MA54653A - Modulateurs du récepteur de cxcr7 pipéridine - Google Patents

Modulateurs du récepteur de cxcr7 pipéridine

Info

Publication number
MA54653A
MA54653A MA054653A MA54653A MA54653A MA 54653 A MA54653 A MA 54653A MA 054653 A MA054653 A MA 054653A MA 54653 A MA54653 A MA 54653A MA 54653 A MA54653 A MA 54653A
Authority
MA
Morocco
Prior art keywords
cxcr7
piperidine
receptor modulators
modulators
receptor
Prior art date
Application number
MA054653A
Other languages
English (en)
Other versions
MA54653B1 (fr
Inventor
Hamed Aissaoui
Philippe Guerry
Francois Lehembre
Julien Pothier
Laetitia Pouzol
Sylvia Richard-Bildstein
Shuguang Yuan
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MA54653A publication Critical patent/MA54653A/fr
Publication of MA54653B1 publication Critical patent/MA54653B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
MA54653A 2016-07-28 2017-07-27 Modulateurs du récepteur de cxcr7 pipéridine MA54653B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2016068052 2016-07-28

Publications (2)

Publication Number Publication Date
MA54653A true MA54653A (fr) 2021-12-29
MA54653B1 MA54653B1 (fr) 2023-04-28

Family

ID=59656027

Family Applications (2)

Application Number Title Priority Date Filing Date
MA45782A MA45782B1 (fr) 2016-07-28 2017-07-27 Modulateurs du récepteur de cxcr7 pipéridine
MA54653A MA54653B1 (fr) 2016-07-28 2017-07-27 Modulateurs du récepteur de cxcr7 pipéridine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA45782A MA45782B1 (fr) 2016-07-28 2017-07-27 Modulateurs du récepteur de cxcr7 pipéridine

Country Status (32)

Country Link
US (2) US10752620B2 (fr)
EP (2) EP3490986B1 (fr)
JP (2) JP6655754B2 (fr)
KR (2) KR102497095B1 (fr)
CN (2) CN110563717B (fr)
AR (2) AR109180A1 (fr)
AU (2) AU2017302079B2 (fr)
CA (1) CA3032017C (fr)
CL (2) CL2019000169A1 (fr)
CY (1) CY1125016T1 (fr)
DK (2) DK3798217T3 (fr)
EA (2) EA037507B1 (fr)
ES (2) ES2905755T3 (fr)
FI (1) FI3798217T3 (fr)
HR (2) HRP20230313T1 (fr)
HU (2) HUE057315T2 (fr)
IL (2) IL264424B (fr)
LT (2) LT3798217T (fr)
MA (2) MA45782B1 (fr)
MX (2) MX383804B (fr)
MY (2) MY198113A (fr)
NZ (1) NZ751006A (fr)
PH (2) PH12021552605A1 (fr)
PL (2) PL3798217T3 (fr)
PT (2) PT3490986T (fr)
RS (2) RS64130B1 (fr)
SG (2) SG10201906942PA (fr)
SI (2) SI3490986T1 (fr)
TW (3) TWI691497B (fr)
UA (2) UA122987C2 (fr)
WO (1) WO2018019929A1 (fr)
ZA (1) ZA201901256B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019145460A1 (fr) * 2018-01-26 2019-08-01 Idorsia Pharmaceuticals Ltd Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-{[5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino}-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide
JP7749552B2 (ja) * 2019-10-31 2025-10-06 イドルシア・ファーマシューティカルズ・リミテッド Cxcr7アンタゴニストのs1p1受容体調節剤との合剤
AU2021405511A1 (en) * 2020-12-22 2023-06-22 Luxembourg Institute Of Health (Lih) Conolidine analogues as selective ackr3 modulators for the treatment of cancer and cardiovascular diseases
EP4326257A4 (fr) * 2021-04-19 2025-03-12 ChemoCentryx, Inc. Azétidinyl-acétamides utilisés comme inhibiteurs de cxcr7
CA3226468A1 (fr) 2021-08-02 2023-02-09 Andrew Edmunds Derives de pyrazole microbiocides
AU2022356017B2 (en) 2021-10-01 2024-05-30 Nextgen Bioscience Co., Ltd. Novel piperidine derivative and pharmaceutical composition for inhibiting autotaxin comprising same
JP2024546927A (ja) 2021-12-17 2024-12-26 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺微生物性ピラゾール誘導体
EP4238970A1 (fr) * 2022-03-03 2023-09-06 InterAx Biotech AG Modulateurs de ackr3 et leurs utilisations
CN115403510B (zh) * 2022-08-11 2023-04-25 南方医科大学 一种pd-l1/cxcl12双靶点抑制剂、制备方法和用途
TW202434579A (zh) 2022-11-16 2024-09-01 瑞士商先正達農作物保護股份公司 殺微生物的四氫異喹啉衍生物
WO2024115512A1 (fr) 2022-11-30 2024-06-06 Syngenta Crop Protection Ag Dérivés de tétrahydroisoquinoline microbiocides
TW202439972A (zh) 2022-11-30 2024-10-16 瑞士商先正達農作物保護股份公司 殺真菌組成物
PY2403614A (es) 2023-01-27 2025-09-11 Syngenta Crop Protection Ag Derivados de pirazol microbiocidas
AR131665A1 (es) 2023-02-01 2025-04-16 Syngenta Crop Protection Ag Composiciones fungicidas
PY2447478A (es) 2023-06-14 2025-03-18 Syngenta Crop Protection Ag Composiciones fungicidas
PY24116120A (es) 2024-01-03 2025-07-30 Pi Industries Ltd Compuestos de pirazol para combatir hongos fitopatógenos
PY24116080A (es) 2024-01-03 2025-08-04 Pi Industries Ltd Amidas heterociclicas biciclicas para combatir hongos fitopatógenos
WO2025163143A1 (fr) 2024-02-02 2025-08-07 Syngenta Crop Protection Ag Dérivés de pyrazole microbiocides
WO2025172368A1 (fr) 2024-02-13 2025-08-21 Syngenta Crop Protection Ag Dérivés de (5-isoxazol-3-yl)-[4-(pyrazol-4-yl)-3,4-dihydro-1h-isoquinolin-2-yl]méthanone destinés à être utilisés en tant que fongicides
WO2026030052A1 (fr) 2024-07-31 2026-02-05 Fmc Corporation Azoles substitués fongicides

