ZA859526B - Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them - Google Patents

Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them

Info

Publication number
ZA859526B
ZA859526B ZA859526A ZA859526A ZA859526B ZA 859526 B ZA859526 B ZA 859526B ZA 859526 A ZA859526 A ZA 859526A ZA 859526 A ZA859526 A ZA 859526A ZA 859526 B ZA859526 B ZA 859526B
Authority
ZA
South Africa
Prior art keywords
group
substituted
tryptophan
pharmaceutical compositions
compositions containing
Prior art date
Application number
ZA859526A
Other languages
English (en)
Inventor
Francesco Makovec
Rolando Chiste
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ZA859526B publication Critical patent/ZA859526B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA859526A 1984-12-12 1985-12-12 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them ZA859526B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT68241/84A IT1179866B (it) 1984-12-12 1984-12-12 Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number Publication Date
ZA859526B true ZA859526B (en) 1986-08-27

Family

ID=11308641

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA859526A ZA859526B (en) 1984-12-12 1985-12-12 Pharmaceutically active derivatives of tryptophan and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US4870097A (da)
EP (1) EP0237522B1 (da)
JP (1) JPS62501292A (da)
AT (1) ATE85976T1 (da)
AU (1) AU589938B2 (da)
CA (1) CA1256441A (da)
DE (1) DE3587122T2 (da)
DK (1) DK168564B1 (da)
ES (1) ES8706630A1 (da)
IE (1) IE58502B1 (da)
IT (1) IT1179866B (da)
PT (1) PT81674B (da)
WO (1) WO1986003489A1 (da)
ZA (1) ZA859526B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4880938A (en) * 1986-06-16 1989-11-14 Merck & Co., Inc. Amino acid analogs
US5089638A (en) * 1986-06-16 1992-02-18 Merck & Co., Inc. Amino acid analogs as CCK-antagonists
SE8901149D0 (sv) * 1989-04-03 1989-04-03 Pharmacia Ab Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
DK0501378T3 (da) * 1991-02-28 1995-03-20 Merrell Dow Pharma NMDA-antagonister
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US20030199523A1 (en) * 2002-02-28 2003-10-23 Snutch Terrance P. Heterocyclic calcium in channel blockers
PT1549333E (pt) 2002-09-20 2012-01-03 Univ Pennsylvania Análogos de compstatina com actividade melhorada
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
EP2662089A3 (en) 2005-10-08 2014-02-19 Potentia Pharmaceuticals, Inc. Compstatin and analogs thereof for eye disorders
CN102977191B (zh) 2005-11-28 2016-08-10 宾夕法尼亚州大学理事会 有效的c3补体抑制素类似物
HUE026001T2 (en) 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system
CA2760839C (en) 2009-05-01 2019-02-12 The Trustees Of The University Of Pennsylvania Modified compstatin with peptide backbone and c-terminal modifications
CA2813049A1 (en) 2010-09-23 2012-03-29 The Trustees Of The University Of Pennsylvania Modified compstatin with improved stability and binding properties
JP2014503592A (ja) 2011-01-26 2014-02-13 ニコ ワールドワイド，インコーポレイテッド 片頭痛の療法
MX356528B (es) 2011-05-11 2018-06-01 Apellis Pharmaceuticals Inc Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y usos de los mismos.
EP3524258B1 (en) 2011-06-22 2025-10-01 Apellis Pharmaceuticals, Inc. Methods of treating chronic disorders with complement inhibitors
CA2847862C (en) 2011-09-07 2021-01-12 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved pharmacokinetic properties
MX366404B (es) 2012-11-15 2019-07-08 Apellis Pharmaceuticals Inc Analogos de compstatina de celula reactiva, de acción prolongada u objetivos y composiciones y metodos relacionados.
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
US10213476B2 (en) 2014-03-17 2019-02-26 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved potency and pharmacokinetic properties
US11903994B2 (en) 2015-10-07 2024-02-20 Apellis Pharmaceuticals, Inc. Dosing regimens
EP3374027B1 (en) * 2015-11-12 2021-06-23 The Trustees of Columbia University in the City of New York Rational drug design targeting resistant gram-negative bacterial infections to polymyxin-class antibiotics
IL269844B2 (en) 2017-04-07 2025-01-01 Apellis Pharmaceuticals Inc Dosage regimens and related compositions and methods
AU2018260628A1 (en) 2017-04-25 2019-12-12 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
WO2019118938A1 (en) 2017-12-15 2019-06-20 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
EP4011905A3 (en) 2018-04-06 2022-06-29 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055518B (it) * 1971-05-18 1982-01-11 Rotta Research Lab Derivatives del triptofano
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics

Also Published As

Publication number Publication date
WO1986003489A1 (en) 1986-06-19
DE3587122T2 (de) 1993-07-15
DK381486D0 (da) 1986-08-11
EP0237522B1 (en) 1993-02-24
IT8468241A0 (it) 1984-12-12
IT8468241A1 (it) 1986-06-12
ES8706630A1 (es) 1987-06-01
JPS62501292A (ja) 1987-05-21
AU5209986A (en) 1986-07-01
US4870097A (en) 1989-09-26
IE58502B1 (en) 1993-10-06
EP0237522A1 (en) 1987-09-23
ES549822A0 (es) 1987-06-01
IE853029L (en) 1986-06-12
CA1256441A (en) 1989-06-27
PT81674B (pt) 1987-10-20
DK168564B1 (da) 1994-04-25
IT1179866B (it) 1987-09-16
DK381486A (da) 1986-08-11
AU589938B2 (en) 1989-10-26
ATE85976T1 (de) 1993-03-15
DE3587122D1 (de) 1993-04-01
PT81674A (en) 1986-01-01

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