DK2772535T3 - ABC5-positive mesenkymale stamceller som immunmodulatorer - Google Patents

ABC5-positive mesenkymale stamceller som immunmodulatorer Download PDF

Info

Publication number
DK2772535T3
DK2772535T3 DK14168199.9T DK14168199T DK2772535T3 DK 2772535 T3 DK2772535 T3 DK 2772535T3 DK 14168199 T DK14168199 T DK 14168199T DK 2772535 T3 DK2772535 T3 DK 2772535T3
Authority
DK
Denmark
Prior art keywords
abc5
stem cells
mesenchymal stem
immune modulators
positive mesenchymal
Prior art date
Application number
DK14168199.9T
Other languages
English (en)
Inventor
Markus H Frank
Original Assignee
Childrens Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Medical Center filed Critical Childrens Medical Center
Application granted granted Critical
Publication of DK2772535T3 publication Critical patent/DK2772535T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK14168199.9T 2006-05-31 2007-05-31 ABC5-positive mesenkymale stamceller som immunmodulatorer DK2772535T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80940706P 2006-05-31 2006-05-31
EP07795647.2A EP2035549B1 (en) 2006-05-31 2007-05-31 Abcb5 positive mesenchymal stem cells as immunomodulators

Publications (1)

Publication Number Publication Date
DK2772535T3 true DK2772535T3 (da) 2022-07-04

Family

ID=38594403

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07795647.2T DK2035549T3 (da) 2006-05-31 2007-05-31 Abcb5-positive mesenkymale stamceller som immunmodulatorer
DK14168199.9T DK2772535T3 (da) 2006-05-31 2007-05-31 ABC5-positive mesenkymale stamceller som immunmodulatorer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK07795647.2T DK2035549T3 (da) 2006-05-31 2007-05-31 Abcb5-positive mesenkymale stamceller som immunmodulatorer

Country Status (12)

