DK3350195T3 - Fremgangsmåde til syntese og oprensning af nukleosid og/eller nukleotid, modificeret nukleosid og/eller nukleotid, dna-molekyle og oligonukleotidbibliotek omfattende det modificerede nukleosid og/eller nukleotid og anvendelse af oligonukleotidet - Google Patents

Fremgangsmåde til syntese og oprensning af nukleosid og/eller nukleotid, modificeret nukleosid og/eller nukleotid, dna-molekyle og oligonukleotidbibliotek omfattende det modificerede nukleosid og/eller nukleotid og anvendelse af oligonukleotidet Download PDF

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Publication number
DK3350195T3
DK3350195T3 DK16846944.3T DK16846944T DK3350195T3 DK 3350195 T3 DK3350195 T3 DK 3350195T3 DK 16846944 T DK16846944 T DK 16846944T DK 3350195 T3 DK3350195 T3 DK 3350195T3
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Denmark
Prior art keywords
nucleotide
nucleoside
nulicide
purification
synthesis
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Application number
DK16846944.3T
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English (en)
Inventor
Przemyslaw Jurek
Filip Jelen
Maciej Mazurek
Piotr Jakimowicz
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Pure Biologics Spolka Akcyjna
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Publication of DK3350195T3 publication Critical patent/DK3350195T3/da

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK16846944.3T 2015-09-17 2016-09-13 Fremgangsmåde til syntese og oprensning af nukleosid og/eller nukleotid, modificeret nukleosid og/eller nukleotid, dna-molekyle og oligonukleotidbibliotek omfattende det modificerede nukleosid og/eller nukleotid og anvendelse af oligonukleotidet DK3350195T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL413941A PL239946B1 (pl) 2015-09-17 2015-09-17 Sposób syntezy i oczyszczania nukleotydu, zmodyfikowany nukleotyd, cząsteczka DNA i biblioteka oligonukleotydów zawierające zmodyfikowany nukleotyd oraz zastosowanie biblioteki oligonukleotydów
PCT/PL2016/050038 WO2017048147A1 (en) 2015-09-17 2016-09-13 The method of synthesis and purification of a nucleoside and/or a nucleotide, a modified nucleoside and/or nucleotide, a dna molecule and an oligonucleotide library comprising said modified nucleoside and/or nucleotide and the use of said oligonucleotide library

Publications (1)

Publication Number Publication Date
DK3350195T3 true DK3350195T3 (da) 2021-08-30

Family

ID=58289513

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16846944.3T DK3350195T3 (da) 2015-09-17 2016-09-13 Fremgangsmåde til syntese og oprensning af nukleosid og/eller nukleotid, modificeret nukleosid og/eller nukleotid, dna-molekyle og oligonukleotidbibliotek omfattende det modificerede nukleosid og/eller nukleotid og anvendelse af oligonukleotidet

Country Status (10)

Country Link
US (1) US10450673B2 (da)
EP (1) EP3350195B9 (da)
DK (1) DK3350195T3 (da)
ES (1) ES2885824T3 (da)
HU (1) HUE055954T2 (da)
LT (1) LT3350195T (da)
PL (2) PL239946B1 (da)
PT (1) PT3350195T (da)
SI (1) SI3350195T1 (da)
WO (1) WO2017048147A1 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL442186A1 (pl) * 2022-09-02 2024-03-04 Pure Biologics Spółka Akcyjna Sposób syntezy i oczyszczania nukleotydu i/lub nukleozydu, zmodyfikowany nukleotyd i/lub nukleozyd, cząsteczka DNA zawierająca jedno- lub dwuniciowy łańcuch oligonukleotydów, biblioteka oligonukleotydów, zastosowanie biblioteki oligonukleotydów

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
US9096856B2 (en) * 2007-07-19 2015-08-04 Georgia State University Research Foundation, Inc. Nucleotides and aptamers containing boronic acid groups having biased binding to glycosylated proteins, and uses thereof

Also Published As

Publication number Publication date
WO2017048147A1 (en) 2017-03-23
LT3350195T (lt) 2021-09-10
HUE055954T2 (hu) 2022-01-28
ES2885824T3 (es) 2021-12-15
US10450673B2 (en) 2019-10-22
PT3350195T (pt) 2021-09-06
SI3350195T1 (sl) 2021-11-30
PL3350195T3 (pl) 2021-10-11
PL239946B1 (pl) 2022-01-31
EP3350195A4 (en) 2019-07-03
EP3350195B1 (en) 2021-06-02
US20180265862A1 (en) 2018-09-20
EP3350195A1 (en) 2018-07-25
EP3350195B9 (en) 2021-09-29
PL413941A1 (pl) 2017-03-27

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