DK410681A - Fremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents
Fremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte derafInfo
- Publication number
- DK410681A DK410681A DK410681A DK410681A DK410681A DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A
- Authority
- DK
- Denmark
- Prior art keywords
- addition salts
- acid addition
- acceptable acid
- procedure
- preparation
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- 150000001409 amidines Chemical class 0.000 title 1
- 230000002391 anti-complement effect Effects 0.000 abstract 2
- 108010008730 anticomplement Proteins 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- ULKSSXOMKDEKPC-UHFFFAOYSA-N 6-hydroxynaphthalene-2-carboximidamide Chemical compound C1=C(O)C=CC2=CC(C(=N)N)=CC=C21 ULKSSXOMKDEKPC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000288 anti-kallikrein effect Effects 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- -1 carboxylic acid compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000002753 trypsin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Pyridine Compounds (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Heat Treatment Of Sheet Steel (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Power Steering Mechanism (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12826980A JPS5753454A (en) | 1980-09-16 | 1980-09-16 | Guanidinobenzoate and anticomplementary agent |
| JP12826980 | 1980-09-16 | ||
| JP6494281 | 1981-04-28 | ||
| JP6494281A JPS57179146A (en) | 1981-04-28 | 1981-04-28 | Amidine compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK410681A true DK410681A (da) | 1982-03-17 |
| DK155003B DK155003B (da) | 1989-01-23 |
| DK155003C DK155003C (da) | 1989-05-29 |
Family
ID=26406084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK410681A DK155003C (da) | 1980-09-16 | 1981-09-15 | Analogifremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4454338A (da) |
| EP (1) | EP0048433B1 (da) |
| KR (1) | KR860000264B1 (da) |
| AT (1) | ATE20051T1 (da) |
| AU (1) | AU527371B2 (da) |
| CA (1) | CA1177488A (da) |
| CS (1) | CS228534B2 (da) |
| DD (1) | DD201779A5 (da) |
| DE (1) | DE3174717D1 (da) |
| DK (1) | DK155003C (da) |
| ES (1) | ES505460A0 (da) |
| FI (1) | FI73975C (da) |
| GB (1) | GB2083818B (da) |
| HU (1) | HU185956B (da) |
| NO (1) | NO153568C (da) |
| PH (1) | PH18109A (da) |
| SU (1) | SU1176832A3 (da) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| DE3207033C2 (de) * | 1981-02-27 | 1984-09-13 | Torii & Co., Ltd., Tokyo | Amidinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel |
| JPS57179147A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine derivative |
| JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
| US4818273A (en) * | 1983-11-14 | 1989-04-04 | The Dow Chemical Company | Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides |
| US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
| JPS6133173A (ja) * | 1984-07-25 | 1986-02-17 | Torii Yakuhin Kk | アミジン化合物 |
| GB2162171B (en) * | 1984-07-26 | 1988-01-27 | Torii & Co Ltd | Amidine compounds |
| FR2568253B1 (fr) * | 1984-07-26 | 1987-01-30 | Torii Co | Nouvelle amidine |
| DE3427865A1 (de) * | 1984-07-27 | 1986-02-06 | Torii & Co., Tokio/Tokyo | Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| US4709082A (en) * | 1984-10-25 | 1987-11-24 | Nissan Chemical Industries, Ltd. | 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof |
| EP0284632A1 (en) * | 1987-03-30 | 1988-10-05 | Shosuke Okamoto | Phenylalanine derivative and proteinase inhibitor |
| US4990537A (en) * | 1988-07-11 | 1991-02-05 | Banyu Pharmaceutical Co., Ltd. | Anti influenza agent |
| DE69017627T2 (de) * | 1989-12-28 | 1995-10-26 | Snow Brand Milk Prod Co Ltd | Isochinolinderivate und ihre Salze als Proteasehemmer. |
