DK2470552T3 - Hidtil ukendte, krystallinske, heteroaromatiske fluorglycosidhydrater, lægemidler, der omfatter disse forbindelser, og deres anvendelse - Google Patents

Hidtil ukendte, krystallinske, heteroaromatiske fluorglycosidhydrater, lægemidler, der omfatter disse forbindelser, og deres anvendelse Download PDF

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Publication number
DK2470552T3
DK2470552T3 DK10747209.4T DK10747209T DK2470552T3 DK 2470552 T3 DK2470552 T3 DK 2470552T3 DK 10747209 T DK10747209 T DK 10747209T DK 2470552 T3 DK2470552 T3 DK 2470552T3
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formula
compound
combination
administered
theta
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DK10747209.4T
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David Rigal
Franceska Fischer
Bernd Becker
Martin Feth
Norbert Nagel
Bruno Baumgartner
Martin Broeckelmann
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Sanofi Sa
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (16)

1. Krystallinsk hydrat med formel I,
I hvor n har en værdi fra 2,1 til 2,5.
2. Krystallinsk hydrat med formel I ifølge krav 1, hvor n har en værdi på 2,25.
3. Krystallinsk hydrat med formel I ifølge et eller flere af kravene 1 til 2, hvor XRPD målt med CuKa-stråling har en hovedtop på 5,8 grader 2 theta ±0,2 grader 2 theta.
4. Krystallinsk hydrat med formel I ifølge et eller flere af kravene 1 til 3, hvor XRPD målt med CuKa-stråling mindst har toppe med følgende 2 theta-værdier: 5.8, 10,3, 14,2 ± 0,2 grader 2 theta.
5. Krystallinsk hydrat med formel I ifølge kravene 1 til 4, hvor XRPD målt med CuKa-stråling mindst har toppe med følgende 2 theta-værdier: 5.8, 7,1, 10,3, 14,2, 19,7 ± 0,2 grader 2 theta.
6. Krystallinsk hydrat med formel I ifølge kravene 1 til 5, hvor XRPD målt med CuKa-stråling mindst har toppe med følgende 2 theta-værdier: 5,8, 7,1, 10,3, 14,2, 19,9, 19,7, 21,8 ± 0,2 grader 2 theta.
7. Medikament i form of en suspension, der omfatter en eller flere af forbindelserne ifølge et eller flere af kravene 1 til 6.
8. Medikament i fast form, der omfatter en eller flere af forbindelserne ifølge et eller flere af kravene 1 til 6.
9. Medikament i form of en suspension, der omfatter en eller flere af forbindelserne ifølge et eller flere af kravene 1 til 6 og en eller flere blodglucosesænkende aktive bestanddele.
10. Medikament i fast form, der omfatter en eller flere af forbindelserne ifølge et eller flere af kravene 1 til 6 og en eller flere blodglucosesænkende aktive bestanddele.
11. Forbindelse ifølge et eller flere af kravene 1 til 6 til anvendelse i en fremgangsmåde til behandling af type 1- og type 2-diabetes.
12. Forbindelse ifølge et eller flere af kravene 1 til 6 til anvendelse i en fremgangsmåde til behandling til sænkning af blodglucose.
13. Forbindelse ifølge et eller flere af kravene 1 til 6 i kombination med mindst én anden blodglucosesænkende aktiv bestanddel til anvendelse i en fremgangsmåde til behandling af type 1- og type 2-diabetes.
14. Forbindelse ifølge et eller flere af kravene 1 til 6 i kombination med mindst én anden blodglucosesænkende aktiv bestanddel til anvendelse i en fremgangsmåde til behandling til sænkning af blodglucose.
15. Fremgangsmåde til fremstilling af et medikament, der omfatter forbindelsen ifølge et eller flere af kravene 1 til 6, som omfatter blanding af den aktive bestanddel med et farmaceutisk egnet bæremateriale og omdannelse af denne blanding til en form, der er egnet til administration.
16. Forbindelse ifølge et eller flere af kravene 1 til 6 til anvendelse som et lægemiddel.
DK10747209.4T 2009-08-26 2010-08-26 Hidtil ukendte, krystallinske, heteroaromatiske fluorglycosidhydrater, lægemidler, der omfatter disse forbindelser, og deres anvendelse DK2470552T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09290650 2009-08-26
PCT/EP2010/062461 WO2011023754A1 (en) 2009-08-26 2010-08-26 Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use

Publications (1)

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DK2470552T3 true DK2470552T3 (da) 2014-02-17

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DK10747209.4T DK2470552T3 (da) 2009-08-26 2010-08-26 Hidtil ukendte, krystallinske, heteroaromatiske fluorglycosidhydrater, lægemidler, der omfatter disse forbindelser, og deres anvendelse

Country Status (16)

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US (1) US8785608B2 (da)
EP (1) EP2470552B1 (da)
JP (1) JP2013503135A (da)
KR (1) KR20120060207A (da)
CN (1) CN102482312A (da)
AU (1) AU2010288523A1 (da)
BR (1) BR112012003973A2 (da)
CA (1) CA2771278A1 (da)
DK (1) DK2470552T3 (da)
ES (1) ES2443016T3 (da)
IL (1) IL218225A0 (da)
MX (1) MX2012001729A (da)
PT (1) PT2470552E (da)
RU (1) RU2012111354A (da)
SG (1) SG178880A1 (da)
WO (1) WO2011023754A1 (da)

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KR101721831B1 (ko) * 2014-11-06 2017-03-31 주식회사 종근당 로베글리타존을 함유하는 경구 투여용 약제학적 조성물
CN120795059A (zh) 2018-08-27 2025-10-17 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN115350184A (zh) * 2020-01-10 2022-11-18 康圣博施医药有限公司 药物的治疗组合以及其使用方法

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