DK2825559T3 - Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat - Google Patents
Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat Download PDFInfo
- Publication number
- DK2825559T3 DK2825559T3 DK13739281.7T DK13739281T DK2825559T3 DK 2825559 T3 DK2825559 T3 DK 2825559T3 DK 13739281 T DK13739281 T DK 13739281T DK 2825559 T3 DK2825559 T3 DK 2825559T3
- Authority
- DK
- Denmark
- Prior art keywords
- liquidable
- information
- bispecific antibodies
- native immunoglobulin
- immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610141P | 2012-03-13 | 2012-03-13 | |
| PCT/IB2013/000902 WO2013136186A2 (en) | 2012-03-13 | 2013-03-13 | Readily isolated bispecific antibodies with native immunoglobulin format |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2825559T3 true DK2825559T3 (da) | 2019-06-03 |
Family
ID=48803578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13739281.7T DK2825559T3 (da) | 2012-03-13 | 2013-03-13 | Letisolerbare bispecifikke antistoffer med nativt immunoglobulinformat |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9815909B2 (da) |
| EP (2) | EP3517548A1 (da) |
| JP (3) | JP6273219B2 (da) |
| AU (2) | AU2013234039B2 (da) |
| CA (1) | CA2867020C (da) |
| DK (1) | DK2825559T3 (da) |
| ES (1) | ES2728301T3 (da) |
| PT (1) | PT2825559T (da) |
| WO (1) | WO2013136186A2 (da) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| ES2595638T3 (es) | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| KR101680906B1 (ko) | 2007-09-26 | 2016-11-30 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| WO2011108714A1 (ja) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | 抗体定常領域改変体 |
| TWI452136B (zh) | 2010-11-17 | 2014-09-11 | 中外製藥股份有限公司 | A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation |
| PT3434767T (pt) | 2010-11-30 | 2026-01-23 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de citotoxicidade |
| AU2013322710A1 (en) | 2012-09-25 | 2015-04-16 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
| WO2015033223A2 (en) * | 2013-09-03 | 2015-03-12 | Novimmune S.A. | Readily isolated bispecific binding molecules with native format having mutated constant regions |
| ES2881306T3 (es) | 2013-09-27 | 2021-11-29 | Chugai Pharmaceutical Co Ltd | Método para la producción de heteromultímeros de polipéptidos |
| GB201411420D0 (en) * | 2014-06-26 | 2014-08-13 | Ucb Biopharma Sprl | Antibody constructs |
| AR101262A1 (es) * | 2014-07-26 | 2016-12-07 | Regeneron Pharma | Plataforma de purificación para anticuerpos biespecíficos |
| GB201414823D0 (en) | 2014-08-20 | 2014-10-01 | Argen X Bv | Multispecific antibodies |
| JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| JP6962819B2 (ja) | 2015-04-10 | 2021-11-05 | アディマブ， エルエルシー | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| EP3885368A1 (en) * | 2015-05-12 | 2021-09-29 | Regeneron Pharmaceuticals, Inc. | Multimeric protein purity determination |
| US12595316B2 (en) | 2015-07-09 | 2026-04-07 | Genmab A/S | Bispecific and multispecific antibodies and method for isolation of such |
| AU2016381992B2 (en) * | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
| WO2017165464A1 (en) | 2016-03-21 | 2017-09-28 | Elstar Therapeutics, Inc. | Multispecific and multifunctional molecules and uses thereof |
| CR20180554A (es) | 2016-04-28 | 2019-01-10 | Chugai Pharmaceutical Co Ltd | Preparaciones que contienen anticuerpos |