Country Link
US (4) US8455245B2 (da)
EP (2) EP2772535B1 (da)
AU (1) AU2007254894B9 (da)
CA (1) CA2685492C (da)
DK (2) DK2035549T3 (da)
ES (2) ES2511791T3 (da)
HU (1) HUE059011T2 (da)
LT (1) LT2772535T (da)
PL (2) PL2035549T3 (da)
PT (2) PT2772535T (da)
SI (2) SI2772535T1 (da)
WO (1) WO2007143139A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290028B1 (en) * 2000-06-05 2009-12-23 The Brigham And Women's Hospital, Inc. A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF
ES2511791T3 (es) 2006-05-31 2014-10-23 Children's Medical Center Corporation Células madre mesenquimales positivas para ABCB5 como moduladoras de inmunidad
HUE039385T2 (hu) 2007-04-12 2018-12-28 Brigham & Womens Hospital Inc ABCB5 rákterápiás célzása
US20110287034A1 (en) 2008-11-14 2011-11-24 The Brigham And Womens Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
WO2014130518A1 (en) * 2013-02-19 2014-08-28 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
JP6600299B2 (ja) * 2013-05-10 2019-10-30 ザ チルドレンズ メディカル センター コーポレーション 創傷治癒および組織工学
US20150310380A1 (en) * 2014-04-28 2015-10-29 Patent Investment & Licensing Company Dispatch system having control shared with dispatched service providers
KR101723265B1 (ko) * 2013-08-16 2017-04-04 가톨릭대학교 산학협력단 mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물
ES2769778T3 (es) 2013-12-13 2020-06-29 Swedish Stromabio Ab Composiciones inmunomoduladoras
WO2015148512A1 (en) 2014-03-24 2015-10-01 Qt Holdings Corp Shaped articles including hydrogels and methods of manufacture and use thereof
US9790467B2 (en) 2015-09-22 2017-10-17 Qt Holdings Corp Methods and compositions for activation or expansion of T lymphocytes
EP3784249A4 (en) 2018-04-25 2022-03-02 Children's Medical Center Corporation ABCB5 LIGANDS AND SUBSTRATES
WO2020041217A1 (en) 2018-08-18 2020-02-27 President And Fellows Of Harvard College In situ gene editing
US20200061365A1 (en) * 2018-08-24 2020-02-27 Instant Systems, Inc. Cell storage container for use with sterile docking systems
BR112021019349A2 (pt) * 2019-03-28 2021-12-07 Childrens Medical Center Células-tronco preparadas altamente funcionais
CA3137899A1 (en) * 2019-04-24 2020-10-29 Children's Medical Center Corporation Abcb5+ stem cell therapeutics for liver disease
EP4125960A4 (en) * 2020-03-30 2024-04-03 Children's Medical Center Corporation USING STEM CELLS TO TREAT EXCESSIVE INFLAMMATION
EP4351721A4 (en) * 2021-05-13 2025-04-30 Primegen US, Inc. Methods and compositions for the treatment of liver diseases
US20230256065A1 (en) * 2022-02-16 2023-08-17 Elena RUSYN Autologous stem cell vaccine and methods
CN115260098B (zh) * 2022-06-09 2024-06-04 澳门科技大学 Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
EP0174810B1 (en) 1984-09-10 1993-07-21 HSC Research Development Corporation Multidrug resistance in mammalian cell lines and isolation of determinant glycoprotein dna
US4837306A (en) 1985-02-25 1989-06-06 The Ontario Cancer Institute Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen
US5837258A (en) 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
IT1257893B (it) 1992-06-17 1996-02-16 Ist Superiore Sanita Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.
WO1994009363A1 (en) 1992-10-14 1994-04-28 Board Of Regents, The University Of Texas System Cancer diagnosis and therapy
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
CA2251983C (en) 1996-04-19 2003-12-16 Sudhakar Kadiyala Regeneration and augmentation of bone using mesenchymal stem cells
US6152142A (en) 1997-02-28 2000-11-28 Tseng; Scheffer C. G. Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries
ES2237089T3 (es) 1998-03-13 2005-07-16 Osiris Therapeutics, Inc. Usos para celulas madre mesenquimatosas humanas no autologas.
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
ES2205792T3 (es) 1998-04-03 2004-05-01 Osiris Therapeutics, Inc. Celulas madre mesenquimatosas como inmunosupresores.
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
CA2328524A1 (en) 1998-05-29 1999-12-02 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
EP1290028B1 (en) 2000-06-05 2009-12-23 The Brigham And Women's Hospital, Inc. A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF
IL153375A0 (en) 2000-06-22 2003-07-06 Genentech Inc Agonist anti-trk-c monoclonal antibodies
SE517275C2 (sv) * 2000-09-20 2002-05-21 Obducat Ab Sätt vid våtetsning av ett substrat
JP2004531213A (ja) 2000-10-27 2004-10-14 インサイト・ゲノミックス・インコーポレイテッド 輸送体及びイオンチャネル
US6905678B2 (en) 2001-07-07 2005-06-14 Crucell Holland B.V. Gene delivery vectors with cell type specificity for mesenchymal stem cells
US7592174B2 (en) * 2002-05-31 2009-09-22 The Board Of Trustees Of The Leland Stanford Junior University Isolation of mesenchymal stem cells
PT1537878E (pt) 2002-07-03 2010-11-18 Ono Pharmaceutical Co Composições de imunopotenciação
WO2004056875A1 (en) 2002-12-23 2004-07-08 Wyeth Antibodies against pd-1 and uses therefor
GB0325130D0 (en) 2003-10-28 2003-12-03 Smith & Nephew Apparatus with scaffold
JP2007512017A (ja) 2003-11-24 2007-05-17 ザ ロックフェラー ユニバーシティー 自己複製多能性遅延周期細胞を単離する方法
AU2005205533B2 (en) 2004-01-07 2012-03-22 Novartis Vaccines And Diagnostics, Inc. M-CSF-specific monoclonal antibody and uses thereof
US20050186672A1 (en) 2004-01-27 2005-08-25 Reliance Life Sciences Pvt. Ltd. Tissue system with undifferentiated stem cells derived from corneal limbus
CA3218940A1 (en) 2004-11-12 2006-05-18 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
WO2006103685A2 (en) 2005-03-28 2006-10-05 Vision Research Foundation A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue
IN2014DN06624A (da) * 2005-10-18 2015-07-10 Univ Colorado
ES2511791T3 (es) 2006-05-31 2014-10-23 Children's Medical Center Corporation Células madre mesenquimales positivas para ABCB5 como moduladoras de inmunidad
EP2526970A1 (en) 2006-09-07 2012-11-28 Stemline Therapeutics, Inc. Monitoring cancer stem cells
HUE039385T2 (hu) 2007-04-12 2018-12-28 Brigham & Womens Hospital Inc ABCB5 rákterápiás célzása
US9011840B2 (en) 2008-03-14 2015-04-21 The Board Of Trustees Of The University Of Illinois Activated mesenchymal stem cells for wound healing and impaired tissue regeneration
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US20110287034A1 (en) 2008-11-14 2011-11-24 The Brigham And Womens Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
WO2014130518A1 (en) 2013-02-19 2014-08-28 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
JP6600299B2 (ja) 2013-05-10 2019-10-30 ザ チルドレンズ メディカル センター コーポレーション 創傷治癒および組織工学
EP3784249A4 (en) 2018-04-25 2022-03-02 Children's Medical Center Corporation ABCB5 LIGANDS AND SUBSTRATES
BR112021019349A2 (pt) 2019-03-28 2021-12-07 Childrens Medical Center Células-tronco preparadas altamente funcionais

