DK2019671T3 - Mellemprodukter til fremstilling af bivalente smac-mimetica - Google Patents

Mellemprodukter til fremstilling af bivalente smac-mimetica Download PDF

Info

Publication number: DK2019671T3
Authority: DK; Denmark
Prior art keywords: optionally substituted; alkyl; compound; nmr; group
Prior art date: 2006-05-05

Application number

DK07794581.4T

Other languages

English (en)

Inventor

Shaomeng Wang

Haiying Sun

Zaneta Nikolovska-Coleska

Su Qiu

Yuefeng Peng

Qian Cai

Dongguang Qin

Original Assignee

Univ Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-05

Filing date

2007-05-04

Publication date

2014-12-08

2007-05-04 Application filed by Univ Michigan filed Critical Univ Michigan

2014-12-08 Application granted granted Critical

2014-12-08 Publication of DK2019671T3 publication Critical patent/DK2019671T3/da

Links

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125000001072 heteroaryl group Chemical group 0.000 claims description 43
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ZPFVQKPWGDRLHL-ZLYBXYBFSA-N zosuquidar trihydrochloride Chemical compound Cl.Cl.Cl.C([C@H](COC=1C2=CC=CN=C2C=CC=1)O)N(CC1)CCN1C1C2=CC=CC=C2[C@H]2C(F)(F)[C@H]2C2=CC=CC=C12 ZPFVQKPWGDRLHL-ZLYBXYBFSA-N 0.000 description 1
125000004933 β-carbolinyl group Chemical group C1(=NC=CC=2C3=CC=CC=C3NC12)* 0.000 description 1
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/12—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK07794581.4T 2006-05-05 2007-05-04 Mellemprodukter til fremstilling af bivalente smac-mimetica DK2019671T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US79801806P	2006-05-05	2006-05-05
US92341507P	2007-04-13	2007-04-13
PCT/US2007/010924 WO2007130626A2 (en)	2006-05-05	2007-05-04	Bivalent smac mimetics and the uses thereof

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DK2019671T3 true DK2019671T3 (da)	2014-12-08

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Country Status (22)

Country	Link
US (1)	US7960372B2 (da)
EP (1)	EP2019671B1 (da)
JP (1)	JP5230610B2 (da)
KR (1)	KR101071516B1 (da)
CN (1)	CN101484151B (da)
AU (1)	AU2007248473B2 (da)
BR (1)	BRPI0711326B8 (da)
CA (1)	CA2651206C (da)
CY (1)	CY1115808T1 (da)
DK (1)	DK2019671T3 (da)
EA (1)	EA017279B1 (da)
ES (1)	ES2525585T3 (da)
HR (1)	HRP20141253T1 (da)
IL (1)	IL195075A (da)
MX (1)	MX2008014140A (da)
NO (1)	NO341896B1 (da)
NZ (1)	NZ572531A (da)
PL (1)	PL2019671T3 (da)
PT (1)	PT2019671E (da)
SI (1)	SI2019671T1 (da)
WO (1)	WO2007130626A2 (da)
ZA (1)	ZA200809496B (da)

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2007
- 2007-05-04 CN CN2007800247572A patent/CN101484151B/zh active Active
- 2007-05-04 JP JP2009509759A patent/JP5230610B2/ja not_active Expired - Fee Related
- 2007-05-04 HR HRP20141253TT patent/HRP20141253T1/hr unknown
- 2007-05-04 ES ES07794581.4T patent/ES2525585T3/es active Active
- 2007-05-04 CA CA2651206A patent/CA2651206C/en active Active
- 2007-05-04 EP EP07794581.4A patent/EP2019671B1/en active Active
- 2007-05-04 MX MX2008014140A patent/MX2008014140A/es active IP Right Grant
- 2007-05-04 WO PCT/US2007/010924 patent/WO2007130626A2/en not_active Ceased
- 2007-05-04 DK DK07794581.4T patent/DK2019671T3/da active
- 2007-05-04 BR BRPI0711326A patent/BRPI0711326B8/pt not_active IP Right Cessation
- 2007-05-04 NZ NZ572531A patent/NZ572531A/en not_active IP Right Cessation
- 2007-05-04 SI SI200731580T patent/SI2019671T1/sl unknown
- 2007-05-04 AU AU2007248473A patent/AU2007248473B2/en not_active Ceased
- 2007-05-04 PT PT77945814T patent/PT2019671E/pt unknown
- 2007-05-04 EA EA200802285A patent/EA017279B1/ru unknown
- 2007-05-04 PL PL07794581T patent/PL2019671T3/pl unknown
- 2007-05-04 KR KR1020087029869A patent/KR101071516B1/ko active Active
- 2007-05-04 US US11/800,220 patent/US7960372B2/en active Active
2008
- 2008-11-03 IL IL195075A patent/IL195075A/en active IP Right Grant
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- 2008-12-04 NO NO20085074A patent/NO341896B1/no unknown
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Also Published As

Publication number	Publication date
CA2651206A1 (en)	2007-11-15
SI2019671T1 (sl)	2015-03-31
CN101484151B (zh)	2012-11-21
WO2007130626A2 (en)	2007-11-15
BRPI0711326B1 (pt)	2020-12-01
PT2019671E (pt)	2014-12-18
AU2007248473A1 (en)	2007-11-15
CA2651206C (en)	2013-11-12
NO341896B1 (no)	2018-02-12
EA017279B1 (ru)	2012-11-30
CY1115808T1 (el)	2017-01-25
EA200802285A1 (ru)	2009-08-28
JP5230610B2 (ja)	2013-07-10
EP2019671B1 (en)	2014-09-24
NO20085074L (no)	2009-02-04
CN101484151A (zh)	2009-07-15
US20080089896A1 (en)	2008-04-17
HK1124536A1 (en)	2009-07-17
IL195075A (en)	2015-03-31
BRPI0711326B8 (pt)	2021-05-25
JP2009536204A (ja)	2009-10-08
AU2007248473B2 (en)	2011-01-27
NZ572531A (en)	2011-09-30
KR101071516B1 (ko)	2011-10-10
BRPI0711326A2 (pt)	2011-08-30
MX2008014140A (es)	2009-01-19
US7960372B2 (en)	2011-06-14
KR20090009307A (ko)	2009-01-22
IL195075A0 (en)	2009-08-03
HRP20141253T1 (en)	2015-03-13
EP2019671A4 (en)	2010-06-02
ZA200809496B (en)	2010-02-24
ES2525585T3 (es)	2014-12-26
PL2019671T3 (pl)	2015-02-27
EP2019671A2 (en)	2009-02-04
WO2007130626A3 (en)	2008-01-17

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JP5416089B2 (ja)	2014-02-12	ジアゾ二環式ｓｍａｃ模倣物およびその使用
US8202902B2 (en)	2012-06-19	Bivalent SMAC mimetics and the uses thereof
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KR100887045B1 (ko)	2009-03-04	구조적으로 강제된 ｓｍａｃ 유사물 및 이들의 용도
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