DK3274478T3 - Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf - Google Patents

Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf Download PDF

Info

Publication number
DK3274478T3
DK3274478T3 DK15888046.8T DK15888046T DK3274478T3 DK 3274478 T3 DK3274478 T3 DK 3274478T3 DK 15888046 T DK15888046 T DK 15888046T DK 3274478 T3 DK3274478 T3 DK 3274478T3
Authority
DK
Denmark
Prior art keywords
ns4a
hcv
polypeptides
modified
Prior art date
Application number
DK15888046.8T
Other languages
English (en)
Inventor
David Y Chien
Doris Guenzi Coit
Toshiya Fujihara
Alexander Gyenes
John Andrew Hall
Angelica Medina-Selby
Jian Zheng
Original Assignee
Ortho Clinical Diagnostics K K
Grifols Worldwide Operations Ltd
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics K K, Grifols Worldwide Operations Ltd, Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics K K
Application granted granted Critical
Publication of DK3274478T3 publication Critical patent/DK3274478T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/02Hepadnaviridae, e.g. hepatitis B virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae
    • G01N2333/183Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
    • G01N2333/186Hepatitis C; Hepatitis NANB
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK15888046.8T 2015-03-27 2015-06-22 Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf DK3274478T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562139183P 2015-03-27 2015-03-27
PCT/US2015/036941 WO2016160046A1 (en) 2015-03-27 2015-06-22 Hcv ns4a/modified ns3 polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
DK3274478T3 true DK3274478T3 (da) 2020-11-23

Family

ID=57004859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15888046.8T DK3274478T3 (da) 2015-03-27 2015-06-22 Hcv-ns4a/modificerede ns3-polypeptider og anvendelser deraf

Country Status (10)

Country Link
US (2) US10267803B2 (da)
EP (1) EP3274478B1 (da)
JP (2) JP6859314B2 (da)
CN (1) CN107735499B (da)
BR (1) BR112017020539B8 (da)
CA (1) CA2980718C (da)
DK (1) DK3274478T3 (da)
ES (1) ES2832335T3 (da)
RU (1) RU2017133463A (da)
WO (1) WO2016160046A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2980718C (en) * 2015-03-27 2021-06-01 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof
AU2020252001B2 (en) 2019-03-29 2026-02-26 Trustees Of Boston University Chimeric antigen receptor (CAR) modulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02500880A (ja) 1987-11-18 1990-03-29 カイロン コーポレイション Nanbvの診断用薬およびワクチン
US5256532A (en) 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
KR0185373B1 (ko) 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
ES2188583T3 (es) 1991-06-24 2003-07-01 Chiron Corp Polipeptidos para el virus de la hepatitis c (hcv).
UA39944C2 (uk) 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
EP0984068B1 (en) * 1993-04-27 2012-03-28 Innogenetics N.V. Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
JP3217600B2 (ja) 1994-07-12 2001-10-09 株式会社先端生命科学研究所 非a非b型肝炎ウイルス関連抗原のイムノアッセイ、それに使用するモノクローナル抗体、およびこの抗体を産生するハイブリドーマ
NZ333431A (en) 1996-05-24 2000-05-26 Chiron Corp Multiple epitope fusion protein selected from HIV or HCV, method of immunoassay and assay device
WO1999028482A2 (en) * 1997-11-28 1999-06-10 Schering Corporation Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide
JP2002534084A (ja) * 1999-01-08 2002-10-15 ブリストル−マイヤーズ スクイブ カンパニー C型肝炎ウイルスns3プロテアーゼの修飾形
SI1354204T2 (sl) 2000-06-15 2010-09-30 Novartis Vaccines & Diagnostic Hcv antigen antitelo kombinacijska analiza
US7491808B2 (en) 2000-06-15 2009-02-17 Novartis Vaccines And Diagnostics, Inc. HCV non-structural protein mutants and uses thereof
AU2003248818A1 (en) * 2002-07-02 2004-01-23 Novartis Vaccines And Diagnostics, Inc. Hcv fusion proteins with modified ns3 domains
EP1802778B1 (en) * 2004-08-27 2011-10-05 Novartis Vaccines and Diagnostics, Inc. Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
MX2008011361A (es) * 2006-03-09 2008-09-15 Transgene Sa Proteina de fusion no-estructural del virus de hepatitis c.
US20100297607A1 (en) * 2009-05-20 2010-11-25 Jian Zheng Reagents For HCV Antigen-Antibody Combination Assays
WO2014093602A1 (en) * 2012-12-14 2014-06-19 Profectus Biosciences, Inc. Compositions and methods for treating and preventing hepatitis c virus infection
CA2980718C (en) * 2015-03-27 2021-06-01 Ortho-Clinical Diagnostics, Inc. Hcv ns4a/modified ns3 polypeptides and uses thereof