| US5116985A (en) * | 1989-12-28 | 1992-05-26 | Snow Brand Milk Products Co., Ltd. | Isoquinoline derivatives and salts thereof |
| JPH078789B2 (ja) * | 1990-04-05 | 1995-02-01 | 鳥居薬品株式会社 | 脳血管攣縮治療剤 |
| US5238964A (en) * | 1990-04-05 | 1993-08-24 | Torii & Co., Ltd. | Agent for treatment of cerebrovascular contraction |
| DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| EP0703216B1 (en) * | 1994-09-20 | 1999-04-07 | Ono Pharmaceutical Co., Ltd. | Amidinophenol derivatives as protease inhibitors |
| PL184824B1 (pl) * | 1994-12-02 | 2002-12-31 | Yamanouchi Pharmaceu | Pochodne amidynonaftylowe oraz ich sole oraz kompozycja farmaceutyczna zawierająca pochodną amidynonaftylową lub jej sól |
| US5885990A (en) * | 1995-01-05 | 1999-03-23 | Torii Pharmaceutical Co., Ltd. | Substituted amidinonaphthyl ester derivative |
| EP0893437A4 (en) | 1996-04-10 | 2000-12-27 | Ono Pharmaceutical Co | GUANIDINO TRYPTASE INHIBITOR |
| AU7808198A (en) | 1997-06-03 | 1998-12-21 | Biocryst Pharmaceuticals, Inc. | Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
| EP1030844A1 (en) * | 1997-11-10 | 2000-08-30 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| US6066673A (en) | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
| EA003101B1 (ru) | 1998-03-19 | 2002-12-26 | Бристол-Майерз Сквибб Компани | Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ лечения диабета с помощью этой системы |
| EP1066272A4 (en) * | 1998-03-27 | 2002-03-13 | Biocryst Pharm Inc | NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION |
| EP1073624A1 (en) * | 1998-04-24 | 2001-02-07 | Proteus Molecular Design Limited | Aminomethyl-benzoic ester derivatives as tryptase inhibitors |
| US6362216B1 (en) | 1998-10-27 | 2002-03-26 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| JP2006096668A (ja) * | 2002-11-08 | 2006-04-13 | Ono Pharmaceut Co Ltd | エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬 |
| AU2003299568B2 (en) | 2002-11-27 | 2010-07-22 | Ampio Pharmaceuticals, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
| WO2005030083A2 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize n-acyl-l-aspartic acid |
| EP2143431A1 (en) * | 2005-05-17 | 2010-01-13 | Santen Pharmaceutical Co., Ltd. | Protective agent for neurocyte comprising amidino derivative as active ingredient |
| EP2119439A3 (en) * | 2005-05-17 | 2010-01-27 | Santen Pharmaceutical Co., Ltd. | Angiogenesis inhibitor for treating macular degeneration |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| JPWO2010005087A1 (ja) * | 2008-07-11 | 2012-01-05 | 味の素株式会社 | アミジン誘導体 |
| AU2009305563C1 (en) | 2008-10-17 | 2015-09-03 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| CN102695545B (zh) | 2009-09-08 | 2016-08-17 | 特色疗法股份有限公司 | 包括酶可剪切的酮改性的阿片样物质药物前体以及其可任选的抑制剂的组合物 |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| WO2011133348A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| WO2011133178A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| WO2012006398A2 (en) | 2010-07-09 | 2012-01-12 | Bhv Pharma, Inc. | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
| CA2814763C (en) | 2011-01-11 | 2019-05-28 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| WO2012096886A1 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| US8685916B2 (en) | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
| JP6148182B2 (ja) | 2011-03-09 | 2017-06-14 | シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. | 複素環式リンカーを有する活性薬剤プロドラッグ |
| WO2013039187A1 (ja) | 2011-09-15 | 2013-03-21 | アステラス製薬株式会社 | グアニジノ安息香酸化合物 |
| CN103012214A (zh) * | 2011-09-28 | 2013-04-03 | 南京长澳医药科技有限公司 | 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法 |