| WO2018151820A1 (en) | 2017-02-16 | 2018-08-23 | Elstar Therapeutics, Inc. | Multifunctional molecules comprising a trimeric ligand and uses thereof |
| CN110461358A (zh) | 2017-03-31 | 2019-11-15 | 公立大学法人奈良县立医科大学 | 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物 |
| WO2018212556A1 (en) * | 2017-05-16 | 2018-11-22 | Cj Healthcare Corporation | A method for purifying an antibody or an antibody fragment thereof using affinity chromatography |
| EP3630836A1 (en) | 2017-05-31 | 2020-04-08 | Elstar Therapeutics, Inc. | Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof |
| KR20200014379A (ko) * | 2017-06-05 | 2020-02-10 | 얀센 바이오테크 인코포레이티드 | 비대칭 ch2-ch3 영역 돌연변이를 갖는 조작된 다중특이성 항체 및 다른 다량체 단백질 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| CN119161488A (zh) | 2017-11-01 | 2024-12-20 | 中外制药株式会社 | 具有降低的生物活性的抗体变体和同种型 |
| AU2018358804A1 (en) * | 2017-11-02 | 2020-04-09 | Bayer Aktiengesellschaft | Bispecific antibodies binding ALK-1 and BMPR-2 |
| AU2018387829B2 (en) | 2017-12-22 | 2024-12-19 | Argenx Bvba | Bispecific antigen binding construct |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| GB201802487D0 (en) | 2018-02-15 | 2018-04-04 | Argenx Bvba | Cytokine combination therapy |
| EP3765516A2 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules and uses thereof |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| EP3810649A1 (en) * | 2018-06-22 | 2021-04-28 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| SG11202102713TA (en) * | 2018-09-21 | 2021-04-29 | Teneobio Inc | Methods for purifying heterodimeric, multispecific antibodies |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| IL319262A (en) | 2018-12-24 | 2025-04-01 | Sanofi Sa | Multispecific FAB pseudoproteins bind |
| JP7737306B2 (ja) | 2019-02-21 | 2025-09-10 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用 |
| EP3927431A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| EP3927746A1 (en) | 2019-02-21 | 2021-12-29 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| GB2599228B (en) | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| EP4084821A4 (en) | 2020-01-03 | 2024-04-24 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| BR112022018452A2 (pt) | 2020-03-25 | 2022-11-01 | Lilly Co Eli | Proteínas de ligação multiespecíficas e métodos de desenvolvimento das mesmas |
| CN115843312A (zh) | 2020-04-24 | 2023-03-24 | 马伦戈治疗公司 | 结合至t细胞相关癌细胞的多功能性分子及其用途 |
| GB2616128A (en) | 2020-08-26 | 2023-08-30 | Marengo Therapeutics Inc | Antibody molecules that bind to NKp30 and uses thereof |
| AU2021331075A1 (en) | 2020-08-26 | 2023-04-06 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| GB2616354A (en) | 2020-08-26 | 2023-09-06 | Marengo Therapeutics Inc | Methods of detecting TRBC1 or TRBC2 |
| WO2022216993A2 (en) | 2021-04-08 | 2022-10-13 | Marengo Therapeutics, Inc. | Multifuntional molecules binding to tcr and uses thereof |
| WO2024086852A1 (en) | 2022-10-21 | 2024-04-25 | Diagonal Therapeutics Inc. | Heteromeric agonistic antibodies to il-18 receptor |
| US20250002588A1 (en) | 2023-04-07 | 2025-01-02 | Diagonal Therapeutics Inc. | Bispecific agonistic antibodies to activin a receptor like type 1 (alk1) |
| AU2024254039A1 (en) | 2023-04-07 | 2025-10-02 | Diagonal Therapeutics Inc. | Hinge-modified bispecific antibodies |
| CN121219320A (zh) | 2023-05-19 | 2025-12-26 | 达科纳治疗有限公司 | 针对il12受体的双特异性激动性抗体 |