Also Published As

Publication number Publication date
US8455245B2 (en) 2013-06-04
CA2685492C (en) 2018-01-16
AU2007254894B2 (en) 2014-10-23
LT2772535T (lt) 2022-08-25
US10017738B2 (en) 2018-07-10
EP2035549A1 (en) 2009-03-18
SI2772535T1 (sl) 2022-08-31
HK1129703A1 (en) 2009-12-04
US20080003206A1 (en) 2008-01-03
US11624054B2 (en) 2023-04-11
SI2035549T1 (sl) 2015-03-31
PT2035549E (pt) 2014-10-06
US20230313136A1 (en) 2023-10-05
CA2685492A1 (en) 2007-12-13
US20180320131A1 (en) 2018-11-08
EP2035549B1 (en) 2014-07-09
AU2007254894A1 (en) 2007-12-13
EP2772535A1 (en) 2014-09-03
ES2918323T3 (es) 2022-07-15
AU2007254894B9 (en) 2014-11-13
PT2772535T (pt) 2022-07-04
DK2035549T3 (da) 2014-10-13
PL2035549T3 (pl) 2014-12-31
WO2007143139A1 (en) 2007-12-13
US20130315880A1 (en) 2013-11-28
PL2772535T3 (pl) 2022-09-05
ES2511791T3 (es) 2014-10-23
EP2772535B1 (en) 2022-04-06
HUE059011T2 (hu) 2022-09-28
HK1201295A1 (en) 2015-08-28

Similar Documents

Publication Publication Date Title
DK2035549T3 (da) Abcb5-positive mesenkymale stamceller som immunmodulatorer
DK2069335T3 (da) Pyridin-3-ylderivater som immunomoduleringsmidler
DK2069336T3 (da) Pyridin-4-yl-derivater som immunomodulerende midler
DK1928845T3 (da) Aminodiazepiner som toll-lignende receptor-modulatorer
ATE490249T1 (de) Purinderivate als immunmodulatoren
DK2313395T3 (da) Pyridon- og pyridazonanaloger som GPR119-modulatorer
DK2086939T3 (da) Pyridiacarboxamid som II-beta-HSDI-inhibitorer
DK2144897T3 (da) 8-Oxy-quinolinderivater som bradykinin B2-receptormodulatorer
DK3192865T3 (da) Enkelt pluripotent stamcelle-kultur
BRPI0917286A2 (pt) válvula de isolação de ânulo
BRPI0813843A2 (pt) Contactor
BRPI0911708A2 (pt) seguidor solar
DK2252609T3 (da) Pyridin-2-yl-derivater som immunomodulerende midler
FI20070168A0 (fi) Pullo
ITFO20060010U1 (it) Croce fotovoltaica
FI20085255A0 (fi) Strukturoitu sementtiä sisältävä sideaine
FI20080232A0 (fi) Monikulmio pyöräelementtinä
ES1069169Y (es) Valvula de retencion
CN300744797S (zh) 接触器
HK1149696A (en) Ampk modulators
UA13869S (uk) Баночка для косметичного засобу
UA15924S (uk) Футляр до пляшки
UA15248S (uk) Пробка для закупорювання пляшок gl
UA13880S (uk) Пляшка
UA14164S (uk) Пляшка