DK190286A - O-sulfaterede beta-lactam-hydroxyamsyrer - Google Patents

O-sulfaterede beta-lactam-hydroxyamsyrer Download PDF

Info

Publication number: DK190286A
Authority: DK; Denmark
Prior art keywords: lactam; sulphated; beta; hydroxyamic acids; hydroxyamic
Prior art date: 1985-04-29

Application number

DK190286A

Other languages

English (en)

Other versions

DK190286D0 (da

Inventor

Joseph E Sundeen

William H Koster

Robert Zahler

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-29

Filing date

1986-04-24

Publication date

1986-10-30

1986-04-24 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1986-04-24 Publication of DK190286D0 publication Critical patent/DK190286D0/da

1986-10-30 Publication of DK190286A publication Critical patent/DK190286A/da

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
150000003952 β-lactams Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 description 3
125000003118 aryl group Chemical group 0.000 description 3
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
125000004435 hydrogen atom Chemical class [H]* 0.000 description 2
206010057190 Respiratory tract infections Diseases 0.000 description 1
125000004423 acyloxy group Chemical group 0.000 description 1
125000005236 alkanoylamino group Chemical group 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 description 1
-1 carbamoyloxy Chemical group 0.000 description 1
125000001589 carboacyl group Chemical group 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
208000019206 urinary tract infection Diseases 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

eller n og m hver især er 1, og X er -S-CHj-S,

,

eller

R2 er alkyl, aryl, hydroxy, alkoxy, alkanoyloxy, carbamoyloxy, alkanoylamino eller ureido, er hydrogen, alkyl, aryl, alkanoyl eller carbamoyl, og R4 er hydrogen, alkyl eller aryl, har antibakteriel aktivitet og er virksomme mod gram-positive og gram-negative organismer.

Forbindelserne og deres salte kan anvendes i lægemidler til bekæmpelse af f.eks. urinvejs- og åndedrætsinfektioner.

DK190286A 1985-04-29 1986-04-24 O-sulfaterede beta-lactam-hydroxyamsyrer DK190286A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72843285		1985-04-29
US06/728,432 US4638060A (en)	1985-04-29	1985-04-29	O-sulfated spiro β-lactam hydroxamic acids

Publications (2)

Publication Number	Publication Date
DK190286D0 DK190286D0 (da)	1986-04-24
DK190286A true DK190286A (da)	1986-10-30

Family

ID=24926831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK190286A DK190286A (da)	1985-04-29	1986-04-24	O-sulfaterede beta-lactam-hydroxyamsyrer

Country Status (20)

Country	Link
US (1)	US4638060A (da)
JP (1)	JPS61257965A (da)
AU (1)	AU601944B2 (da)
BE (1)	BE904699A (da)
CA (1)	CA1273938C (da)
CH (1)	CH668073A5 (da)
DE (1)	DE3614317A1 (da)
DK (1)	DK190286A (da)
ES (1)	ES8800916A1 (da)
FI (1)	FI861693A7 (da)
FR (1)	FR2581062B1 (da)
GB (1)	GB2174392B (da)
HU (1)	HU194822B (da)
IE (1)	IE59630B1 (da)
IT (1)	IT1215652B (da)
NL (1)	NL8601051A (da)
NZ (1)	NZ215665A (da)
PT (1)	PT82467B (da)
SE (1)	SE8601963L (da)
ZA (1)	ZA862429B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5143913A (en) *	1988-04-04	1992-09-01	E. R. Squibb & Sons, Inc.	[3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate
UY34585A (es)	2012-01-24	2013-09-02	Aicuris Gmbh & Co Kg	Compuestos b-lactámicos sustituidos con amidina, su preparación y uso
US20140275007A1 (en) *	2013-03-14	2014-09-18	Rempex Pharmaceuticals, Inc.	Oxamazin antibiotics
CN113754651B (zh)	2020-06-02	2023-04-18	中国医学科学院医药生物技术研究所	一种β-内酰胺化合物、其用途及其制备方法
CN113975396B (zh) *	2021-11-09	2022-11-29	中国医学科学院医药生物技术研究所	包含β-内酰胺类化合物的药物组合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4260743A (en) *	1979-12-31	1981-04-07	Gist-Brocades N.V.	Preparation of β-lactams and intermediates therefor
US4337197A (en) *	1980-10-31	1982-06-29	E. R. Squibb & Sons, Inc.	O-sulfated β-lactam hydroxamic acids and intermediates
JPS586589A (ja)	1981-07-01	1983-01-14	Hitachi Ltd	論理回路
JPS58113174A (ja) *	1981-12-26	1983-07-05	Toyama Chem Co Ltd	新規なアゼチジン誘導体またはその塩類を含有する抗菌剤
JPS58194856A (ja)	1982-05-10	1983-11-12	Yamanouchi Pharmaceut Co Ltd	新規２−アゼチジノン誘導体

