DK226987A - Styrylpyrazoler,-isoxazoler og analoge forbindelser med aktivitet som inhibitorer for 5-lipoxygenase samt farmaceutiske midler med indhold af saadanne forbindelser - Google Patents
Styrylpyrazoler,-isoxazoler og analoge forbindelser med aktivitet som inhibitorer for 5-lipoxygenase samt farmaceutiske midler med indhold af saadanne forbindelserInfo
- Publication number
- DK226987A DK226987A DK226987A DK226987A DK226987A DK 226987 A DK226987 A DK 226987A DK 226987 A DK226987 A DK 226987A DK 226987 A DK226987 A DK 226987A DK 226987 A DK226987 A DK 226987A
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- isoxazoles
- lipoxygenase
- activity
- inhibitors
- Prior art date
Links
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 title abstract 2
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 title abstract 2
- 150000003217 pyrazoles Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003854 isothiazoles Chemical class 0.000 abstract 1
- 150000002545 isoxazoles Chemical class 0.000 abstract 1
- 230000000475 sunscreen effect Effects 0.000 abstract 1
- 239000000516 sunscreening agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86117986A | 1986-05-09 | 1986-05-09 | |
| US86117986 | 1986-05-09 | ||
| US91069286A | 1986-09-22 | 1986-09-22 | |
| US91069286 | 1986-09-22 | ||
| US3273087A | 1987-04-06 | 1987-04-06 | |
| US3273087 | 1987-04-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK226987D0 DK226987D0 (da) | 1987-05-04 |
| DK226987A true DK226987A (da) | 1987-11-10 |
| DK175824B1 DK175824B1 (da) | 2005-03-14 |
Family
ID=27364200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198702269A DK175824B1 (da) | 1986-05-09 | 1987-05-04 | Styrylpyrazoler,-isoxazoler og analoge forbindelser farmaceutiske præparater med aktivitet mod 5-lipoxygenase eller cyclooxygenase eller............ |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5208251A (da) |
| EP (1) | EP0245825B1 (da) |
| JP (1) | JP2656035B2 (da) |
| KR (1) | KR870011113A (da) |
| AT (1) | ATE61582T1 (da) |
| AU (1) | AU613579B2 (da) |
| DE (1) | DE3768553D1 (da) |
| DK (1) | DK175824B1 (da) |
| ES (1) | ES2037681T3 (da) |
| FI (1) | FI872015A7 (da) |
| GR (1) | GR3001831T3 (da) |
| IE (1) | IE59813B1 (da) |
| NO (1) | NO871917L (da) |
| NZ (1) | NZ220248A (da) |
| PT (1) | PT84840B (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL91418A (en) * | 1988-09-01 | 1997-11-20 | Rhone Poulenc Agrochimie | (hetero) cyclic amide derivatives, process for their preparation and fungicidal compositions containing them |
| DE3923649A1 (de) * | 1989-07-18 | 1991-01-31 | Hoechst Ag | Neue pyrazoline und ihre verwendung als safener |
| GB8920519D0 (en) * | 1989-09-11 | 1989-10-25 | Rhone Poulenc Ltd | New compositions of matter |
| DE3939010A1 (de) * | 1989-11-25 | 1991-05-29 | Hoechst Ag | Isoxazoline, verfahren zu ihrer herstellung und ihre verwendung als pflanzenschuetzende mittel |
| US5324840A (en) * | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
| JPH06135948A (ja) * | 1992-10-30 | 1994-05-17 | Taiho Yakuhin Kogyo Kk | スチレン誘導体又はその塩 |
| JP2738486B2 (ja) * | 1992-11-20 | 1998-04-08 | ファイザー製薬株式会社 | 抗炎症剤としての新規なイソオキサゾリン類 |
| US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
| US6172115B1 (en) | 1993-02-11 | 2001-01-09 | Allergan Sales, Inc. | Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid |
| WO1995014680A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | 3-aryl-2-isoxazolines as antiinflammatory agents |
| AU1326795A (en) * | 1994-03-09 | 1995-09-25 | Pfizer Inc. | Isoxazoline compounds as 5-lipoxygenase inhibitors |
