TR201909709T4 - Fosfordiesteraz inhibitörleri olarak benzodioksol türevleri. - Google Patents
Fosfordiesteraz inhibitörleri olarak benzodioksol türevleri. Download PDFInfo
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- TR201909709T4 TR201909709T4 TR2019/09709T TR201909709T TR201909709T4 TR 201909709 T4 TR201909709 T4 TR 201909709T4 TR 2019/09709 T TR2019/09709 T TR 2019/09709T TR 201909709 T TR201909709 T TR 201909709T TR 201909709 T4 TR201909709 T4 TR 201909709T4
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- Prior art keywords
- phosphodiesterase inhibitors
- schf2
- scf3
- ochf2
- chf2
- Prior art date
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- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical class C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 title 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 title 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 241000534944 Thia Species 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 amino, thioxo Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract
Genel formül (I)'e sahip olan bileşikler olup, burada m ve n ifadelerinin her biri bağımsız olarak 0 ya da 1'dir; tutundukları karbon atomu ile birlikte R1 ve R2 ifadeleri oksijen, sülfür, -S(O)- ve -S(O)2'den seçilen bir ya da iki heteroatom içeren bir heterosiklik halka oluşturur; R3 ifadesi -CHF2, -CF3, -OCHF2, - OCF3, -SCHF2 ya da -SCF3'tür; X ifadesi bir bağ, -CH2- ya da -NH-`tır; A ifadesi isteğe bağlı olarak R4'ten seçilen bir ya da daha fazla, aynı ya da farklı ornatıkla ornatılan aril, sikloalkil, sikloalkenil, arilalkil, heteroaril, heteroarilalkil, heterosikloalkil ya da heterosikloalkenildir; ve R4 ifadesi hidrojen, amino, tiokso, alkil, haloalkil, hidroksialkil, alkoksi, haloalkoksi, halojen, okso, tia ya da hidroksidir; ya da bunların farmasötik olarak kabul edilebilir tuzları, hidratları ya da solvatlarıdır ve bunların PDE4 inhibe edici aktivite sergiledikleri saptanmıştır ve bu nedenle inflamatuar hastalık ve bozuklukların tedavisinde kullanışlı olabilirler.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35820910P | 2010-06-24 | 2010-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201909709T4 true TR201909709T4 (tr) | 2019-07-22 |
Family
ID=44351701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/09709T TR201909709T4 (tr) | 2010-06-24 | 2011-06-24 | Fosfordiesteraz inhibitörleri olarak benzodioksol türevleri. |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8980905B2 (tr) |
| EP (2) | EP2585469B1 (tr) |
| JP (2) | JP6174997B2 (tr) |
| KR (1) | KR101864578B1 (tr) |
| CN (1) | CN102958937B (tr) |
| AU (1) | AU2011269429B2 (tr) |
| BR (1) | BR112012032813B1 (tr) |
| CA (1) | CA2802895C (tr) |
| CY (2) | CY1117862T1 (tr) |
| DK (2) | DK2585469T3 (tr) |
| ES (2) | ES2733092T3 (tr) |
| HR (2) | HRP20160919T1 (tr) |
| HU (2) | HUE030081T2 (tr) |
| IL (1) | IL223329A (tr) |
| LT (2) | LT3070091T (tr) |
| MX (1) | MX2012014131A (tr) |
| MY (1) | MY157481A (tr) |
| NZ (1) | NZ603895A (tr) |
| PL (2) | PL3070091T3 (tr) |
| PT (2) | PT2585469T (tr) |
| RS (2) | RS58945B1 (tr) |
| RU (1) | RU2583787C2 (tr) |
| SG (1) | SG186140A1 (tr) |
| SI (2) | SI3070091T1 (tr) |
| TR (1) | TR201909709T4 (tr) |
| TW (1) | TWI507410B (tr) |
| UA (1) | UA109140C2 (tr) |
| WO (1) | WO2011160632A1 (tr) |
| ZA (1) | ZA201209031B (tr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2925364A1 (en) * | 2012-11-30 | 2015-10-07 | Leo Pharma A/S | A method of inhibiting the expression of il-22 in activated t-cells |
| MX2016016378A (es) | 2014-06-23 | 2017-10-16 | Leo Pharma As | Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| DK3390407T3 (da) * | 2015-12-18 | 2023-11-06 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| DK3642210T3 (da) * | 2017-06-20 | 2024-12-09 | Union Therapeutics As | Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser |
| PT3724196T (pt) | 2017-12-15 | 2023-01-13 | Union Therapeutics As | Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase |
| CN120097995A (zh) | 2018-05-21 | 2025-06-06 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| PL3911304T3 (pl) | 2019-01-15 | 2023-12-04 | UNION therapeutics A/S | Preparat w postaci tabletek o zmodyfikowanym uwalnianiu, zawierający inhibitory fosfodiesterazy |
| WO2021016409A1 (en) * | 2019-07-24 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibition in combination therapies for the treatment of cancers |
| WO2021016414A1 (en) | 2019-07-24 | 2021-01-28 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 7-chloro-2-(4-(3-methoxyazetidin-1-yl)cyclohexyl)-2,4-dimethyl-n-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)benzo[d][1,3]dioxole-5-carboxamide |
| CN112552276B (zh) * | 2019-09-25 | 2023-03-21 | 中国科学院上海药物研究所 | 苯并氧杂卓-5-酮类化合物及其制备方法和用途 |
| KR20230159485A (ko) | 2021-03-22 | 2023-11-21 | 유니온 테라퓨틱스 에이/에스 | 오리스밀라스트를 사용한 화농땀샘염의 치료 |
| GB202205715D0 (en) | 2022-04-19 | 2022-06-01 | Union Therapeutics As | Treatment of neutrophilic dermatoses |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
| GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
| ATE325110T1 (de) | 1995-05-19 | 2006-06-15 | Kyowa Hakko Kogyo Kk | Sauerstoff enthaltende heterocyclische verbindungen |
| CN1219171A (zh) * | 1996-05-20 | 1999-06-09 | 达尔文发现有限公司 | 苯并呋喃甲酰胺及其治疗用途 |
| WO1998022455A1 (en) | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygenic heterocyclic compounds |
| JP2005060375A (ja) * | 2003-07-28 | 2005-03-10 | Kyowa Hakko Kogyo Co Ltd | 含酸素複素環化合物 |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| AP2334A (en) * | 2004-12-17 | 2011-12-06 | Glenmark Pharmaceuticals Sa | Novel heterocyclic compounds useful for the treatment of inflamatory and allergic disorders. |
| UA98639C2 (en) * | 2007-02-28 | 2012-06-11 | Лео Фарма А/С | Phosphodiesterase inhibitors |
| CA2676933C (en) * | 2007-02-28 | 2015-09-29 | Leo Pharma A/S | Novel phosphodiesterase inhibitors |
| PL2794603T3 (pl) * | 2011-12-21 | 2017-08-31 | Leo Pharma A/S | [1,2,4]triazolopirydyny i ich zastosowanie jako inhibitory fosfodiesterazy |
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