DK175228B1 - Anvendelse af 4H-1-benzopyran-4-on-derivater til fremstilling af et lægemiddel med en virkning mod tumorer - Google Patents

Anvendelse af 4H-1-benzopyran-4-on-derivater til fremstilling af et lægemiddel med en virkning mod tumorer Download PDF

Info

Publication number: DK175228B1
Authority: DK; Denmark
Prior art keywords: benzopyran; methyl; hcl; alkyl; hydroxy
Prior art date: 1988-10-28

Application number

DK198905372A

Other languages

Danish (da)

English (en)

Other versions

DK537289D0 (da

DK537289A (da

Inventor

Gerhard Dickneite

Bansi Lal

Richard Helmut Rupp

Hans Harald Sedlacek

Joerg Czech

Ramchandra Ganapati Naik

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-28

Filing date

1989-10-27

Publication date

2004-07-19

1989-10-27 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-10-27 Publication of DK537289D0 publication Critical patent/DK537289D0/da

1990-04-29 Publication of DK537289A publication Critical patent/DK537289A/da

2004-07-19 Application granted granted Critical

2004-07-19 Publication of DK175228B1 publication Critical patent/DK175228B1/da

Links

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239000004927 clay Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
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239000008120 corn starch Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 description 1
125000004663 dialkyl amino group Chemical group 0.000 description 1
125000004986 diarylamino group Chemical group 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000001640 fractional crystallisation Methods 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
125000001188 haloalkyl group Chemical group 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
125000004356 hydroxy functional group Chemical group O* 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
230000002519 immonomodulatory effect Effects 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
125000005647 linker group Chemical group 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
230000036212 malign transformation Effects 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
229940124531 pharmaceutical excipient Drugs 0.000 description 1
125000003884 phenylalkyl group Chemical group 0.000 description 1
YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
238000000053 physical method Methods 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000000746 purification Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
238000011160 research Methods 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
239000012265 solid product Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
241000894007 species Species 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
QERYCTSHXKAMIS-UHFFFAOYSA-N thiophene-2-carboxylic acid Chemical compound OC(=O)C1=CC=CS1 QERYCTSHXKAMIS-UHFFFAOYSA-N 0.000 description 1
125000001239 threonyl group Chemical group 0.000 description 1
239000003106 tissue adhesive Substances 0.000 description 1
125000005490 tosylate group Chemical group 0.000 description 1
230000009466 transformation Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
230000007306 turnover Effects 0.000 description 1
125000002233 tyrosyl group Chemical group 0.000 description 1
241001430294 unidentified retrovirus Species 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)

DK198905372A 1988-10-28 1989-10-27 Anvendelse af 4H-1-benzopyran-4-on-derivater til fremstilling af et lægemiddel med en virkning mod tumorer DK175228B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3836676A DE3836676A1 (de)	1988-10-28	1988-10-28	Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel
DE3836676		1988-10-28

Publications (3)

Publication Number	Publication Date
DK537289D0 DK537289D0 (da)	1989-10-27
DK537289A DK537289A (da)	1990-04-29
DK175228B1 true DK175228B1 (da)	2004-07-19

Family

ID=6366059

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198905372A DK175228B1 (da)	1988-10-28	1989-10-27	Anvendelse af 4H-1-benzopyran-4-on-derivater til fremstilling af et lægemiddel med en virkning mod tumorer

Country Status (14)

Country	Link
EP (1)	EP0366061B1 (fr)
JP (1)	JP2879910B2 (fr)
KR (1)	KR100194505B1 (fr)
AT (1)	ATE133170T1 (fr)
AU (1)	AU628409B2 (fr)
CA (1)	CA1336715C (fr)
CY (1)	CY2026A (fr)
DE (2)	DE3836676A1 (fr)
DK (1)	DK175228B1 (fr)
ES (1)	ES2084593T3 (fr)
GR (1)	GR3018739T3 (fr)
HK (1)	HK1006167A1 (fr)
IE (1)	IE69982B1 (fr)
PT (1)	PT92145B (fr)

