DK2654964T3 - Mikrofluidindretning til manipulering af partikler - Google Patents

Mikrofluidindretning til manipulering af partikler Download PDF

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Publication number
DK2654964T3
DK2654964T3 DK11815589.4T DK11815589T DK2654964T3 DK 2654964 T3 DK2654964 T3 DK 2654964T3 DK 11815589 T DK11815589 T DK 11815589T DK 2654964 T3 DK2654964 T3 DK 2654964T3
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DK
Denmark
Prior art keywords
microfluidic device
manipulating particles
manipulating
particles
microfluidic
Prior art date
Application number
DK11815589.4T
Other languages
English (en)
Inventor
Gianni Medoro
Nicolò Manaresi
Original Assignee
Menarini Silicon Biosystems Spa
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Publication of DK2654964T3 publication Critical patent/DK2654964T3/da

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using Bluetooth®
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK11815589.4T 2010-12-22 2011-12-22 Mikrofluidindretning til manipulering af partikler DK2654964T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO2010A000755A IT1403518B1 (it) 2010-12-22 2010-12-22 Dispositivo microfluidico per la manipolazione di particelle
PCT/IB2011/055920 WO2012085884A1 (en) 2010-12-22 2011-12-22 Microfluidic device for the manipulation of particles

Publications (1)

Publication Number Publication Date
DK2654964T3 true DK2654964T3 (da) 2016-08-22

Family

ID=43736787

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11815589.4T DK2654964T3 (da) 2010-12-22 2011-12-22 Mikrofluidindretning til manipulering af partikler

Country Status (9)

Country Link
US (1) US9950322B2 (da)
EP (1) EP2654964B1 (da)
JP (2) JP6084575B2 (da)
CN (1) CN103282127B (da)
CA (1) CA2845690C (da)
DK (1) DK2654964T3 (da)
ES (1) ES2586404T3 (da)
IT (1) IT1403518B1 (da)
WO (1) WO2012085884A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102447457B1 (ko) * 2016-07-06 2022-09-27 프레시젼 나노시스템스 유엘씨 지능형 미세 유체 혼합 기기 및 카트리지
SG11201903247VA (en) * 2016-10-18 2019-05-30 Menarini Silicon Biosystems Spa Microfluidic device, microfluidic system and method for the isolation of particles
IT201600104601A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico
IT201700105948A1 (it) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per il recupero di particelle
IT201700105911A1 (it) 2017-09-21 2019-03-21 Menarini Silicon Biosystems Spa Metodo ed apparato per la riduzione del volume di un campione
CN112119311B (zh) * 2018-07-27 2024-12-20 泽普托生命技术股份有限公司 用于处理基于gmr的生物标志物检测中的分析物信号的系统和方法
IT201900002777A1 (it) 2019-02-26 2020-08-26 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per l'isolamento di particelle
EP4087625A4 (en) 2020-01-08 2024-03-13 Zepto Life Technology, LLC POLYMER COMPOSITIONS AND BIOSURFACES INCLUDING THEM ON SENSORS
IT202100013715A1 (it) 2021-05-26 2022-11-26 Menarini Silicon Biosystems Spa Metodo e sistema microfluidico per l'isolamento di particelle

