DK2338508T3 - rDEN3/4delta 30(ME), rDEN2/4delta30(ME) eller rDEN1/4delta30(ME) rekombinant kimær Dengue-virus indeholdende en 30 nukleotiddeletion (delta30) i en sektion af den 3'-utranslaterede region af Dengue type 4 genom, hvor 30-nukleotiddeletionen svarer til TL2-hårnålestrukturen - Google Patents
rDEN3/4delta 30(ME), rDEN2/4delta30(ME) eller rDEN1/4delta30(ME) rekombinant kimær Dengue-virus indeholdende en 30 nukleotiddeletion (delta30) i en sektion af den 3'-utranslaterede region af Dengue type 4 genom, hvor 30-nukleotiddeletionen svarer til TL2-hårnålestrukturen Download PDFInfo
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- DK2338508T3 DK2338508T3 DK10177735.7T DK10177735T DK2338508T3 DK 2338508 T3 DK2338508 T3 DK 2338508T3 DK 10177735 T DK10177735 T DK 10177735T DK 2338508 T3 DK2338508 T3 DK 2338508T3
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- virus
- dengue
- rden4
- rden2
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Claims (12)
1. Rekombinant kimær Denguevirus omfattende en nukleinsyre-kimære omfattende en første nukleotidsekvens der koder for strukturproteinet C fra Dengue type 4 virus og strukturproteinerne M og E fra Denguevirus type 1, Denguevirus type 2 eller Denguevirus type 3, hvor regionen af Dengue type 4 virus, der koder for strukturproteinerne M og E, er erstattet af regionen, der koder for strukturproteinerne M og E fra Denguevirus type 1, Denguevirus type 2, eller Denguevirus type 3, og en anden nukleotidsekvens der koder for ikke-strukturproteiner fra Dengue type 4 virus og den 3'-utranslaterede region af Dengue type 4-genomet indeholdende en 30 nukleotiddeletion, der svarer til TL2-hårnålestrukturen mellem nukleotiderne 10478-10507 af Dengue type 4-genomet.
2. Rekombinant kimær Denguevirus ifølge krav 1, yderligere omfattende en mutation der tilvejebringer en fænotype, hvor fænotypen er temperaturfølsomhed i Vero-celler eller den humane levercellelinje HuH-7, værts-cellerestriktion i moskitoceller eller den humane levercellelinje HuH-7, værts-celletilpasning til forbedret replikation i Vero-ceWer, eller svækkelse i mus eller aber.
3. Rekombinant kimær Denguevirus ifølge krav 1 eller 2 til anvendelse i induktionen af et beskyttende immunrespons.
4. Rekombinant kimær Denguevirus til anvendelse i inducering af et beskyttende immunrespons ifølge krav 3, hvor den rekombinante kimære Denguevirus er omfattet i en vaccine, der skal administreres til et individ i en effektiv mængde.
5. Rekombinant kimær Denguevirus ifølge krav 1 eller 2 til anvendelse i forebyggelsen af en sygdom forårsaget af Denguevirus.
6. Rekombinant kimær Denguevirus til anvendelse i forebyggelse afen sygdom forårsaget af Denguevirus ifølge krav 5, hvor den rekombinante kimære Denguevirus er omfattet i en vaccine, der skal administreres til et individ i en effektiv mængde.
7. Vaccine eller immunogen sammensætning omfattende mindst én rekombinant kimær Denguevirus ifølge krav 1 eller 2.
8. Vaccinen eller den immunogene sammensætning ifølge krav 7 der er en Denguevirus vaccine eller en Denguevirus-immunogen sammensætning.
9. Vaccinen eller den immunogene sammensætning ifølge krav 7 eller 8 der er en tetravalent vaccine eller en tetravalent immunogen sammensætning.
