ES2087065T3 - Procedimiento para la solubilizacion y naturalizacion de la somatotropina. - Google Patents

Procedimiento para la solubilizacion y naturalizacion de la somatotropina.

Info

Publication number
ES2087065T3
ES2087065T3 ES89119409T ES89119409T ES2087065T3 ES 2087065 T3 ES2087065 T3 ES 2087065T3 ES 89119409 T ES89119409 T ES 89119409T ES 89119409 T ES89119409 T ES 89119409T ES 2087065 T3 ES2087065 T3 ES 2087065T3
Authority
ES
Spain
Prior art keywords
somatotropin
solubilization
naturalization
procedure
naturation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89119409T
Other languages
English (en)
Inventor
Kevin Michael Mccoy
Robert A Frost
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2087065T3 publication Critical patent/ES2087065T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

DICHO METODO UTILIZA UNA SOLUCION ALCALINA ACUOSA QUE RESULTA DE UNA FORMACION REBAJADA Y ELIMINA DESNATURALIZANTES Y SEPARA LOS PASOS DE RENATURALIZACION DE ESTA.
ES89119409T 1988-12-16 1989-10-19 Procedimiento para la solubilizacion y naturalizacion de la somatotropina. Expired - Lifetime ES2087065T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/285,477 US5064943A (en) 1988-12-16 1988-12-16 Method for solubilization and naturation of somatotropin

Publications (1)

Publication Number Publication Date
ES2087065T3 true ES2087065T3 (es) 1996-07-16

Family

ID=23094405

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89119409T Expired - Lifetime ES2087065T3 (es) 1988-12-16 1989-10-19 Procedimiento para la solubilizacion y naturalizacion de la somatotropina.

Country Status (18)

Country Link
US (1) US5064943A (es)
EP (1) EP0373325B1 (es)
JP (1) JPH02222697A (es)
KR (1) KR0148681B1 (es)
AT (1) ATE136309T1 (es)
AU (1) AU628443B2 (es)
CA (1) CA2005478C (es)
DE (1) DE68926153T2 (es)
DK (1) DK174662B1 (es)
ES (1) ES2087065T3 (es)
FI (1) FI102179B (es)
GR (1) GR3019691T3 (es)
HU (1) HU213572B (es)
IE (1) IE74848B1 (es)
IL (1) IL92135A (es)
NZ (1) NZ231681A (es)
PT (1) PT92305B (es)
ZA (1) ZA899626B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340926A (en) * 1983-03-25 1994-08-23 Celltech, Limited Process for the recovery of recombinantly produced protein from insoluble aggregate
US5332805A (en) * 1984-02-03 1994-07-26 Celltech Limited Process for the recovery of recombinantly produced chymosin from insoluble aggregate
US5317324A (en) * 1991-06-20 1994-05-31 Sumitomo Metal Mining Co., Ltd. Printed antenna
US5151501A (en) * 1991-12-20 1992-09-29 American Cyanamid Company Method for solubilization and naturation of somatotropins utilizing sulfolane
AU4665193A (en) * 1992-07-02 1994-01-31 Pitman-Moore, Inc. A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
ZA94169B (en) * 1993-01-26 1994-09-07 Lilly Co Eli Non-denaturing potency assay for bovine somatotropin
US5567620A (en) * 1993-01-26 1996-10-22 Eli Lilly And Company Non-denaturing potency assay for somatotropin
EP1095056B1 (en) 1998-07-09 2006-12-27 BaroFold, Inc. High pressure refolding of protein aggregates and inclusion bodies
EP1149160B1 (en) * 1999-01-25 2006-04-19 Novozymes A/S Recovery of a protein at high ph
CA2434045A1 (en) * 2000-10-31 2002-08-15 The Regents Of The University Of Colorado, A Body Corporate Improved protein disaggregation and refolding using high pressure
CA2443365C (en) * 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
AR062069A1 (es) * 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
CA2663416A1 (en) * 2006-09-15 2008-03-20 Barofold, Inc. High pressure treatment of proteins for reduced immunogenicity
BR102013026129A2 (pt) * 2013-10-10 2016-05-24 Ouro Fino Participações E Empreendimentos S A processo para a produção de somatotropina bovina recombinate ativa e produto obtido

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55163B1 (en) * 1982-06-07 1990-06-20 Celltech Ltd A process for the preparation of chymosin
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0122080B1 (en) * 1983-03-25 1989-09-13 Celltech Limited A process for the production of a protein
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms
ES8800957A1 (es) * 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
AU3439089A (en) * 1988-08-05 1990-03-05 Ralph Akyuz Skin protection lotion
JP2531272B2 (ja) * 1988-08-11 1996-09-04 日本電気株式会社 フレ―ム同期制御方式

Also Published As

Publication number Publication date
CA2005478C (en) 2000-01-04
FI102179B1 (fi) 1998-10-30
FI896021A0 (fi) 1989-12-15
IE74848B1 (en) 1997-08-13
HU213572B (en) 1997-08-28
JPH02222697A (ja) 1990-09-05
DK639089D0 (da) 1989-12-15
AU628443B2 (en) 1992-09-17
EP0373325A3 (en) 1991-06-12
IL92135A (en) 1995-05-26
CA2005478A1 (en) 1990-06-16
EP0373325A2 (en) 1990-06-20
HU896639D0 (en) 1990-02-28
DE68926153T2 (de) 1996-10-24
DK639089A (da) 1990-06-17
ZA899626B (en) 1990-09-26
EP0373325B1 (en) 1996-04-03
DK174662B1 (da) 2003-08-18
PT92305B (pt) 1995-07-18
AU4675089A (en) 1990-06-21
PT92305A (pt) 1990-06-29
FI102179B (fi) 1998-10-30
US5064943A (en) 1991-11-12
KR0148681B1 (ko) 1998-08-01
GR3019691T3 (en) 1996-07-31
IE893561L (en) 1990-06-16
ATE136309T1 (de) 1996-04-15
KR900009971A (ko) 1990-07-06
HUT52563A (en) 1990-07-28
DE68926153D1 (de) 1996-05-09
NZ231681A (en) 1993-09-27
IL92135A0 (en) 1990-07-12

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