DK2281815T3 - 4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound - Google Patents

4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound

Info

Publication number: DK2281815T3
Authority: DK; Denmark
Prior art keywords: acetylamino; indole; chlorophenyl; thio; methyl
Prior art date: 2003-05-27

Application number

DK10180348.4T

Other languages

English (en)

Inventor

Rukhsana Tasneem Mohammed

Roger Victor Bonnert

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-27

Filing date

2004-05-25

Publication date

2012-06-18

2004-05-25 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2012-06-18 Application granted granted Critical

2012-06-18 Publication of DK2281815T3 publication Critical patent/DK2281815T3/da

Links

150000001875 compounds Chemical class 0.000 title 1
NJAHLZZJVRKNSE-UHFFFAOYSA-N ethyl 2-[4-acetamido-3-(4-chlorophenyl)sulfanyl-2-methylindol-1-yl]acetate Chemical compound C12=C(NC(C)=O)C=CC=C2N(CC(=O)OCC)C(C)=C1SC1=CC=C(Cl)C=C1 NJAHLZZJVRKNSE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK10180348.4T 2003-05-27 2004-05-25 4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound DK2281815T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE0301569A SE0301569D0 (sv)	2003-05-27	2003-05-27	Novel compounds
SE0302305A SE0302305D0 (sv)	2003-05-27	2003-08-27	Novel Compounds
EP08165755A EP2025670B1 (en)	2003-05-27	2004-05-25	Use of 3-phenylthio-1H-indole-1-acetic acid derivatives as modulators of CRTh2 receptor activity

Publications (1)

Publication Number	Publication Date
DK2281815T3 true DK2281815T3 (da)	2012-06-18

Family

ID=33492578

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK08165755.3T DK2025670T3 (da)	2003-05-27	2004-05-25	Anvendelse af 3-phenylthio-1H-indol-1-eddikesyre-derivater som modulatorer af CRTh2-receptor aktivitet
DK04734774T DK1656346T3 (da)	2003-05-27	2004-05-25	1,2,3,4-tetrasubstituerede indol til behandling af luftvejssygdomme
DK10180348.4T DK2281815T3 (da)	2003-05-27	2004-05-25	4-(Acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid ethyl ester intermediate compound

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK08165755.3T DK2025670T3 (da)	2003-05-27	2004-05-25	Anvendelse af 3-phenylthio-1H-indol-1-eddikesyre-derivater som modulatorer af CRTh2-receptor aktivitet
DK04734774T DK1656346T3 (da)	2003-05-27	2004-05-25	1,2,3,4-tetrasubstituerede indol til behandling af luftvejssygdomme

Country Status (30)

Country	Link
US (4)	US7687535B2 (da)
EP (3)	EP2025670B1 (da)
JP (2)	JP4541361B2 (da)
KR (3)	KR20110050754A (da)
CN (2)	CN1795174B (da)
AR (1)	AR044552A1 (da)
AT (3)	ATE502010T1 (da)
AU (1)	AU2004242624B2 (da)
BR (1)	BRPI0410711B8 (da)
CA (1)	CA2526866C (da)
CO (1)	CO5630030A2 (da)
CY (3)	CY1109104T1 (da)
DE (2)	DE602004031894D1 (da)
DK (3)	DK2025670T3 (da)
ES (3)	ES2322650T3 (da)
HR (3)	HRP20090281T1 (da)
IL (4)	IL171928A (da)
IS (2)	IS2722B (da)
MX (1)	MXPA05012680A (da)
MY (1)	MY144483A (da)
NO (1)	NO20056130L (da)
NZ (1)	NZ543722A (da)
PL (3)	PL2281815T3 (da)
PT (3)	PT2025670E (da)
RU (1)	RU2361860C2 (da)
SE (2)	SE0301569D0 (da)
SI (3)	SI2281815T1 (da)
TW (2)	TWI328004B (da)
WO (1)	WO2004106302A1 (da)
ZA (1)	ZA200509598B (da)

