DK2861210T3 - Fremgangsmåde til behandling af cancer i bygspytkirtlen under anvendelse af kombinationsbehandlinger omfattende liposomal irinotecan - Google Patents
Fremgangsmåde til behandling af cancer i bygspytkirtlen under anvendelse af kombinationsbehandlinger omfattende liposomal irinotecan Download PDFInfo
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- DK2861210T3 DK2861210T3 DK13731230.2T DK13731230T DK2861210T3 DK 2861210 T3 DK2861210 T3 DK 2861210T3 DK 13731230 T DK13731230 T DK 13731230T DK 2861210 T3 DK2861210 T3 DK 2861210T3
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- irinotecan
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Claims (5)
1. Liposomal irinotecan til anvendelse i en fremgangsmåde til behandling af cancer i bygspytkirtlen hos en patient der er et menneske, hvor patienten udviser tegn på tilbagevendende eller vedvarende cancer i bygspytkirtlen efter primær kemoterapi og hvor patienten har mislykkedes med tidligere behandling med gemcitabin eller er blevet resistent over for gemcitabin, idet fremgangsmåden omfatter samtidig indgivelse af en effektiv mængde af hver af liposomal irinotecan, 5-fluoruracil (5-FU) og leucovorin til patienten i mindst en cyklus hvor cyklussen er en periode på 2 uger og, for hver cyklus: (a) liposomal irinotecan indgives til patienter der ikke er homozygote over for UGT1A1 *28 allelen på dag 1 af hver cyklus med en dosis på 80 mg/m2 og til patienter der er homozygote over for UGT1A1 *28 allelen på dag 1 af cyklus 1 med en dosis på 60 mg/m2 og på dag 1 af hver efterfølgende cyklus med en dosis på 60 mg/m2 eller 80 mg/m2; (b) 5-FU indgives med en dosis på 2400 mg/m2; og (c) leucovorin indgives med en dosis på 200 mg/m2 (I form) eller 400 mg/m2 (I + d racemisk form); og hvor i hver cyklus, indgives liposomal irinotecan inden leucovorin, leucovorin indgives inden 5-FU.
2. Liposomal irinotecan til anvendelse ifølge krav 1 hvor: (a) efter cyklus 1 øges dosen af liposomal irinotecan indgivet til patienten der er homozygot over for UGT1A1 *28 allel til 80 mg/m2; og/eller (b) 5-FU indgives intravenøst i løbet af 46 timer; og/eller (c) leucovorin indgives intravenøst i løbet af 30 minutter.
3. Liposomal irinotecan til anvendelse ifølge krav 1 eller krav 2 hvor: (a) liposomal irinotecan indgives intravenøst i løbet af 90 minutter; og/eller (b) inden hver indgivelse af liposomal irinotecan, præmedicineres patienten med dexamethason og/eller en 5-HT3-antagonist eller et andet antiemetikum; og/eller (c) canceren i bygspytkirtlen er eksokrin cancer i bygspytkirtlen valgt fra gruppen bestående af acinære cellecarcinomer, adenocarcinomer, adenosquamøse carcinomer, kæmpe celletumor, intraduktal papillær mucinøs neoplasm (IPMN), mucinøse cystadenocarcinomer, pancreatoblastomer, serøse cystadenocarcinomer, og solide og pseudopapillære tumorer.
Liposomal irinotecan til anvendelse ifølge et hvilket som helst af de foregående <rav, hvor liposomal irinotecan er irinotecansucroseoctasulfatsaltliposom-njektion.
5. Liposomal irinotecan til anvendelse ifølge et hvilket som helst af de foregående <rav, hvor canceren er fremskreden cancer i bygspytkirtlen, som er en Dygspytkirteltumor der udviser: (a) den ene eller den anden af fjernmetastase eller peripancreatisk udvidelse af tumoren; eller (b) både fjernmetastase og peripancreatisk udvidelse af tumoren.
