PT92145A - Processo para a preparacao de novos derivados de 4h-1-benzopirano-4-ona e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados de 4h-1-benzopirano-4-ona e de composicoes farmaceuticas que os contem

Info

Publication number
PT92145A
PT92145A PT92145A PT9214589A PT92145A PT 92145 A PT92145 A PT 92145A PT 92145 A PT92145 A PT 92145A PT 9214589 A PT9214589 A PT 9214589A PT 92145 A PT92145 A PT 92145A
Authority
PT
Portugal
Prior art keywords
derivatives
benzopyrane
preparation
new
pharmaceutical compositions
Prior art date
Application number
PT92145A
Other languages
English (en)
Other versions
PT92145B (pt
Inventor
Hans Harald Sedlacek
Bansi Lal
Jorg Czech
Ramchandra Ganapati Naik
Richard Helmut Rupp
Gerhard Dickneite
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT92145A publication Critical patent/PT92145A/pt
Publication of PT92145B publication Critical patent/PT92145B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
PT92145A 1988-10-28 1989-10-27 Processo para a preparacao de novos derivados de 4h-1-benzopirano-4-ona e de composicoes farmaceuticas que os contem PT92145B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836676A DE3836676A1 (de) 1988-10-28 1988-10-28 Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
PT92145A true PT92145A (pt) 1990-04-30
PT92145B PT92145B (pt) 1995-06-30

Family

ID=6366059

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92145A PT92145B (pt) 1988-10-28 1989-10-27 Processo para a preparacao de novos derivados de 4h-1-benzopirano-4-ona e de composicoes farmaceuticas que os contem

Country Status (14)

Country Link
EP (1) EP0366061B1 (pt)
JP (1) JP2879910B2 (pt)
KR (1) KR100194505B1 (pt)
AT (1) ATE133170T1 (pt)
AU (1) AU628409B2 (pt)
CA (1) CA1336715C (pt)
CY (1) CY2026A (pt)
DE (2) DE3836676A1 (pt)
DK (1) DK175228B1 (pt)
ES (1) ES2084593T3 (pt)
GR (1) GR3018739T3 (pt)
HK (1) HK1006167A1 (pt)
IE (1) IE69982B1 (pt)
PT (1) PT92145B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
EP0508347A1 (en) * 1991-04-10 1992-10-14 Hoechst Aktiengesellschaft 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use
US5464871A (en) * 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
DK0795334T3 (da) * 1996-03-12 2006-06-06 Sanofi Aventis Deutschland Nye prodrugs til behandling af tumorer og betændelsessygdomme
DE19802449A1 (de) 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von (-)cis-3-Hydroxy-1-methyl-4-(2,4,6-trimethoxypyhenyl)-piperidin
DE19959546A1 (de) * 1999-12-09 2001-06-21 Rhone Poulenc Rorer Gmbh Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen
US6576647B2 (en) 2000-01-18 2003-06-10 Aventis Pharmaceuticals Inc. Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
IL150643A0 (en) * 2000-01-18 2003-02-12 Aventis Pharma Inc Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8 [4r-(3s-hydroxy-1-methyl) piperidinyl]-4h-1-benzopyran-4-one
US6821990B2 (en) 2000-01-18 2004-11-23 Aventis Pharma Deutschland Gmbh Ethanol solvate of (-)-cis-2-(2-chlorophenyl)-5, 7-dihydroxy-8 [4R-(3S-hydroxy-1-M ethyl) piperidinyl]-4H-1-benzopyran-4-one
FR2805538B1 (fr) * 2000-02-29 2006-08-04 Hoechst Marion Roussel Inc Nouveaux derives de flavones, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
KR100392468B1 (ko) * 2000-09-18 2003-07-22 주식회사 엘지생명과학 사이클린 의존 키나아제의 저해제로서 유용한3-히드록시크로멘-4-온 유도체
DE10113513A1 (de) * 2001-03-20 2002-10-02 Medinnova Ges Med Innovationen Kombinationspräparat zur Prophylaxe und/oder Therapie von Nervenzell- und/oder Gliazellschäden durch ein neues Behandlungsverfahren
EP1402890B1 (en) 2001-06-08 2008-01-09 Institute of Medicinal Molecular Design, Inc. Sulfonamide derivatives
JP4664597B2 (ja) 2002-04-17 2011-04-06 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
TWI331034B (en) * 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
ATE423110T1 (de) 2002-07-17 2009-03-15 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen
CN102438452B (zh) * 2009-05-08 2015-02-25 乔治亚州大学研究基金会 包含cdk抑制剂的化合物和组合物以及用于癌症治疗的方法
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
EP2593099A1 (en) 2010-07-12 2013-05-22 DKFZ Deutsches Krebsforschungszentrum Wogonin for the prevention and therapy of cardiac hypertrophy
WO2013113762A1 (en) 2012-01-31 2013-08-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of having a cutaneous melanoma in a subject
AU2016252609B2 (en) 2015-04-20 2022-06-30 Sumitomo Pharma Oncology, Inc. Predicting response to alvocidib by mitochondrial profiling
HUE045585T2 (hu) 2015-05-18 2020-01-28 Tolero Pharmaceuticals Inc Megnövelt biológiai hozzáférhetõséggel rendelkezõ Alvocidib gyógyszer-elõanyagok
AU2016301315C1 (en) 2015-08-03 2022-07-07 Sumitomo Pharma Oncology, Inc. Combination therapies for treatment of cancer
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
JP7196160B2 (ja) 2017-09-12 2022-12-26 スミトモ ファーマ オンコロジー， インコーポレイテッド Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
JP2022525149A (ja) 2019-03-20 2022-05-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド ベネトクラクスが失敗した急性骨髄性白血病（ａｍｌ）の処置
CN110028475B (zh) * 2019-05-13 2022-07-01 中国药科大学 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3329186A1 (de) * 1983-08-12 1985-02-21 Hoechst Ag, 6230 Frankfurt Chromonalkaloid, verfahren zu seiner isolierung aus dysoxylum binectariferum, und seine verwendung als arzneimittel
IN164232B (pt) * 1986-04-11 1989-02-04 Hoechst India

Also Published As

Publication number Publication date
CY2026A (en) 1998-02-20
JPH02178225A (ja) 1990-07-11
EP0366061B1 (de) 1996-01-17
KR900006325A (ko) 1990-05-07
KR100194505B1 (ko) 1999-06-15
CA1336715C (en) 1995-08-15
ATE133170T1 (de) 1996-02-15
IE69982B1 (en) 1996-10-16
DE58909573D1 (de) 1996-02-29
IE893481L (en) 1990-04-28
HK1006167A1 (en) 1999-02-12
DE3836676A1 (de) 1990-05-03
DK537289D0 (da) 1989-10-27
GR3018739T3 (en) 1996-04-30
DK537289A (da) 1990-04-29
PT92145B (pt) 1995-06-30
AU4384189A (en) 1990-05-03
DK175228B1 (da) 2004-07-19
EP0366061A1 (de) 1990-05-02
JP2879910B2 (ja) 1999-04-05
AU628409B2 (en) 1992-09-17
ES2084593T3 (es) 1996-05-16

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