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58211272A (ja) 1982-06-02 1983-12-08 Hitachi Ltd 閾値決定法
US5252493A (en) 1986-09-22 1993-10-12 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor
JPH02162213A (ja) * 1988-12-15 1990-06-21 Anritsu Corp Ｉｃカードを使用する測定装置
DE3931851A1 (de) 1989-09-23 1991-04-11 Heinrich Joern Dipl Chem Computergesteuerter potentialdifferenz-leitfaehigkeitsscanner fuer traegerfreie elektrophorese
JPH05501612A (ja) 1989-11-13 1993-03-25 チルドレンズ・メデイカル・センター・コーポレーシヨン 胎児ｄｎａ単離および検出のための非侵入性方法
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
GB8926781D0 (en) 1989-11-27 1990-01-17 Nat Res Dev Identification of micro-organisms
US6149789A (en) 1990-10-31 2000-11-21 Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Process for manipulating microscopic, dielectric particles and a device therefor
DE4214320C1 (da) 1992-05-04 1993-06-03 Erwin Halder Kg, 7958 Laupheim, De
JP2541081B2 (ja) * 1992-08-28 1996-10-09 日本電気株式会社 バイオセンサ及びバイオセンサの製造・使用方法
US5690893A (en) * 1994-06-10 1997-11-25 Hitachi, Ltd. Analyzer having sensor with memory device
JP3332664B2 (ja) * 1994-06-10 2002-10-07 株式会社日立製作所 分析装置及び要素パッケージ
DE19500660B4 (de) 1994-12-10 2007-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung und Verfahren zur Manipulation mikroskopisch kleiner Partikel sowie deren Verwendung
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5888370A (en) 1996-02-23 1999-03-30 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation
US5945281A (en) 1996-02-02 1999-08-31 Becton, Dickinson And Company Method and apparatus for determining an analyte from a sample fluid
GB9615775D0 (en) 1996-07-26 1996-09-04 British Tech Group Apparatus and method for characterising particles using dielectrophoresis
DK0925494T3 (da) 1996-09-04 2002-07-01 Scandinavian Micro Biodevices Mikrostrømningssystem til partikelseparation og analyse
WO1999017883A1 (en) 1997-10-06 1999-04-15 California Institute Of Technology Electrostatic particle transportation
EP1179585B1 (en) * 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US6203683B1 (en) 1998-11-09 2001-03-20 Princeton University Electrodynamically focused thermal cycling device
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US20030228565A1 (en) 2000-04-26 2003-12-11 Cytokinetics, Inc. Method and apparatus for predictive cellular bioinformatics
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
IT1309430B1 (it) 1999-05-18 2002-01-23 Guerrieri Roberto Metodo ed apparato per la manipolazione di particelle per mezzo delladielettroforesi
US6824664B1 (en) 1999-11-04 2004-11-30 Princeton University Electrode-less dielectrophorises for polarizable particles
DE60130052T2 (de) 2000-04-13 2008-05-15 Wako Pure Chemical Industries, Ltd. Elektroden-Bau für dielektrophoretische Anordnung und dielektrophoretische Trennung
US6899849B2 (en) 2000-07-28 2005-05-31 The Regents Of The University Of California Integrated sensor
WO2002012896A1 (en) 2000-08-08 2002-02-14 Aviva Biosciences Corporation Methods for manipulating moieties in microfluidic systems
US6833542B2 (en) 2000-11-13 2004-12-21 Genoptix, Inc. Method for sorting particles
DE10059152C2 (de) 2000-11-29 2003-03-27 Evotec Ag Mikrosystem zur dielektrischen und optischen Manipulierung von Partikeln
US6764583B2 (en) 2000-12-13 2004-07-20 The Regents Of The University Of California Using impedance measurements for detecting pathogens trapped in an electric field
JP3868788B2 (ja) 2001-10-15 2007-01-17 株式会社東芝 電気泳動表示装置
JP2002311461A (ja) 2001-04-17 2002-10-23 Sharp Corp 表示素子
ITTO20010411A1 (it) 2001-05-02 2002-11-02 Silicon Biosystems S R L Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti.
US20030073110A1 (en) 2001-07-03 2003-04-17 Masaharu Aritomi Method for isolating nucleic acid and a cartridge for chemical reaction and for nucleic acid isolation
ITTO20010801A1 (it) 2001-08-07 2003-02-07 Silicon Biosystems S R L Metodo e dispositivo per analisi biomolecolari integrate.
ATE325364T1 (de) 2001-08-23 2006-06-15 Koninkl Philips Electronics Nv Elektrophoretische anzeigevorrichtung
US6726820B1 (en) * 2001-09-19 2004-04-27 Applera Corporation Method of separating biomolecule-containing samples with a microdevice with integrated memory
US7163612B2 (en) 2001-11-26 2007-01-16 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
JP3845583B2 (ja) 2002-01-09 2006-11-15 株式会社東芝 電気泳動表示装置及びその製造方法
DE10203636B4 (de) 2002-01-30 2004-02-12 Testo Gmbh & Co Vorrichtung zum Nachweis von Partikeln in einem Fluid
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US7147763B2 (en) 2002-04-01 2006-12-12 Palo Alto Research Center Incorporated Apparatus and method for using electrostatic force to cause fluid movement
DK1499548T3 (da) 2002-04-26 2008-09-01 Ventana Med Syst Inc Fremgangsmåde og apparat til automatiseret pålægning af dækglas
US20060086309A1 (en) 2002-06-24 2006-04-27 Fluiding Corporation Recirculating fluidic network and methods for using the same
US6838056B2 (en) * 2002-07-08 2005-01-04 Innovative Micro Technology Method and apparatus for sorting biological cells with a MEMS device
US20040011652A1 (en) 2002-07-16 2004-01-22 Bressler Vincent Edward Separation of particles using multiple conductive layers
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US7329545B2 (en) 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
EP2359689B1 (en) 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