1985
- 1985-04-29 US US06/728,432 patent/US4638060A/en not_active Expired - Lifetime
1986
- 1986-03-26 CA CA505239A patent/CA1273938C/en not_active Expired
- 1986-04-02 NZ NZ215665A patent/NZ215665A/xx unknown
- 1986-04-02 ZA ZA862429A patent/ZA862429B/xx unknown
- 1986-04-02 AU AU55568/86A patent/AU601944B2/en not_active Ceased
- 1986-04-18 GB GB08609596A patent/GB2174392B/en not_active Expired
- 1986-04-22 FI FI861693A patent/FI861693A7/fi not_active Application Discontinuation
- 1986-04-22 IE IE106786A patent/IE59630B1/en not_active IP Right Cessation
- 1986-04-24 DK DK190286A patent/DK190286A/da not_active Application Discontinuation
- 1986-04-24 NL NL8601051A patent/NL8601051A/nl not_active Application Discontinuation
- 1986-04-28 PT PT82467A patent/PT82467B/pt not_active IP Right Cessation
- 1986-04-28 DE DE19863614317 patent/DE3614317A1/de not_active Ceased
- 1986-04-28 IT IT8620227A patent/IT1215652B/it active
- 1986-04-28 ES ES554438A patent/ES8800916A1/es not_active Expired
- 1986-04-28 CH CH1723/86A patent/CH668073A5/fr not_active IP Right Cessation
- 1986-04-28 SE SE8601963A patent/SE8601963L/xx not_active Application Discontinuation
- 1986-04-28 FR FR8606108A patent/FR2581062B1/fr not_active Expired - Fee Related
- 1986-04-29 HU HU861785A patent/HU194822B/hu not_active IP Right Cessation
- 1986-04-29 BE BE0/216606A patent/BE904699A/fr not_active IP Right Cessation
- 1986-04-30 JP JP61100786A patent/JPS61257965A/ja active Pending

Also Published As

Publication number	Publication date
HU194822B (en)	1988-03-28
PT82467A (en)	1986-05-01
CH668073A5 (fr)	1988-11-30
NZ215665A (en)	1988-11-29
ZA862429B (en)	1986-11-26
GB2174392A (en)	1986-11-05
NL8601051A (nl)	1986-11-17
DE3614317A1 (de)	1986-11-06
DK190286D0 (da)	1986-04-24
GB8609596D0 (en)	1986-05-21
IE861067L (en)	1986-10-29
ES8800916A1 (es)	1987-12-01
SE8601963D0 (sv)	1986-04-28
FR2581062B1 (fr)	1990-10-19
CA1273938A (en)	1990-09-11
SE8601963L (sv)	1986-10-30
IE59630B1 (en)	1994-03-09
ES554438A0 (es)	1987-12-01
FR2581062A1 (fr)	1986-10-31
FI861693A0 (fi)	1986-04-22
GB2174392B (en)	1988-11-09
HUT41384A (en)	1987-04-28
AU601944B2 (en)	1990-09-27
IT8620227A0 (it)	1986-04-28
PT82467B (pt)	1988-03-03
JPS61257965A (ja)	1986-11-15
FI861693A7 (fi)	1986-10-30
US4638060A (en)	1987-01-20
AU5556886A (en)	1986-11-06
CA1273938C (en)	1990-09-11
IT1215652B (it)	1990-02-22
BE904699A (fr)	1986-08-18

Legal Events

Date	Code	Title	Description
1995-12-27	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
ES527249A0 (es)	1985-10-01	Un procedimiento para la preparacion de 4"-epi-9-desoxo-9a-metil-9a-aza-9a-homoeritromicina a
ES8106908A1 (es)	1981-09-01	Un procedimiento para la preparacion de (6r,7r)-7-((z)-2- (2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetami- do)-3-(1-piridiniometil)cef-3-em-4-carboxilato pentahidrata-do
MY106399A (en)	1995-05-30	Cephalosporins and homologeus, preparation and pharmaceutical composition
DK190286A (da)	1986-10-30	O-sulfaterede beta-lactam-hydroxyamsyrer
IE823087L (en)	1983-07-04	Azetidinones.
DE3888587D1 (de)	1994-04-28	AB-006-Antibiotika und Verfahren zu deren Herstellung.
EP0157544A3 (en)	1987-08-05	Antibiotics, their production and use
NL7513793A (nl)	1976-06-01	Antibacterieel middel tegen gram-positieve en gram-negatieve bacterien.
FI891325L (fi)	1989-09-30	1-metyyli-3,5,7-triatsa-1-atsoniatrisyklodekaaniyhdisteitä ja niiden käyttö mikro-organismien kontrolloimiseksi vesijärjestelmissä
BG42676A3 (en)	1988-01-15	Method for preparang derivatives of 6- aminoalkyl- penicillanic acid
DK431284A (da)	1985-03-13	Antibiotisk forbindelse betegnet cl-1957b eller salte deraf, dens fremstilling samt dens anvendelse
DK283186A (da)	1986-12-19	Antibiotikum tan-749, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende det
Schweinburg et al.	1949	A simple method for determining sulfonamide sensitivity in vitro and its clinical application
BR9609932A (pt)	1999-06-08	Uso de derivados de prostano e a combinação dos mesmos com antibióticos no tratamento das infecções bacterianas
Rey et al.	1997	Tsukamurella infections. Case report and literature review
SE8303727D0 (sv)	1983-06-29	Cefalosporinantibiotika
FI864769L (fi)	1986-11-24	Icke-adjuvanserad vaccin.
PT83712B (pt)	1989-07-31	Processo para a preparacao de derivados de cefalosporina
JPS57109786A (en)	1982-07-08	Antibiotic c-19393e5 and its preparation
Corcoran	1986	Molecular biology of sensitivity and resistance to antimicrobial agents.
Gentry et al.	1983	A random comparative trial of 0 multiplied by 25, 0 multiplied by 5 and 1 multiplied by 0 g ceftazidime twice daily in urinary tract infection.
YAO	1986	A randomized comparative study on the effect of gatifloxacin and ciprofloxacin therapy in urinary tract and genital bacterial infections
Batyrbekov et al.	1985	Immobilization of tubazide on polyurethane matrix.
Starke	1987	When can oral antibiotics be used to treat osteomyelitis?.
Hussein	1994	< The> effect of clindamycin on the adherence of staphylococcus aureus to hydrocarbons and fibrin clots