Also Published As

Publication number Publication date
BR112017020539B8 (pt) 2024-01-09
CA2980718C (en) 2021-06-01
ES2832335T3 (es) 2021-06-10
US10267803B2 (en) 2019-04-23
JP6859314B2 (ja) 2021-04-14
US10753939B2 (en) 2020-08-25
CA2980718A1 (en) 2016-10-06
JP2020129001A (ja) 2020-08-27
RU2017133463A3 (da) 2019-04-29
BR112017020539A2 (pt) 2018-07-10
EP3274478A4 (en) 2018-08-08
EP3274478B1 (en) 2020-09-23
RU2017133463A (ru) 2019-04-29
JP2018513390A (ja) 2018-05-24
ES2832335T8 (es) 2021-06-23
CN107735499B (zh) 2022-05-03
US20190271700A1 (en) 2019-09-05
US20180011096A1 (en) 2018-01-11
EP3274478A1 (en) 2018-01-31
BR112017020539B1 (pt) 2023-12-12
CN107735499A (zh) 2018-02-23
WO2016160046A1 (en) 2016-10-06

Similar Documents

Publication Publication Date Title
IL285286A (en) Transposase polypeptides and uses thereof
IL282704A (en) De novo binding domain containing polypeptides and uses thereof
DK3727426T3 (da) Incretinanaloger og anvendelser deraf
DK3494134T3 (da) Manipulerede polypeptider og deres anvendelse
DK3480213T3 (da) Syntac-polypeptider og anvendelser deraf
DK3412302T3 (da) Modificerede fgf-21-polypeptider og anvendelser deraf
DK3390444T3 (da) Anti-tl1a-antigenbindende proteiner og anvendelser deraf
DK3452463T3 (da) Amidsubstituerede pyridinyltriazolderivater og anvendelser deraf
DK3303379T3 (da) Tigit-bindende midler og anvendelser deraf
DK3283106T3 (da) Terapeutiske antistoffer og anvendelser deraf
DK3559227T3 (da) Proteasevarianter og anvendelser deraf
DK3333191T3 (da) Anti-C10ORF54-antistoffer og anvendelser deraf
DK3126388T3 (da) Anti-EGFRvIII-antistoffer og anvendelser deraf
DK3532499T3 (da) ANTI-IL-33-antistoffer og anvendelser deraf
DK3402821T5 (da) Psma-bindende antistof og anvendelser deraf
DK3368655T3 (da) Forbedret proteinekspression og fremgangsmåder dertil
DK3161139T3 (da) Tlr-4-specifikke aptamerer og anvendelser heraf
DK3128005T3 (da) Sirp-alfa-variantkonstruktioner og anvendelser deraf
DK3145945T3 (da) Hidtil ukendte specifikt bindende polypeptider og anvendelser deraf
DK3321279T3 (da) Exenatidmodificeringsmiddel og anvendelse deraf
DK3365321T3 (da) Solabegron-zwitterion og anvendelser deraf
DK3448419T3 (da) Interferon-beta-antistoffer og anvendelser deraf
DK3337506T3 (da) Kombinationer og anvendelser deraf
DK3388085T3 (da) Farmaceutisk sammensætning og anvendelser deraf
DK3512544T3 (da) Peptidforbindelser og terapeutiske anvendelser deraf