DK332983D0 - Derivater af morpholinyldaunorubicin og morpholinyldoxorubicin og analoge deraf samt fremgangsmade til fremstilling deraf - Google Patents

Derivater af morpholinyldaunorubicin og morpholinyldoxorubicin og analoge deraf samt fremgangsmade til fremstilling deraf

Info

Publication number: DK332983D0
Authority: DK; Denmark
Prior art keywords: morpholinyldoxorubicin; morpholinyldaunorubicin; analogues; procedures; derivatives
Prior art date: 1982-07-20

Application number

DK3329/83A

Other languages

English (en)

Other versions

DK158269C (da

DK332983A (da

DK158269B (da

Inventor

Carol Walker Mosher

George Low Tong

Edward Mcintosh Acton

Original Assignee

Stanford Res Inst Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-20

Filing date

1983-07-19

Publication date

1983-07-19

1983-07-19 Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int

1983-07-19 Publication of DK332983D0 publication Critical patent/DK332983D0/da

1984-01-21 Publication of DK332983A publication Critical patent/DK332983A/da

1990-04-23 Publication of DK158269B publication Critical patent/DK158269B/da

1990-10-08 Application granted granted Critical

1990-10-08 Publication of DK158269C publication Critical patent/DK158269C/da

Links

SXCIMUIAZXOVIR-PUCKCBAPSA-N (7s,9s)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7-[(2r,4s,5s,6s)-5-hydroxy-6-methyl-4-morpholin-4-yloxan-2-yl]oxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound N1([C@H]2C[C@@H](O[C@@H](C)[C@H]2O)O[C@H]2C[C@@](O)(CC=3C(O)=C4C(=O)C=5C=CC=C(C=5C(=O)C4=C(O)C=32)OC)C(=O)CO)CCOCC1 SXCIMUIAZXOVIR-PUCKCBAPSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

DK332983A 1982-07-20 1983-07-19 Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivater DK158269C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US40012082A	1982-07-20	1982-07-20
US40012082		1982-07-20
US49612283		1983-05-24
US06/496,122 US4464529A (en)	1982-07-20	1983-05-24	Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Publications (4)

Publication Number	Publication Date
DK332983D0 true DK332983D0 (da)	1983-07-19
DK332983A DK332983A (da)	1984-01-21
DK158269B DK158269B (da)	1990-04-23
DK158269C DK158269C (da)	1990-10-08

Family

ID=27016900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK332983A DK158269C (da)	1982-07-20	1983-07-19	Analogifremgangsmaade til fremstilling af morpholinyldaunorubicin- eller morpholinyldoxorubicinderivater

Country Status (24)

Country	Link
US (1)	US4464529A (da)
KR (1)	KR880002461B1 (da)
AT (1)	AT381319B (da)
AU (1)	AU555902B2 (da)
BE (1)	BE897312A (da)
CA (1)	CA1239396A (da)
CH (1)	CH655729A5 (da)
DE (1)	DE3325816A1 (da)
DK (1)	DK158269C (da)
ES (2)	ES8501415A1 (da)
FI (1)	FI75174C (da)
FR (1)	FR2530640B1 (da)
GB (1)	GB2124224B (da)
GR (1)	GR78885B (da)
IE (1)	IE55795B1 (da)
IL (1)	IL69260A (da)
IT (1)	IT1163818B (da)
NL (1)	NL188905C (da)
NO (1)	NO157146C (da)
NZ (1)	NZ204911A (da)
PH (1)	PH21860A (da)
PT (1)	PT77060B (da)
SE (1)	SE459921B (da)
YU (2)	YU155083A (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4826964A (en) *	1982-07-20	1989-05-02	Sri International	Bridged oxygen analogs of daunorubcin and doxorubicin
JPS59212499A (ja) *	1983-05-13	1984-12-01	アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド	抗腫瘍性抗生物質アントラサイクリンの４−デメトキシ−３′−デアミノ−３′（４−モリホリニル）誘導体
GB2140006A (en) *	1983-05-17	1984-11-21	Erba Farmitalia	Anthracycline derivatives
US4585859A (en) *	1983-05-24	1986-04-29	Sri International	Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
FR2560876B1 (fr) *	1984-03-09	1987-01-16	Hoechst Lab	Nouvelles anthracyclinones, leur procede de preparation, nouveaux glycosides (anthracyclines) obtenus a partir de ces anthracyclinones, utilisation de ces glycosides en tant que medicaments
FR2565982B1 (fr) *	1984-06-15	1988-01-15	Hoechst Lab	Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
GB8426672D0 (en) *	1984-10-22	1984-11-28	Erba Farmitalia	Pharmaceutical compositions
US4705850A (en) *	1984-10-25	1987-11-10	Sri International	C-glycosidic adriamycin analogs
US4591637A (en) *	1985-01-17	1986-05-27	Sri International	Open chain-morpholino adriamycins
US4710564A (en) *	1985-01-18	1987-12-01	Microbial Chemistry Research Foundation	Anthracycline compounds
GB2172594B (en) *	1985-03-22	1988-06-08	Erba Farmitalia	New morpholino derivatives of daunorubicin and doxorubicin
GB8519452D0 (en) *	1985-08-02	1985-09-11	Erba Farmitalia	Injectable solutions
US5124317A (en) *	1985-08-02	1992-06-23	Farmitalia Carlo Erba S.P.A.	Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5137877B1 (en) *	1990-05-14	1996-01-30	Bristol Myers Squibb Co	Bifunctional linking compounds conjugates and methods for their production
GB9019933D0 (en) *	1990-09-12	1990-10-24	Erba Carlo Spa	13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
US5196522A (en) *	1990-11-01	1993-03-23	Board Of Regents, The University Of Texas System	Anthracycline analogues bearing latent alkylating substituents
US5843903A (en) *	1995-11-27	1998-12-01	The Administrators Of The Tulane Educational Fund	Targeted cytotoxic anthracycline analogs
ES2274823T3 (es) *	1999-12-29	2007-06-01	Immunogen, Inc.	Agentes cototoxicos que comprenden doxorrubicinas y daunorrubicinas y su utilizacion terapeutica.
WO2005086951A2 (en) *	2004-03-10	2005-09-22	Threshold Pharmaceuticals, Inc.	Hypoxia-activated anti-cancer agents
US20070060534A1 (en) *	2005-06-30	2007-03-15	Threshold Pharmaceuticals, Inc.	Anthracycline analogs
AU2009235897B2 (en) *	2008-04-11	2012-04-12	Tianjin Hemay Oncology Pharmaceutical Co., Ltd	Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
RU2013103763A (ru)	2010-07-02	2014-08-10	Ангиохем Инк.	Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
US10149913B2 (en)	2014-09-12	2018-12-11	Genentech, Inc.	Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en)	2021-11-10	2023-05-17	Nerviano Medical Sciences S.r.l.	Anthracycline derivative linker reagents, antibody-drug conjugates and methods
WO2025168481A1 (en)	2024-02-05	2025-08-14	Nerviano Medical Sciences S.R.L.	Imino-anthracycline derivatives and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4109076A (en) *	1977-09-08	1978-08-22	Sri International	5-iminodaunomycin
US4202967A (en) *	1978-10-02	1980-05-13	Sri International	N,N-pentamethylene derivatives of daunomycin and adriamycin
US4301277A (en) *	1980-10-20	1981-11-17	Sri International	3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxorubicin
US4314054A (en) *	1981-03-23	1982-02-02	Sri International	3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin

