DK1960428T3 - Antistoffer mod amyloid beta med glycosylering i den variable region - Google Patents

Antistoffer mod amyloid beta med glycosylering i den variable region

Info

Publication number
DK1960428T3
DK1960428T3 DK06829502.1T DK06829502T DK1960428T3 DK 1960428 T3 DK1960428 T3 DK 1960428T3 DK 06829502 T DK06829502 T DK 06829502T DK 1960428 T3 DK1960428 T3 DK 1960428T3
Authority
DK
Denmark
Prior art keywords
glycosylation
antibodies
variable region
amyloid beta
amyloid
Prior art date
Application number
DK06829502.1T
Other languages
English (en)
Inventor
Diana Schuhbauer
Bernd Bohrmann
Hansruedi Loetscher
Walter Huber
Karl Weyer
Manfred Brockhaus
Hans Koll
Andreas Schaubmar
Kurt Lang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1960428T3 publication Critical patent/DK1960428T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DK06829502.1T 2005-12-12 2006-12-11 Antistoffer mod amyloid beta med glycosylering i den variable region DK1960428T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05027090 2005-12-12
PCT/EP2006/011914 WO2007068429A1 (en) 2005-12-12 2006-12-11 Antibodies against amyloid beta 4 with glycosylated in the variable region

Publications (1)

Publication Number Publication Date
DK1960428T3 true DK1960428T3 (da) 2011-08-22

Family

ID=37745986

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06829502.1T DK1960428T3 (da) 2005-12-12 2006-12-11 Antistoffer mod amyloid beta med glycosylering i den variable region

Country Status (33)

Country Link
US (2) US8906370B2 (da)
EP (2) EP1960428B1 (da)
JP (1) JP5145241B2 (da)
KR (2) KR101401159B1 (da)
CN (2) CN102659943B (da)
AR (1) AR057233A1 (da)
AT (1) ATE517923T1 (da)
AU (1) AU2006326301B2 (da)
BR (1) BRPI0619605B8 (da)
CA (1) CA2632828C (da)
CR (1) CR10000A (da)
CY (1) CY1114783T1 (da)
DK (1) DK1960428T3 (da)
DO (1) DOP2006000278A (da)
EC (1) ECSP088524A (da)
ES (1) ES2368591T3 (da)
IL (1) IL191004A (da)
JO (1) JO2824B1 (da)
MA (1) MA30038B1 (da)
MY (1) MY155286A (da)
NO (1) NO346105B1 (da)
NZ (1) NZ568241A (da)
PE (3) PE20100684A1 (da)
PL (1) PL1960428T3 (da)
PT (1) PT1960428E (da)
RS (1) RS52004B (da)
RU (1) RU2438706C2 (da)
SI (1) SI1960428T1 (da)
TW (1) TWI382990B (da)
UA (1) UA99097C2 (da)
UY (1) UY30003A1 (da)
WO (1) WO2007068429A1 (da)
ZA (1) ZA200805038B (da)

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Also Published As

Publication number Publication date
RS52004B (sr) 2012-04-30
US9272031B2 (en) 2016-03-01
CN101351476A (zh) 2009-01-21
RU2008128138A (ru) 2010-01-20
RU2438706C2 (ru) 2012-01-10
PE20100748A1 (es) 2010-11-12
ECSP088524A (es) 2008-07-30
AR057233A1 (es) 2007-11-21
PT1960428E (pt) 2011-10-07
HK1176075A1 (en) 2013-07-19
PL1960428T3 (pl) 2012-02-29
AU2006326301B2 (en) 2011-04-21
BRPI0619605A8 (pt) 2019-01-15
CA2632828A1 (en) 2007-06-21
CN102659943A (zh) 2012-09-12
IL191004A (en) 2013-08-29
EP1960428B1 (en) 2011-07-27
UY30003A1 (es) 2007-08-31
JO2824B1 (en) 2014-09-15
US8906370B2 (en) 2014-12-09
MA30038B1 (fr) 2008-12-01
NZ568241A (en) 2011-08-26
SI1960428T1 (sl) 2011-10-28
KR20080077132A (ko) 2008-08-21
EP2377886A1 (en) 2011-10-19
UA99097C2 (ru) 2012-07-25
BRPI0619605B1 (pt) 2019-08-13
ATE517923T1 (de) 2011-08-15
BRPI0619605B8 (pt) 2021-05-25
DOP2006000278A (es) 2007-07-15
CA2632828C (en) 2012-07-10
TWI382990B (zh) 2013-01-21
NO20082874L (no) 2008-08-28
ZA200805038B (en) 2009-06-24
JP5145241B2 (ja) 2013-02-13
BRPI0619605A2 (pt) 2011-10-11
KR20120089483A (ko) 2012-08-10
ES2368591T3 (es) 2011-11-18
CY1114783T1 (el) 2016-12-14
HK1130066A1 (en) 2009-12-18
CN102659943B (zh) 2015-07-01
US20090252724A1 (en) 2009-10-08
PE20071002A1 (es) 2007-11-19
NO346105B1 (no) 2022-02-21
MY155286A (en) 2015-09-30
CN101351476B (zh) 2013-04-03
CR10000A (es) 2008-07-29
US20150165022A1 (en) 2015-06-18
WO2007068429A1 (en) 2007-06-21
JP2009520691A (ja) 2009-05-28
TW200736273A (en) 2007-10-01
PE20100684A1 (es) 2010-10-04
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EP1960428A1 (en) 2008-08-27
AU2006326301A1 (en) 2007-06-21

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