10. Vaccinen eller den immunogene sammensætning ifølge et hvilket som helst af kravene 7 til 9 omfattende rDENl/4A30 (ME), rDEN2/4A30 (ME) og rDEN3/4A30 (ME), hvor: rDENl/4A30 (ME) er en kimær Denguevirus ifølge krav 1 omfattende en nukleinsyre-kimære omfattende en første nukleotidsekvens der koder for strukturproteinet C fra Dengue type 4 virus og strukturproteinerne M og E fra Denguevirus type 1, hvor regionen af Dengue type 4 virusen, der koder for strukturproteinerne M og E, er erstattet af regionen, der koder for strukturproteinerne M og E fra Denguevirus type 1, og en anden nukleotidsekvens der koder for ikke-strukturproteiner fra Dengue type 4 virus, og den 3'-utranslaterede region af Dengue type 4-genomet indeholdende 30 nukleotiddeletionen; rDEN2/4A30 (ME) er en kimær Denguevirus ifølge krav 1 omfattende en nukleinsyre-kimære omfattende en første nukleotidsekvens der koder for strukturproteinet C fra Dengue type 4 virus og strukturproteinerne M og E fra Denguevirus type 2, hvor regionen af Dengue type 4 virusen, der koder for strukturproteinerne M og E, er erstattet af regionen, der koder for strukturproteinerne M og E fra Denguevirus type 2, og en anden nukleotidsekvens der koder for ikke-strukturproteiner fra Dengue type 4 virus, og den 3'-utranslaterede region af Dengue type 4-genomet indeholdende 30 nukleotiddeletionen; og rDEN3/4A30 (ME) er en kimær Dengue-virus ifølge krav 1 omfattende en nukleinsyre-kimære omfattende en første nukleotidsekvens der koder for strukturproteinet C fra Dengue type 4 virus og strukturproteinerne M og E fra Denguevirus type 3, hvor regionen af Dengue type 4 virusen, der koder for strukturproteinerne M og E, er erstattet af regionen, der koder for strukturproteinerne M og E fra Denguevirus type 3, og en anden nukleotidsekvens der koder for ikke-strukturproteiner fra Dengue type 4 virus, og den 3'-utranslaterede region af Dengue type 4-genomet indeholdende 30 nukleotiddeletionen.
11. Rekombinant kimær Denguevirus til anvendelse i induktionen afen beskyttende immunrespons ifølge krav 3 eller 4, der skal administreres til et humant individ.
12. Rekombinant kimær Denguevirus til anvendelse i forebyggelse af en sygdom forårsaget af Denguevirus ifølge krav 5 eller 6, der skal administreres til et humant individ.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37786002P | 2002-05-03 | 2002-05-03 | |
| US43650002P | 2002-12-23 | 2002-12-23 | |
| EP03724319A EP1554301B1 (en) | 2002-05-03 | 2003-04-25 | Dengue vaccine containing a common 30 nucleotide deletion in the 3'-utr of dengue types 1 and 2. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2338508T3 true DK2338508T3 (da) | 2018-05-28 |
Family
ID=29406814
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03724319.3T DK1554301T3 (da) | 2002-05-03 | 2003-04-25 | Dengue-vaccine med en fælles udeladelse af 30 nukleotider i Dengue-typerne 1's og 2's3'UTR |
| DK10177735.7T DK2338508T3 (da) | 2002-05-03 | 2003-04-25 | rDEN3/4delta 30(ME), rDEN2/4delta30(ME) eller rDEN1/4delta30(ME) rekombinant kimær Dengue-virus indeholdende en 30 nukleotiddeletion (delta30) i en sektion af den 3'-utranslaterede region af Dengue type 4 genom, hvor 30-nukleotiddeletionen svarer til TL2-hårnålestrukturen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03724319.3T DK1554301T3 (da) | 2002-05-03 | 2003-04-25 | Dengue-vaccine med en fælles udeladelse af 30 nukleotider i Dengue-typerne 1's og 2's3'UTR |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US7517531B2 (da) |
| EP (5) | EP3763382A1 (da) |
| JP (1) | JP4977811B2 (da) |
