NO153568C - Analogifremgangsmaate for fremstilling av fysiologisk aktive amidinderivater. - Google Patents
Analogifremgangsmaate for fremstilling av fysiologisk aktive amidinderivater.Info
- Publication number
- NO153568C NO153568C NO813138A NO813138A NO153568C NO 153568 C NO153568 C NO 153568C NO 813138 A NO813138 A NO 813138A NO 813138 A NO813138 A NO 813138A NO 153568 C NO153568 C NO 153568C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- physiologically active
- amidino
- amidine derivatives
- analogy procedure
- Prior art date
Links
- 150000001409 amidines Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 230000002391 anti-complement effect Effects 0.000 abstract 2
- 108010008730 anticomplement Proteins 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- ULKSSXOMKDEKPC-UHFFFAOYSA-N 6-hydroxynaphthalene-2-carboximidamide Chemical compound C1=C(O)C=CC2=CC(C(=N)N)=CC=C21 ULKSSXOMKDEKPC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000288 anti-kallikrein effect Effects 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- -1 carboxylic acid compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000002753 trypsin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heat Treatment Of Sheet Steel (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Power Steering Mechanism (AREA)
- Medicinal Preparation (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12826980A JPS5753454A (en) | 1980-09-16 | 1980-09-16 | Guanidinobenzoate and anticomplementary agent |
| JP6494281A JPS57179146A (en) | 1981-04-28 | 1981-04-28 | Amidine compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO813138L NO813138L (no) | 1982-03-17 |
| NO153568B NO153568B (no) | 1986-01-06 |
| NO153568C true NO153568C (no) | 1986-05-21 |
Family
ID=26406084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO813138A NO153568C (no) | 1980-09-16 | 1981-09-15 | Analogifremgangsmaate for fremstilling av fysiologisk aktive amidinderivater. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US4454338A (da) |
| EP (1) | EP0048433B1 (da) |
| KR (1) | KR860000264B1 (da) |
| AT (1) | ATE20051T1 (da) |
| AU (1) | AU527371B2 (da) |
| CA (1) | CA1177488A (da) |
| CS (1) | CS228534B2 (da) |
| DD (1) | DD201779A5 (da) |
| DE (1) | DE3174717D1 (da) |
| DK (1) | DK155003C (da) |
| ES (1) | ES8206443A1 (da) |
| FI (1) | FI73975C (da) |
| GB (1) | GB2083818B (da) |
| HU (1) | HU185956B (da) |
| NO (1) | NO153568C (da) |
| PH (1) | PH18109A (da) |
| SU (1) | SU1176832A3 (da) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| GB2095239B (en) * | 1981-02-27 | 1985-03-06 | Torii & Co Ltd | Novel amidine compounds |
| JPS57179147A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine derivative |
| JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
| US4818273A (en) * | 1983-11-14 | 1989-04-04 | The Dow Chemical Company | Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides |
| US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
| JPS6133173A (ja) * | 1984-07-25 | 1986-02-17 | Torii Yakuhin Kk | アミジン化合物 |
| GB2162171B (en) * | 1984-07-26 | 1988-01-27 | Torii & Co Ltd | Amidine compounds |
| FR2568253B1 (fr) * | 1984-07-26 | 1987-01-30 | Torii Co | Nouvelle amidine |
| DE3427865A1 (de) * | 1984-07-27 | 1986-02-06 | Torii & Co., Tokio/Tokyo | Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel |
| US4709082A (en) * | 1984-10-25 | 1987-11-24 | Nissan Chemical Industries, Ltd. | 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof |
| US4873253A (en) * | 1987-03-30 | 1989-10-10 | Shosuke Okamoto | Phenylalanine derivative and proteinase inhibitor |
| US4990537A (en) * | 1988-07-11 | 1991-02-05 | Banyu Pharmaceutical Co., Ltd. | Anti influenza agent |
| US5116985A (en) * | 1989-12-28 | 1992-05-26 | Snow Brand Milk Products Co., Ltd. | Isoquinoline derivatives and salts thereof |