US6888721B1 (en) 2002-10-18 2005-05-03 Atec Corporation Electrohydrodynamic (EHD) thin film evaporator with splayed electrodes
US7118708B2 (en) * 2002-11-12 2006-10-10 Automated Biotechnology, Inc. System of sample medium carriers with built-in memory elements and information input/output station for the carriers
US7445926B2 (en) 2002-12-30 2008-11-04 The Regents Of The University Of California Fluid control structures in microfluidic devices
DE10304653B4 (de) 2003-02-05 2005-01-27 Evotec Technologies Gmbh Mehrparametrige Detektion in einem fluidischen Mikrosystem
GB0303305D0 (en) 2003-02-12 2003-03-19 Secr Defence Apparatus for collecting particles
US20050181429A1 (en) 2003-04-03 2005-08-18 Monaliza Medical Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
DE602004022559D1 (de) * 2003-08-04 2009-09-24 Caliper Life Sciences Inc Verfahren und system zur bearbeitung von bauelementen im mikromassstab zur wiederverwendung
DE10352887A1 (de) * 2003-11-10 2005-04-21 Infineon Technologies Ag Vorrichtung zur Vervielfältigung und Charakterisierung von Nukleinsäure-Proben mit flexiblem Speicherelement zur Speicherung von probenspezifischen Daten
US7476360B2 (en) 2003-12-09 2009-01-13 Genefluidics, Inc. Cartridge for use with electrochemical sensor
JP2007516449A (ja) * 2003-12-23 2007-06-21 イージーン，インコーポレイティド 生体分析カートリッジの記録及び保護機構
US7160425B2 (en) 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
DE102004017474A1 (de) 2004-04-08 2005-10-27 Evotec Technologies Gmbh Messeinrichtung zur Impedanzspektroskopie und zugehöriges Messverfahren
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
DE102004047752B3 (de) 2004-09-30 2006-01-26 Infineon Technologies Ag Halbleiterbauteil mit Temperatursensor
WO2006058245A2 (en) 2004-11-29 2006-06-01 The Regents Of The University Of California Dielectrophoretic particle sorter
US20080264068A1 (en) 2004-12-03 2008-10-30 Shinichi Nakasuka Magnetic Convection Heat Circulation Pump
US20060223178A1 (en) 2005-04-05 2006-10-05 Tom Barber Devices and methods for magnetic enrichment of cells and other particles
US20070026415A1 (en) 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP2007017163A (ja) 2005-07-05 2007-01-25 Sumitomo Chemical Co Ltd 粒状製品の評価方法
ITBO20050481A1 (it) 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US8480053B2 (en) 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
US20070059683A1 (en) 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
WO2007044888A2 (en) 2005-10-11 2007-04-19 The Johns Hopkins Univerisity Microfluidic device and method for high-throughput cellular gradient and dose response studies
ITBO20050643A1 (it) 2005-10-24 2007-04-25 Si Bio S R L Metodo ed apparato per la manipolazione di particelle in soluzioni conduttive
ITBO20050646A1 (it) 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
GB2435925A (en) 2006-03-09 2007-09-12 Cytokinetics Inc Cellular predictive models for toxicities
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
ITTO20060273A1 (it) 2006-04-12 2007-10-13 Silicon Biosystem S P A Metodi ed apparati per la selezione e/o il processamento di particellle, in particolare per la lisi selettiva e/o ottimizzata di cellule
US20080090239A1 (en) 2006-06-14 2008-04-17 Daniel Shoemaker Rare cell analysis using sample splitting and dna tags
EP4170042A1 (en) 2006-06-14 2023-04-26 Verinata Health, Inc. Methods for the diagnosis of fetal abnormalities
US7295141B1 (en) 2006-07-17 2007-11-13 Fortemedia, Inc. Method for mixing signals with an analog-to-digital converter
KR100818274B1 (ko) 2006-09-05 2008-04-01 삼성전자주식회사 미세유동 시스템 제어장치 및 그 방법, 및 미세유동 시스템
US20100233693A1 (en) 2007-04-16 2010-09-16 On-O-ity, Inc Methods for diagnosing, prognosing, or theranosing a condition using rare cells
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
JP2009058352A (ja) * 2007-08-31 2009-03-19 Konica Minolta Medical & Graphic Inc 検査装置
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
ITTO20080104A1 (it) 2008-02-08 2009-08-09 Silicon Biosystems Spa Apparato e metodo per il conteggio e l'identificazione di particelle di interesse in un fluido
CN108088824B (zh) * 2008-03-14 2021-06-04 雅培快速诊断耶拿有限公司 一种用于检测分析物的系统
WO2009137415A2 (en) * 2008-05-03 2009-11-12 Advanced Liquid Logic, Inc. Reagent and sample preparation, loading, and storage
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
JP5834001B2 (ja) 2009-03-17 2015-12-16 シリコン・バイオシステムズ・ソシエタ・ペル・アチオニ 細胞を分離するためのマイクロ流体デバイス
RU2011142784A (ru) * 2009-03-23 2013-04-27 Конинклейке Филипс Электроникс Н.В. Манипуляция магнитными частицами в биологическом образце
IT1397819B1 (it) 2009-12-17 2013-02-04 Silicon Biosystems Spa Sistema microfluidico
IT1398480B1 (it) 2009-12-17 2013-03-01 Silicon Biosystems Spa Sistema microfluidico
IT1397820B1 (it) 2009-12-17 2013-02-04 Silicon Biosystems Spa Sistema microfluidico

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EP2654964B1 (en) 2016-05-11
CN103282127B (zh) 2016-02-24
JP2017077557A (ja) 2017-04-27
JP2014508026A (ja) 2014-04-03
US20130343966A1 (en) 2013-12-26
CA2845690A1 (en) 2012-06-28
EP2654964A1 (en) 2013-10-30
JP6084575B2 (ja) 2017-02-22
ITBO20100755A1 (it) 2012-06-23
CN103282127A (zh) 2013-09-04
ES2586404T3 (es) 2016-10-14
IT1403518B1 (it) 2013-10-31
WO2012085884A8 (en) 2012-09-07
CA2845690C (en) 2019-11-05
WO2012085884A1 (en) 2012-06-28
US9950322B2 (en) 2018-04-24

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