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040102324A1 (en) * 2002-02-28 2004-05-27 Annis Gary David Heterocyclic diamide invertebrate pest control agents
EP1565436B1 (fr) 2002-11-27 2012-04-25 Incyte Corporation Derives de la 3-aminopyrrolidine modulateurs des recepteurs de la chemoquine
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
US7115646B2 (en) 2003-10-08 2006-10-03 Bristol Myers Squibb, Co. Cyclic diamines and derivatives as factor Xa inhibitors
JP4058106B2 (ja) * 2005-02-18 2008-03-05 アストラゼネカ アクチボラグ 抗菌性のピペリジン誘導体
CA2742515C (fr) * 2008-11-04 2017-07-11 Chemocentryx, Inc. Modulateurs 1,4-diazepane de cxcr7
JP6094578B2 (ja) 2011-06-09 2017-03-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝性障害の治療のためのgpr119モジュレーターとしての置換ピペリジン
WO2013084241A1 (fr) * 2011-12-09 2013-06-13 Cadila Healthcare Limited Composés inhibiteurs de rénine
AR091516A1 (es) 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida
MX359651B (es) * 2012-11-29 2018-10-05 Chemocentryx Inc Antagonistas de cxcr7.
MA38679B1 (fr) * 2013-05-30 2019-12-31 Idorsia Pharmaceuticals Ltd Modulateurs du récepteur de cxcr7
CN105705489B (zh) 2013-09-04 2019-04-26 百时美施贵宝公司 用作免疫调节剂的化合物
HUE038169T2 (hu) 2013-09-06 2018-09-28 Aurigene Discovery Tech Ltd 1,2,4-Oxadiazol származékok mint immunomodulátorok
WO2015044900A1 (fr) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Composés immunomodulateurs thérapeutiques
CA2960280A1 (fr) * 2014-09-10 2016-03-17 Epizyme, Inc. Composes piperidines substitues
JP6582056B2 (ja) 2014-12-01 2019-09-25 イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd Cxcr7受容体調節剤
WO2019145460A1 (fr) 2018-01-26 2019-08-01 Idorsia Pharmaceuticals Ltd Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-{[5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino}-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide