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US5284856A (en) *	1988-10-28	1994-02-08	Hoechst Aktiengesellschaft	Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
EP0508347A1 (fr) *	1991-04-10	1992-10-14	Hoechst Aktiengesellschaft	5,7-dihydroxy-2-méthyl-8-[4-(3-hydroxy-1-(1-propyl))pipéridinyl]4H-1-benzopyran-4-one, sa préparation et son utilisation
US5464871A (en) *	1993-05-12	1995-11-07	Octamer, Inc.	Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5733920A (en) *	1995-10-31	1998-03-31	Mitotix, Inc.	Inhibitors of cyclin dependent kinases
DK0795334T3 (da) *	1996-03-12	2006-06-06	Sanofi Aventis Deutschland	Nye prodrugs til behandling af tumorer og betændelsessygdomme
DE19802449A1 (de)	1998-01-23	1999-07-29	Hoechst Marion Roussel De Gmbh	Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
DE19959546A1 (de) *	1999-12-09	2001-06-21	Rhone Poulenc Rorer Gmbh	Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US6576647B2 (en)	2000-01-18	2003-06-10	Aventis Pharmaceuticals Inc.	Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
IL150643A0 (en) *	2000-01-18	2003-02-12	Aventis Pharma Inc	Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 [4r-(3s-hydroxy-1-methyl) piperidinyl]-4h-1-benzopyran-4-one
US6821990B2 (en)	2000-01-18	2004-11-23	Aventis Pharma Deutschland Gmbh	Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) *	2000-02-29	2006-08-04	Hoechst Marion Roussel Inc	Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100392468B1 (ko) *	2000-09-18	2003-07-22	주식회사 엘지생명과학	사이클린 의존 키나아제의 저해제로서 유용한3-히드록시크로멘-4-온 유도체
DE10113513A1 (de) *	2001-03-20	2002-10-02	Medinnova Ges Med Innovationen	Kombinationspräparat zur Prophylaxe und/oder Therapie von Nervenzell- und/oder Gliazellschäden durch ein neues Behandlungsverfahren
EP1402890B1 (fr)	2001-06-08	2008-01-09	Institute of Medicinal Molecular Design, Inc.	Derives de sulfonamide
JP4664597B2 (ja)	2002-04-17	2011-04-06	サイトキネティクス・インコーポレーテッド	化合物、組成物および方法
TWI331034B (en) *	2002-07-08	2010-10-01	Piramal Life Sciences Ltd	Inhibitors of cyclin-dependent kinases and their use
ATE423110T1 (de)	2002-07-17	2009-03-15	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
CN102438452B (zh) *	2009-05-08	2015-02-25	乔治亚州大学研究基金会	包含cdk抑制剂的化合物和组合物以及用于癌症治疗的方法
WO2011159726A2 (fr)	2010-06-14	2011-12-22	The Scripps Research Institute	Reprogrammation de cellules pour leur conférer un nouveau destin
EP2593099A1 (fr)	2010-07-12	2013-05-22	DKFZ Deutsches Krebsforschungszentrum	Wogonine utilisée pour prévenir et traiter une hypertrophie cardiaque
WO2013113762A1 (fr)	2012-01-31	2013-08-08	INSERM (Institut National de la Santé et de la Recherche Médicale)	Procédés et kits pour prédire le risque d'avoir un mélanome cutané chez un sujet
AU2016252609B2 (en)	2015-04-20	2022-06-30	Sumitomo Pharma Oncology, Inc.	Predicting response to alvocidib by mitochondrial profiling
HUE045585T2 (hu)	2015-05-18	2020-01-28	Tolero Pharmaceuticals Inc	Megnövelt biológiai hozzáférhetõséggel rendelkezõ Alvocidib gyógyszer-elõanyagok
AU2016301315C1 (en)	2015-08-03	2022-07-07	Sumitomo Pharma Oncology, Inc.	Combination therapies for treatment of cancer
WO2018094275A1 (fr)	2016-11-18	2018-05-24	Tolero Pharmaceuticals, Inc.	Promédicaments de l'alvocidib et leur utilisation en tant qu'inhibiteurs de protéines kinases
JP7196160B2 (ja)	2017-09-12	2022-12-26	スミトモファーマオンコロジー，インコーポレイテッド	Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン
US11034710B2 (en)	2018-12-04	2021-06-15	Sumitomo Dainippon Pharma Oncology, Inc.	CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
JP2022525149A (ja)	2019-03-20	2022-05-11	スミトモダイニッポンファーマオンコロジー，インコーポレイテッド	ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置
CN110028475B (zh) *	2019-05-13	2022-07-01	中国药科大学	基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用