| WO2025090519A1 (en) | 2023-10-23 | 2025-05-01 | Diagonal Therapeutics Inc. | Heteromeric agonistic antibodies to il-18 receptor |
| US20250388688A1 (en) | 2024-04-04 | 2025-12-25 | Ethyreal Bio, Inc. | Anti-tshr antibodies and uses thereof |
| WO2026011013A1 (en) | 2024-07-02 | 2026-01-08 | Epibiologics, Inc. | Binding agents and uses thereof |
| WO2026037841A1 (en) | 2024-08-12 | 2026-02-19 | ONA Therapeutics S.L. | Anti-fgfr4 molecules and uses thereof |
| WO2026044000A1 (en) | 2024-08-20 | 2026-02-26 | Ethyreal Bio, Inc. | Multispecific antibodies and methods of use thereof |
| WO2026050572A2 (en) | 2024-08-29 | 2026-03-05 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
| WO2026080748A2 (en) | 2024-10-09 | 2026-04-16 | Diagonal Therapeutics Inc. | Bone morphogenetic protein receptor type 2 (bmprii) antibodies |
| WO2026080752A2 (en) | 2024-10-09 | 2026-04-16 | Diagonal Therapeutics Inc. | De novo antibodies to activin a receptor like type 1 (alk1) |
| WO2026080757A2 (en) | 2024-10-09 | 2026-04-16 | Diagonal Therapeutics Inc. | Activin receptor type ii a/b (actriia/b) antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| KR101151957B1 (ko) * | 2004-07-22 | 2012-06-01 | 로저 킹돈 크레이그 | 결합 분자 |
| JP2009541275A (ja) * | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| EP2143345A1 (en) * | 2008-07-09 | 2010-01-13 | Reemtsma Cigarettenfabriken GmbH | Cigarette paper |
| MY192182A (en) | 2009-06-26 | 2022-08-04 | Regeneron Pharma | Readily isolated bispecific antibodies with native immunoglobulin format |
-
2013
- 2013-03-13 EP EP19159351.6A patent/EP3517548A1/en not_active Withdrawn
- 2013-03-13 EP EP13739281.7A patent/EP2825559B1/en active Active
- 2013-03-13 JP JP2014561539A patent/JP6273219B2/ja active Active
- 2013-03-13 ES ES13739281T patent/ES2728301T3/es active Active
- 2013-03-13 US US13/798,485 patent/US9815909B2/en active Active
- 2013-03-13 CA CA2867020A patent/CA2867020C/en active Active
- 2013-03-13 AU AU2013234039A patent/AU2013234039B2/en active Active
- 2013-03-13 DK DK13739281.7T patent/DK2825559T3/da active
- 2013-03-13 WO PCT/IB2013/000902 patent/WO2013136186A2/en not_active Ceased
- 2013-03-13 PT PT13739281T patent/PT2825559T/pt unknown
-
2017
- 2017-11-13 US US15/811,126 patent/US10494446B2/en active Active
- 2017-12-22 AU AU2017279804A patent/AU2017279804B2/en active Active
-
2018
- 2018-01-05 JP JP2018000542A patent/JP2018083829A/ja active Pending
-
2019
- 2019-11-27 US US16/698,248 patent/US20200231707A1/en not_active Abandoned
-
2021
- 2021-02-26 JP JP2021029357A patent/JP2021091701A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017279804B2 (en) | 2020-03-12 |
| JP2021091701A (ja) | 2021-06-17 |
| PT2825559T (pt) | 2019-06-07 |
| US20200231707A1 (en) | 2020-07-23 |
| US10494446B2 (en) | 2019-12-03 |
| CA2867020A1 (en) | 2013-09-19 |
| WO2013136186A2 (en) | 2013-09-19 |
| CA2867020C (en) | 2022-11-15 |
| US20140051833A1 (en) | 2014-02-20 |
| EP2825559A2 (en) | 2015-01-21 |
| JP2018083829A (ja) | 2018-05-31 |
| US20180057611A1 (en) | 2018-03-01 |
| AU2013234039A1 (en) | 2014-09-25 |
| ES2728301T3 (es) | 2019-10-23 |
| JP2015510764A (ja) | 2015-04-13 |
| AU2017279804A1 (en) | 2018-01-25 |
| JP6273219B2 (ja) | 2018-01-31 |
| WO2013136186A3 (en) | 2014-01-23 |
| EP3517548A1 (en) | 2019-07-31 |
| EP2825559B1 (en) | 2019-02-27 |
| US9815909B2 (en) | 2017-11-14 |
| AU2013234039B2 (en) | 2018-02-01 |
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