DK2869837T3 - Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse - Google Patents

Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse Download PDF

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Publication number
DK2869837T3
DK2869837T3 DK13737564.8T DK13737564T DK2869837T3 DK 2869837 T3 DK2869837 T3 DK 2869837T3 DK 13737564 T DK13737564 T DK 13737564T DK 2869837 T3 DK2869837 T3 DK 2869837T3
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Denmark
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antibody
ser
val
thr
amino acid
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DK13737564.8T
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English (en)
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Ulrich Brinkmann
Guy Georges
Eike Hoffmann
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Hoffmann La Roche
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (11)

1. Anti-theophyllin-antistof, hvor antistoffet omfatter (a) HVR-H1 omfattende aminosyresekvensen af SEQ ID NO: 01, (b) HVR-H2 omfattende aminosyresekvensen af SEQ ID NO: 02, og (c) HVR-H3 omfattende aminosyresekvensen af SEQ ID NO: 03, (d) HVR-L1 omfattende aminosyresekvensen af SEQ ID NO: 05; (e) HVR-L2 omfattende aminosyresekvensen af SEQ ID NO: 06; og (f) HVR-L3 omfattende aminosyresekvensen af SEQ ID NO: 07, hvor antistoffet er et humaniseret antistof og omfatter ved position 71 af det tung-kæde variable domæne nummereret ifølge Kabat aminosyregruppen arginin, og omfatter ved position 46 af det let-kæde variable domæne nummereret ifølge Kabat aminosyregruppen leucin.
2. Antistoffet ifølge krav 1, omfattende (a) en VH-sekvens med mindst 95% sekvensidentitet med aminosyresekvensen af SEQ ID NO: 04; (b) en VL-sekvens med mindst 95% sekvensidentitet med aminosyresekvensen af SEQ ID NO: 08; eller (c) en VH-sekvens som i (a) og en VL-sekvens som i (b), hvor aminosyregruppen ved position 71 af det tung-kæde variable domæne nummereret ifølge Kabat er arginin og aminosyregruppen ved position 46 af det let-kæde variable domæne nummereret ifølge Kabat er leucin.
3. Antistoffet ifølge krav 1, omfattende en VH-sekvens af SEQ ID NO: 04.
4. Antistoffet ifølge krav 3, omfattende en VL-sekvens of SEQ ID NO: 08.
5. Antistof omfattende en VH-sekvens af SEQ ID NO: 04 og en VL-sekvens af SEQ ID NO: 08.
6. Antistoffet ifølge et hvilket som helst af de foregående krav, der er et fuldlængde-IgGl-antistof eller et fuldlængde-IgG4-antistof.
7. Antistoffet ifølge et hvilket som helst af de foregående krav, der er et monoklonalt antistof.
8. Antistoffet ifølge et hvilket som helst af de foregående krav, der er et antistoffragment der binder theophyllin.
9. Farmaceutisk formulering omfattende antistoffet ifølge et hvilket som helst af de foregående krav og en farmaceutisk acceptabel bærer.
10. Antistoffet ifølge et hvilket som helst af kravene 1 til 8 til anvendelse som et medikament.
11. Anvendelse af antistoffet ifølge et hvilket som helst af kravene 1 til 8 i fremstillingen af et medikament.
DK13737564.8T 2012-07-04 2013-07-04 Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse DK2869837T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12174958 2012-07-04
PCT/EP2013/064090 WO2014006118A1 (en) 2012-07-04 2013-07-04 Anti-theophylline antibodies and methods of use

Publications (1)

Publication Number Publication Date
DK2869837T3 true DK2869837T3 (da) 2016-09-26

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DK13737564.8T DK2869837T3 (da) 2012-07-04 2013-07-04 Anti-theophyllin-antistoffer og fremgangsmåder til anvendelse

Country Status (15)

Country Link
US (1) US9925272B2 (da)
EP (2) EP2869837B1 (da)
JP (2) JP6324376B2 (da)
KR (1) KR20150023938A (da)
CN (2) CN107082810B (da)
BR (1) BR112014030843A2 (da)
CA (1) CA2872184A1 (da)
DK (1) DK2869837T3 (da)
ES (1) ES2600154T3 (da)
HU (1) HUE029435T2 (da)
MX (1) MX353951B (da)
PL (1) PL2869837T3 (da)
RU (2) RU2017128512A (da)
SI (1) SI2869837T1 (da)
WO (1) WO2014006118A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014030844A2 (pt) 2012-07-04 2019-10-15 Hoffmann La Roche anticorpo anti-biotina humanizado, formulação farmacêutica e uso do anticorpo
JP6324376B2 (ja) * 2012-07-04 2018-05-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗テオフィリン抗体および使用方法
BR112014029403A2 (pt) 2012-07-04 2018-10-09 F. Hoffmann-La Roche Ag conjugados, anticorpo e formulação farmacêutica
ES2895752T3 (es) 2014-01-03 2022-02-22 Hoffmann La Roche Anticuerpos biespecíficos anti-hapteno/anti-receptor de la barrera hematoencefálica, complejos de los mismos y su uso como lanzaderas a través de la barrera hematoencefálica
EP3089758B1 (en) 2014-01-03 2021-01-27 F.Hoffmann-La Roche Ag Covalently linked helicar-anti-helicar antibody conjugates and uses thereof
EP3089759B1 (en) 2014-01-03 2018-12-05 F. Hoffmann-La Roche AG Covalently linked polypeptide toxin-antibody conjugates
CN106687476B (zh) 2014-06-26 2020-11-13 豪夫迈·罗氏有限公司 抗brdu抗体及使用方法

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