| SI2975023T1 (sl) | 2013-03-13 | 2018-10-30 | Takeda Pharmaceutical Company Limited | Spojina ester gvanidinobenzojske kisline |
| CN103641749B (zh) * | 2013-12-02 | 2016-02-10 | 山东永泰化工有限公司 | 一种甲磺酸萘莫司他的制备方法 |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| CN110330447B (zh) * | 2019-07-16 | 2022-04-15 | 北京赛升药业股份有限公司 | 一种甲磺酸萘莫司他中间体的制备方法及其应用 |
| WO2021147272A1 (zh) * | 2020-01-21 | 2021-07-29 | 中国人民解放军军事科学院军事医学研究院 | 苯甲酸酯类化合物在治疗SARS-CoV-2感染方面的应用 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN111574409A (zh) * | 2020-05-14 | 2020-08-25 | 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) | 一种甲磺酸萘莫司他的重结晶工艺方法 |
| MX2024003466A (es) | 2021-09-29 | 2024-06-04 | Ensysce Biosciences Inc | Profarmacos de metadona escindibles por enzimas y metodos de uso de los mismos. |
| CN113999145B (zh) * | 2021-11-12 | 2023-02-03 | 开封明仁药业有限公司 | 一种甲磺酸萘莫司他的合成方法 |
| CA3238128A1 (en) | 2021-12-23 | 2023-06-29 | Subintro Limited | Novel antiviral compositions comprising oleic acid |
| EP4475835A4 (en) * | 2022-02-07 | 2026-01-14 | Council Scient Ind Res | METHOD FOR PREPARING NAFAMOSTAT, CAMOSTAT AND THEIR DERIVATIVES |
| CN118439976A (zh) * | 2024-04-25 | 2024-08-06 | 南京海纳医药科技股份有限公司 | 一种甲磺酸萘莫司他晶型及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD89611A (da) * | ||||
| DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
| GB1472700A (en) * | 1974-11-01 | 1977-05-04 | Ono Pharmaceutical Co | Guanidinobehzoic acid derivatives and process for preparing the same |
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
-
1981
- 1981-09-08 AU AU75062/81A patent/AU527371B2/en not_active Expired
- 1981-09-09 US US06/300,534 patent/US4454338A/en not_active Expired - Lifetime
- 1981-09-10 CA CA000385570A patent/CA1177488A/en not_active Expired
- 1981-09-14 ES ES505460A patent/ES505460A0/es active Granted
- 1981-09-15 NO NO813138A patent/NO153568C/no unknown
- 1981-09-15 PH PH26206A patent/PH18109A/en unknown
- 1981-09-15 DK DK410681A patent/DK155003C/da not_active IP Right Cessation
- 1981-09-15 DE DE8181107274T patent/DE3174717D1/de not_active Expired
- 1981-09-15 HU HU812665A patent/HU185956B/hu unknown
- 1981-09-15 AT AT81107274T patent/ATE20051T1/de not_active IP Right Cessation
- 1981-09-15 EP EP81107274A patent/EP0048433B1/en not_active Expired
- 1981-09-15 GB GB8127837A patent/GB2083818B/en not_active Expired
- 1981-09-15 CS CS816809A patent/CS228534B2/cs unknown
- 1981-09-15 SU SU813384251A patent/SU1176832A3/ru active
- 1981-09-15 KR KR1019810003427A patent/KR860000264B1/ko not_active Expired
- 1981-09-15 FI FI812876A patent/FI73975C/fi not_active IP Right Cessation
- 1981-09-16 DD DD81233339A patent/DD201779A5/de not_active IP Right Cessation
-
1984
- 1984-01-20 US US06/572,269 patent/US4532255A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK155003C (da) | 1989-05-29 |
| NO153568B (no) | 1986-01-06 |
| FI812876L (fi) | 1982-03-17 |
| US4454338A (en) | 1984-06-12 |
| NO153568C (no) | 1986-05-21 |
| PH18109A (en) | 1985-03-22 |
| EP0048433B1 (en) | 1986-05-28 |
| US4532255A (en) | 1985-07-30 |
| ES8206443A1 (es) | 1982-08-16 |
| SU1176832A3 (ru) | 1985-08-30 |
| ATE20051T1 (de) | 1986-06-15 |
| GB2083818A (en) | 1982-03-31 |
| FI73975B (fi) | 1987-08-31 |
| GB2083818B (en) | 1984-05-10 |
| AU7506281A (en) | 1982-03-25 |
| ES505460A0 (es) | 1982-08-16 |
| EP0048433A3 (en) | 1982-07-21 |
| DE3174717D1 (en) | 1986-07-03 |
| CS228534B2 (en) | 1984-05-14 |
| HU185956B (en) | 1985-04-28 |
| CA1177488A (en) | 1984-11-06 |
| FI73975C (fi) | 1987-12-10 |
| KR830007527A (ko) | 1983-10-21 |
| AU527371B2 (en) | 1983-03-03 |
| NO813138L (no) | 1982-03-17 |
| DD201779A5 (de) | 1983-08-10 |
| KR860000264B1 (ko) | 1986-03-22 |
| DK155003B (da) | 1989-01-23 |
| EP0048433A2 (en) | 1982-03-31 |
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