1983
- 1983-05-24 US US06/496,122 patent/US4464529A/en not_active Expired - Lifetime
- 1983-07-15 AT AT0260883A patent/AT381319B/de not_active IP Right Cessation
- 1983-07-15 GB GB08319165A patent/GB2124224B/en not_active Expired
- 1983-07-15 NZ NZ204911A patent/NZ204911A/en unknown
- 1983-07-18 YU YU01550/83A patent/YU155083A/xx unknown
- 1983-07-18 IL IL69260A patent/IL69260A/xx unknown
- 1983-07-18 DE DE19833325816 patent/DE3325816A1/de active Granted
- 1983-07-18 NO NO832610A patent/NO157146C/no unknown
- 1983-07-18 PH PH29236A patent/PH21860A/en unknown
- 1983-07-18 FR FR8311803A patent/FR2530640B1/fr not_active Expired
- 1983-07-18 AU AU16946/83A patent/AU555902B2/en not_active Ceased
- 1983-07-18 BE BE0/211190A patent/BE897312A/fr not_active IP Right Cessation
- 1983-07-19 GR GR71976A patent/GR78885B/el unknown
- 1983-07-19 PT PT77060A patent/PT77060B/pt not_active IP Right Cessation
- 1983-07-19 FI FI832637A patent/FI75174C/fi not_active IP Right Cessation
- 1983-07-19 CA CA000432737A patent/CA1239396A/en not_active Expired
- 1983-07-19 KR KR1019830003323A patent/KR880002461B1/ko not_active Expired
- 1983-07-19 CH CH3949/83A patent/CH655729A5/de not_active IP Right Cessation
- 1983-07-19 SE SE8304045A patent/SE459921B/sv not_active IP Right Cessation
- 1983-07-19 ES ES524271A patent/ES8501415A1/es not_active Expired
- 1983-07-19 DK DK332983A patent/DK158269C/da not_active IP Right Cessation
- 1983-07-19 NL NLAANVRAGE8302586,A patent/NL188905C/xx not_active IP Right Cessation
- 1983-07-19 IE IE1680/83A patent/IE55795B1/en not_active IP Right Cessation
- 1983-07-20 IT IT22143/83A patent/IT1163818B/it active
1984
- 1984-03-14 ES ES530593A patent/ES530593A0/es active Granted
1985
- 1985-09-09 YU YU01405/85A patent/YU140585A/xx unknown