| DE4408084A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | 3,5-Disubstituierte und 3,4,5-trisubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US5510361A (en) * | 1994-10-20 | 1996-04-23 | The Procter & Gamble Company | Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents |
| CA2170661A1 (en) | 1995-03-22 | 1996-09-23 | John K. Thottathil | Novel methods for the preparation of taxanes using oaxzolidine intermediates |
| US6011052A (en) * | 1996-04-30 | 2000-01-04 | Warner-Lambert Company | Pyrazolone derivatives as MCP-1 antagonists |
| AU6207698A (en) * | 1997-01-17 | 1998-08-07 | Basf Aktiengesellschaft | Process for preparing sulphurous 2-chloro-3-(4,5-dihydroisoxazol-3-yl)-benzoic acids |
| CA2319131A1 (en) | 1998-01-26 | 1999-07-29 | Walter H. Moos | Mitochondria protecting agents for treating mitochondria associated diseases |
| DE69940958D1 (de) | 1998-12-23 | 2009-07-16 | Glaxo Group Ltd | Bestimmungsmethode fur liganden der nuklearen rezeptoren |
| EP1368306B1 (en) * | 2001-01-18 | 2013-01-16 | Welichem Biotech Inc. | Novel 1,2-diphenylethene derivatives for treatment of immune diseases |
| DE10121252A1 (de) * | 2001-04-30 | 2002-11-07 | Christos C Zouboulis | Behandlung der Akne |
| AU2002314566A1 (en) * | 2002-06-17 | 2003-12-31 | Ho-Jeong Kwon | Novel curcumin derivatives |
| FR2842806B1 (fr) * | 2002-07-26 | 2005-07-29 | Mayoly Spindler Lab | Nouveau procede de preparation de derives styryle pyrazoles, isoxazoles et isothiazoles |
| AU2003275637A1 (en) * | 2002-10-24 | 2004-05-13 | Wakamoto Pharmaceutical Co., Ltd. | Pyrazole-4-alkanoate derivatives inhibiting cyclooxygenase and 5-lipoxygenase |
| AU2003285454A1 (en) * | 2002-10-29 | 2004-05-25 | L'oreal | Hair treatment composition containing a styryl-pyrazole compound |
| FR2846232B1 (fr) * | 2002-10-29 | 2004-12-10 | Oreal | Composition capillaire contenant un compose styryl-pyrazole, son utilisation pour stimuler ou induire la pousse des cheveux et/ou freiner leur chute |
| CA2579313A1 (en) | 2004-09-17 | 2006-03-30 | Exelixis, Inc. | Pyrazole kinase modulators and methods of use as c-kit or fit-3 kinase inhibitors |
| KR100604696B1 (ko) * | 2004-12-16 | 2006-07-31 | 연세대학교 산학협력단 | 신규한 커큐민 유도체 |
| EP1901618B1 (en) * | 2005-07-05 | 2009-06-17 | Symrise GmbH & Co. KG | Hydroxyphenylalkadiones and their use for masking bitter taste and/or for intensifying sweet taste |
| WO2010045395A2 (en) * | 2008-10-14 | 2010-04-22 | Danyang Chen | Curcumin analog compositions and related methods |
| NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| KR101952222B1 (ko) | 2011-04-11 | 2019-02-26 | 그린 테크 가부시키가이샤 | 신규 피라졸 유도체 |
| HK1213253A1 (en) * | 2012-10-10 | 2016-06-30 | Green Tech Co., Ltd. | Novel pyrazole derivatives |
| JP6052673B2 (ja) * | 2013-04-25 | 2016-12-27 | 富士フイルム株式会社 | ピラゾール誘導体またはその塩ならびにそれらを含有する医薬組成物 |
| CN104304244B (zh) * | 2014-09-11 | 2016-08-24 | 广西田园生化股份有限公司 | 一种用于农药制剂中的抗紫外线吸收剂 |
| CN109563053B (zh) | 2016-06-28 | 2023-02-28 | 肯塔基大学研究基金会 | 前列腺素e合成酶抑制剂及使用其的方法 |
Family Cites Families (52)
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|---|---|---|---|---|
| US3133080A (en) * | 1964-05-12 | Optical whitening agents of the | ||
| GB669590A (en) * | 1949-06-03 | 1952-04-02 | Ilford Ltd | Improvements in or relating to a process for improving the whiteness of colour materials |
| US2640056A (en) * | 1949-06-03 | 1953-05-26 | Ilford Ltd | Pyrazoline sulphonic acids |
| US2721143A (en) * | 1950-11-18 | 1955-10-18 | Knoll Ag | 3-phenyl pyrazol compounds and preserved composition containing said compounds |
| DE1039743B (de) * | 1957-03-27 | 1958-09-25 | Bayer Ag | Verfahren zur Stabilisierung von halogenhaltigen Polymerisaten und Mischpolymerisaten aus Vinylhalogeniden |
| US3239533A (en) * | 1963-01-24 | 1966-03-08 | Shionogi & Co | (phenyl-isoxazolyl)-diazomethylketones |
