DK2968269T3 - Fremgangsmåde til fremstilling af beta-3-agonister og mellemprodukter - Google Patents
Fremgangsmåde til fremstilling af beta-3-agonister og mellemprodukter Download PDFInfo
- Publication number
- DK2968269T3 DK2968269T3 DK14768236.3T DK14768236T DK2968269T3 DK 2968269 T3 DK2968269 T3 DK 2968269T3 DK 14768236 T DK14768236 T DK 14768236T DK 2968269 T3 DK2968269 T3 DK 2968269T3
- Authority
- DK
- Denmark
- Prior art keywords
- agonists
- intermediates
- procedure
- preparing beta
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791247P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/023858 WO2014150639A1 (en) | 2013-03-15 | 2014-03-12 | Process for preparing beta 3 agonists and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2968269T3 true DK2968269T3 (da) | 2019-10-07 |
Family
ID=51580798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14768236.3T DK2968269T3 (da) | 2013-03-15 | 2014-03-12 | Fremgangsmåde til fremstilling af beta-3-agonister og mellemprodukter |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US10287289B2 (da) |
| EP (2) | EP2968269B1 (da) |
| JP (1) | JP6383403B2 (da) |
| CY (1) | CY1122690T1 (da) |
| DK (1) | DK2968269T3 (da) |
| ES (1) | ES2746801T3 (da) |
| HR (1) | HRP20191546T1 (da) |
| HU (1) | HUE045260T2 (da) |
| LT (1) | LT2968269T (da) |
| ME (1) | ME03506B (da) |
| PL (1) | PL2968269T3 (da) |
| PT (1) | PT2968269T (da) |
| RS (1) | RS59402B1 (da) |
| SI (1) | SI2968269T1 (da) |
| SM (1) | SMT201900508T1 (da) |
| WO (1) | WO2014150639A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
| WO2013062881A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| JP6383403B2 (ja) | 2013-03-15 | 2018-08-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | β−3作動薬および中間体の製造方法 |
| CN104496875B (zh) * | 2014-12-12 | 2017-09-08 | 常州大学 | 2‑烯丙基‑2‑甲醛基‑n‑苯基吡咯碄的合成方法 |
| KR20250099259A (ko) | 2017-06-06 | 2025-07-01 | 유로반트 사이언시즈 게엠베하 | 과민성 방광의 치료를 위한 비베그론의 용도 |
| CN110869053A (zh) | 2017-06-06 | 2020-03-06 | 乌洛万特科学有限公司 | 给药维贝隆以治疗膀胱过度活动症 |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| SG11202010683PA (en) | 2018-05-23 | 2020-12-30 | Urovant Sciences Gmbh | Use of vibegron to treat pain associated with irritable bowel syndrome |
| TW202038963A (zh) | 2018-12-05 | 2020-11-01 | 瑞士商優洛凡特科學公司 | 維貝隆(vibegron)於治療患有良性前列腺增生之男性中膀胱過動症症狀之用途 |
| TW202506129A (zh) | 2019-03-18 | 2025-02-16 | 瑞士商優洛凡特科學公司 | 維貝隆(vibegron)用於治療膀胱過動症之用途 |
| GB201903832D0 (en) | 2019-03-20 | 2019-05-01 | Atrogi Ab | New compounds and methods |
| AR124479A1 (es) | 2020-12-22 | 2023-03-29 | Urovant Sciences Gmbh | Métodos de monitoreo de la digoxina con el uso de vibegrón para el tratamiento de la vejiga hiperactiva |
| TW202245781A (zh) | 2021-02-16 | 2022-12-01 | 瑞士商優洛凡特科學公司 | 用維貝格龍(vibegron)治療心臟衰竭之方法 |
| CN113816917B (zh) * | 2021-11-19 | 2022-02-18 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体的制备方法 |
| CN115850286B (zh) * | 2022-12-05 | 2023-08-22 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体及其制备方法 |
| CN117467628B (zh) * | 2023-09-18 | 2024-04-16 | 长兴制药股份有限公司 | 一种酮还原酶及其制备高光学纯度β-3肾上腺素能激动剂中间体的方法 |
| WO2025262600A1 (en) | 2024-06-17 | 2025-12-26 | Urovant Sciences Gmbh | Crystalline form of vibegron hemihydrate |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| DOP2003000587A (es) | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
| FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
| PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| SI2329014T1 (sl) * | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| US20120202819A1 (en) | 2009-10-07 | 2012-08-09 | Merck Sharp & Dohme Corporation | Combination therapy using a beta 3 adrenergic receptor agonists and an antimuscarinic agent |
| CA2796877A1 (en) * | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel beta 3 adrenergic receptor agonists |
| ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
| WO2013062881A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| CN106479990B (zh) * | 2011-11-18 | 2020-09-18 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| JP6383403B2 (ja) | 2013-03-15 | 2018-08-29 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | β−3作動薬および中間体の製造方法 |
-
2014
- 2014-03-12 JP JP2016501364A patent/JP6383403B2/ja active Active
- 2014-03-12 ES ES14768236T patent/ES2746801T3/es active Active
- 2014-03-12 SI SI201431333T patent/SI2968269T1/sl unknown
- 2014-03-12 PL PL14768236T patent/PL2968269T3/pl unknown
- 2014-03-12 HR HRP20191546 patent/HRP20191546T1/hr unknown
- 2014-03-12 WO PCT/US2014/023858 patent/WO2014150639A1/en not_active Ceased
- 2014-03-12 PT PT147682363T patent/PT2968269T/pt unknown
- 2014-03-12 EP EP14768236.3A patent/EP2968269B1/en active Active
- 2014-03-12 RS RSP20191136 patent/RS59402B1/sr unknown
- 2014-03-12 SM SM20190508T patent/SMT201900508T1/it unknown
- 2014-03-12 US US14/776,366 patent/US10287289B2/en active Active
- 2014-03-12 HU HUE14768236A patent/HUE045260T2/hu unknown
- 2014-03-12 ME MEP-2019-255A patent/ME03506B/me unknown
- 2014-03-12 EP EP19184972.8A patent/EP3597737A1/en active Pending
- 2014-03-12 DK DK14768236.3T patent/DK2968269T3/da active
- 2014-03-12 LT LT14768236T patent/LT2968269T/lt unknown
-
2019
- 2019-03-11 US US16/298,467 patent/US10696681B2/en active Active
- 2019-10-09 CY CY20191101059T patent/CY1122690T1/el unknown
-
2020
- 2020-06-26 US US16/914,138 patent/US11091493B2/en active Active
-
2021
- 2021-08-11 US US17/399,274 patent/US11649243B2/en active Active
-
2023
- 2023-11-14 US US18/508,594 patent/US20240300955A1/en not_active Abandoned
-
2024
- 2024-04-29 US US18/649,712 patent/US12180219B2/en active Active
- 2024-12-27 US US19/003,660 patent/US20250304588A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SMT201900508T1 (it) | 2019-11-13 |
| US10696681B2 (en) | 2020-06-30 |
| JP6383403B2 (ja) | 2018-08-29 |
| WO2014150639A1 (en) | 2014-09-25 |
| RS59402B1 (sr) | 2019-11-29 |
| JP2016515117A (ja) | 2016-05-26 |
| US11091493B2 (en) | 2021-08-17 |
| US20250304588A1 (en) | 2025-10-02 |
| EP2968269B1 (en) | 2019-07-10 |
| HUE045260T2 (hu) | 2019-12-30 |
| US20170145014A1 (en) | 2017-05-25 |
| ES2746801T3 (es) | 2020-03-06 |
| CY1122690T1 (el) | 2021-03-12 |
| ME03506B (me) | 2020-04-20 |
| LT2968269T (lt) | 2019-10-25 |
| EP3597737A1 (en) | 2020-01-22 |
| PT2968269T (pt) | 2019-10-08 |
| US20240300955A1 (en) | 2024-09-12 |
| PL2968269T3 (pl) | 2020-03-31 |
| EP2968269A4 (en) | 2016-12-28 |
| US20240300960A1 (en) | 2024-09-12 |
| US20190194211A1 (en) | 2019-06-27 |
| US12180219B2 (en) | 2024-12-31 |
| US20200392141A1 (en) | 2020-12-17 |
| US11649243B2 (en) | 2023-05-16 |
| EP2968269A1 (en) | 2016-01-20 |
| HRP20191546T1 (hr) | 2019-11-29 |
| US10287289B2 (en) | 2019-05-14 |
| US20220073523A1 (en) | 2022-03-10 |
| SI2968269T1 (sl) | 2019-12-31 |
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