NO172185C - Fremgangsmaate for fremstilling av glukagon - Google Patents

Fremgangsmaate for fremstilling av glukagon

Info

Publication number: NO172185C
Authority: NO; Norway
Prior art keywords: glucagon; derivatives; expression; yeast; fragments
Prior art date: 1985-01-22

Application number

NO860178A

Other languages

English (en)

Norwegian (no)

Other versions

NO860178L (no

NO172185B (no

Inventor

Kjeld Norris

Lars Thim

Fanny Norris

Mogens Trier Hansen

Alister James Moody

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-22

Filing date

1986-01-20

Publication date

1993-06-16

1986-01-20 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1986-07-23 Publication of NO860178L publication Critical patent/NO860178L/no

1993-03-08 Publication of NO172185B publication Critical patent/NO172185B/no

1993-06-16 Publication of NO172185C publication Critical patent/NO172185C/no

Links

102000051325 Glucagon Human genes 0.000 title abstract 4
108060003199 Glucagon Proteins 0.000 title abstract 4
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 4
229960004666 glucagon Drugs 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 3
239000012634 fragment Substances 0.000 abstract 2
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108700005078 Synthetic Genes Proteins 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Mycology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO860178A 1985-01-22 1986-01-20 Fremgangsmaate for fremstilling av glukagon NO172185C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK27885A DK27885A (da)	1985-01-22	1985-01-22	Fremstilling af peptider

Publications (3)

Publication Number	Publication Date
NO860178L NO860178L (no)	1986-07-23
NO172185B NO172185B (no)	1993-03-08
NO172185C true NO172185C (no)	1993-06-16

Family

ID=8091749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO860178A NO172185C (no)	1985-01-22	1986-01-20	Fremgangsmaate for fremstilling av glukagon

Country Status (17)

Country	Link
US (1)	US4826763A (da)
EP (1)	EP0189998B1 (da)
JP (2)	JPH0720435B2 (da)
AT (1)	ATE48643T1 (da)
AU (1)	AU587218B2 (da)
CA (1)	CA1294232C (da)
DE (1)	DE3667488D1 (da)
DK (1)	DK27885A (da)
ES (1)	ES8708250A1 (da)
FI (1)	FI87800C (da)
GR (1)	GR860149B (da)
IE (1)	IE58726B1 (da)
MX (1)	MX163776B (da)
NO (1)	NO172185C (da)
NZ (1)	NZ214883A (da)
PT (1)	PT81872B (da)
ZA (1)	ZA86393B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5151354A (en) *	1986-08-21	1992-09-29	Cornelius Hollenberg	Fermentation processes using amylolytic enzyme producing microorganisms
DK175919B1 (da) *	1986-09-19	2005-06-27	Univ Washington	Ekspression af biologisk aktiv faktor XIII
JPH01187499A (ja) *	1988-01-21	1989-07-26	Science & Tech Agency	原子炉解体用ロボット
IL93173A0 (en) *	1989-02-01	1990-11-05	Shionogi & Co	Production of glucagon
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5234906A (en) *	1991-01-10	1993-08-10	Amylin Pharmaceuticals, Inc.	Hyperglycemic compositions
US5510459A (en) *	1991-01-17	1996-04-23	Zymogenetics, Inc.	Glucagon antagonists
US5408037A (en) *	1991-01-17	1995-04-18	Zymogenetics, Inc.	Methods for detecting glucagon antagonists
WO1994001215A1 (en) *	1992-07-06	1994-01-20	Beckman Instruments, Inc.	Fluid delivery system utilizing multiple port valve
DK144093D0 (da) *	1993-12-23	1993-12-23	Novo Nordisk As
US5652216A (en) *	1994-05-26	1997-07-29	Novo Nordisk A/S	Pharmaceutical preparation
ATE253375T1 (de) *	1997-05-16	2003-11-15	Ontario Inc 1149336	Verwendung von glp-2 agonisten zur verbesserung der wirkung des oberen gastrointestinaltraktes
NZ541365A (en) *	2002-12-27	2009-09-25	Diobex Inc	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en) *	2002-12-27	2010-02-02	Diobex, Inc.	Compositions and methods for the prevention and control of insulin-induced hypoglycemia
DK3178835T3 (da)	2009-02-03	2019-06-24	Amunix Pharmaceuticals Inc	Forlængede rekombinante polypeptider og sammensætninger omfattende samme
WO2010144508A1 (en)	2009-06-08	2010-12-16	Amunix Operating Inc.	Glucose-regulating polypeptides and methods of making and using same
CN104302408B (zh)	2012-02-27	2016-12-14	阿穆尼克斯运营公司	Xten缀合组合物和制造其的方法
ES2938734T3 (es)	2018-10-09	2023-04-14	Fresenius Kabi Ipsum S R L	Procedimiento para la fabricación de análogos de GLP-1
EP3753946A1 (en)	2019-06-18	2020-12-23	Fresenius Kabi iPSUM S.r.l.	Improved process for the preparation of high purity glucagon
WO2020254479A1 (en)	2019-06-18	2020-12-24	Fresenius Kabi Ipsum S.R.L.	Process for the manufacture of glucagon
EP4058466A1 (en)	2019-11-13	2022-09-21	Amunix Pharmaceuticals, Inc.	Barcoded xten polypeptides and compositions thereof, and methods for making and using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4401759A (en) *	1980-05-01	1983-08-30	Harvey Rubin	Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
DK283180A (da) *	1980-07-01	1982-01-02	Novo Industri As	Polypeptider og derivater deraf
US4546082A (en) *	1982-06-17	1985-10-08	Regents Of The Univ. Of California	E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