Also Published As

Publication number Publication date
US11306078B2 (en) 2022-04-19
TW201922738A (zh) 2019-06-16
JP6655754B2 (ja) 2020-02-26
AU2017302079B2 (en) 2021-07-22
UA129887C2 (uk) 2025-09-03
PH12021552605A1 (en) 2023-01-23
CL2019000169A1 (es) 2019-06-21
PL3798217T3 (pl) 2023-06-12
EP3798217A1 (fr) 2021-03-31
AU2017302079A1 (en) 2019-03-21
SG10201906942PA (en) 2019-09-27
EA202091262A1 (ru) 2020-08-13
WO2018019929A1 (fr) 2018-02-01
HRP20230313T1 (hr) 2023-05-12
NZ751006A (en) 2021-07-30
TWI683812B (zh) 2020-02-01
IL264424B (en) 2021-08-31
HUE057315T2 (hu) 2022-04-28
SG11201900633XA (en) 2019-02-27
KR20200092420A (ko) 2020-08-03
UA122987C2 (uk) 2021-01-27
HRP20211988T1 (hr) 2022-03-18
LT3798217T (lt) 2023-05-25
KR102497091B1 (ko) 2023-02-06
MX383804B (es) 2025-03-14
MX2019001042A (es) 2019-06-10
US10752620B2 (en) 2020-08-25
CA3032017C (fr) 2023-04-18
AU2020204578A1 (en) 2020-07-30
CY1125016T1 (el) 2023-03-24
EP3798217B1 (fr) 2023-02-22
RS64130B1 (sr) 2023-05-31
ES2905755T3 (es) 2022-04-12
PT3798217T (pt) 2023-05-23
EP3490986A1 (fr) 2019-06-05
CA3032017A1 (fr) 2018-02-01
HUE062019T2 (hu) 2023-09-28
MX2021004000A (es) 2021-06-23
IL264424A (en) 2019-02-28
MA45782A (fr) 2019-06-05
TWI691497B (zh) 2020-04-21
ES2954152T3 (es) 2023-11-20
FI3798217T3 (fi) 2023-05-03
LT3490986T (lt) 2022-02-10
IL282942B (en) 2022-01-01
IL282942A (en) 2021-06-30
CN109563085A (zh) 2019-04-02
JP2019142874A (ja) 2019-08-29
KR102497095B1 (ko) 2023-02-06
CN110563717A (zh) 2019-12-13
AU2020204578B2 (en) 2022-03-10
SI3798217T1 (sl) 2023-05-31
PL3490986T3 (pl) 2022-04-04
JP6655742B2 (ja) 2020-02-26
ZA201901256B (en) 2021-08-25
NZ755815A (en) 2025-02-28
RS62855B1 (sr) 2022-02-28
MY199657A (en) 2023-11-14
MY198113A (en) 2023-08-03
US20200385373A1 (en) 2020-12-10
CN109563085B (zh) 2022-08-09
AR109180A1 (es) 2018-11-07
DK3490986T3 (da) 2022-03-07
MA45782B1 (fr) 2021-12-31
TW201932454A (zh) 2019-08-16
JP2019525927A (ja) 2019-09-12
US20190169180A1 (en) 2019-06-06
EA201990388A1 (ru) 2019-08-30
EP3490986B1 (fr) 2021-11-24
MA54653B1 (fr) 2023-04-28
DK3798217T3 (da) 2023-05-22
PH12019500188A1 (en) 2019-10-21
KR20190034620A (ko) 2019-04-02
CN110563717B (zh) 2022-08-09
TWI691494B (zh) 2020-04-21
AR115662A2 (es) 2021-02-10
CL2019003281A1 (es) 2020-05-04
PT3490986T (pt) 2022-02-01
SI3490986T1 (sl) 2022-02-28
TW201806940A (zh) 2018-03-01
BR112019001551A2 (pt) 2019-05-14
EA037507B1 (ru) 2021-04-06

Similar Documents

Publication Publication Date Title
MA54653A (fr) Modulateurs du récepteur de cxcr7 pipéridine
MA43382A (fr) Modulateurs des récepteurs des chimiokines
EP3442971A4 (fr) Modulateurs du récepteur des estrogènes
EP3521427A4 (fr) Co-récepteur de récepteur odorant
PT3494133T (pt) Recetores de células t anti-kras-g12d
DK3359160T3 (da) Farnesoid x receptor modulatorer
HUE047929T2 (hu) Kiméra antigén receptor
MA55328A (fr) Modulateurs de ror-gamma
PT3223850T (pt) Receptores de células t anti-kras mutado
MA53943A (fr) Modulateurs de ror-gamma
PT3101032T (pt) Onjugado de anticorpo anti-her2-fármaco
MA42133A (fr) Modulateurs du ccr2
EP3219592C0 (fr) Fixation
EP3286210C0 (fr) Récepteur de lymphocyte t
EP3565543A4 (fr) Modulateurs du récepteur opioïde de type mu
MA52555A (fr) Modulateurs du récepteur des oestrogènes
EP3529267C0 (fr) Récepteur de lymphocytes t
DK3819287T3 (da) Amorft tapentadolphosphat
IL247140A0 (en) Pyrazines modulators of gpr6
EP3532062A4 (fr) Modulateurs de ror-gamma
EP3421454A4 (fr) Dérivé de pipéridine
EP3408286C0 (fr) Protéines g
DK3126521T3 (da) HNF4G-RSPO2-fusionsgen
PT3302948T (pt) Unidade de força de fecho
FR3018292B1 (fr) Module de construction du type gabion