Also Published As

Publication number	Publication date
DK158269C (da)	1990-10-08
SE8304045L (sv)	1984-01-21
ES8602032A1 (es)	1985-11-01
DE3325816A1 (de)	1984-01-26
FI832637A7 (fi)	1984-01-21
NL8302586A (nl)	1984-02-16
DK332983A (da)	1984-01-21
KR840005443A (ko)	1984-11-12
DK158269B (da)	1990-04-23
ES530593A0 (es)	1985-11-01
FI75174B (fi)	1988-01-29
IL69260A (en)	1987-03-31
IT1163818B (it)	1987-04-08
YU155083A (en)	1986-02-28
NO157146B (no)	1987-10-19
IT8322143A0 (it)	1983-07-20
YU140585A (en)	1986-02-28
ATA260883A (de)	1986-02-15
GB8319165D0 (en)	1983-08-17
IE831680L (en)	1984-01-20
NO832610L (no)	1984-01-23
NZ204911A (en)	1986-04-11
SE459921B (sv)	1989-08-21
FI75174C (fi)	1988-05-09
PT77060A (en)	1983-08-01
AU555902B2 (en)	1986-10-16
IL69260A0 (en)	1983-11-30
NL188905C (nl)	1992-11-02
ES524271A0 (es)	1984-11-16
GB2124224A (en)	1984-02-15
FR2530640A1 (fr)	1984-01-27
CA1239396A (en)	1988-07-19
PT77060B (en)	1986-04-09
GB2124224B (en)	1985-12-04
AT381319B (de)	1986-09-25
AU1694683A (en)	1984-01-26
GR78885B (da)	1984-10-02
PH21860A (en)	1988-03-25
NO157146C (no)	1988-01-27
IE55795B1 (en)	1991-01-16
IT8322143A1 (it)	1985-01-20
FI832637A0 (fi)	1983-07-19
FR2530640B1 (fr)	1985-07-12
DE3325816C2 (da)	1990-05-03
ES8501415A1 (es)	1984-11-16
SE8304045D0 (sv)	1983-07-19
US4464529A (en)	1984-08-07
KR880002461B1 (ko)	1988-11-14
CH655729A5 (de)	1986-05-15
BE897312A (fr)	1984-01-18

Legal Events

Date	Code	Title	Description
1994-03-28	PBP	Patent lapsed

Publication	Publication Date	Title
DK332983A (da)	1984-01-21	Derivater af morpholinyldaunorubicin og morpholinyldoxorubicin og analoge deraf samt fremgangsmaade til fremstilling deraf
DK470583A (da)	1984-04-14	Fremgangsmaade til fremstilling af 1-phenyl-2-piperidinopropanolderivater
DK307883D0 (da)	1983-07-04	Carbostyrilderivater samt fremgangsmade til fremstilling deraf
DK493583A (da)	1984-04-29	Azolderivater og fremgangsmaade til fremstilling deraf
DK492783D0 (da)	1983-10-27	Fremgangsmade til fremstilling af 3-aryl-5-pyrazol-derivater
DK421879A (da)	1980-04-23	Formstofnet og fremgangsmaade til fremstilling af dette
DK497682A (da)	1983-05-10	Fremgangsmaade til fremstilling af 7-oxabicycloheptan- og 7-oxabicycloheptenprostaglandinanaloge
DK95483D0 (da)	1983-02-25	Fremgangsmade til fremstilling af tetrahydropyranderivater
DK606084A (da)	1985-06-23	Fremgangsmaade til fremstilling af 2-fluor-17beta-oestradiol
DK157683D0 (da)	1983-04-11	N-phosphonomethylglycinderivater og fremgangsmade til fremstilling og anvendelse deraf
DK386784D0 (da)	1984-08-10	Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
DK93684D0 (da)	1984-02-23	Fremgangsmade til adjuvering af oliefri vacciner
DK563883D0 (da)	1983-12-07	Fremgangsmaade til fremstilling af 2-thiacephemer og(5r)-penem-derivater
DK71783A (da)	1983-08-21	Fremgangsmaade til fremstilling af pyrimidonderivater
DK423284A (da)	1985-03-09	Naphthalenylimidazopyridin og derivater heraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK364483D0 (da)	1983-08-10	14-aminosteroid-derivater samt fremgangsmade til fremstilling deraf
DK37890A (da)	1990-02-13	Fremgangsmaade til fremstilling af 6-deoxyanthracycliner
DK422783D0 (da)	1983-09-16	Fremgangsmade til fremstilling af blatungevaccine og fremgangsmade til at immunisere droevtyggere hermed
DK493384D0 (da)	1984-10-16	Fremgangsmaade til fremstilling af bis-dioxopiperazin-derivater
DK90083A (da)	1983-09-09	Isoxazolopyrimidinderivater og fremgangsmaade til fremstilling deraf
DK110582A (da)	1982-09-20	2-benzoylamino-substituerede benzylaminderivater samt fremgangsmaade til fremstilling af samme
DK84183D0 (da)	1983-02-24	Benzyletherderivater af pentiter og fremgangsmade til fremstilling deraf
DK573184D0 (da)	1984-12-03	Fremgangsmaade til fremstilling af polyphenylenoxid
DK253283D0 (da)	1983-06-03	Fremgangsmade til fremstilling af benzylsulfinylacetamidderivater
DK549983A (da)	1984-06-02	Fremgangsmaade til fremstilling af 4(5)-acetyl-2-methylimidazol eller benzylderivater deraf