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2003
- 2003-05-27 SE SE0301569A patent/SE0301569D0/xx unknown
- 2003-08-27 SE SE0302305A patent/SE0302305D0/xx unknown
2004
- 2004-05-19 TW TW093114113A patent/TWI328004B/zh not_active IP Right Cessation
- 2004-05-19 TW TW099109193A patent/TW201024261A/zh unknown
- 2004-05-24 AR ARP040101792A patent/AR044552A1/es unknown
- 2004-05-25 ES ES04734774T patent/ES2322650T3/es not_active Expired - Lifetime
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- 2004-05-25 WO PCT/SE2004/000808 patent/WO2004106302A1/en not_active Ceased
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- 2004-05-25 EP EP04734774A patent/EP1656346B1/en not_active Expired - Lifetime
- 2004-05-25 RU RU2005137403/04A patent/RU2361860C2/ru active
- 2004-05-25 DK DK08165755.3T patent/DK2025670T3/da active
- 2004-05-25 KR KR1020117009790A patent/KR20110050754A/ko not_active Ceased
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2008
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2009
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Also Published As

Publication number	Publication date
DE602004031894D1 (de)	2011-04-28
KR20060015303A (ko)	2006-02-16
CY1111469T1 (el)	2015-08-05
CO5630030A2 (es)	2006-04-28
TWI328004B (en)	2010-08-01
CY1109104T1 (el)	2014-07-02
EP2025670B1 (en)	2011-03-16
RU2361860C2 (ru)	2009-07-20
PL2025670T3 (pl)	2011-07-29
HRP20120390T1 (hr)	2012-06-30
US20080249110A1 (en)	2008-10-09
IL212265A0 (en)	2011-06-30
SE0301569D0 (sv)	2003-05-27
PL1656346T3 (pl)	2009-07-31
JP2010155862A (ja)	2010-07-15
SE0302305D0 (sv)	2003-08-27
NZ543722A (en)	2007-05-31
AU2004242624A1 (en)	2004-12-09
HK1126773A1 (en)	2009-09-11
US7687535B2 (en)	2010-03-30
IL194872A0 (en)	2011-08-01
ATE552243T1 (de)	2012-04-15
CY1112853T1 (el)	2016-02-10
HRP20090281T1 (hr)	2009-06-30
CN1795174B (zh)	2011-09-28
ES2361485T3 (es)	2011-06-17
BRPI0410711B8 (pt)	2021-05-25
ES2382606T3 (es)	2012-06-11
AR044552A1 (es)	2005-09-21
TW200510301A (en)	2005-03-16
IS8920A (is)	2010-08-09
BRPI0410711A (pt)	2006-06-13
KR101067586B1 (ko)	2011-09-27
HRP20110359T1 (hr)	2011-06-30
JP4541361B2 (ja)	2010-09-08
IL171928A0 (en)	2006-04-10
TW201024261A (en)	2010-07-01
NO20056130L (no)	2006-02-27
DK1656346T3 (da)	2009-06-15
MY144483A (en)	2011-09-30
CA2526866C (en)	2012-10-16
US20090163518A1 (en)	2009-06-25
EP1656346B1 (en)	2009-03-18
HK1149563A1 (en)	2011-10-07
WO2004106302A1 (en)	2004-12-09
KR20110051297A (ko)	2011-05-17
SI2281815T1 (sl)	2012-06-29
RU2005137403A (ru)	2006-05-27
CN102391171A (zh)	2012-03-28
HK1090635A1 (zh)	2006-12-29
PT1656346E (pt)	2009-05-20
ATE502010T1 (de)	2011-04-15
IS2722B (is)	2011-03-15
ES2322650T3 (es)	2009-06-24
EP1656346A1 (en)	2006-05-17
MXPA05012680A (es)	2006-02-08
PL2281815T3 (pl)	2012-08-31
DK2025670T3 (da)	2011-06-06
EP2025670A1 (en)	2009-02-18
CA2526866A1 (en)	2004-12-09
IS8189A (is)	2005-12-20
PT2025670E (pt)	2011-05-24
JP2007501269A (ja)	2007-01-25
KR101067535B1 (ko)	2011-09-27
BRPI0410711B1 (pt)	2018-09-25
EP2281815B1 (en)	2012-04-04
US20110263614A1 (en)	2011-10-27
ATE425965T1 (de)	2009-04-15
SI1656346T1 (sl)	2009-08-31
KR20110050754A (ko)	2011-05-16
EP2281815A1 (en)	2011-02-09
DE602004020072D1 (de)	2009-04-30
IL212371A0 (en)	2011-06-30
CN1795174A (zh)	2006-06-28
ZA200509598B (en)	2006-12-27
US20120178764A1 (en)	2012-07-12
PT2281815E (pt)	2012-05-24
IL171928A (en)	2011-06-30
AU2004242624B2 (en)	2008-03-13
SI2025670T1 (sl)	2011-06-30

Publication	Publication Date	Title
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ATE368042T1 (de)	2007-08-15	Cephemverbindungen
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