1985
- 1985-01-22 DK DK27885A patent/DK27885A/da unknown
1986
- 1986-01-20 JP JP61009822A patent/JPH0720435B2/ja not_active Expired - Lifetime
- 1986-01-20 ZA ZA86393A patent/ZA86393B/xx unknown
- 1986-01-20 AT AT86300384T patent/ATE48643T1/de not_active IP Right Cessation
- 1986-01-20 FI FI860251A patent/FI87800C/fi not_active IP Right Cessation
- 1986-01-20 EP EP86300384A patent/EP0189998B1/en not_active Expired
- 1986-01-20 NO NO860178A patent/NO172185C/no not_active IP Right Cessation
- 1986-01-20 GR GR860149A patent/GR860149B/el active IP Right Revival
- 1986-01-20 MX MX1277A patent/MX163776B/es unknown
- 1986-01-20 DE DE8686300384T patent/DE3667488D1/de not_active Expired - Lifetime
- 1986-01-20 IE IE16286A patent/IE58726B1/en not_active IP Right Cessation
- 1986-01-20 PT PT81872A patent/PT81872B/pt active IP Right Revival
- 1986-01-20 ES ES551042A patent/ES8708250A1/es not_active Expired
- 1986-01-20 CA CA000499911A patent/CA1294232C/en not_active Expired - Lifetime
- 1986-01-20 AU AU52472/86A patent/AU587218B2/en not_active Expired
- 1986-01-21 US US06/820,144 patent/US4826763A/en not_active Expired - Lifetime
- 1986-01-21 NZ NZ214883A patent/NZ214883A/en unknown
1993
- 1993-10-13 JP JP5255433A patent/JPH0746986B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0189998A1 (en)	1986-08-06
MX163776B (es)	1992-06-22
FI87800B (fi)	1992-11-13
IE860162L (en)	1986-07-22
ES8708250A1 (es)	1987-10-01
EP0189998B1 (en)	1989-12-13
AU587218B2 (en)	1989-08-10
IE58726B1 (en)	1993-11-03
GR860149B (en)	1986-05-21
ZA86393B (en)	1987-03-25
PT81872A (en)	1986-02-01
FI860251L (fi)	1986-07-23
JPS61181398A (ja)	1986-08-14
NZ214883A (en)	1988-04-29
AU5247286A (en)	1986-07-31
FI87800C (fi)	1993-02-25
DE3667488D1 (de)	1990-01-18
FI860251A0 (fi)	1986-01-20
NO860178L (no)	1986-07-23
ATE48643T1 (de)	1989-12-15
NO172185B (no)	1993-03-08
PT81872B (pt)	1988-05-27
DK27885D0 (da)	1985-01-22
US4826763A (en)	1989-05-02
ES551042A0 (es)	1987-10-01
JPH06292594A (ja)	1994-10-21
CA1294232C (en)	1992-01-14
JPH0720435B2 (ja)	1995-03-08
JPH0746986B2 (ja)	1995-05-24
DK27885A (da)	1986-07-23

Legal Events

Date	Code	Title	Description
2004-12-13	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO860178L (no)	1986-07-23	Fremgangsmaate for fremstilling av glukagon.
AU573768B2 (en)	1988-06-23	Hyaluronic acid from streptococci
AU2790292A (en)	1993-04-27	Viral recombinant vectors for expression in muscle cells
HU9201712D0 (en)	1992-09-28	A mammalian cytokine, il-11
AU4833897A (en)	1998-04-23	Glial mitogenic factors, their preparation and use
NO871785D0 (no)	1987-04-29	Fremgangsmaate for fremstilling av et proteinprodukt, samt vektorsystem for fremgangsmaatens utfoerelse.
DE3855523D1 (de)	1996-10-17	Proteine mit Faktor-VIII-Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende pharmazeutische Zusammensetzungen
ES8305042A1 (es)	1983-04-01	"procedimiento para la obtencion de un plasmido de expresion para la expresion de un gen heterologo".
BG49717A3 (bg)	1992-01-15	Метод за получаване на хирудин
IL68366A (en)	1990-08-31	Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
AU6569386A (en)	1987-06-04	Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process
IE840258L (en)	1984-08-07	Expression of gene products.
IL75963A0 (en)	1985-12-31	Interferon derivatives,their preparation and pharmaceutical compositions containing them
EP0363127A3 (en)	1992-03-04	Improvements in or relating to eukaryotic expression
DE69130704D1 (de)	1999-02-11	Polypeptide beteiligt an der kobalamin- und/oder kobamid-biosynthese, für diese kodierende dns-sequencen, und ihre herstellung und vewendung.
AU2430588A (en)	1989-04-27	Mutant acidic fibroblast growth factor
EP0276778A3 (en)	1990-01-10	High level expression in e. coli of soluble mature hil-1beta and derivatives with altered biological activity
EP0343388A3 (en)	1990-09-12	Expression of interferon-gamma in methylotrophic yeasts
IT8521507A0 (it)	1985-07-10	Vettore di clonaggio, molecole di dna ricombinante, ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni.
AU6560886A (en)	1987-05-28	DNA sequence containing the DNA sequence coding for human tissue plasminogen activator originating from human normal cells, recombinant DNA incorporating the DNA sequence, host cells transformed with the recombinant DNA, and process for producing human tissue plasminogen activator by use of the host cells
EP0165759A3 (en)	1987-08-19	Mammalian promotors useful in yeast expression
WU	1981	SYNTHESIS AND SECRETION OF HUMAN IFN-? B IN SACCHAROMYCE CEREVISIAE
UA5743C2 (uk)	1994-12-29	Препарат тканинних біологічно активних речовин, який має регенаторну дію, та спосіб його одержання
DK28386A (da)	1986-07-23	Fremstilling af peptider