DK2673048T3 - Behandling af bipolære lidelser - Google Patents
Behandling af bipolære lidelser Download PDFInfo
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- DK2673048T3 DK2673048T3 DK12706085.3T DK12706085T DK2673048T3 DK 2673048 T3 DK2673048 T3 DK 2673048T3 DK 12706085 T DK12706085 T DK 12706085T DK 2673048 T3 DK2673048 T3 DK 2673048T3
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- ebselen
- pharmaceutically acceptable
- per day
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D293/12—Selenazoles; Hydrogenated selenazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (9)
1. Forbindelse med formel I, eller et farmaceutisk acceptabelt salt deraf, til anvendelse i behandlingen af bipolære lidelser, i hvilken formel I er:
formel I hvor: E er S eller Se og hver af phenylringene A og B er eventuelt substitueret med én eller flere substituenter, hvor hver substituent er valgt uafhængigt fra: (1) halogen, der fortrinsvis er valgt fra F, Cl og Br; (2) C1-C4 alkyl, såsom C1-C2 alkyl eller Ci alkyl, eventuelt substitueret med ét eller flere halogenatomer, der hver fortrinsvis er valgt fra F, Cl og Br; og (3) C1-C4 alkoxy, såsom C1-C2 alkoxy or Ci alkoxy; eventuelt substitueret med ét eller flere halogenatomer, der hver fortrinsvis er valgt fra F, Cl og Br.
2. Anvendelse afen forbindelse med formel I ifølge krav 1, eller et farmaceutisk acceptabelt salt deraf, i fremstillingen af et medikament til behandlingen af bipolære lidelser.
3. Forbindelsen til anvendelse eller anvendelse ifølge krav 1 eller krav 2, hvor mængden af forbindelsen med formel I eller farmaceutisk acceptabelt salt deraf administreres til patienten eller hvilket er til stede i medikamentet i området på fra 10 til 2000 mg pr. dag, fx fra 10 til 300 mg pr. dag.
4. Forbindelsen til anvendelse eller anvendelse ifølge krav 3, hvor forbindelsen med formel I, eller farmaceutisk acceptabelt salt deraf, er tilvejebragt i en dosis pr. dag eller mere udover end én dosis pr. dag, fx to eller tre doser pr. dag.
5. Forbindelsen til anvendelse ifølge et hvilket som helst af kravene 1 til 4, hvor forbindelsen med formel I, eller farmaceutisk acceptabelt salt deraf, anvendes i kombination med én eller flere yderligere forbindelser der er effektive til behandling af bipolære lidelser.
6. Forbindelsen til anvendelse ifølge krav 5, hvor den ene eller flere yderligere forbindelser er valgt fra én eller flere af valpronsyre, lamotrigin, carbamazapin, farmaceutisk acceptable salte af én eller flere deraf, og farmaceutisk acceptable salte af lithium.
7. Forbindelsen til anvendelse ifølge krav 5 eller krav 6, hvor forbindelsen med formel I og den ene eller flere yderligere forbindelser der er effektiv til behandling af bipolære lidelser er til administration simultant, sekventielt eller separat.
8. Forbindelsen til anvendelse ifølge et hvilket som helst af kravene 1 til 7, hvor forbindelsen er valgt fra;
(2-phenyl-l,2-benzisothiazol-3(2H)-on) og
(2-phenyl-l,2-benzisoselenazol-3(2H)-on eller ebselen).