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Publication number	Priority date	Publication date	Assignee	Title
DE3329186A1 (de) *	1983-08-12	1985-02-21	Hoechst Ag, 6230 Frankfurt	Chromonalkaloid, verfahren zu seiner isolierung aus dysoxylum binectariferum, und seine verwendung als arzneimittel
IN164232B (fr) *	1986-04-11	1989-02-04	Hoechst India

1988
- 1988-10-28 DE DE3836676A patent/DE3836676A1/de not_active Withdrawn
1989
- 1989-09-29 CA CA000614537A patent/CA1336715C/fr not_active Expired - Lifetime
- 1989-10-24 DE DE58909573T patent/DE58909573D1/de not_active Expired - Lifetime
- 1989-10-24 ES ES89119710T patent/ES2084593T3/es not_active Expired - Lifetime
- 1989-10-24 AT AT89119710T patent/ATE133170T1/de not_active IP Right Cessation
- 1989-10-24 EP EP89119710A patent/EP0366061B1/fr not_active Expired - Lifetime
- 1989-10-27 DK DK198905372A patent/DK175228B1/da not_active IP Right Cessation
- 1989-10-27 JP JP1278756A patent/JP2879910B2/ja not_active Expired - Lifetime
- 1989-10-27 AU AU43841/89A patent/AU628409B2/en not_active Expired
- 1989-10-27 PT PT92145A patent/PT92145B/pt not_active IP Right Cessation
- 1989-10-27 KR KR1019890015509A patent/KR100194505B1/ko not_active Expired - Lifetime
- 1989-10-27 IE IE348189A patent/IE69982B1/en not_active IP Right Cessation
1996
- 1996-01-19 GR GR960400124T patent/GR3018739T3/el unknown
1998
- 1998-02-20 CY CY202698A patent/CY2026A/xx unknown
- 1998-06-12 HK HK98105251A patent/HK1006167A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CY2026A (en)	1998-02-20
JPH02178225A (ja)	1990-07-11
EP0366061B1 (fr)	1996-01-17
KR900006325A (ko)	1990-05-07
KR100194505B1 (ko)	1999-06-15
CA1336715C (fr)	1995-08-15
ATE133170T1 (de)	1996-02-15
IE69982B1 (en)	1996-10-16
DE58909573D1 (de)	1996-02-29
PT92145A (pt)	1990-04-30
IE893481L (en)	1990-04-28
HK1006167A1 (en)	1999-02-12
DE3836676A1 (de)	1990-05-03
DK537289D0 (da)	1989-10-27
GR3018739T3 (en)	1996-04-30
DK537289A (da)	1990-04-29
PT92145B (pt)	1995-06-30
AU4384189A (en)	1990-05-03
EP0366061A1 (fr)	1990-05-02
JP2879910B2 (ja)	1999-04-05
AU628409B2 (en)	1992-09-17
ES2084593T3 (es)	1996-05-16

Legal Events

Date	Code	Title	Description
2009-11-16	PUP	Patent expired

Publication	Publication Date	Title
US5284856A (en)	1994-02-08	Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
CA1336715C (fr)	1995-08-15	Derives de la 8-(4-piperidinyl)-4h-1-benzopyran-4-one et leur utilisation
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