ES2037681T3 - Procedimiento para preparar nuevos estirilpirazoles, isoxazoles y analogos de los mismos que tienen actividad como inhibidores de 5-lipoxigenasa. - Google Patents

Procedimiento para preparar nuevos estirilpirazoles, isoxazoles y analogos de los mismos que tienen actividad como inhibidores de 5-lipoxigenasa.

Info

Publication number
ES2037681T3
ES2037681T3 ES87106822T ES87106822T ES2037681T3 ES 2037681 T3 ES2037681 T3 ES 2037681T3 ES 87106822 T ES87106822 T ES 87106822T ES 87106822 T ES87106822 T ES 87106822T ES 2037681 T3 ES2037681 T3 ES 2037681T3
Authority
ES
Spain
Prior art keywords
isoxazoles
analogs
activity
styrilpirazoles
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87106822T
Other languages
English (en)
Inventor
Thomas R. Belliotti
David T. Connor
Daniel L. Flynn
Catherine R. Kostlan
Donald E. Nies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2037681T3 publication Critical patent/ES2037681T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A ISOXAZOLES, PIRAZOLES, ISOTIAZOLES 3,5-SUSTITUIDOS, Y ANALOGOS DE LOS ISMOS, QUE TIENEN ACTIVIDAD INHIBIDORA DE LA 5-LIPOXIGENASA O DE LA CICLOOXIGENASE O CAPACIDAD DE ACTUAR COMO PANTALLA DE PROTECCION CONTRA EL SOL.
ES87106822T 1986-05-09 1987-05-11 Procedimiento para preparar nuevos estirilpirazoles, isoxazoles y analogos de los mismos que tienen actividad como inhibidores de 5-lipoxigenasa. Expired - Lifetime ES2037681T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86117986A 1986-05-09 1986-05-09
US91069286A 1986-09-22 1986-09-22
US3273087A 1987-04-06 1987-04-06

Publications (1)

Publication Number Publication Date
ES2037681T3 true ES2037681T3 (es) 1993-07-01

Family

ID=27364200

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87106822T Expired - Lifetime ES2037681T3 (es) 1986-05-09 1987-05-11 Procedimiento para preparar nuevos estirilpirazoles, isoxazoles y analogos de los mismos que tienen actividad como inhibidores de 5-lipoxigenasa.

Country Status (15)

Country Link
US (1) US5208251A (es)
EP (1) EP0245825B1 (es)
JP (1) JP2656035B2 (es)
KR (1) KR870011113A (es)
AT (1) ATE61582T1 (es)
AU (1) AU613579B2 (es)
DE (1) DE3768553D1 (es)
DK (1) DK175824B1 (es)
ES (1) ES2037681T3 (es)
FI (1) FI872015A7 (es)
GR (1) GR3001831T3 (es)
IE (1) IE59813B1 (es)
NO (1) NO871917L (es)
NZ (1) NZ220248A (es)
PT (1) PT84840B (es)

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ES2287542T3 (es) * 2002-10-29 2007-12-16 L'oreal Composicion capilar que contiene un compuesto estirilpirazol.
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KR100604696B1 (ko) * 2004-12-16 2006-07-31 연세대학교 산학협력단 신규한 커큐민 유도체
WO2007003527A1 (en) * 2005-07-05 2007-01-11 Symrise Gmbh & Co. Kg Hydroxyphenylalkadiones and their use for masking bitter taste and/or for intensifying sweet taste
WO2010045395A2 (en) * 2008-10-14 2010-04-22 Danyang Chen Curcumin analog compositions and related methods
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WO2012141228A1 (ja) 2011-04-11 2012-10-18 株式会社ファルマエイト 新規ピラゾール誘導体
CN104903297A (zh) * 2012-10-10 2015-09-09 绿色科技株式会社 新型吡唑衍生物
JP6052673B2 (ja) * 2013-04-25 2016-12-27 富士フイルム株式会社 ピラゾール誘導体またはその塩ならびにそれらを含有する医薬組成物
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Also Published As

Publication number Publication date
ATE61582T1 (de) 1991-03-15
NO871917L (no) 1987-11-10
EP0245825B1 (en) 1991-03-13
DE3768553D1 (de) 1991-04-18
PT84840A (en) 1987-06-01
IE871041L (en) 1987-11-09
FI872015A0 (fi) 1987-05-06
EP0245825A1 (en) 1987-11-19
KR870011113A (ko) 1987-12-21
DK226987A (da) 1987-11-10
FI872015A7 (fi) 1987-11-10
PT84840B (pt) 1990-02-08
IE59813B1 (en) 1994-04-06
GR3001831T3 (en) 1992-11-23
DK226987D0 (da) 1987-05-04
NO871917D0 (no) 1987-05-08
US5208251A (en) 1993-05-04
AU613579B2 (en) 1991-08-08
AU7197387A (en) 1987-11-12
JP2656035B2 (ja) 1997-09-24
NZ220248A (en) 1989-05-29
JPS6322079A (ja) 1988-01-29
DK175824B1 (da) 2005-03-14

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