DK174662B1 - Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin - Google Patents

Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin Download PDF

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Publication number
DK174662B1
DK174662B1 DK198906390A DK639089A DK174662B1 DK 174662 B1 DK174662 B1 DK 174662B1 DK 198906390 A DK198906390 A DK 198906390A DK 639089 A DK639089 A DK 639089A DK 174662 B1 DK174662 B1 DK 174662B1
Authority
DK
Denmark
Prior art keywords
somatotropin
naturalizing
solubilizing
dimerization
reducing dimerization
Prior art date
Application number
DK198906390A
Other languages
English (en)
Other versions
DK639089D0 (da
DK639089A (da
Inventor
Kevin Michael Mccoy
Robert A Frost
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK639089D0 publication Critical patent/DK639089D0/da
Publication of DK639089A publication Critical patent/DK639089A/da
Application granted granted Critical
Publication of DK174662B1 publication Critical patent/DK174662B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
DK198906390A 1988-12-16 1989-12-15 Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin DK174662B1 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/285,477 US5064943A (en) 1988-12-16 1988-12-16 Method for solubilization and naturation of somatotropin

Publications (3)

Publication Number Publication Date
DK639089D0 DK639089D0 (da) 1989-12-15
DK639089A DK639089A (da) 1990-06-17
DK174662B1 true DK174662B1 (da) 2003-08-18

Family

ID=23094405

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198906390A DK174662B1 (da) 1988-12-16 1989-12-15 Fremgangsmåde til opløseliggørelse, naturering og nedsættelse af dimerisering af somatotropin

Country Status (18)

Country Link
US (1) US5064943A (da)
EP (1) EP0373325B1 (da)
JP (1) JPH02222697A (da)
KR (1) KR0148681B1 (da)
AT (1) ATE136309T1 (da)
AU (1) AU628443B2 (da)
CA (1) CA2005478C (da)
DE (1) DE68926153T2 (da)
DK (1) DK174662B1 (da)
ES (1) ES2087065T3 (da)
FI (1) FI102179B (da)
GR (1) GR3019691T3 (da)
HU (1) HU213572B (da)
IE (1) IE74848B1 (da)
IL (1) IL92135A (da)
NZ (1) NZ231681A (da)
PT (1) PT92305B (da)
ZA (1) ZA899626B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340926A (en) * 1983-03-25 1994-08-23 Celltech, Limited Process for the recovery of recombinantly produced protein from insoluble aggregate
US5332805A (en) * 1984-02-03 1994-07-26 Celltech Limited Process for the recovery of recombinantly produced chymosin from insoluble aggregate
US5317324A (en) * 1991-06-20 1994-05-31 Sumitomo Metal Mining Co., Ltd. Printed antenna
US5151501A (en) * 1991-12-20 1992-09-29 American Cyanamid Company Method for solubilization and naturation of somatotropins utilizing sulfolane
AU4665193A (en) * 1992-07-02 1994-01-31 Pitman-Moore, Inc. A process for recovering a recombinant protein, in biologically active form, from a solution containing inactive protein
ZA94169B (en) * 1993-01-26 1994-09-07 Lilly Co Eli Non-denaturing potency assay for bovine somatotropin
US5567620A (en) * 1993-01-26 1996-10-22 Eli Lilly And Company Non-denaturing potency assay for somatotropin
EP1095056B1 (en) 1998-07-09 2006-12-27 BaroFold, Inc. High pressure refolding of protein aggregates and inclusion bodies
EP1149160B1 (en) * 1999-01-25 2006-04-19 Novozymes A/S Recovery of a protein at high ph
CA2434045A1 (en) * 2000-10-31 2002-08-15 The Regents Of The University Of Colorado, A Body Corporate Improved protein disaggregation and refolding using high pressure
CA2443365C (en) * 2002-11-19 2010-01-12 F. Hoffmann-La Roche Ag Methods for the recombinant production of antifusogenic peptides
AR062069A1 (es) * 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
CA2663416A1 (en) * 2006-09-15 2008-03-20 Barofold, Inc. High pressure treatment of proteins for reduced immunogenicity
BR102013026129A2 (pt) * 2013-10-10 2016-05-24 Ouro Fino Participações E Empreendimentos S A processo para a produção de somatotropina bovina recombinate ativa e produto obtido

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55163B1 (en) * 1982-06-07 1990-06-20 Celltech Ltd A process for the preparation of chymosin
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
EP0122080B1 (en) * 1983-03-25 1989-09-13 Celltech Limited A process for the production of a protein
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms
ES8800957A1 (es) * 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
AU3439089A (en) * 1988-08-05 1990-03-05 Ralph Akyuz Skin protection lotion
JP2531272B2 (ja) * 1988-08-11 1996-09-04 日本電気株式会社 フレ―ム同期制御方式

Also Published As

Publication number Publication date
CA2005478C (en) 2000-01-04
FI102179B1 (fi) 1998-10-30
FI896021A0 (fi) 1989-12-15
IE74848B1 (en) 1997-08-13
HU213572B (en) 1997-08-28
JPH02222697A (ja) 1990-09-05
DK639089D0 (da) 1989-12-15
AU628443B2 (en) 1992-09-17
EP0373325A3 (en) 1991-06-12
IL92135A (en) 1995-05-26
CA2005478A1 (en) 1990-06-16
EP0373325A2 (en) 1990-06-20
HU896639D0 (en) 1990-02-28
DE68926153T2 (de) 1996-10-24
DK639089A (da) 1990-06-17
ZA899626B (en) 1990-09-26
EP0373325B1 (en) 1996-04-03
ES2087065T3 (es) 1996-07-16
PT92305B (pt) 1995-07-18
AU4675089A (en) 1990-06-21
PT92305A (pt) 1990-06-29
FI102179B (fi) 1998-10-30
US5064943A (en) 1991-11-12
KR0148681B1 (ko) 1998-08-01
GR3019691T3 (en) 1996-07-31
IE893561L (en) 1990-06-16
ATE136309T1 (de) 1996-04-15
KR900009971A (ko) 1990-07-06
HUT52563A (en) 1990-07-28
DE68926153D1 (de) 1996-05-09
NZ231681A (en) 1993-09-27
IL92135A0 (en) 1990-07-12

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