DK1976559T3 - Influenzavacciner indeholdende hæmagglutinin og matrixproteiner - Google Patents

Influenzavacciner indeholdende hæmagglutinin og matrixproteiner Download PDF

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DK1976559T3
DK1976559T3 DK07734467.9T DK07734467T DK1976559T3 DK 1976559 T3 DK1976559 T3 DK 1976559T3 DK 07734467 T DK07734467 T DK 07734467T DK 1976559 T3 DK1976559 T3 DK 1976559T3
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vaccine
influenza
seq
vol
virus
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DK07734467.9T
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DK1976559T6 (da
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Michael Broeker
Holger Kost
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Novartis Influenza Vaccines Marburg Gmbh
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Priority claimed from GB0620175A external-priority patent/GB0620175D0/en
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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Claims (16)

1. Oprenset overfladeantigen eller spaltet virion-influenzavaccine, omfattende influenzavirus hæmagglutinin og et fragment med en molekylvægt på <10kDa af Ml matrixprotein, hvor fragmentet omfatter en T-celleepitop, som danner er stabilt kompleks, og hvor sammensætningen ikke indeholder ovalbumin.
2. Vaccinen ifølge krav 1, hvor molekylvægten af matrixproteinfragmentet falder inden for området på 2-8kDa.
3. Vaccinen ifølge krav 2, hvor matrixproteinfragmentet har en molekylvægt på ca. 5kDa.
4. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor matrixproteinfragmentet omfatter sekvensen LEDVFAGK (SEQ ID NO: 17).
5. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor matrixproteinfragmentet omfatter en sekvens på 20 aminosyrer der har mindst 80% identitet med SEQ ID NO: 2.
6. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor matrixproteinfragmentet omfatter sekvensen YSXGAL (SEQ ID NO: 27).
7. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor matrixproteinfragmentet mangler det N-terminale methionin af den naturlige Ml-sekvens.
8. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor matrixproteinfragmentet har en N-terminal sekvens EISLSYSAGALA (SEQ ID NO: 18).
9. Vaccinen ifølge krav 8, hvor matrixproteinfragmentet har en N-terminal sekvens SLLTEVETYVLS (SEQ ID NO: 30).
10. Vaccinen ifølge krav 9, hvor det N-terminale serin af SEQ ID NO: 30 er kovalent modificeret fx acetyleret.
11. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen omfatter: (i) et første matrixproteinfragment med en N-terminal sekvens SLLTEVETYVLS (SEQ ID NO: 30); og (ii) et andet matrixprotein med en N-terminal sekvens EISLSYSAGALA (SEQ ID NO: 18).
12. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor matrixproteinet er til stede ved en koncentration mellem lpg/ml og 15pg/ml.
13. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor hæmagglutininet er fra en Hl, H2, H3, H5, H7 eller H9 influenza A virus undertype.
14. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen indeholder mellem 0,1 og 20 pg hæmagglutinin pr. viral stamme.
15. Vaccinen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen omfatter en adjuvans.
16. Vaccinen ifølge krav 15, hvor adjuvansen omfatter en olie-i-vand-emulsion.
DK07734467.9T 2006-01-27 2007-01-26 Influenzavacciner indeholdende hæmagglutinin og matrixproteiner DK1976559T6 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0601733A GB0601733D0 (en) 2006-01-27 2006-01-27 Vaccines
GB0620175A GB0620175D0 (en) 2006-10-11 2006-10-11 Vaccines
PCT/IB2007/001150 WO2007085969A2 (en) 2006-01-27 2007-01-26 Influenza vaccines containing hemagglutinin and matrix proteins

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DK1976559T3 true DK1976559T3 (da) 2017-02-27
DK1976559T6 DK1976559T6 (da) 2020-04-06

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US (2) US20110027314A1 (da)
EP (3) EP3753574A1 (da)
JP (3) JP6087041B2 (da)
KR (2) KR20110110853A (da)
AU (1) AU2007209019B2 (da)
BR (2) BR122019013216B8 (da)
CA (1) CA2640248A1 (da)
DK (2) DK2478916T3 (da)
EA (1) EA015271B1 (da)
ES (2) ES2796603T3 (da)
FR (1) FR20C1046I1 (da)
HU (1) HUE049580T2 (da)
NZ (1) NZ570106A (da)
PL (2) PL1976559T6 (da)
PT (1) PT2478916T (da)
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