR3019691T3/el unknown

Also Published As

Publication number	Publication date
ATE136309T1 (de)	1996-04-15
NZ231681A (en)	1993-09-27
IE74848B1 (en)	1997-08-13
HUT52563A (en)	1990-07-28
FI896021A0 (fi)	1989-12-15
HU896639D0 (en)	1990-02-28
EP0373325A2 (en)	1990-06-20
HU213572B (en)	1997-08-28
IL92135A (en)	1995-05-26
PT92305B (pt)	1995-07-18
EP0373325B1 (en)	1996-04-03
DK639089A (da)	1990-06-17
EP0373325A3 (en)	1991-06-12
AU628443B2 (en)	1992-09-17
DE68926153T2 (de)	1996-10-24
KR900009971A (ko)	1990-07-06
DE68926153D1 (de)	1996-05-09
ES2087065T3 (es)	1996-07-16
KR0148681B1 (ko)	1998-08-01
CA2005478C (en)	2000-01-04
FI102179B (fi)	1998-10-30
FI102179B1 (fi)	1998-10-30
CA2005478A1 (en)	1990-06-16
AU4675089A (en)	1990-06-21
IE893561L (en)	1990-06-16
IL92135A0 (en)	1990-07-12
PT92305A (pt)	1990-06-29
DK639089D0 (da)	1989-12-15
JPH02222697A (ja)	1990-09-05
ZA899626B (en)	1990-09-26
GR3019691T3 (en)	1996-07-31
US5064943A (en)	1991-11-12

Legal Events

Date	Code	Title	Description
2006-07-31	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK639089D0 (da)	1989-12-15	Fremgangsmaade til oploeseliggoerelse og naturering af somatotropin
NO2006013I1 (no)	2006-11-06	Humant parathyreoidahormon (humant parathyroid hormon)
DK80986D0 (da)	1986-02-21	Fremgangsmaade til at solubilisere somatotropinproteiner og bringe disse tilbage til naturlig tilstand
NO20013316D0 (no)	2001-07-04	Löselig BR43x2-reseptor og metoder for anvendelse
DE3773271D1 (de)	1991-10-31	Integrierte logische schaltung, welche einen ausgangsschaltkreis zur erzeugung eines zeitlich begrenzten ansteigenden ausgangsstromes enthaelt.
TR199802584T2 (xx)	1999-03-22	Denat�re proteinin aktive edilmesi i�in y�ntem.
EP0241022A3 (en)	1989-10-25	Process for the renaturation of proteins
ATE125818T1 (de)	1995-08-15	Verfahren zur naturation von somatotropin.
ATE76435T1 (de)	1992-06-15	Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen.
PT96058A (pt)	1991-09-30	Metodo para a solubilizacao e naturacao de somatotropinas utilizando uma concentracao baixa de ureia
IT8721233A0 (it)	1987-07-09	Apparato laser e metodo per pompare il medesimo.
DE58908025D1 (de)	1994-08-18	Verfahren zur Bestimmung von Thyroxin und dazu geeignete Standardlösung.
ATE164229T1 (de)	1998-04-15	Verfahren und standardlösung zur bestimmung von thyroxin (t4) oder trijodthyronin (t3)
ES549217A0 (es)	1987-02-16	Procedimiento de control del estado de una via ferrea.
JPS577986A (en)	1982-01-16	Processing device with laser
ATE32034T1 (de)	1988-02-15	Verbesserung an vorrichtungen zum zusammenfuegen von hohlkoerpern durch falzen.