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| PCT/US2013/045495 WO2013188586A1 (en) | 2012-06-13 | 2013-06-12 | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
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| DK21171689.9T DK3919048T3 (da) | 2012-06-13 | 2013-06-12 | Fremgangsmåder til behandling af bugspytkirtelkræft ved hjælp af kombinationsterapier, der indeholder liposomalt irinotecan |
| DK13731230.2T DK2861210T3 (da) | 2012-06-13 | 2013-06-12 | Fremgangsmåde til behandling af cancer i bygspytkirtlen under anvendelse af kombinationsbehandlinger omfattende liposomal irinotecan |
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| DK21171689.9T DK3919048T3 (da) | 2012-06-13 | 2013-06-12 | Fremgangsmåder til behandling af bugspytkirtelkræft ved hjælp af kombinationsterapier, der indeholder liposomalt irinotecan |
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| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| MX386070B (es) | 2014-01-14 | 2025-03-18 | Nektar Therapeutics | Metodo de tratamiento basado en combinacion. |
| MA39599A (fr) | 2014-05-14 | 2016-10-05 | Merrimack Pharmaceuticals Inc | Dosage et administration d'agents thérapeutiques anti-egfr |
| JP7113619B2 (ja) * | 2014-12-09 | 2022-08-05 | イプセン バイオファーム リミティド | リポソーマルイリノテカンによる乳がんの治療 |
| WO2016168451A1 (en) * | 2015-04-14 | 2016-10-20 | Merrimack Pharmaceuticals, Inc. | Compositions for improving the pharmacokinetics and therapeutic index of cancer treatment |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| PL3337467T3 (pl) * | 2015-08-20 | 2021-06-14 | Ipsen Biopharm Ltd. | Terapia skojarzona z zastosowaniem liposomalnego irynotekanu i inhibitora parp do leczenia nowotworu |
| PL3337478T5 (pl) * | 2015-08-21 | 2026-05-04 | Ipsen Biopharm Ltd. | Kombinacja leków obejmująca liposomalny irynotekan, oksaliplatynę, 5-fluorouracyl i leukoworynę do leczenia nowotworu trzustki z przerzutami |
| EP3349731B1 (en) * | 2015-09-16 | 2023-11-01 | Board of Regents, The University of Texas System | Combination of topoisomerase-i inhibitors with immunotherapy in the treatment of cancer |
| AU2016340153B2 (en) | 2015-10-16 | 2022-06-02 | Ipsen Biopharm Ltd. | Stabilizing camptothecin pharmaceutical compositions |
| WO2017172678A1 (en) * | 2016-03-30 | 2017-10-05 | Merrimack Pharmaceuticals, Inc. | Methods for treating cancer using combination therapies comprising an oligoclonal anti-egfr antibody preparation and lipsomal irinotecan |
| MA45046A (fr) * | 2016-05-18 | 2019-03-27 | Ipsen Biopharm Ltd | Irinotécan nanoliposomal utilisé dans le traitement du cancer bronchique à petites cellules |
| EP3535026A1 (en) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
| US12291570B2 (en) * | 2018-10-17 | 2025-05-06 | Biolinerx Ltd. | Treatment of metastatic pancreatic adenocarcinoma |
| WO2020148744A1 (en) * | 2019-01-17 | 2020-07-23 | Biolinerx Ltd. | Combination therapy for treatment of pancreatic cancer |
| WO2020148745A1 (en) * | 2019-01-17 | 2020-07-23 | Biolinerx Ltd. | Specific combination therapy for treatment of pancreatic cancer |
| US11286344B2 (en) | 2020-01-10 | 2022-03-29 | Tyndall Formulation Services, LLC | Polymer excipients for drug delivery applications |
| BR112022013685A2 (pt) | 2020-01-10 | 2022-09-06 | R Pharm Us Operating Llc | Composições de ixabepilona |
| WO2021142020A1 (en) * | 2020-01-10 | 2021-07-15 | Tyndall Formulation Services, LLC | Formulations of sn-38 with poly(amino acid) block polymers |
| KR20240082379A (ko) * | 2021-10-03 | 2024-06-10 | 시스트이뮨, 인코포레이티드 | 암 치료 방법 및 이의 약제학적 조성물 |
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