DK177282A - Optisk aktive eller racemiske 13-thia-prostacyclinderivater,deres fremstilling og anvendelse som farmaceutika - Google Patents

Optisk aktive eller racemiske 13-thia-prostacyclinderivater,deres fremstilling og anvendelse som farmaceutika Download PDF

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Publication number
DK177282A
DK177282A DK177282A DK177282A DK177282A DK 177282 A DK177282 A DK 177282A DK 177282 A DK177282 A DK 177282A DK 177282 A DK177282 A DK 177282A DK 177282 A DK177282 A DK 177282A
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DK
Denmark
Prior art keywords
thia
racemic
pharmaceuticals
preparation
optically active
Prior art date
Application number
DK177282A
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English (en)
Inventor
P Koermoeczy
I Stadler
C Sszantay
L Novak
V Simonidesz
G Galambos
G Kovacs
S Virag
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of DK177282A publication Critical patent/DK177282A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Description

Figure DK177282AD00021
(III) eller det tilsvarende, oxiderede 1-oxidderivat med et halogeneringsmiddel efterfulgt af behandling af det opnåede 5-halogen-13-thia*-prostacyclinderivat roed formel (II)
Figure DK177282AD00022
hvor E er halogen, med en base. Basebehandlingen sker på isomerblandingen, hvis E er iod, men efter fraskillelse af endoisomeren, hvis E er brom. Om ønsket fjernes beskyttelsesgruppen X og/eller Y derefter, og/eller forbindelsen omdannes til et salt eller frigøres fra et salt.
Forbindelserne med formel (I) er farmakologisk aktive med et virkningsspektrum, især antiblodpladeaggregerende og tracheasammentrækkende virkning, som ligner spektret af prostacyclin. De er dog ikke så kraftige som dette, men til gengæld langt mere stabile.
DK177282A 1981-04-22 1982-04-21 Optisk aktive eller racemiske 13-thia-prostacyclinderivater,deres fremstilling og anvendelse som farmaceutika DK177282A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU811035A HU184952B (en) 1981-04-22 1981-04-22 Process for producing new optically active and raceme 13-thia-prostacycline derivatives
HU103581 1981-04-22

Publications (1)

Publication Number Publication Date
DK177282A true DK177282A (da) 1982-10-23

Family

ID=10952556

Family Applications (1)

Application Number Title Priority Date Filing Date
DK177282A DK177282A (da) 1981-04-22 1982-04-21 Optisk aktive eller racemiske 13-thia-prostacyclinderivater,deres fremstilling og anvendelse som farmaceutika

Country Status (10)

Country Link
US (1) US4425358A (da)
EP (1) EP0063779A1 (da)
JP (1) JPS57188582A (da)
CS (1) CS229929B2 (da)
DK (1) DK177282A (da)
FI (1) FI821361L (da)
GR (1) GR75414B (da)
HU (1) HU184952B (da)
IL (1) IL65539A0 (da)
PL (1) PL129428B1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3201764A1 (de) * 1982-01-21 1983-09-08 Merck Patent Gmbh, 6100 Darmstadt 13-thia-prostacycline, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
ATE80314T1 (de) * 1987-07-14 1992-09-15 Sankyo Co Zusammensetzung zur herstellung von antithrombotischen medizinischen erzeugnissen.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2422924A1 (de) * 1974-05-11 1975-11-27 Merck Patent Gmbh Thiaprostaglandine
JPS54115368A (en) 1978-03-01 1979-09-07 Ono Pharmaceut Co Ltd Prostaglandin i2 analog, its preparation, and drug composition containing it as active constituent

Also Published As

Publication number Publication date
HU184952B (en) 1984-11-28
FI821361A0 (fi) 1982-04-20
FI821361A7 (fi) 1982-10-23
US4425358A (en) 1984-01-10
PL129428B1 (en) 1984-05-31
CS229929B2 (en) 1984-07-16
PL236045A1 (da) 1982-12-06
IL65539A0 (en) 1982-07-30
GR75414B (da) 1984-07-16
EP0063779A1 (de) 1982-11-03
JPS57188582A (en) 1982-11-19
FI821361L (fi) 1982-10-23

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