| AT (1) | ATE481982T1 (da) |
| BR (1) | BRPI0309631B1 (da) |
| CA (1) | CA2483653C (da) |
| CY (1) | CY1120558T1 (da) |
| DE (1) | DE60334310D1 (da) |
| DK (2) | DK1554301T3 (da) |
| ES (2) | ES2677348T3 (da) |
| HU (1) | HUE037330T2 (da) |
| PT (2) | PT2338508T (da) |
| SI (2) | SI2338508T1 (da) |
| TR (1) | TR201806655T4 (da) |
| WO (1) | WO2003092592A2 (da) |
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| HUE037330T2 (hu) * | 2002-05-03 | 2018-08-28 | The Government Of The Us Secretary Department Of Health And Human Services | rDEN3/4delta30(ME), rDEN2/4delta30(ME) vagy rDEN1/4delta30(ME) rekombináns kiméra dengue virus, amely 30 nukleotidos deléciót tartalmaz (delta 30) a 4-es típusú dengue genom 3' nem-transzlálódó régiójában, ahol a szóban forgó 30 nukleotidos deléció megfelel a TL2 nyél-hurok szerkezetnek |
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| MY192543A (en) | 2014-12-22 | 2022-08-26 | Merck Sharp & Dohme | Dengue virus vaccine compositions and methods of use thereof |
| US10004795B2 (en) * | 2015-09-08 | 2018-06-26 | Fundacao Butantan | Process for preparing an attenuated tetravalent dengue vaccine |
| US11123420B2 (en) | 2015-09-30 | 2021-09-21 | Panacea Biotec Limited | Stable live attenuated recombinant dengue vaccine |
| US11285202B2 (en) * | 2016-01-26 | 2022-03-29 | University Of South Carolina | Polymer-protein core-shell particles as effective vaccine delivery vehicles and treatments methods using the same |
| CN109152828A (zh) | 2016-03-11 | 2019-01-04 | 美国政府(由卫生和人类服务部的部长所代表) | 减毒活zika病毒疫苗 |
| EP3442571A1 (en) * | 2016-04-13 | 2019-02-20 | Takeda Vaccines, Inc. | Compositions and methods of vaccination against dengue virus in children and young adults |
| WO2018129160A1 (en) | 2017-01-06 | 2018-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Live attenuated flavivirus vaccines and methods of using and making same |
| US20200390877A1 (en) | 2017-12-07 | 2020-12-17 | Merck Sharp & Dohme Corp. | Formulations of dengue virus vaccine compositions |
| BR112021004049A2 (pt) * | 2018-09-04 | 2021-05-25 | The Board Of Regents Of The University Of Texas System | vacinas vivas atenuadas lançadas por plasmídeo de dna para vírus de rna de fita simples de sentido positivo |
| WO2021173597A1 (en) * | 2020-02-28 | 2021-09-02 | Merck Sharp & Dohme Corp. | Dengue serotype specific rt-pcr multiplex assay |
| JP2025508605A (ja) * | 2022-02-22 | 2025-03-26 | フートル バイオ エルティーディーエー． | 次世代ｍＲＮＡワクチン |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU776638B2 (en) * | 1999-03-26 | 2004-09-16 | Walter Reed Army Institute Of Research | Adaptation of virus to vertebrate cells |
| EP1159969A1 (fr) * | 2000-05-30 | 2001-12-05 | Aventis Pasteur | Vaccine composition |
| EP1402075B1 (en) * | 2001-05-22 | 2012-11-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, | Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses |
| HUE037330T2 (hu) * | 2002-05-03 | 2018-08-28 | The Government Of The Us Secretary Department Of Health And Human Services | rDEN3/4delta30(ME), rDEN2/4delta30(ME) vagy rDEN1/4delta30(ME) rekombináns kiméra dengue virus, amely 30 nukleotidos deléciót tartalmaz (delta 30) a 4-es típusú dengue genom 3' nem-transzlálódó régiójában, ahol a szóban forgó 30 nukleotidos deléció megfelel a TL2 nyél-hurok szerkezetnek |
| DK2589602T3 (da) * | 2006-08-15 | 2016-07-25 | The Government Of The U S A As Repr By The Secretary Dept Of Health & Human Services The Nat Inst Of | Udvikling af dengue-virusvaccinekomponenter |
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