| DE1287997B (da) * | 1964-04-05 | 1969-01-23 | ||
| US3551440A (en) * | 1966-07-25 | 1970-12-29 | Bristol Myers Co | 3 phenyl - 5(alkyl)isothiazole - 4 - carboxylic acids and intermediates thereof |
| US3631169A (en) * | 1966-09-22 | 1971-12-28 | Dainippon Pharmaceutical Co | 3-(5-nitro-2-furyl)isoxazoline derivatives |
| US3772284A (en) * | 1966-12-20 | 1973-11-13 | American Cyanamid Co | Azirine compounds |
| US3479365A (en) * | 1967-05-19 | 1969-11-18 | Bristol Banyu Res Inst Ltd | New isothiazole synthesis |
| GB1164510A (en) * | 1967-06-15 | 1969-09-17 | Ici Ltd | Novel Isoxazole Derivatives, the preparation thereof, and Compositions containing the same |
| US3464999A (en) * | 1967-07-27 | 1969-09-02 | R & L Molecular Research Ltd | Thiadiazolylisothiazoles |
| GB1180268A (en) * | 1967-09-26 | 1970-02-04 | Ici Ltd | Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives |
| US3835126A (en) * | 1968-04-19 | 1974-09-10 | Hoechst Ag | Styryl-pyrazoline compounds |
| DE1900349A1 (de) * | 1969-01-04 | 1970-08-06 | Basf Ag | Neue Pyrazolinderivate |
| FR2073284B1 (da) * | 1969-12-23 | 1973-07-13 | Ferlux | |
| US3711495A (en) * | 1970-01-07 | 1973-01-16 | Merck & Co Inc | Isoxazalin-3-yl-substituted-5-nitroimidazoles |
| US3687971A (en) * | 1970-06-22 | 1972-08-29 | Merck & Co Inc | 4-(pyrrolyl)-salicylic acid derivatives |
| GB1373212A (en) * | 1970-12-07 | 1974-11-06 | Wyeth John & Brother Ltd | Pyrazole compounds |
| US4045169A (en) * | 1971-09-09 | 1977-08-30 | Hoechst Aktiengesellschaft | 3-[3',4'-Dichloro-6'-alkyl-phenyl]-Δ 2-pyrazoline derivatives and their use as optical brighteners |
| US3948937A (en) * | 1972-02-29 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Pyrazole plant growth regulants |
| US3849436A (en) * | 1972-10-04 | 1974-11-19 | Du Pont | Cyclization of 2-(3-aryl-5-pyrazolyl)benzoic acids,esters and amides to 2-arylpyrazolo(5,1-a)isoindol-8-ones |
| US3895027A (en) * | 1974-04-12 | 1975-07-15 | Lilly Co Eli | Process for preparing pyrazole-3-carboxylic acids |
| US3910949A (en) * | 1974-12-09 | 1975-10-07 | American Cyanamid Co | Manufacture of 1,2-dimethyl-3,5-diphenylpyrazolium methylsulfate in a single reaction zone |
| DE2526469A1 (de) * | 1975-06-13 | 1976-12-30 | Bayer Ag | 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2536003C2 (de) * | 1975-08-08 | 1985-11-14 | Schering AG, 1000 Berlin und 4709 Bergkamen | Pyrazol-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Derivate |
| US4032644A (en) * | 1975-12-29 | 1977-06-28 | Sandoz, Inc. | Isoxazolyl benzoic acids |
| US4153707A (en) * | 1976-08-12 | 1979-05-08 | The Upjohn Company | Fungicidal isoxazolyl phenols and method of use |
| US4129568A (en) * | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
| US4139366A (en) * | 1977-05-12 | 1979-02-13 | Monsanto Company | 2-[5-aryl-2-isoxazolin-3-yl]benzoates and use as herbicides |
| US4140515A (en) * | 1977-05-12 | 1979-02-20 | Monsanto Company | Aryl-3-isoxazole benzoates as plant growth regulants and herbicides |
| SU717046A1 (ru) * | 1978-03-01 | 1980-02-25 | Предприятие П/Я Р-6496 | Способ получени 3-арил-5-фенил-1(4-формилфенил)-2-пиразолинов |
| DE2818999A1 (de) * | 1978-04-29 | 1979-11-15 | Basf Ag | Aminoderivate von 3-alkyl-5-(2- hydroxystyryl)-isoxazolen |
| DD138770A1 (de) * | 1978-09-20 | 1979-11-21 | Juergen Liebscher | Verfahren zur herstellung von 5-styryl-pyrazolen und ihren vinylogen |
| US4229204A (en) * | 1978-12-04 | 1980-10-21 | Monsanto Company | Trifluoromethylphenyl isoxazolyl benzoates |
| SU792872A1 (ru) * | 1979-01-15 | 1981-09-07 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латсср | Способ получени 2-(изоксазолил-5)-бензойных кислот |