9. Forbindelsen til anvendelse ifølge krav 8, hvor forbindelsen er ebselen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1102248.0A GB201102248D0 (en) | 2011-02-09 | 2011-02-09 | Treatment of bipolar disorder |
| PCT/GB2012/050105 WO2012107735A2 (en) | 2011-02-09 | 2012-01-18 | Treatment of bipolar disorder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2673048T3 true DK2673048T3 (da) | 2016-03-29 |
Family
ID=43836453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12706085.3T DK2673048T3 (da) | 2011-02-09 | 2012-01-18 | Behandling af bipolære lidelser |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8901158B2 (da) |
| EP (1) | EP2673048B1 (da) |
| DK (1) | DK2673048T3 (da) |
| ES (1) | ES2566769T3 (da) |
| GB (1) | GB201102248D0 (da) |
| WO (1) | WO2012107735A2 (da) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10058542B1 (en) | 2014-09-12 | 2018-08-28 | Thioredoxin Systems Ab | Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith |
| GB2550110A (en) | 2016-04-28 | 2017-11-15 | Univ Oxford Innovation Ltd | Treatment of impulsivity-related disorders |
| US11053236B2 (en) * | 2016-06-21 | 2021-07-06 | The University Of Toledo | Substituted isoselenazolone anti-infective, anti-inflammatory, anti-cancer, cytoprotective, neuroprotective, and anti-oxidant agents |
| GB201717629D0 (en) | 2017-10-26 | 2017-12-13 | Univ Oxford Innovation Ltd | Treatment of unipolar depressive disorder |
| EP4551214A1 (fr) | 2022-07-05 | 2025-05-14 | Association Française contre les Myopathies | Utilisation de l'ebselen ou l'un de ses derives pour traiter des pathologies ou dysfonctionnements des mitochondries |
| IT202200018339A1 (it) * | 2022-09-08 | 2024-03-08 | Univ Degli Studi Di Trento | Composti del selenio e dello zolfo quali inibitori del riconoscimento degli RNA modificati da N6-metiladenosina da parte delle proteine YTHDF |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3720493A1 (de) | 1987-06-20 | 1989-01-26 | Nattermann A & Cie | Arzneizubereitungen mit mikronisierten ebselen-kristallen |
| US4981980A (en) | 1989-09-14 | 1991-01-01 | Merck & Co., Inc. | Drug for treating manic depression |
| DE4024885C2 (de) | 1990-08-06 | 2002-07-18 | Nattermann A & Cie | Verwendung von 2-Phenyl-1,2-benzisoselenazol-3(2H)-on |
| GB9202915D0 (en) | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| DE69626010T2 (de) | 1995-05-24 | 2003-07-24 | Gruppo Lepetit S.P.A., Lainate | Verwendung von tropolon derivate zur hemmung des inositmono phosphatase |
| ES2177849T3 (es) | 1996-08-27 | 2002-12-16 | Nattermann A & Cie | Preparado farmaceutico, que contiene 2-fenil-1,2-benzoisoselenazol-3(2h)-ona, para el tratamiento de la enfermedad de alzheimer. |
| AU3201599A (en) | 1998-03-24 | 1999-10-18 | Bellsouth Intellectual Property Corporation | Wireless telemetry methods and systems for communicating with or controlling intelligent devices |
| CA2363942A1 (en) | 1999-04-06 | 2000-10-12 | Sepracor Inc. | Methods and compositions for the treatment of psychotic and related disorders using ziprasidone metabolites |
| US20040029934A1 (en) | 2000-12-28 | 2004-02-12 | Kiyoshi Ebihara | Pharmaceutical emulsion preparation |
| RU2003119972A (ru) | 2001-01-04 | 2004-12-27 | Дайити Фармасьютикал Ко., Лтд. (JP) | Препараты циклодекстрина |
| EP1558608A1 (en) | 2002-10-28 | 2005-08-03 | Warner-Lambert Company LLC | Oxindole substituted piperazine derivatives |
| KR20070113262A (ko) | 2005-03-08 | 2007-11-28 | 사운드 파마슈티칼스 인코퍼레이티드 | 암의 치료 방법 및 암 치료용 조성물 |
| JP2008007446A (ja) | 2006-06-28 | 2008-01-17 | Gunma Prefecture | 神経栄養因子とその利用法 |
| US20100222326A1 (en) | 2007-04-27 | 2010-09-02 | Ucb Pharma, S.A. | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders |
| CA2723946A1 (en) | 2008-05-15 | 2009-11-19 | Ben-Gurion University Of The Negev Research And Development Authority | Molecules interfering with binding of calbindin to inositol monophosphatase for the treatment of mood disorders |
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2011
- 2011-02-09 GB GBGB1102248.0A patent/GB201102248D0/en not_active Ceased
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2012
- 2012-01-18 DK DK12706085.3T patent/DK2673048T3/da active
- 2012-01-18 EP EP12706085.3A patent/EP2673048B1/en active Active
- 2012-01-18 WO PCT/GB2012/050105 patent/WO2012107735A2/en not_active Ceased
- 2012-01-18 US US13/983,011 patent/US8901158B2/en active Active
- 2012-01-18 ES ES12706085.3T patent/ES2566769T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8901158B2 (en) | 2014-12-02 |
| GB201102248D0 (en) | 2011-03-23 |
| WO2012107735A2 (en) | 2012-08-16 |
| ES2566769T3 (es) | 2016-04-15 |
| EP2673048B1 (en) | 2016-01-13 |
| EP2673048A2 (en) | 2013-12-18 |
| WO2012107735A3 (en) | 2013-01-03 |
| US20140094449A1 (en) | 2014-04-03 |
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