| ATE119523T1 (de) * | 1989-12-28 | 1995-03-15 | Snow Brand Milk Products Co Ltd | Isochinolinderivate und ihre salze als proteasehemmer. |
| US5238964A (en) * | 1990-04-05 | 1993-08-24 | Torii & Co., Ltd. | Agent for treatment of cerebrovascular contraction |
| JPH078789B2 (ja) * | 1990-04-05 | 1995-02-01 | 鳥居薬品株式会社 | 脳血管攣縮治療剤 |
| DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| ATE178589T1 (de) * | 1994-09-20 | 1999-04-15 | Ono Pharmaceutical Co | Amidinophenol-derivate als protease-hemmende verbindungen |
| DE69529770T2 (de) * | 1994-12-02 | 2003-12-24 | Yamanouchi Pharmaceutical Co., Ltd. | Neues amidinonaphthylderivat oder dessen salz |
| KR100258496B1 (ko) * | 1995-01-05 | 2000-06-15 | 쓰까다 후미끼 | 치환아미디노나프틸에스테르유도체 |
| US6388122B1 (en) | 1996-04-10 | 2002-05-14 | Ono Pharmaceutical Co., Ltd. | Tryptase inhibitor and novel guanidino derivatives |
| US6653340B1 (en) | 1997-06-03 | 2003-11-25 | Biocryst Pharmaceuticals, Inc. | Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
| WO1999024407A1 (en) * | 1997-11-10 | 1999-05-20 | Array Biopharma, Inc. | Compounds which inhibit tryptase activity |
| US6066673A (en) | 1998-03-12 | 2000-05-23 | The Procter & Gamble Company | Enzyme inhibitors |
| EP1063973B1 (en) | 1998-03-19 | 2016-11-16 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
| EP1066272A4 (en) * | 1998-03-27 | 2002-03-13 | Biocryst Pharm Inc | NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION |
| AU3620099A (en) * | 1998-04-24 | 1999-11-16 | Proteus Molecular Design Limited | Aminomethyl-benzoic ester derivatives as tryptase inhibitors |
| US6362216B1 (en) | 1998-10-27 | 2002-03-26 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| JP2006096668A (ja) * | 2002-11-08 | 2006-04-13 | Ono Pharmaceut Co Ltd | エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬 |
| JP5204947B2 (ja) * | 2002-11-27 | 2013-06-05 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | リン酸受容体化合物の使用、ならびにリン酸受容体化合物を含んでいる、薬学的組成物、スキンケア用の組成物、およびキット |
| US20050192348A1 (en) * | 2003-09-25 | 2005-09-01 | David Bar-Or | Methods and products which utilize N-acyl-L-aspartic acid |
| EP1884237B1 (en) * | 2005-05-17 | 2010-12-08 | Santen Pharmaceutical Co., Ltd. | Amidino derivatives for use in the prevention or treatment of glaucoma |
| EP1884236B1 (en) * | 2005-05-17 | 2011-03-02 | Santen Pharmaceutical Co., Ltd. | Angiogenesis inhibitor containing amine derivative as active ingredient |
| GB2445920A (en) * | 2007-01-25 | 2008-07-30 | Mucokinetica Ltd | Amidino compounds for treatment of respiratory disease |
| EP2311810A4 (en) * | 2008-07-11 | 2012-04-04 | Ajinomoto Kk | AMIDINE DERIVATIVE |
| US8802681B2 (en) | 2008-10-17 | 2014-08-12 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| BR112012005124B1 (pt) | 2009-09-08 | 2021-11-09 | Signature Therapeutics, Inc. | Pro-fármaco de opioide modificado por cetona, seu método de preparação, sua composição farmacêutica, sua unidade de dose, métodos e usos |
| US20130059914A1 (en) | 2010-04-21 | 2013-03-07 | Signature Therapeutics, Inc. | Compositions Comprising Enzyme-Cleavable Amphetamine Prodrugs and Inhibitors Thereof |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| CN103153288B (zh) | 2010-07-09 | 2017-02-15 | 詹姆斯·特林卡·格林 | 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统 |
| ES2584634T3 (es) | 2011-01-11 | 2016-09-28 | Signature Therapeutics, Inc. | Composiciones que comprenden un profármaco de oxicodona escindible enzimáticamente |
| WO2012096886A1 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| AU2012225337B2 (en) | 2011-03-09 | 2016-04-28 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| CN103796992B (zh) | 2011-09-15 | 2016-04-27 | 安斯泰来制药株式会社 | 胍基苯甲酸化合物 |
| CN103012214A (zh) * | 2011-09-28 | 2013-04-03 | 南京长澳医药科技有限公司 | 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法 |
| AU2014230583B2 (en) * | 2013-03-13 | 2017-09-28 | Takeda Pharmaceutical Company Limited | Guanidinobenzoic acid ester compound |