| JPS6043064B2 (ja) * | 1979-11-28 | 1985-09-26 | ウェルファイド株式会社 | 新規イソオキサゾ−ル誘導体 |
| DE3006809A1 (de) * | 1980-02-23 | 1981-09-24 | Basf Ag, 6700 Ludwigshafen | 2-((3-amino-2-hydroxy-propoxy)-styryl)-isoxazole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| JPS5740468A (en) * | 1980-08-25 | 1982-03-06 | Kuraray Co Ltd | Vinyl substituted pyrazole derivative and its preparation |
| US4346094A (en) * | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| BE891489A (fr) * | 1980-12-16 | 1982-06-15 | Wellcome Found | Composes heterocycliques |
| DE3148291A1 (de) * | 1981-12-05 | 1983-06-09 | Basf Ag, 6700 Ludwigshafen | Harnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
| JPS58177977A (ja) * | 1982-04-09 | 1983-10-18 | Grelan Pharmaceut Co Ltd | ４−フエニルピラゾ−ル類 |
| US4495195A (en) * | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| US4451476A (en) * | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
| DE3418395A1 (de) * | 1984-05-17 | 1985-11-21 | Bayer Ag, 5090 Leverkusen | Biologisch aktive mittel enthaltend substituierte isoxazolidine sowie neue isoxazolidine und ihre herstellung |
| US4560695A (en) * | 1984-06-18 | 1985-12-24 | Eli Lilly And Company | Isoxazolyl and isothiazolyl aromatase inhibitors |
| US4609666A (en) * | 1984-06-18 | 1986-09-02 | Eli Lilly And Company | Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles |
| CA1280753C (en) * | 1985-07-02 | 1991-02-26 | Philip Michael Carabateas | Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans |
| AU611437B2 (en) * | 1987-05-29 | 1991-06-13 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same |
| JPS6440266A (en) * | 1987-08-04 | 1989-02-10 | Toshiba Machine Co Ltd | Working pressure control device for polishing machine |
-
1987
- 1987-04-22 IE IE104187A patent/IE59813B1/en not_active IP Right Cessation
- 1987-04-24 AU AU71973/87A patent/AU613579B2/en not_active Ceased
- 1987-05-04 DK DK198702269A patent/DK175824B1/da not_active IP Right Cessation
- 1987-05-06 FI FI872015A patent/FI872015A7/fi not_active Application Discontinuation
- 1987-05-08 PT PT84840A patent/PT84840B/pt unknown
- 1987-05-08 NO NO871917A patent/NO871917L/no unknown
- 1987-05-08 JP JP62110955A patent/JP2656035B2/ja not_active Expired - Fee Related
- 1987-05-08 NZ NZ220248A patent/NZ220248A/xx unknown
- 1987-05-09 KR KR870004564A patent/KR870011113A/ko not_active Withdrawn
- 1987-05-11 ES ES87106822T patent/ES2037681T3/es not_active Expired - Lifetime
- 1987-05-11 AT AT87106822T patent/ATE61582T1/de not_active IP Right Cessation
- 1987-05-11 EP EP87106822A patent/EP0245825B1/en not_active Expired - Lifetime
- 1987-05-11 DE DE8787106822T patent/DE3768553D1/de not_active Expired - Fee Related
-
1989
- 1989-08-16 US US07/395,165 patent/US5208251A/en not_active Expired - Lifetime
-
1991
- 1991-04-23 GR GR91400516T patent/GR3001831T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0245825B1 (en) | 1991-03-13 |
| KR870011113A (ko) | 1987-12-21 |
| EP0245825A1 (en) | 1987-11-19 |
| GR3001831T3 (en) | 1992-11-23 |
| DK175824B1 (da) | 2005-03-14 |
| DK226987D0 (da) | 1987-05-04 |
| IE59813B1 (en) | 1994-04-06 |
| JPS6322079A (ja) | 1988-01-29 |
| AU613579B2 (en) | 1991-08-08 |
| JP2656035B2 (ja) | 1997-09-24 |
| PT84840B (pt) | 1990-02-08 |
| IE871041L (en) | 1987-11-09 |
| ES2037681T3 (es) | 1993-07-01 |
| AU7197387A (en) | 1987-11-12 |
| PT84840A (en) | 1987-06-01 |
| NZ220248A (en) | 1989-05-29 |
| NO871917D0 (no) | 1987-05-08 |
| FI872015A7 (fi) | 1987-11-10 |
| ATE61582T1 (de) | 1991-03-15 |
| FI872015A0 (fi) | 1987-05-06 |
| NO871917L (no) | 1987-11-10 |
| DE3768553D1 (de) | 1991-04-18 |
| US5208251A (en) | 1993-05-04 |
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