| CN103641749B (zh) * | 2013-12-02 | 2016-02-10 | 山东永泰化工有限公司 | 一种甲磺酸萘莫司他的制备方法 |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN110330447B (zh) * | 2019-07-16 | 2022-04-15 | 北京赛升药业股份有限公司 | 一种甲磺酸萘莫司他中间体的制备方法及其应用 |
| WO2021147272A1 (zh) * | 2020-01-21 | 2021-07-29 | 中国人民解放军军事科学院军事医学研究院 | 苯甲酸酯类化合物在治疗SARS-CoV-2感染方面的应用 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| CN111574409A (zh) * | 2020-05-14 | 2020-08-25 | 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) | 一种甲磺酸萘莫司他的重结晶工艺方法 |
| US12599578B2 (en) | 2021-03-09 | 2026-04-14 | Ensysce Biosciences Inc. | Compositions comprising enzyme-cleavable prodrugs and controlled release nafamostat and methods of use thereof |
| MX2024003466A (es) | 2021-09-29 | 2024-06-04 | Ensysce Biosciences Inc | Profarmacos de metadona escindibles por enzimas y metodos de uso de los mismos. |
| CN113999145B (zh) * | 2021-11-12 | 2023-02-03 | 开封明仁药业有限公司 | 一种甲磺酸萘莫司他的合成方法 |
| AU2022422584A1 (en) | 2021-12-23 | 2024-05-30 | Subintro Limited | Novel antiviral compositions comprising oleic acid |
| WO2023148783A1 (en) * | 2022-02-07 | 2023-08-10 | Council Of Scientific & Industrial Research | Process for the preparation of nafamostat, camostat and their derivatives |
| CN118439976A (zh) * | 2024-04-25 | 2024-08-06 | 南京海纳医药科技股份有限公司 | 一种甲磺酸萘莫司他晶型及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD89611A (da) * | ||||
| DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
| GB1472700A (en) * | 1974-11-01 | 1977-05-04 | Ono Pharmaceutical Co | Guanidinobehzoic acid derivatives and process for preparing the same |
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
-
1981
- 1981-09-08 AU AU75062/81A patent/AU527371B2/en not_active Expired
- 1981-09-09 US US06/300,534 patent/US4454338A/en not_active Expired - Lifetime
- 1981-09-10 CA CA000385570A patent/CA1177488A/en not_active Expired
- 1981-09-14 ES ES505460A patent/ES8206443A1/es not_active Expired
- 1981-09-15 DK DK410681A patent/DK155003C/da not_active IP Right Cessation
- 1981-09-15 KR KR1019810003427A patent/KR860000264B1/ko not_active Expired
- 1981-09-15 DE DE8181107274T patent/DE3174717D1/de not_active Expired
- 1981-09-15 GB GB8127837A patent/GB2083818B/en not_active Expired
- 1981-09-15 AT AT81107274T patent/ATE20051T1/de not_active IP Right Cessation
- 1981-09-15 NO NO813138A patent/NO153568C/no unknown
- 1981-09-15 CS CS816809A patent/CS228534B2/cs unknown
- 1981-09-15 FI FI812876A patent/FI73975C/fi not_active IP Right Cessation
- 1981-09-15 EP EP81107274A patent/EP0048433B1/en not_active Expired
- 1981-09-15 SU SU813384251A patent/SU1176832A3/ru active
- 1981-09-15 HU HU812665A patent/HU185956B/hu unknown
- 1981-09-15 PH PH26206A patent/PH18109A/en unknown
- 1981-09-16 DD DD81233339A patent/DD201779A5/de not_active IP Right Cessation
-
1984
- 1984-01-20 US US06/572,269 patent/US4532255A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0048433B1 (en) | 1986-05-28 |
| GB2083818B (en) | 1984-05-10 |
| EP0048433A2 (en) | 1982-03-31 |
| DK155003B (da) | 1989-01-23 |
| HU185956B (en) | 1985-04-28 |
| KR830007527A (ko) | 1983-10-21 |
| AU7506281A (en) | 1982-03-25 |
| PH18109A (en) | 1985-03-22 |
| KR860000264B1 (ko) | 1986-03-22 |
| DK410681A (da) | 1982-03-17 |
| DD201779A5 (de) | 1983-08-10 |
| CS228534B2 (en) | 1984-05-14 |
| AU527371B2 (en) | 1983-03-03 |
| EP0048433A3 (en) | 1982-07-21 |
| CA1177488A (en) | 1984-11-06 |
| ATE20051T1 (de) | 1986-06-15 |
| FI73975C (fi) | 1987-12-10 |
| DK155003C (da) | 1989-05-29 |
| FI812876L (fi) | 1982-03-17 |
| SU1176832A3 (ru) | 1985-08-30 |
| ES505460A0 (es) | 1982-08-16 |
| DE3174717D1 (en) | 1986-07-03 |
| US4532255A (en) | 1985-07-30 |
| NO813138L (no) | 1982-03-17 |
| US4454338A (en) | 1984-06-12 |
| NO153568B (no) | 1986-01-06 |
| FI73975B (fi) | 1987-08-31 |
| GB2083818A (en) | 1982-03-31 |
| ES8206443A1 (es) | 1982-08-16 |
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